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This exploratory study investigated whether DD and RC share molecular features associated with fibroproliferative contracture. Pathological tissues from DD nodules and contracted tissues from RC together with their respective control tissues (n = 6\/group), were analyzed using label-free quantitative proteomics. The analysis identified 12 significantly upregulated proteins shared between both pathological conditions relative to their controls (|log2FC| \u2265 1, p \u2264 0.05). These proteins included structural, signaling and tensile stress ECM proteins. Functional enrichment and network analyses revealed partially overlapping dysregulation of pathways associated with ECM organization and degradation, ECM\u2013receptor interaction, matricellular signaling and mechanobiological processes. In DD samples (n = 10), immunohistochemistry confirmed increased expression of fibrosis-associated proteins (\u03b1-SMA, TGF-\u03b21, TGFBI, COL III, COL VI, and COL XII) (at least p &lt; 0.01). Despite these similarities, differences in individual protein abundance and collagen crosslinking were observed between tissues. The findings suggest that DD and RC may share aspects of fibrotic ECM-remodeling despite differences in age, localization, and disease origin. These findings provide initial insights into shared ECM-remodeling processes, although their interpretation should consider the relatively small sample size and biological heterogeneity of the analyzed tissues.<\/jats:p>","DOI":"10.3390\/cells15110977","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T13:28:21Z","timestamp":1779802101000},"page":"977","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Shared Extracellular Matrix Remodeling and Proteomic Signature in Dupuytren\u2019s Disease and Relapsed Clubfoot Tissue"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-0038","authenticated-orcid":false,"given":"Tomas","family":"Novotny","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, University J.E. Purkyne, Masaryk Hospital, 401 13 Usti nad Labem, Czech Republic"},{"name":"Department of Histology and Embryology, Second Faculty of Medicine, Charles University, 150 06 Prague 5, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4757-5226","authenticated-orcid":false,"given":"Adam","family":"Eckhardt","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Metabolism, Institute of Physiology of theCzech Academy of Sciences, Videnska 1083, 142 00 Prague 4, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarmila","family":"Knitlova","sequence":"additional","affiliation":[{"name":"Laboratory of Biomaterials and Tissue Engineering, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague 4, Czech Republic"},{"name":"Faculty of Science, Charles University, Albertov 6, 128 00 Prague 2, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4955-4093","authenticated-orcid":false,"given":"Martina","family":"Doubkova","sequence":"additional","affiliation":[{"name":"Laboratory of Biomaterials and Tissue Engineering, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague 4, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1228-7662","authenticated-orcid":false,"given":"Roman","family":"Stachon","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Bulovka Hospital, First Faculty of Medicine, Charles University, Budinova 67\/2, 180 81 Prague 8, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Hrdina","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Bulovka Hospital, First Faculty of Medicine, Charles University, Budinova 67\/2, 180 81 Prague 8, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0294-3638","authenticated-orcid":false,"given":"Tatyana","family":"Kobets","sequence":"additional","affiliation":[{"name":"Metabolomics Service Laboratory, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague 4, Czech Republic"},{"name":"Laboratory of Genomics and Bioinformatics, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague 4, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ostadal","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Bulovka Hospital, First Faculty of Medicine, Charles University, Budinova 67\/2, 180 81 Prague 8, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.yjmcc.2009.08.003","article-title":"Contribution of extracellular matrix to the mechanical properties of the heart","volume":"48","author":"Fomovsky","year":"2010","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41586-020-2938-9","article-title":"Fibrosis: From mechanisms to medicines","volume":"587","author":"Henderson","year":"2020","journal-title":"Nature"},{"key":"ref_3","first-page":"218","article-title":"A Critical Review on Tendon Structure and Load Remodeling","volume":"13","author":"Kahraman","year":"2023","journal-title":"Muscles Ligaments Tendons J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1126\/science.1176009","article-title":"The extracellular matrix: Not just pretty fibrils","volume":"326","author":"Hynes","year":"2009","journal-title":"Science"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nrm3896","article-title":"Mechanotransduction and extracellular matrix homeostasis","volume":"15","author":"Humphrey","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J. Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1186\/s13018-020-01999-7","article-title":"The worldwide prevalence of the Dupuytren disease: A comprehensive systematic review and meta-analysis","volume":"15","author":"Salari","year":"2020","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_8","first-page":"383","article-title":"Molecular mechanisms and treatment strategies for Dupuytren\u2019s disease","volume":"6","author":"Vi","year":"2010","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nrrheum.2010.180","article-title":"Scientific understanding and clinical management of Dupuytren disease","volume":"6","author":"Shih","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1177\/1753193410362848","article-title":"Re-visiting Luck\u2019s classification: A histological analysis of Dupuytren\u2019s disease","volume":"35","author":"Lam","year":"2010","journal-title":"J. Hand Surg. Eur. Vol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"102759","DOI":"10.1016\/j.fjurol.2024.102759","article-title":"When fibrosis intersect: Association and risk factors between Peyronie\u2019s and Dupuytren\u2019s diseases","volume":"34","author":"Lethuillier","year":"2024","journal-title":"Fr. J. Urol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e00195","DOI":"10.1002\/edm2.195","article-title":"Fibroproliferative disorders and diabetes: Understanding the pathophysiologic relationship between Peyronie\u2019s disease, Dupuytren disease and diabetes","volume":"4","author":"Gelbard","year":"2021","journal-title":"Endocrinol. Diabetes Metab."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1177\/1071100713505535","article-title":"Plantar fibromatosis\u2014topical review","volume":"34","author":"Veith","year":"2013","journal-title":"Foot Ankle Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e102","DOI":"10.1055\/s-0036-1593355","article-title":"Dupuytren-Like Contracture of the Foot: Ledderhose Disease","volume":"2","author":"Akdag","year":"2016","journal-title":"Surg. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/bmb\/ldw020","article-title":"Collagenase clostridium histolyticum in Dupuytren\u2019s contracture: A systematic review","volume":"118","author":"Smeraglia","year":"2016","journal-title":"Br. Med. Bull."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s11552-011-9326-8","article-title":"A systematic review of outcomes of fasciotomy, aponeurotomy, and collagenase treatments for Dupuytren\u2019s contracture","volume":"6","author":"Chen","year":"2011","journal-title":"Hand"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1177\/1558944721994220","article-title":"Outcomes of Management of Recurrent Dupuytren Contracture: A Systematic Review and Meta-analysis","volume":"17","author":"Wong","year":"2022","journal-title":"Hand"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cpm.2021.08.006","article-title":"Clubfoot","volume":"39","author":"Rieger","year":"2022","journal-title":"Clin. Podiatr. Med. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"403","DOI":"10.33549\/physiolres.933404","article-title":"Possible pathogenetic mechanisms and new therapeutic approaches of pes equinovarus","volume":"66","author":"Ostadal","year":"2017","journal-title":"Physiol. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1302\/0301-620X.80B4.0800641","article-title":"Pathogenesis of soft-tissue contracture in club foot","volume":"80","author":"Sano","year":"1998","journal-title":"J. Bone Jt. Surg. Br."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1177\/0300060517706801","article-title":"Comparison of different conservative treatments for idiopathic clubfoot: Ponseti\u2019s versus non-Ponseti\u2019s methods","volume":"45","author":"He","year":"2017","journal-title":"J. Int. Med. Res."},{"key":"ref_22","first-page":"100198","article-title":"Pearls to Address Challenges in Initial Casting Treatment for Idiopathic Clubfoot","volume":"12","author":"Williams","year":"2025","journal-title":"J. Pediatr. Soc. N. Am."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1007\/s11999-009-0734-9","article-title":"Update on clubfoot: Etiology and treatment","volume":"467","author":"Dobbs","year":"2009","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5704\/MOJ.1911.005","article-title":"Factors Related to Early Recurrence of Idiopathic Clubfoot Post the Ponseti Method","volume":"13","author":"Limpaphayom","year":"2019","journal-title":"Malays. Orthop. J."