{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:05:57Z","timestamp":1779692757216,"version":"3.53.1"},"reference-count":173,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Supplemental oxygen is a cornerstone intervention in modern clinical practice, widely used to correct hypoxemia in emergency, perioperative, and critical care settings. While oxygen therapy is lifesaving, accumulating evidence indicates that excessive oxygen exposure can induce significant pathophysiological disturbances, particularly within the cardiovascular and pulmonary systems. Hyperoxia (PaO2 &gt; 100 mm Hg) promotes the generation of reactive oxygen species (ROS), leading to oxidative stress, mitochondrial dysfunction, and the activation of pro-fibrotic pathways. When combined with mechanical ventilation, these effects are further amplified through alterations in intrathoracic pressure, reduced venous return, and increased pulmonary vascular resistance, collectively imposing hemodynamic stress on the myocardium. These mechanical and biochemical perturbations converge to drive structural, functional, and electrical remodeling of the heart, including conduction abnormalities and arrhythmogenesis. Emerging clinical insights, particularly from critically ill and COVID-19 populations, underscore the importance of titrated oxygen strategies that balance adequate tissue oxygenation with minimization of hyperoxic injury. This review synthesizes current evidence on hyperoxia-induced oxidative stress, heart-lung interactions, and mechanisms underlying myocardial remodeling to provide a comprehensive framework for optimizing oxygen therapy.<\/jats:p>","DOI":"10.3390\/cells15100871","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T06:42:18Z","timestamp":1779691338000},"page":"871","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Supplemental Oxygen on Cardiovascular Physiology"],"prefix":"10.3390","volume":"15","author":[{"given":"Drithi","family":"Chidanand","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Cheruku","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi Sree","family":"Perla","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adhira","family":"Darapaneni","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4242-8537","authenticated-orcid":false,"given":"Siva Kumar","family":"Panguluri","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA"},{"name":"Department of Cell Biology, Microbiology and Molecular Biology, College of Arts and Sciences, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104393","DOI":"10.1016\/j.amsu.2022.104393","article-title":"Hyperoxia in the management of respiratory failure: A literature review","volume":"81","author":"Lius","year":"2022","journal-title":"Ann. Med. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.ccc.2022.06.010","article-title":"Oxygen as an Essential Medicine","volume":"38","author":"Mart","year":"2022","journal-title":"Crit. Care Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"6653","DOI":"10.2741\/3179","article-title":"Molecular mechanisms of hyperoxia-induced acute lung injury","volume":"13","author":"Bhandari","year":"2008","journal-title":"Front. Biosci."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Busani, S., Sarti, M., Serra, F., Gelmini, R., Venturelli, S., Munari, E., and Girardis, M. (2021). Revisited Hyperoxia Pathophysiology in the Perioperative Setting: A Narrative Review. Front. Med., 8.","DOI":"10.3389\/fmed.2021.689450"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.taap.2014.10.019","article-title":"High level of oxygen treatment causes cardiotoxicity with arrhythmias and redox modulation","volume":"282","author":"Chapalamadugu","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"969","DOI":"10.2147\/CIA.S521584","article-title":"Normobaric Hyperoxia Therapy in Treating Stroke","volume":"20","author":"Duan","year":"2025","journal-title":"Clin. Interv. Aging"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1164\/rccm.202102-0417CI","article-title":"Oxygen Toxicity in Critically Ill Adults","volume":"204","author":"Hochberg","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1152\/japplphysiol.00021.2022","article-title":"Supplemental Oxygen Administration during Mechanical Ventilation Reduces Diaphragm Blood Flow and Oxygen Delivery","volume":"132","author":"Horn","year":"2022","journal-title":"J. Appl. Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.bjae.2019.02.005","article-title":"Hyperoxia in anaesthesia and intensive care","volume":"19","author":"Horncastle","year":"2019","journal-title":"BJA Educ."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/cc5704","article-title":"Hyperoxia increases ventilator-induced lung injury via mitogen-activated protein kinases: A prospective, controlled animal experiment","volume":"11","author":"Li","year":"2007","journal-title":"Crit. Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40635-023-00501-x","article-title":"Effect of low-to-moderate hyperoxia on lung injury in preclinical animal models: A systematic review and meta-analysis","volume":"11","author":"Minkove","year":"2023","journal-title":"Intensiv. Care Med. Exp."