{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:49:51Z","timestamp":1777052991773,"version":"3.51.4"},"reference-count":32,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Atypical Parkinsonisms are a diverse group of diseases associated with multiple pathologies, including synucleinopathies and tauopathies. Atypical Parkinsonisms include progressive supranuclear palsy, corticobasal degeneration, multiple system atrophy, and dementia with Lewy bodies. The examination of these diseases is complicated due to their overlapping clinical manifestations. Hence, tools enabling reliable supplementary assessment of atypical Parkinsonisms are needed. The most common methods involve neuroimaging; however, these evaluations generally involve basic magnetic resonance imaging and indicate possible morphological changes. Less attention is given to disease background assessment. Biochemical assessment enables a more detailed examination of the factors impacting neurodegenerative processes. The features that may impact the pathophysiology of these diseases include metabolic abnormalities, excessive inflammation, and environmental factors. In this context, proteomic evaluation, as analyzed in this article, could partly address the insufficiently described aspects of the unclear pathological mechanisms related to atypical Parkinsonisms.<\/jats:p>","DOI":"10.3390\/cells15090759","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:26:18Z","timestamp":1777051578000},"page":"759","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Possible Significance of Proteomics in Understanding Molecular Mechanisms of Progressive Supranuclear Palsy, Corticobasal Degeneration, Multiple System Atrophy, and Dementia with Lewy Bodies"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8685-475X","authenticated-orcid":false,"given":"Natalia","family":"Madetko-Alster","sequence":"first","affiliation":[{"name":"Department of Neurology, Medical University of Warsaw, 03-242 Warszawa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmara","family":"Otto-\u015alusarczyk","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medical University of Warsaw, 02-091 Warszawa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0181-3607","authenticated-orcid":false,"given":"Marta","family":"Struga","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medical University of Warsaw, 02-091 Warszawa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5371-6817","authenticated-orcid":false,"given":"Piotr","family":"Alster","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Warsaw, 03-242 Warszawa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/mds.26987","article-title":"Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria","volume":"32","author":"Respondek","year":"2017","journal-title":"Mov. Disord."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1212\/WNL.0b013e31827f0fd1","article-title":"Criteria for the diagnosis of corticobasal degeneration","volume":"80","author":"Armstrong","year":"2013","journal-title":"Neurology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1002\/mds.29005","article-title":"The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy","volume":"37","author":"Wenning","year":"2022","journal-title":"Mov. Disord."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium","volume":"89","author":"McKeith","year":"2017","journal-title":"Neurology"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Alster, P., Madetko, N., Koziorowski, D., and Friedman, A. (2020). Microglial Activation and Inflammation as a Factor in the Pathogenesis of Progressive Supranuclear Palsy (PSP). Front. Neurosci., 14.","DOI":"10.3389\/fnins.2020.00893"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Le\u0144ska-Mieciek, M., Madetko-Alster, N., Alster, P., Kr\u00f3licki, L., Fiszer, U., and Koziorowski, D. (2023). Inflammation in multiple system atrophy. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1214677"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.parkreldis.2004.01.005","article-title":"Inflammation and neurodegeneration in Parkinson\u2019s disease","volume":"10","author":"McGeer","year":"2004","journal-title":"Park. Relat. Disord."},{"key":"ref_8","first-page":"66","article-title":"Corticobasal degeneration and corticobasal syndrome: A review","volume":"1","author":"Constantinides","year":"2019","journal-title":"Clin. Park. Relat. Disord."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"105698","DOI":"10.1016\/j.nbd.2022.105698","article-title":"Inflammation in dementia with Lewy bodies","volume":"168","author":"Amin","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.1007\/s10072-021-05601-8","article-title":"\u201cParkinson\u2019s disease\u201d on the way to progressive supranuclear palsy: A review on PSP-parkinsonism","volume":"42","author":"Borsek","year":"2021","journal-title":"Neurol. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41531-024-00768-1","article-title":"Serum neurofilament light at diagnosis: A prognostic indicator for accelerated disease progression in Parkinson\u2019s Disease","volume":"10","author":"Pedersen","year":"2024","journal-title":"npj Park. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Madetko-Alster, N., Otto-\u015alusarczyk, D., Wierci\u0144ska-Drapa\u0142o, A., Koziorowski, D., Szlufik, S., Samborska-\u0106wik, J., Struga, M., Friedman, A., and Alster, P. (2023). Clinical Phenotypes of Progressive Supranuclear Palsy\u2014The Differences in Interleukin Patterns. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242015135"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1038\/s41598-024-53355-y","article-title":"The significance of glial cell line-derived neurotrophic factor analysis in Progressive Supranuclear Palsy","volume":"14","author":"Alster","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"148","DOI":"10.5603\/PJNNS.a2022.0014","article-title":"Platelet-to-lymphocyte ratio and neutrophil-tolymphocyte ratio may reflect differences in PD and MSA-P neuroinflammation patterns","volume":"56","author":"Madetko","year":"2022","journal-title":"Neurol. Neurochir. Polska"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.5603\/PJNNS.a2020.0097","article-title":"Neutrophil-to-lymphocyte ratio (NLR) at boundaries of Progressive Supranuclear Palsy Syndrome (PSPS) and Corticobasal Syndrome (CBS)","volume":"55","author":"Alster","year":"2021","journal-title":"Neurol. Neurochir. Polska"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e209585","DOI":"10.1212\/WNL.0000000000209585","article-title":"CSF Proteomics in Patients with Progressive Supranuclear Palsy","volume":"103","author":"Wise","year":"2024","journal-title":"Neurology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1007\/s12035-024-04422-y","article-title":"Brain Proteome Profiling Reveals Common and Divergent Signatures in Parkinson\u2019s Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy","volume":"62","author":"Dick","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e1076","DOI":"10.1002\/ctm2.1076","article-title":"Mass spectrometry-based proteomics analysis of human globus pallidus from progressive supranuclear palsy patients discovers multiple disease pathways","volume":"12","author":"Jang","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12014-024-09507-3","article-title":"Biomarker discovery in progressive supranuclear palsy from human cerebrospinal fluid","volume":"21","author":"Jang","year":"2024","journal-title":"Clin. Proteom."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e70116","DOI":"10.1002\/alz.70116","article-title":"Novel blood-based proteomic signatures across multiple neurodegenerative diseases","volume":"21","author":"Durcan","year":"2025","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s00018-022-04378-z","article-title":"Brain proteome profiling implicates the complement and coagulation cascade in multiple system atrophy brain pathology","volume":"79","author":"Rydbirk","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Smandzich, N.J., Pich, A., Gschwendtberger, T., Greten, S., Ye, L., Klietz, M., Di Fonzo, A., Henkel, L.M., and Wegner, F. (2025). Proteomics of Patient-Derived Striatal Medium Spiny Neurons in Multiple System Atrophy. Cells, 14.","DOI":"10.3390\/cells14171394"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1176\/jnp.17.3.364","article-title":"Proteomic Analysis of Corticobasal Degeneration: A Case Study of Corticobasal Degeneration at the Proteome Level","volume":"17","author":"Chen","year":"2005","journal-title":"J Neuropsychiatry Clin. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e14375","DOI":"10.1002\/alz.14375","article-title":"Proteomic signatures of Alzheimer\u2019s disease and Lewy body dementias: A comparative analysis","volume":"21","author":"Branca","year":"2025","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.1038\/s41467-023-41122-y","article-title":"CSF proteome profiling reveals biomarkers to discriminate dementia with Lewy bodies from Alzheimer\u00b4s disease","volume":"14","author":"Vermunt","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0896-6273(00)80782-5","article-title":"Synaptic Clustering of AMPA Receptors by the Extracellular Immediate-Early Gene Product Narp","volume":"23","author":"Xu","year":"1999","journal-title":"Neuron"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.neuron.2015.02.020","article-title":"Pentraxins Coordinate Excitatory Synapse Maturation and Circuit Integration of Parvalbumin Interneurons","volume":"85","author":"Pelkey","year":"2015","journal-title":"Neuron"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e200365","DOI":"10.1212\/CPJ.0000000000200365","article-title":"Corticobasal Syndrome: Are There Central or Peripheral Triggers?","volume":"15","author":"Lenka","year":"2025","journal-title":"Neurol Clin Pract."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Koziorowski, D., Figura, M., Milanowski, \u0141.M., Szlufik, S., Alster, P., Madetko, N., and Friedman, A. (2021). Mechanisms of Neurodegeneration in Various Forms of Parkinsonism\u2014Similarities and Differences. Cells, 10.","DOI":"10.3390\/cells10030656"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Arias-Carri\u00f3n, O., Romero-Guti\u00e9rrez, E., and Ortega-Robles, E. (2025). Toward Biology-Driven Diagnosis of Atypical Parkinsonian Disorders. NeuroSci, 6.","DOI":"10.20944\/preprints202509.1299.v1"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/ene.13412","article-title":"Atypical parkinsonian syndromes: A general neurologist\u2019s perspective","volume":"25","author":"Ross","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4103\/aian.AIAN_611_20","article-title":"Subtypes of PSP and Prognosis: A Retrospective Analysis","volume":"24","author":"Mahale","year":"2021","journal-title":"Ann. Indian Acad. Neurol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/9\/759\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:30:24Z","timestamp":1777051824000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/9\/759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":32,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["cells15090759"],"URL":"https:\/\/doi.org\/10.3390\/cells15090759","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]}}}