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Janatov\u00e1, K., Nov\u00e1kov\u00e1, T., and Lopot, F. (2023). The Incidence of Clubfoot in the Czech Republic: A Nationwide Epidemiological Study from 2000 to 2014. Children, 10.","DOI":"10.3390\/children10040714"},{"key":"ref_26","first-page":"781","article-title":"Dupuytren\u2019s Disease-Etiology and Treatment","volume":"118","author":"Ruettermann","year":"2021","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s12195-026-00885-2","article-title":"Development of a 3D In Vitro Model of Dupuytren\u2019s Disease as a Platform for Drug Screening","volume":"19","author":"Knitlova","year":"2026","journal-title":"Cell. Mol. Bioeng."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Heinm\u00e4e, E., M\u00e4emets-Allas, K., Maasalu, K., Vast\u0161jonok, D., and Klaas, M. (2025). Pathological Changes in Extracellular Matrix Composition Orchestrate the Fibrotic Feedback Loop Through Macrophage Activation in Dupuytren\u2019s Contracture. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26073146"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/jor.24211","article-title":"Novel contribution to clubfoot pathogenesis: The possible role of extracellular matrix proteins","volume":"37","author":"Eckhardt","year":"2019","journal-title":"J. Orthop. Res."},{"key":"ref_30","first-page":"Cd010143","article-title":"Surgery for Dupuytren\u2019s contracture of the fingers","volume":"2015","author":"Rodrigues","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1177\/18632521241301942","article-title":"Ankle and foot deformities and malformations in proximal femoral focal deficiency","volume":"19","author":"Chomiak","year":"2025","journal-title":"J. Child. Orthop."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1302\/0301-620X.76B3.8175852","article-title":"The pathogenesis of club foot. A histomorphometric and immunohistochemical study of fetuses","volume":"76","author":"Fukuhara","year":"1994","journal-title":"J. Bone Jt. Surg. Br."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/01.prs.0000438455.37604.0f","article-title":"A systematic review and meta-analysis on the prevalence of Dupuytren disease in the general population of Western countries","volume":"133","author":"Lanting","year":"2014","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/tmi.12833","article-title":"Birth prevalence of congenital talipes equinovarus in low- and middle-income countries: A systematic review and meta-analysis","volume":"22","author":"Smythe","year":"2017","journal-title":"Trop. Med. Int. Health"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"8427","DOI":"10.1074\/jbc.M805582200","article-title":"Type XIV Collagen Regulates Fibrillogenesis: Premature Collagen Fibril Growth and Tissue Dysfunction in Null Mice","volume":"284","author":"Ansorge","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s13052-023-01559-9","article-title":"Incidence and prevalence of congenital clubfoot in Apulia: A regional model for future prospective national studies","volume":"49","author":"Panza","year":"2023","journal-title":"Ital. J. Pediatr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/01241398-200105000-00021","article-title":"Potential treatment for clubfeet based on growth factor blockade","volume":"21","author":"Li","year":"2001","journal-title":"J. Pediatr. Orthop."},{"key":"ref_38","first-page":"55","article-title":"The congenital clubfoot\u2014Immunohistological analysis of the extracellular matrix","volume":"10","author":"Kerling","year":"2018","journal-title":"Orthop. Res. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11010-014-2300-3","article-title":"Proteomic analysis of the extracellular matrix in idiopathic pes equinovarus","volume":"401","author":"Ostadal","year":"2015","journal-title":"Mol. Cell Biochem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1080\/03008207.2020.1816992","article-title":"Minoxidil decreases collagen I deposition and tissue-like contraction in clubfoot-derived cells: A way to improve conservative treatment of relapsed clubfoot?","volume":"62","author":"Knitlova","year":"2020","journal-title":"Connect. Tissue Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"E407","DOI":"10.1016\/S2665-9913(22)00093-5","article-title":"Anti-tumour necrosis factor therapy for early-stage Dupuytren\u2019s disease (RIDD): A phase 2b, randomised, double-blind, placebo-controlled trial","volume":"4","author":"Nanchahal","year":"2022","journal-title":"Lancet Rheumatol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Knitlova, J., Doubkova, M., Eckhardt, A., Ostadal, M., Musilkova, J., Bacakova, L., and Novotny, T. (2021). Increased Collagen Crosslinking in Stiff Clubfoot Tissue: Implications for the Improvement of Therapeutic Strategies. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111903"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6485","DOI":"10.1021\/acs.biomac.4c00653","article-title":"Harnessing the Biomimetic Effect of Macromolecular Crowding in the Cell-Derived Model of Clubfoot Fibrosis","volume":"25","author":"Eckhardt","year":"2024","journal-title":"Biomacromolecules"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3109\/17453674.2013.814011","article-title":"Expression of VEGF, its receptors, and HIF-1\u03b1 in Dupuytren\u2019s disease","volume":"84","author":"Holzer","year":"2013","journal-title":"Acta Orthop."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1097\/BPO.0000000000001563","article-title":"Increased Microvessel and Arteriole Density in the Contracted Side of the Relapsed Clubfoot","volume":"40","author":"Novotny","year":"2020","journal-title":"J. Pediatr. Orthop."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1038\/s41598-022-08519-z","article-title":"The possible role of hypoxia in the affected tissue of relapsed clubfoot","volume":"12","author":"Novotny","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"753e","DOI":"10.1097\/PRS.0000000000008420","article-title":"Factors Associated with the Development, Progression, and Outcome of Dupuytren Disease Treatment: A Systematic Review","volume":"148","author":"Geoghegan","year":"2021","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1007\/s00264-013-2033-z","article-title":"Comparison of the short-term and long-term results of the Ponseti method in the treatment of idiopathic pes equinovarus","volume":"37","author":"Ostadal","year":"2013","journal-title":"Int. Orthop."},{"key":"ref_49","first-page":"59","article-title":"Treatment of idiopathic clubfoot: An historical review","volume":"20","author":"Dobbs","year":"2000","journal-title":"Iowa Orthop. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1302\/0301-620X.101B6.BJJ-2018-1421.R1","article-title":"Congenital talipes equinovarus: A systematic review of relapse as a primary outcome of the Ponseti method","volume":"101-B","author":"Gelfer","year":"2019","journal-title":"Bone Jt. J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.7150\/ijms.97797","article-title":"Common and Key Differential Pathogenic Pathways in Desminopathy and Titinopathy","volume":"21","author":"Li","year":"2024","journal-title":"Int. J. Med. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41413-025-00442-z","article-title":"Current cutting-edge omics techniques on musculoskeletal tissues and diseases","volume":"13","author":"Li","year":"2025","journal-title":"Bone Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1002\/art.22876","article-title":"Comparative proteomic characterization of articular cartilage tissue from normal donors and patients with osteoarthritis","volume":"56","author":"Wu","year":"2007","journal-title":"Arthritis Rheum."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1177\/1747493018778713","article-title":"Multisociety Consensus Quality Improvement Revised Consensus Statement for Endovascular Therapy of Acute Ischemic Stroke","volume":"13","author":"Sacks","year":"2018","journal-title":"Int. J. Stroke"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1186\/1755-1536-5-S1-S10","article-title":"Proteomics approaches to fibrotic disorders","volume":"5","author":"Gucek","year":"2012","journal-title":"Fibrogenes. Tissue Repair"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1177\/09287329251414507","article-title":"ECM-Targeted and cell-based therapies in musculoskeletal and aging-related disorders: A review","volume":"34","author":"Ahn","year":"2026","journal-title":"Technol. Health Care"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Dutta, S., Chen, S., Ahmad, W., Huang, W., Liang, J., and Wang, Y. (2026). Targeting Cardiac Fibroblast Plasticity for Antifibrotic and Regenerative Therapy in Heart Failure. Cells, 15.","DOI":"10.3390\/cells15020112"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1329061","DOI":"10.1155\/2023\/1329061","article-title":"Label-Free Proteomics of Oral Mucosa Tissue to Identify Potential Biomarkers That Can Flag Predilection of Precancerous Lesions to Oral Cell Carcinoma: A Preliminary Study","volume":"2023","author":"Sharma","year":"2023","journal-title":"Dis. Markers"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1074\/mcp.M113.034769","article-title":"The one hour yeast proteome","volume":"13","author":"Hebert","year":"2014","journal-title":"Mol. Cell Proteom."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1093\/bioinformatics\/btu305","article-title":"MSstats: An R package for statistical analysis of quantitative mass spectrometry-based proteomic experiments","volume":"30","author":"Choi","year":"2014","journal-title":"Bioinformatics"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1021\/acs.jproteome.2c00834","article-title":"MSstats Version 4.0: Statistical Analyses of Quantitative Mass Spectrometry-Based Proteomic Experiments with Chromatography-Based Quantification at Scale","volume":"22","author":"Kohler","year":"2023","journal-title":"J. Proteome Res."