{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:22:28Z","timestamp":1785424948822,"version":"3.56.0"},"reference-count":27,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/18\/1\/33234"],"award-info":[{"award-number":["FS\/18\/1\/33234"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/17\/60\/33474"],"award-info":[{"award-number":["FS\/17\/60\/33474"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["AA\/18\/1\/34219"],"award-info":[{"award-number":["AA\/18\/1\/34219"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"award":["FS\/18\/1\/33234"],"award-info":[{"award-number":["FS\/18\/1\/33234"]}],"id":[{"id":"https:\/\/ror.org\/02wdwnk04","id-type":"ROR","asserted-by":"publisher"}]},{"award":["FS\/17\/60\/33474"],"award-info":[{"award-number":["FS\/17\/60\/33474"]}],"id":[{"id":"https:\/\/ror.org\/02wdwnk04","id-type":"ROR","asserted-by":"publisher"}]},{"award":["AA\/18\/1\/34219"],"award-info":[{"award-number":["AA\/18\/1\/34219"]}],"id":[{"id":"https:\/\/ror.org\/02wdwnk04","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Myocardial infarction (MI) triggers a robust inflammatory response that is essential for tissue repair but, when excessive or prolonged, drives pathological cardiac remodelling and heart failure. Colony-stimulating factor 2 (CSF2) signalling has been implicated in driving pro-inflammatory macrophage activation post-MI. Here, we investigated the role of macrophage-specific CSF2 receptor alpha (CSF2RA) signalling in post-MI remodelling using a tamoxifen-inducible genetic mouse model and permanent coronary artery ligation. Macrophage-specific Csf2ra deficiency significantly improved left ventricular systolic function post-MI without altering cardiac fibrosis burden. Functional improvement was associated with enhanced collagen scar maturation, characterised by an increased proportion of mature collagen fibres, and with accumulation of anti-inflammatory, pro-reparative macrophages within the infarct. These macrophage changes were accompanied by increased fibroblast density, consistent with altered macrophage\u2013fibroblast crosstalk. Collectively, these findings identify macrophage-intrinsic CSF2RA signalling as a critical regulator of inflammatory resolution and scar maturation after MI and provide mechanistic support for the rationale of selective CSF2RA inhibition as a therapeutic strategy to limit adverse cardiac remodelling and improve post-infarction recovery.<\/jats:p>","DOI":"10.3390\/cells15090764","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:26:18Z","timestamp":1777051578000},"page":"764","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Deficiency of the Macrophage Csf2ra Receptor Modulates Inflammatory Responses Following Cardiac Ischaemic Injury in Mice"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1198-3484","authenticated-orcid":false,"given":"Georgios","family":"Kremastiotis","sequence":"first","affiliation":[{"name":"Laboratory of Cardiovascular Pathology, Bristol Medical School, Faculty of Health & Life Sciences, University of Bristol, Bristol BS2 8HW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6266-8717","authenticated-orcid":false,"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pathology, Bristol Medical School, Faculty of Health & Life Sciences, University of Bristol, Bristol BS2 8HW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4255-4488","authenticated-orcid":false,"given":"Andrew","family":"Bond","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pathology, Bristol Medical School, Faculty of Health & Life Sciences, University of Bristol, Bristol BS2 8HW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daire","family":"Shanahan","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pathology, Bristol Medical School, Faculty of Health & Life Sciences, University of Bristol, Bristol BS2 8HW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6152-369X","authenticated-orcid":false,"given":"Karina","family":"Di Gregoli","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pathology, Bristol Medical School, Faculty of Health & Life Sciences, University of Bristol, Bristol BS2 8HW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair W.","family":"Poole","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pathology, Bristol Medical School, Faculty of Health & Life Sciences, University of Bristol, Bristol BS2 8HW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1426-8257","authenticated-orcid":false,"given":"Sarah J.","family":"George","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pathology, Bristol Medical School, Faculty of Health & Life Sciences, University of Bristol, Bristol BS2 8HW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0630-9183","authenticated-orcid":false,"given":"Jason L.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pathology, Bristol Medical School, Faculty of Health & Life Sciences, University of Bristol, Bristol BS2 8HW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"ref_1","first-page":"e41","article-title":"2025 Heart Disease and Stroke Statistics: A Report of US and Global Data from the American Heart Association","volume":"151","author":"Martin","year":"2025","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1161\/CIRCULATIONAHA.108.784215","article-title":"Long-term trends in the incidence of heart failure after myocardial infarction","volume":"118","author":"Velagaleti","year":"2008","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Sulo, G., Igland, J., Vollset, S.E., Nyg\u00e5rd, O., Ebbing, M., Sulo, E., Egeland, G.M., and Tell, G.S. 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