{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:07:19Z","timestamp":1780632439370,"version":"3.54.1"},"reference-count":71,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Polish Minister of Science","award":["2024\u20132027 edition"],"award-info":[{"award-number":["2024\u20132027 edition"]}]},{"name":"NCN Preludium","award":["2025\/57\/N\/NZ9\/01854"],"award-info":[{"award-number":["2025\/57\/N\/NZ9\/01854"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Background: Anxiety is a frequent clinical problem that becomes disabling when excessive or persistent. Cyclitols are naturally occurring polyhydroxy compounds, and inositols are the most abundant cyclitols in eukaryotic cells; several stereoisomers have been proposed as candidates for CNS-relevant effects. Methods: A narrative review was conducted using a structured search of biomedical bibliographic databases. The search was centered on myo-inositol, scyllo-inositol, and D-chiro-inositol in relation to anxiety-related outcomes. Results: The retrieved literature suggests some biological plausibility for anxiolytic effects of selected inositol stereoisomers through pathways related to intracellular signaling and neurotransmission. However, the available evidence is uneven and remains limited. The most informative findings concern myo-inositol and include both preclinical and clinical studies, whereas data on scyllo-inositol and D-chiro-inositol are scarce, particularly in relation to anxiety-related outcomes. Conclusions: Current evidence suggests a possible anxiolytic role of selected inositol stereoisomers; however, the existing data are limited and heterogeneous, and do not allow for definitive clinical conclusions. Further research is required.<\/jats:p>","DOI":"10.3390\/cells15110970","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T10:19:52Z","timestamp":1779877192000},"page":"970","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential Anxiolytic Effects of Selected Inositol Stereoisomers\u2014A Narrative Review"],"prefix":"10.3390","volume":"15","author":[{"given":"Maria","family":"Derkaczew","sequence":"first","affiliation":[{"name":"Department of Human Physiology and Pathophysiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-082 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6577-7545","authenticated-orcid":false,"given":"Kamila","family":"Zglejc-Waszak","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-082 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9162-5449","authenticated-orcid":false,"given":"Piotr","family":"Podlasz","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Forensic Veterinary Medicine and Administration, Faculty of Veterinary Medicine, University of Warmia and Mazury, 10-719 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3401-2758","authenticated-orcid":false,"given":"Marcin","family":"Jozwik","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Collegium Medicum, University of Warmia and Mazury, 10-045 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0856-3644","authenticated-orcid":false,"given":"Joanna","family":"Wojtkiewicz","sequence":"additional","affiliation":[{"name":"Department of Human Physiology and Pathophysiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-082 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Tuma, A.H., and Maser, J.D. 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