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Dziobak, M.K., Curtin, T., Wells, R.S., Takeshita, R., Smith, C.R., Zolman, E., Toms, C.N., Allen, R.F., and Hart, L.B. (2025). Comparing phthalate exposure between bottlenose dolphins (Tursiops truncatus) residing in urban and rural environments. Front. Mar. Sci., 12.","DOI":"10.3389\/fmars.2025.1554075"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: Therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13069-016-0046-0","article-title":"Matrix and cell phenotype differences in Dupuytren\u2019s disease","volume":"9","author":"Werker","year":"2016","journal-title":"Fibrogenes. Tissue Repair"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jhsa.2007.11.010","article-title":"Molecular phenotypic descriptors of Dupuytren\u2019s disease defined using informatics analysis of the transcriptome","volume":"33","author":"Rehman","year":"2008","journal-title":"J. Hand Surg. Am."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.jhsa.2008.04.002","article-title":"Metalloproteinase gene expression correlates with clinical outcome in Dupuytren\u2019s disease","volume":"33","author":"Johnston","year":"2008","journal-title":"J. Hand Surg. Am."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jhsa.2008.09.017","article-title":"Identification of biomarkers in Dupuytren\u2019s disease by comparative analysis of fibroblasts versus tissue biopsies in disease-specific phenotypes","volume":"34","author":"Shih","year":"2009","journal-title":"J. Hand Surg. Am."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.biopha.2008.10.005","article-title":"Screening of potential prodrugs on cells derived from Dupuytren\u2019s disease patients","volume":"63","author":"Bratulic","year":"2009","journal-title":"Biomed. Pharmacother."},{"key":"ref_70","first-page":"5","article-title":"Treatment with Conditioned Medium from Tenocytes Primary Cell Cultures Accelerates Histological and Functional Recovery of Achilles Tendon in Tenotomized Mice","volume":"14","author":"Maciel","year":"2024","journal-title":"Muscles Ligaments Tendons J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1007\/s11999-008-0692-7","article-title":"Beta-catenin mediates soft tissue contracture in clubfoot","volume":"467","author":"Poon","year":"2009","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1159\/000360085","article-title":"Vitronectin regulation of vascular endothelial growth factor-mediated angiogenesis","volume":"51","author":"Li","year":"2014","journal-title":"J. Vasc. Res."},{"key":"ref_73","first-page":"100097","article-title":"The role of extracellular matrix in angiogenesis: Beyond adhesion and structure","volume":"15","author":"Libby","year":"2024","journal-title":"Biomater. Biosyst."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/micmic\/ozac012","article-title":"Microstructural Analysis of Collagenous Structures in Relapsed Clubfoot Tissue","volume":"29","author":"Hadraba","year":"2023","journal-title":"Microsc. Microanal."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s40610-016-0045-3","article-title":"Connective Tissue Degeneration: Mechanisms of Palmar Fascia Degeneration (Dupuytren\u2019s Disease)","volume":"2","author":"Karkampouna","year":"2016","journal-title":"Curr. Mol. Biol. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e71008","DOI":"10.1096\/fj.202500970R","article-title":"Targeting Inflammation and Fibrosis in Cardiovascular Disease: Emerging Mechanisms and Therapies","volume":"39","author":"Barreto","year":"2025","journal-title":"Faseb J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"16749","DOI":"10.1038\/s41598-018-35194-w","article-title":"Hepatokine \u03b11-Microglobulin Signaling Exacerbates Inflammation and Disturbs Fibrotic Repair in Mouse Myocardial Infarction","volume":"8","author":"Hakuno","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_78","first-page":"201","article-title":"Morphological Changes and Pathological Findings in the Achilles Tendons of Diabetic Patients: A Meta-Analysis of Comparative Clinical Studies","volume":"13","author":"Yammine","year":"2023","journal-title":"Muscles Ligaments Tendons J."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/11\/977\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T13:38:25Z","timestamp":1779802705000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/11\/977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":78,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["cells15110977"],"URL":"https:\/\/doi.org\/10.3390\/cells15110977","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]}}}