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1186\/s13054-021-03815-y","article-title":"Dangers of hyperoxia","volume":"25","author":"Singer","year":"2021","journal-title":"Crit. Care"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"112435","DOI":"10.1016\/j.exger.2024.112435","article-title":"Influence of age and sex on physical, cardiac electrical and functional alterations in progressive hyperoxia treatment: A time course study in a murine model","volume":"191","author":"Ayalasomayajula","year":"2024","journal-title":"Exp. Gerontol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"23086","DOI":"10.1038\/s41598-021-02550-2","article-title":"The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice","volume":"11","author":"Bojkovic","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"H1651","DOI":"10.1152\/ajpheart.00474.2012","article-title":"Hyperoxia-induced hypertrophy and ion channel remodeling in left ventricle","volume":"304","author":"Panguluri","year":"2013","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"12595","DOI":"10.1002\/jcp.28136","article-title":"Impact of hyperoxia on cardiac pathophysiology","volume":"234","author":"Rodgers","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1002\/jcp.27010","article-title":"Sex differences in murine cardiac pathophysiology with hyperoxia exposure","volume":"234","author":"Rodgers","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00380-017-1100-6","article-title":"Hyperoxia-induced cardiotoxicity and ventricular remodeling in type-II diabetes mice","volume":"33","author":"Rodgers","year":"2018","journal-title":"Heart Vessel."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1002\/jcp.30165","article-title":"Electrical remodeling and cardiotoxicity precedes structural and functional remodeling of mouse hearts under hyperoxia treatment","volume":"236","author":"Rodgers","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Saleem, F., Mansour, N., Vichare, R., Ayalasomayajula, Y., Yassine, J., Hesaraghatta, A., and Panguluri, S.K. (2023). Influence of Age on Hyperoxia-Induced Cardiac Pathophysiology in Type 1 Diabetes Mellitus (T1DM) Mouse Model. Cells, 12.","DOI":"10.3390\/cells12111457"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"111727","DOI":"10.1016\/j.mad.2022.111727","article-title":"Impact of age and sex on hyperoxia-induced cardiovascular pathophysiology","volume":"208","author":"Vichare","year":"2022","journal-title":"Mech. Ageing Dev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1002\/jcp.26263","article-title":"Elevated potassium outward currents in hyperoxia treated atrial cardiomyocytes","volume":"233","author":"Vysotskaya","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jcrc.2017.02.031","article-title":"Hyperoxia: At what level of SpO2 is a patient safe? A study in mechanically ventilated ICU patients","volume":"39","author":"Durlinger","year":"2017","journal-title":"J. Crit. Care"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.redox.2015.08.020","article-title":"Reperfusion injury and reactive oxygen species: The evolution of a concept","volume":"6","author":"Granger","year":"2015","journal-title":"Redox Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"349","DOI":"10.21037\/atm.2018.04.29","article-title":"Heart-lung interactions during mechanical ventilation: The basics","volume":"6","author":"Mahmood","year":"2018","journal-title":"Ann. Transl. Med."},{"key":"ref_26","unstructured":"Weekley, M.S., Lobo, C.M., and Bland, L.E. (2025). Oxygen Administration. Statpearls, StatPearls Publishing."},{"key":"ref_27","unstructured":"Fuentes, S., and Chowdhury, Y.S. (2025). Fraction of Inspired Oxygen. Statpearls, StatPearls Publishing."},{"key":"ref_28","first-page":"837","article-title":"Noninvasive Ventilation in Acute Respiratory Failure","volume":"9","author":"Mas","year":"2014","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2101574","DOI":"10.1183\/13993003.01574-2021","article-title":"ERS clinical practice guidelines: High-flow nasal cannula in acute respiratory failure","volume":"59","author":"Oczkowski","year":"2022","journal-title":"Eur. Respir. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"102","DOI":"10.4187\/respcare.09540102","article-title":"The Physiologic Effects of Noninvasive Ventilation","volume":"54","author":"Kallet","year":"2009","journal-title":"Respir. Care"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/0140-6736(92)90288-E","article-title":"Effects of increased inspired oxygen concentrations on exercise performance in chronic heart failure","volume":"339","author":"Moore","year":"1992","journal-title":"Lancet"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0735-1097(95)00474-2","article-title":"Hemodynamic effects of supplemental oxygen administration in congestive heart failure","volume":"27","author":"Haque","year":"1996","journal-title":"JACC"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1172\/JCI104454","article-title":"Effects of Oxygen Breathing on the Heart Rate, Blood Pressure, and Cardiac Index of Normal Men--Resting, with Reactive Hyperemia, and after Atropine","volume":"41","author":"Daly","year":"1962","journal-title":"J. Clin. Investig."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"L1150","DOI":"10.1152\/ajplung.2001.281.5.L1150","article-title":"Hyperoxia increases leptin production: A mechanism mediated through endogenous elevation of corticosterone","volume":"281","author":"Muzzin","year":"2001","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"453","DOI":"10.21037\/atm.2017.10.15","article-title":"Relationship between hyperoxemia and ventilator associated pneumonia","volume":"5","author":"Jaffal","year":"2017","journal-title":"Ann. Transl. Med."},{"key":"ref_36","first-page":"236","article-title":"Pulmonary atelectasis in anaesthesia and critical care","volume":"14","author":"Ray","year":"2014","journal-title":"Contin. Educ. Anaesth. Crit. Care Pain"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.chest.2016.09.001","article-title":"Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine","volume":"151","author":"Wu","year":"2017","journal-title":"Chest"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1152\/advan.00190.2016","article-title":"Cardiopulmonary physiology: Why the heart and lungs are inextricably linked","volume":"41","author":"Verhoeff","year":"2017","journal-title":"Adv. Physiol. Educ."