{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:05:47Z","timestamp":1779692747579,"version":"3.53.1"},"reference-count":124,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Endothelial cell activation is one of the major pathophysiological aspects of sickle cell disease (SCD). In this review, we discuss the interaction of endothelial cells of various tissue beds, highlighting the specific biomarkers linked to endothelial cell activation and damage, and elaborate on endothelial cells\u2019 role in the development of acute and chronic organ damage in SCD using existing clinical and preclinical data. Finally, we focus on liver sinusoidal endothelial cells (LSECs) and their role in hemoglobin scavenging, sterile inflammation, and organ damage in SCD, as well as potential therapeutic strategies to reverse organ damage induced by LSEC dysfunction in SCD.<\/jats:p>","DOI":"10.3390\/cells15090846","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T13:23:37Z","timestamp":1777987417000},"page":"846","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Understanding Sickle Cell Disease Endothelial Pathology Through the Lens of Liver Sinusoidal Endothelial Cells"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8763-4844","authenticated-orcid":false,"given":"Tirthadipa","family":"Pradhan-Sundd","sequence":"first","affiliation":[{"name":"Thrombosis and Hemostasis Research Program, Versiti Blood Research Institute, Milwaukee, WI 53226, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4076-270X","authenticated-orcid":false,"given":"Brian","family":"Branchford","sequence":"additional","affiliation":[{"name":"Thrombosis and Hemostasis Research Program, Versiti Blood Research Institute, Milwaukee, WI 53226, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7903-944X","authenticated-orcid":false,"given":"Joan","family":"Beckman","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"18010","DOI":"10.1038\/nrdp.2018.10","article-title":"Sickle cell disease","volume":"4","author":"Kato","year":"2018","journal-title":"Nat. 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