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Femine, F.C.D., D\u2019arienzo, D., Liccardo, B., Pastore, M.C., Ilardi, F., Mandoli, G.E., Sperlongano, S., Malagoli, A., Lisi, M., and Benfari, G. (2024). Echocardiography in the Ventilated Patient: What the Clinician Has to Know. J. Clin. Med., 14.","DOI":"10.3390\/jcm14010077"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/adc.80.5.475","article-title":"Cardiovascular Effects of Mechanical Ventilation","volume":"80","author":"Shekerdemian","year":"1999","journal-title":"Arch. Dis. Child"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"350","DOI":"10.21037\/atm.2018.05.27","article-title":"Determinants of systemic venous return and the impact of positive pressure ventilation","volume":"6","author":"Berger","year":"2018","journal-title":"Ann. Transl. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1097\/CCM.0000000000000345","article-title":"Mechanical Ventilation-Induced Intrathoracic Pressure Distribution and Heart-Lung Interactions","volume":"42","author":"Lansdorp","year":"2014","journal-title":"Crit. Care Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.yjmcc.2020.03.007","article-title":"Intact myocardial preparations reveal intrinsic transmural heterogeneity in cardiac mechanics","volume":"141","author":"Pitoulis","year":"2020","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Tsuda, T. (2021). Clinical Assessment of Ventricular Wall Stress in Understanding Compensatory Hypertrophic Response and Maladaptive Ventricular Remodeling. J. Cardiovasc. Dev. Dis., 8.","DOI":"10.3390\/jcdd8100122"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00424-011-0951-4","article-title":"Mechanotransduction: The role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function","volume":"462","author":"McCain","year":"2011","journal-title":"Pfl\u00fcgers Arch. Eur. J. Physiol."},{"key":"ref_46","first-page":"9","article-title":"Molecular candidates for cardiac stretch-activated ion channels","volume":"2014","author":"Reed","year":"2014","journal-title":"Glob. Cardiol. Sci. Pract."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Tan, P.M., Buchholz, K.S., Omens, J.H., McCulloch, A.D., and Saucerman, J.J. (2017). Predictive model identifies key network regulators of cardiomyocyte mechano-signaling. PLoS Comput. Biol., 13.","DOI":"10.1371\/journal.pcbi.1005854"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1074\/jbc.M112.429449","article-title":"Transcriptional Regulation Patterns Revealed by High Resolution Chromatin Immunoprecipitation during Cardiac Hypertrophy","volume":"288","author":"Sayed","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.1038\/s41598-018-23042-w","article-title":"Mechanical stretch induced transcriptomic profiles in cardiac myocytes","volume":"8","author":"Tokola","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1113\/jphysiol.2012.233015","article-title":"A murine experimental model for the mechanical behaviour of viable right-ventricular myocardium","volume":"590","author":"Simon","year":"2012","journal-title":"J. Physiol."},{"key":"ref_51","unstructured":"Widrich, J., and Shetty, M. (2025). Physiology, Pulmonary Vascular Resistance. Statpearls, StatPearls Publishing."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"w14491","DOI":"10.4414\/smw.2017.14491","article-title":"Basic concepts of heart-lung interactions during mechanical ventilation","volume":"147","author":"Wigger","year":"2017","journal-title":"Swiss Med. Wkly."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Pan, P., Li, L., Xie, F., Hu, X., Guo, Y., Xie, L., and Su, L. (2023). Physiological Regulation of Pulmonary Microcirculation under Mechanical Ventilation at Different Cardiac Outputs and Positive End-Expiratory Pressures in a Porcine Model. J. Pers. Med., 13.","DOI":"10.3390\/jpm13010107"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2045894019895420","DOI":"10.1177\/2045894019895420","article-title":"Echocardiographic estimation of right ventricular wall tension: Haemodynamic comparison and long-term follow-up","volume":"9","author":"Annone","year":"2019","journal-title":"Pulm. Circ."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/1074248406298293","article-title":"Pathophysiological Basis of Right Ventricular Remodeling","volume":"12","author":"Kret","year":"2007","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"568095","DOI":"10.4061\/2011\/568095","article-title":"Right Ventricular Dysfunction and Failure in Chronic Pressure Overload","volume":"2011","author":"Simon","year":"2011","journal-title":"Cardiol. Res. Pract."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1093\/cvr\/cvx160","article-title":"The overloaded right heart and ventricular interdependence","volume":"113","author":"Naeije","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Petit, M., and Vieillard-Baron, A. (2023). Ventricular interdependence in critically ill patients: From physiology to bedside. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1232340"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1161\/CIRCIMAGING.116.004612","article-title":"Impact of Pulmonary Hemodynamics and Ventricular Interdependence on Left Ventricular Diastolic Function in Children with Pulmonary Hypertension","volume":"9","author":"Burkett","year":"2016","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1172\/JCI69830","article-title":"Myocardial stress and hypertrophy: A complex interface between biophysics and cardiac remodeling","volume":"123","author":"Grossman","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00000542-198902000-00011","article-title":"Changes in Muscle Sympathetic Nerve Activity, Venous Plasma Catecholamines, and Calf Vascular Resistance during Mechanical Ventilation with PEEP in Humans","volume":"70","author":"Wallin","year":"1989","journal-title":"Anesthesiology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s10741-007-9007-4","article-title":"Cardiac hypertrophy induced by sustained \u03b2-adrenoreceptor activation: Pathophysiological aspects","volume":"12","author":"Osadchii","year":"2007","journal-title":"Heart Fail. Rev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1073\/pnas.97.2.931","article-title":"Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling","volume":"97","author":"Paradis","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s000590050024","article-title":"Aldosterone and Myocardial Fibrosis in Heart Failure","volume":"25","author":"Brilla","year":"2000","journal-title":"Herz"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1161\/HYPERTENSIONAHA.118.11065","article-title":"Role of Renin-Angiotensin-Aldosterone System Activation in Promoting Cardiovascular Fibrosis and Stiffness","volume":"72","author":"Jia","year":"2018","journal-title":"Hypertension"},{"key":"ref_66","first-page":"E233","article-title":"Scai\/Hfsa Clinical Expert Consensus Document on the Use of Invasive Hemodynamics for the Diagnosis and Management of Cardiovascular Disease","volume":"89","author":"Sorajja","year":"2017","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Xingzheng, L., Weiguang, G., Quanqiu, Y., Huifen, Z., Zijun, Z., Qiming, Z., Suhua, Y., Fu, Z., and Zhigang, J. (2024). The impact of positive end-expiratory pressure on right ventricular function in patients with moderate-to-severe ARDS: A prospective paired-design study. Front. Med., 11.","DOI":"10.3389\/fmed.2024.1424090"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1164\/rccm.201611-2268OC","article-title":"Adverse Heart\u2013Lung Interactions in Ventilator-induced Lung Injury","volume":"196","author":"Katira","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1146\/annurev.physiol.68.072304.113443","article-title":"The Contribution of Biophysical Lung Injury to the Development of Biotrauma","volume":"68","author":"Slutsky","year":"2006","journal-title":"Annu. Rev. Physiol."},{"key":"ref_70","first-page":"519","article-title":"Role of Inflammation and Apoptosis in Right Ventricular Dysfunction Induced by Injurious Mechanical Ventilation in Rats","volume":"34","author":"Liu","year":"2022","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1161\/CIRCRESAHA.110.226928","article-title":"Multiple Facets of Nf-\u039ab in the Heart: To Be or Not to Nf-\u039ab","volume":"108","author":"Gordon","year":"2011","journal-title":"Circ. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1161\/01.RES.75.1.23","article-title":"Alterations in cardiac gene expression during the transition from stable hypertrophy to heart failure. Marked upregulation of genes encoding extracellular matrix components","volume":"75","author":"Boluyt","year":"1994","journal-title":"Circ. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e004965","DOI":"10.1161\/JAHA.116.004965","article-title":"Intracellular Angiotensin-II Interacts with Nuclear Angiotensin Receptors in Cardiac Fibroblasts and Regulates RNA Synthesis, Cell Proliferation, and Collagen Secretion","volume":"6","author":"Tadevosyan","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1016\/j.jacc.2020.03.019","article-title":"Myocardial Interstitial Fibrosis in Nonischemic Heart Disease, Part 3\/4","volume":"75","author":"Kovacic","year":"2020","journal-title":"JACC"},{"key":"ref_75","first-page":"273","article-title":"Animal models of cardiac fibrosis","volume":"117","author":"Sun","year":"2005","journal-title":"Methods Mol. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s00059-002-2354-y","article-title":"Cardiac fibrosis as a cause of diastolic dysfunction","volume":"27","author":"Burlew","year":"2002","journal-title":"Herz"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1076-7460.2004.00059.x","article-title":"Diastolic Dysfunction in the Elderly\u2014The Interstitial Issue","volume":"13","author":"Burlew","year":"2004","journal-title":"Am. J. Geriatr. Cardiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"101674","DOI":"10.1016\/j.redox.2020.101674","article-title":"Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement","volume":"37","author":"Braganza","year":"2020","journal-title":"Redox Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1093\/cvr\/cvae231","article-title":"Advances in myocardial energy metabolism: Metabolic remodelling in heart failure and beyond","volume":"120","author":"Sun","year":"2024","journal-title":"Cardiovasc. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1042\/bj3540539","article-title":"The effect of Mg2+ on cardiac muscle function: Is CaATP the substrate for priming myofibril cross-bridge formation and Ca2+ reuptake by the sarcoplasmic reticulum?","volume":"354","author":"Smith","year":"2001","journal-title":"Biochem. J."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/eurheartj\/11.suppl_C.30","article-title":"Diastolic Dysfunction and Myocardial Energetics","volume":"11","author":"Pouleur","year":"1990","journal-title":"Eur. Heart J."},{"key":"ref_82","first-page":"e96184","article-title":"Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation","volume":"2","author":"Nabeebaccus","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1089\/ars.2013.5724","article-title":"Myofibroblast Differentiation: Main Features, Biomedical Relevance, and the Role of Reactive Oxygen Species","volume":"21","author":"Siani","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Shaito, A., Aramouni, K., Assaf, R., Parenti, A., Orekhov, A., El Yazbi, A., Pintus, G., and Eid, A.H. (2022). Oxidative Stress-Induced Endothelial Dysfunction in Cardiovascular Diseases. Front. Biosci., 27.","DOI":"10.31083\/j.fbl2703105"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Thomas, T.P., and Grisanti, L.A. (2020). The Dynamic Interplay Between Cardiac Inflammation and Fibrosis. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.529075"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1113\/JP271477","article-title":"Nature versus exposure: Matched exposure to circulatory stressors of different natures elicits adaptive remodelling","volume":"593","author":"Wright","year":"2015","journal-title":"J. Physiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1378\/chest.08-0492","article-title":"The Right Ventricle under Pressure: Cellular and Molecular Mechanisms of Right-Heart Failure in Pulmonary Hypertension","volume":"135","author":"Bogaard","year":"2009","journal-title":"Chest"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1161\/CIRCHEARTFAILURE.112.969279","article-title":"Troponin T and Plasma Collagen Peptides in Heart Failure","volume":"5","author":"Florea","year":"2012","journal-title":"Circ. Heart Fail."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/ejhf.2085","article-title":"Dynamics of myocardial fibrosis after left ventricular assist device implantation: Should speeding up the scar have us scared stiff?","volume":"23","author":"Asleh","year":"2021","journal-title":"Eur. J. Heart Fail."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1161\/CIRCHEARTFAILURE.114.001297","article-title":"Cardiomyocyte p65 Nuclear Factor-\u03baB Is Necessary for Compensatory Adaptation to Pressure Overload","volume":"8","author":"Javan","year":"2015","journal-title":"Circ. Heart Fail."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1378\/chest.12-1849","article-title":"Monitoring Tissue Perfusion, Oxygenation, and Metabolism in Critically Ill Patients","volume":"143","author":"Ekbal","year":"2013","journal-title":"Chest"},{"key":"ref_92","first-page":"36","article-title":"Hemodynamic monitoring in the mechanically ventilated patient","volume":"17","author":"Magder","year":"2011","journal-title":"Curr. Opin. Crit. Care"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1055\/s-0042-1744447","article-title":"Physiological and Pathophysiological Consequences of Mechanical Ventilation","volume":"43","author":"Silva","year":"2022","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1152\/ajplegacy.1957.189.3.609","article-title":"Venous Return at Various Right Atrial Pressures and the Normal Venous Return Curve","volume":"189","author":"Guyton","year":"1957","journal-title":"Am. J. Physiol. Content"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/00000542-196609000-00009","article-title":"Hemodynamic Effects of Intermittent Positive Pressure Respiration","volume":"27","author":"Morgan","year":"1966","journal-title":"Anesthesiology"},{"key":"ref_96","unstructured":"LaCombe, P., Jose, A., Basit, H., and Lappin, S.L. (2025). Physiology, Starling Relationships. Statpearls, StatPearls Publishing."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s00134-016-4326-3","article-title":"Experts\u2019 opinion on management of hemodynamics in ARDS patients: Focus on the effects of mechanical ventilation","volume":"42","author":"Matthay","year":"2016","journal-title":"Intensiv. Care Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1111\/aas.12581","article-title":"Microcirculatory dysfunction and tissue oxygenation in critical illness","volume":"59","author":"Granfeldt","year":"2015","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_99","first-page":"1100","article-title":"The Hemodynamic Consequences of Mechanical Ventilation","volume":"23","author":"Jardin","year":"1997","journal-title":"Intensive Care Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1097\/00000542-199006000-00003","article-title":"Reevaluation of Hemodynamic Consequences of Positive Pressure Ventilation: Emphasis on Cyclic Right Ventricular Afterloading by Mechanical Lung Inflation","volume":"72","author":"Jardin","year":"1990","journal-title":"Anesthesiology"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1164\/rccm.202111-2483OC","article-title":"Right Ventricular Loading by Lung Inflation during Controlled Mechanical Ventilation","volume":"205","author":"Slobod","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1164\/rccm.202402-0383OC","article-title":"The Effect of Positive End-Expiratory Pressure on Pulmonary Vascular Resistance Depends on Lung Recruitability in Patients with Acute Respiratory Distress Syndrome","volume":"210","author":"Borlino","year":"2024","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/s13054-016-1440-0","article-title":"The right ventricle: Interaction with the pulmonary circulation","volume":"20","author":"Pinsky","year":"2016","journal-title":"Crit. Care"},{"key":"ref_104","first-page":"129","article-title":"Acute right ventricular failure, pathophysiology and treatment","volume":"50","author":"Romand","year":"1995","journal-title":"Monaldi Arch. Chest Dis."},{"key":"ref_105","first-page":"2","article-title":"Pulmonary Vascular Resistance and Direct Ventricular Interaction during Mechanical Ventilation in an Oleic Acid Induced Acute Lung Injury Model: A Review","volume":"4","author":"Mitchell","year":"2011","journal-title":"J. Allergy Ther. S"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1378\/chest.14-0877","article-title":"Acute Cor Pulmonale in Ards: Rationale for Protecting the Right Ventricle","volume":"147","author":"Charron","year":"2015","journal-title":"Chest"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1378\/chest.90.1.74","article-title":"Mechanisms of Decreased Left Ventricular Preload during Continuous Positive Pressure Ventilation in ARDS","volume":"90","author":"Dhainaut","year":"1986","journal-title":"Chest"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Spathoulas, K., Tsolaki, V., Zakynthinos, G.E., Karelas, D., Makris, D., Zakynthinos, E., and Papanikolaou, J. (2022). The Role of Left Ventricular Ejection Fraction and Left Ventricular Outflow Tract Velocity-Time Integral in Assessing Cardiovascular Impairment in Septic Shock. J. Pers. Med., 12.","DOI":"10.3390\/jpm12111786"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1097\/MAT.0000000000000900","article-title":"Left Ventricular Ejection Fraction Depends on Loading Conditions","volume":"65","author":"Morimont","year":"2019","journal-title":"Asaio J."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.4081\/monaldi.2019.1058","article-title":"Utility and limitations of ejection fraction and of diastolic dysfunction in heart failure patients","volume":"89","author":"Mureddu","year":"2019","journal-title":"Monaldi Arch. Chest Dis."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/978-0-387-71764-7_23","article-title":"Normal Cardiac Output, Oxygen Delivery and Oxygen Extraction","volume":"599","author":"Wolff","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1748-1716.1986.tb07875.x","article-title":"Sympathetic nerve activity and central haemodynamics during mechanical ventilation with positive end-expiratory pressure in rats","volume":"127","author":"Ricksten","year":"1986","journal-title":"Acta Physiol. Scand."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1186\/cc12727","article-title":"Re-thinking resuscitation: Leaving blood pressure cosmetics behind and moving forward to permissive hypotension and a tissue perfusion-based approach","volume":"17","author":"Takala","year":"2013","journal-title":"Crit. Care"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"e2305","DOI":"10.1097\/CCM.0000000000006805","article-title":"Assessment of Tissue Perfusion Pressure in Patients with Septic Shock: Beyond Mean Arterial Pressure","volume":"53","author":"Sanchez","year":"2025","journal-title":"Crit. Care Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"R136","DOI":"10.1186\/cc5050","article-title":"Mechanical ventilation interacts with endotoxemia to induce extrapulmonary organ dysfunction","volume":"10","author":"Liles","year":"2006","journal-title":"Crit. Care"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1007\/s00134-011-2368-0","article-title":"New insights into weaning from mechanical ventilation: Left ventricular diastolic dysfunction is a key player","volume":"37","author":"Papanikolaou","year":"2011","journal-title":"Intensiv. Care Med."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Bode, D., Wen, Y., Hegemann, N., Primessnig, U., Parwani, A., Boldt, L.-H., Pieske, B.M., Heinzel, F.R., and Hohendanner, F. (2020). Oxidative Stress and Inflammatory Modulation of Ca2+ Handling in Metabolic HFpEF-Related Left Atrial Cardiomyopathy. Antioxidants, 9.","DOI":"10.3390\/antiox9090860"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Fayssoil, A., Mansencal, N., Bergounioux, J., Wahbi, K., and Stojkovic, T. (2022). Cyclic Change in Right and Left Ventricular Systolic and Diastolic Function in Patients with Neuromuscular Disorders on Permanent Mechanical Ventilation. J. Pers. Med., 12.","DOI":"10.3390\/jpm12101694"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"100134","DOI":"10.1016\/j.ahjo.2022.100134","article-title":"Hyperdynamic left ventricular ejection fraction is associated with higher mortality in COVID-19 patients","volume":"14","author":"Rahman","year":"2022","journal-title":"Am. Heart J. Plus Cardiol. Res. Pract."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1152\/japplphysiol.00724.2024","article-title":"Intrathoracic pressure deviations attenuate left ventricular filling and stroke volume without pronounced myocardial mechanical alterations in healthy adults","volume":"138","author":"Wright","year":"2025","journal-title":"J. Appl. Physiol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s10020-025-01074-z","article-title":"Endocrine and metabolic alterations in response to systemic inflammation and sepsis: A review article","volume":"31","author":"Mehdi","year":"2025","journal-title":"Mol. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1152\/physrev.00024.2019","article-title":"Cardiac transmembrane ion channels and action potentials: Cellular physiology and arrhythmogenic behavior","volume":"101","author":"Tomek","year":"2021","journal-title":"Physiol. Rev."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Atia, J., McCloskey, C., Shmygol, A.S., Rand, D.A., Berg, H.A.v.D., and Blanks, A.M. (2016). Reconstruction of Cell Surface Densities of Ion Pumps, Exchangers, and Channels from mRNA Expression, Conductance Kinetics, Whole-Cell Calcium, and Current-Clamp Voltage Recordings, with an Application to Human Uterine Smooth Muscle Cells. PLoS Comput. Biol., 12.","DOI":"10.1371\/journal.pcbi.1004828"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4161\/chan.2.2.6104","article-title":"Mechanisms linking short- and long-term electrical remodeling in the heart\u2026is it a stretch?","volume":"2","author":"Marrus","year":"2008","journal-title":"Channels"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"4585","DOI":"10.1113\/JP284439","article-title":"Electrophysiological effects of stretch-activated ion channels: A systematic computational characterization","volume":"602","author":"Buonocunto","year":"2024","journal-title":"J. Physiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1177\/1535370218777972","article-title":"Dysfunctional Nav1.5 channels due to SCN5A mutations","volume":"243","author":"Han","year":"2018","journal-title":"Exp. Biol. Med."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"King, J.H., Huang, C.L.-H., and Fraser, J.A. (2013). Determinants of myocardial conduction velocity: Implications for arrhythmogenesis. Front. Physiol., 4.","DOI":"10.3389\/fphys.2013.00154"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e202313382","DOI":"10.1085\/jgp.202313382","article-title":"Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction","volume":"155","author":"Weinberg","year":"2023","journal-title":"J. Gen. Physiol."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Le Dinh, M., Carreira, S., Obert, J., Gayan-Ramirez, G., Riou, B., Beuvin, M., Similowski, T., Coirault, C., and Demoule, A. (2018). Prolonged mechanical ventilation worsens sepsis-induced diaphragmatic dysfunction in the rat. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0200429"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"5607","DOI":"10.1097\/MS9.0000000000003499","article-title":"Inflammatory cytokines and cardiac arrhythmias: From pathogenesis to potential therapies","volume":"87","author":"Obeagu","year":"2025","journal-title":"Ann. Med. Surg."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"R54","DOI":"10.1186\/cc13800","article-title":"Decreased cardiac excitability secondary to reduction of sodium current may be a significant contributor to reduced contractility in a rat model of sepsis","volume":"18","author":"Koesters","year":"2014","journal-title":"Crit. Care"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"e007622","DOI":"10.1161\/JAHA.117.007622","article-title":"Sodium Channel Remodeling in Subcellular Microdomains of Murine Failing Cardiomyocytes","volume":"6","author":"Rivaud","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1161\/01.RES.56.5.696","article-title":"The effects of antiarrhythmic drugs, stimulation frequency, and potassium-induced resting membrane potential changes on conduction velocity and dV\/dtmax in guinea pig myocardium","volume":"56","author":"Buchanan","year":"1985","journal-title":"Circ. Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1161\/01.RES.66.2.367","article-title":"Unidirectional block and reentry of cardiac excitation: A model study","volume":"66","author":"Quan","year":"1990","journal-title":"Circ. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00001573-200101000-00001","article-title":"Basic mechanisms of reentrant arrhythmias","volume":"16","author":"Antzelevitch","year":"2001","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Boyle, P.M., Park, C.J., Arevalo, H.J., Vigmond, E.J., and ATrayanova, N. (2014). Sodium Current Reduction Unmasks a Structure-Dependent Substrate for Arrhythmogenesis in the Normal Ventricles. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0086947"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1196\/annals.1420.013","article-title":"Molecular Basis of Cardiac Action Potential Repolarization","volume":"1123","author":"Rudy","year":"2008","journal-title":"Ann. New York Acad. Sci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1152\/physrev.00002.2005","article-title":"Molecular Physiology of Cardiac Repolarization","volume":"85","author":"Nerbonne","year":"2005","journal-title":"Physiol. Rev."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/eurheartj\/ehn585","article-title":"Ventricular transmural repolarization sequence: Its relationship with ventricular relaxation and role in ventricular diastolic function","volume":"30","author":"Zhu","year":"2009","journal-title":"Eur. Heart J."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"13289","DOI":"10.1074\/jbc.C400025200","article-title":"Impairment of Herg K(+) Channel Function by Tumor Necrosis Factor-Alpha: Role of Reactive Oxygen Species as a Mediator","volume":"279","author":"Wang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1161\/01.RES.0000195844.31466.e9","article-title":"Oxidative Mediated Lipid Peroxidation Recapitulates Proarrhythmic Effects on Cardiac Sodium Channels","volume":"97","author":"Fukuda","year":"2005","journal-title":"Circ. Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1161\/01.RES.73.2.379","article-title":"Alterations of K+ currents in isolated human ventricular myocytes from patients with terminal heart failure","volume":"73","author":"Beuckelmann","year":"1993","journal-title":"Circ. Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/europace\/eun193","article-title":"Role of potassium currents in cardiac arrhythmias","volume":"10","author":"Ravens","year":"2008","journal-title":"Europace"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"701","DOI":"10.7326\/0003-4819-122-9-199505010-00009","article-title":"Electrophysiologic Mechanisms of the Long QT Interval Syndromes and Torsade de Pointes","volume":"122","author":"Tan","year":"1995","journal-title":"Ann. Intern. Med."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"437","DOI":"10.4330\/wjc.v12.i9.437","article-title":"Dispersion of ventricular repolarization: Temporal and spatial","volume":"12","author":"Arteyeva","year":"2020","journal-title":"World J. Cardiol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1152\/physrev.00025.2003","article-title":"Basic Mechanisms of Cardiac Impulse Propagation and Associated Arrhythmias","volume":"84","author":"Rudy","year":"2004","journal-title":"Physiol. Rev."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/cvr\/cvt104","article-title":"Early afterdepolarizations in cardiac myocytes: Beyond reduced repolarization reserve","volume":"99","author":"Qu","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.pbiomolbio.2017.08.008","article-title":"An integrative appraisal of mechano-electric feedback mechanisms in the heart","volume":"130","author":"Timmermann","year":"2017","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1161\/CIRCRESAHA.117.310083","article-title":"Calcium Signaling and Cardiac Arrhythmias","volume":"120","author":"Landstrom","year":"2017","journal-title":"Circ. Res."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1161\/CIRCRESAHA.117.310230","article-title":"Calcium and Excitation-Contraction Coupling in the Heart","volume":"121","author":"Eisner","year":"2017","journal-title":"Circ. Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/978-981-10-7757-9_8","article-title":"The Sarcoendoplasmic Reticulum Calcium Atpase","volume":"87","author":"Primeau","year":"2018","journal-title":"Subcell. Biochem."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"e000184","DOI":"10.1161\/JAHA.113.000184","article-title":"Hydrogen Peroxide\u2013Mediated SERCA Cysteine 674 Oxidation Contributes to Impaired Cardiac Myocyte Relaxation in Senescent Mouse Heart","volume":"2","author":"Qin","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Roshan, N., and Pandit, R. (2026). Abnormal calcium release and delayed afterdepolarizations: A comparison of two mathematical models for human ventricular myocytes. PLoS ONE, 21.","DOI":"10.1371\/journal.pone.0338873"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"H2552","DOI":"10.1152\/ajpheart.00274.2003","article-title":"Effects of Na+\/Ca2+ exchange induced by SR Ca2+ release on action potentials and afterdepolarizations in guinea pig ventricular myocytes","volume":"285","author":"Spencer","year":"2003","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/CIRCRESAHA.108.183475","article-title":"Oxidative Stress\u2013Induced Afterdepolarizations and Calmodulin Kinase II Signaling","volume":"104","author":"Xie","year":"2009","journal-title":"Circ. Res."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.pharmthera.2009.03.006","article-title":"Ryanodine receptor-mediated arrhythmias and sudden cardiac death","volume":"123","author":"Blayney","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"ref_157","first-page":"111","article-title":"Cellular Mechanisms of Cardiac Mechano-Electric Feedback in a Mathematical Model","volume":"14","author":"Kohl","year":"1998","journal-title":"Can. J. Cardiol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"dmm050407","DOI":"10.1242\/dmm.050407","article-title":"Reduced connexin-43 expression, slow conduction and repolarisation dispersion in a model of hypertrophic cardiomyopathy","volume":"17","author":"Lim","year":"2024","journal-title":"Dis. Model. Mech."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1098\/rsta.2001.0824","article-title":"Mechanoelectric feedback in cardiac cells","volume":"359","author":"Kohl","year":"2001","journal-title":"Philos. Trans. R. Soc. A Math. Phys. Eng. Sci."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1152\/physrev.00036.2019","article-title":"Cardiac Mechano-Electric Coupling: Acute Effects of Mechanical Stimulation on Heart Rate and Rhythm","volume":"101","author":"Quinn","year":"2021","journal-title":"Physiol. Rev."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"H2016","DOI":"10.1152\/ajpheart.1998.275.6.H2016","article-title":"Temperature dependence of early and late currents in human cardiac wild-type and long Q-T \u0394KPQ Na+ channels","volume":"275","author":"Nagatomo","year":"1998","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1038\/s41467-025-57358-9","article-title":"HCN4 channels sense temperature and determine heart rate responses to heat","volume":"16","author":"Wu","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/j.hrthm.2016.06.019","article-title":"Febrile Temperature Facilitates Herg\/Ikr Degradation through an Altered K(+) Dependence","volume":"13","author":"Zhao","year":"2016","journal-title":"Heart Rhythm"},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Cluitmans, M.J.M., Bayer, J., Bear, L.R., ter Bekke, R.M.A., Heijman, J., Coronel, R., and Volders, P.G.A. (2023). The circle of reentry: Characteristics of trigger-substrate interaction leading to sudden cardiac arrest. Front. Cardiovasc. Med., 10.","DOI":"10.3389\/fcvm.2023.1121517"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1755-5922.2010.00210.x","article-title":"REVIEW: Sodium Channel (Dys)Function and Cardiac Arrhythmias","volume":"28","author":"Remme","year":"2010","journal-title":"Cardiovasc. Ther."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1002\/j.2040-4603.2017.tb00771.x","article-title":"Cardiac Fibrosis and Arrhythmogenesis","volume":"7","author":"Nguyen","year":"2017","journal-title":"Compr. Physiol."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Lei, M., Salvage, S.C., Jackson, A.P., and Huang, C.L.-H. (2024). Cardiac arrhythmogenesis: Roles of ion channels and their functional modification. Front. Physiol., 15.","DOI":"10.3389\/fphys.2024.1342761"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Arango-Ibanez, J.P., Cordoba-Melo, B.D., Rengifo, M.M.B., Tobar-Arteaga, J.D., Castro-Trujillo, M.L., Herrera, C.J., Da Silva, M.\u00c1.Q., Sandoval, A.F.B., Gilio, M.L.C., and Long, F.P.C. (2025). Two-year follow-up of patients with myocardial injury during acute COVID-19: Insights from the CARDIO COVID 20\u201321 registry. Front. Cardiovasc. Med., 12.","DOI":"10.3389\/fcvm.2025.1584732"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"C\u00e1rdenas-Mar\u00edn, P.A., Cordoba-Melo, B.D., Carrillo-G\u00f3mez, D.C., Le\u00f3n-Giraldo, H., Mendoza, I., Fl\u00f3rez, N., Larrea G\u00f3mez, R.E., Mercedes, J.M., Herrera, C.J., and Lugo-Pe\u00f1a, J. (2025). Impact of Myocardial Injury on Cardiovascular Complications in Hospitalized Patients with COVID-19: Insights from Latin America. Front. Cardiovasc. Med., 12.","DOI":"10.3389\/fcvm.2025.1545142"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13613-024-01248-8","article-title":"Right ventricular injury in critically ill patients with COVID-19: A descriptive study with standardized echocardiographic follow-up","volume":"14","author":"Jozwiak","year":"2024","journal-title":"Ann. Intensiv. Care"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Bonnemain, J., Ltaief, Z., and Liaudet, L. (2021). The Right Ventricle in COVID-19. J. Clin. Med., 10.","DOI":"10.3390\/jcm10122535"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1186\/s13054-020-03385-5","article-title":"Right ventricular-arterial uncoupling independently predicts survival in COVID-19 ARDS","volume":"24","author":"Marra","year":"2020","journal-title":"Crit. Care"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJMoa2032510","article-title":"Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure","volume":"384","author":"Klitgaard","year":"2021","journal-title":"New Engl. J. 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