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Adipocyte catecholamine resistance is a common feature of pediatric obesity, often impeding weight loss and the maintenance of a healthy body fat percentage. Our aim was to identify possible mechanisms that may be responsible for the development of catecholamine resistance in adipocytes. We demonstrate that Lim homeobox 8 (LHX8), a transcription factor previously known for its role in gametogenesis, is essential for catecholamine-induced thermogenesis in human adipocytes. LHX8 is expressed in developing human adipocytes throughout intrauterine and perinatal life, as well as in adulthood, and its expression levels positively correlate with the expression of key thermogenesis genes. Pediatric obesity diminished adipocyte expression of LHX8. Functionally, ADRB stimulation failed to induce thermogenesis in both mouse and human adipocytes when LHX8 was absent. Conversely, LHX8 overexpression enhanced thermogenesis in murine adipocytes. Mechanistically, LHX8 stimulated adipocyte interleukin-33 (IL-33) synthesis in response to ADRB activation, which subsequently increased thermogenic gene expression in both human and mouse adipocytes. In conclusion, adipocyte LHX8 is indispensable for catecholamine-responsive thermogenesis and represents a promising novel therapeutic target to overcome catecholamine resistance and promote effective weight management.<\/jats:p>","DOI":"10.3390\/cells15111000","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:57:18Z","timestamp":1780070238000},"page":"1000","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lim Homeobox 8 Is Essential for Beta Adrenergic Stimulation of Thermogenesis in Human Adipocytes"],"prefix":"10.3390","volume":"15","author":[{"given":"Katalin","family":"Gyurina","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5907-2725","authenticated-orcid":false,"given":"\u00c1d\u00e1m","family":"Radv\u00e1nyi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"},{"name":"K\u00e1lm\u00e1n Laki Doctoral School, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Sasi-Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enik\u0151","family":"Felszeghy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emese","family":"R\u00e1cz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"M\u00e9hes","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0527-4946","authenticated-orcid":false,"given":"Andrea","family":"K\u00e1d\u00e1r","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Neuroendocrinology, Hun-Ren Institute of Experimental Medicine, 1083 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8206-562X","authenticated-orcid":false,"given":"Csaba","family":"Fekete","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Neuroendocrinology, Hun-Ren Institute of Experimental Medicine, 1083 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1903-7922","authenticated-orcid":false,"given":"Tam\u00e1s","family":"R\u00f6szer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(25)00397-6","article-title":"Global, regional, and national prevalence of child and adolescent overweight and obesity, 1990\u20132021, with forecasts to 2050: A forecasting study for the Global Burden of Disease Study 2021","volume":"405","author":"Kerr","year":"2025","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/joim.13547","article-title":"Pediatric obesity-Long-term consequences and effect of weight loss","volume":"292","author":"Marcus","year":"2022","journal-title":"J. Intern. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1126\/science.abl7108","article-title":"Fueling the fire of adipose thermogenesis","volume":"375","author":"Wolfrum","year":"2022","journal-title":"Science"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/s42255-022-00683-w","article-title":"Mitochondrial RNA stimulates beige adipocyte development in young mice","volume":"4","author":"Hoang","year":"2022","journal-title":"Nat. Metab."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Rockstroh, D., Landgraf, K., Wagner, I.V., Gesing, J., Tauscher, R., Lakowa, N., Kiess, W., B\u00fchligen, U., Wojan, M., and Till, H. (2015). Direct evidence of brown adipocytes in different fat depots in children. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0117841"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41580-021-00350-0","article-title":"The cellular and functional complexity of thermogenic fat","volume":"22","author":"Cohen","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Alcal\u00e1, M., Calderon-Dominguez, M., Serra, D., Herrero, L., and Viana, M. (2019). Mechanisms of Impaired Brown Adipose Tissue Recruitment in Obesity. Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.00094"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e153357","DOI":"10.1172\/JCI153357","article-title":"\u03b23-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity","volume":"132","author":"Valentine","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.cmet.2013.04.011","article-title":"A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans","volume":"17","author":"Jespersen","year":"2013","journal-title":"Cell Metab."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1073\/pnas.0610615104","article-title":"Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages","volume":"104","author":"Timmons","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Sharp, L.Z., Shinoda, K., Ohno, H., Scheel, D.W., Tomoda, E., Ruiz, L., Hu, H., Wang, L., Pavlova, Z., and Gilsanz, V. (2012). Human BAT possesses molecular signatures that resemble beige\/brite cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0049452"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"101284","DOI":"10.1016\/j.molmet.2021.101284","article-title":"The transcriptional co-regulator LDB1 is required for brown adipose function","volume":"53","author":"Kepple","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Breitfeld, J., Kehr, S., M\u00fcller, L., Stadler, P.F., B\u00f6ttcher, Y., Bl\u00fcher, M., Stumvoll, M., and Kovacs, P. (2020). Developmentally Driven Changes in Adipogenesis in Different Fat Depots Are Related to Obesity. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.00138"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Carey, A.L., Vorlander, C., Reddy-Luthmoodoo, M., Natoli, A.K., Formosa, M.F., Bertovic, D.A., Anderson, M.J., Duffy, S.J., and Kingwell, B.A. (2014). Reduced UCP-1 content in in vitro differentiated beige\/brite adipocytes derived from preadipocytes of human subcutaneous white adipose tissues in obesity. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0091997"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"E2102","DOI":"10.1073\/pnas.1416546112","article-title":"The human sex ratio from conception to birth","volume":"112","author":"Orzack","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/jpc.16677","article-title":"Inguinal hernias in children: Update on management guidelines","volume":"60","author":"Morgado","year":"2024","journal-title":"J. Paediatr. Child Health"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/humrep\/deh662","article-title":"The epigenetic environment: Secondary sex ratio depends on differential survival in embryogenesis","volume":"20","author":"Boklage","year":"2005","journal-title":"Hum. Reprod."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Gyurina, K., Yarmak, M., Sasi-Szab\u00f3, L., Moln\u00e1r, S., M\u00e9hes, G., and R\u00f6szer, T. (2023). Loss of Uncoupling Protein 1 Expression in the Subcutaneous Adipose Tissue Predicts Childhood Obesity. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242316706"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"pdb.prot5230","DOI":"10.1101\/pdb.prot5230","article-title":"Magnetofection: The Use of Magnetic Nanoparticles for Nucleic Acid Delivery","volume":"2009","author":"Plank","year":"2009","journal-title":"Cold Spring Harb. Protoc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/nm.2156","article-title":"Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection","volume":"16","author":"Souto","year":"2010","journal-title":"Nat. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: A fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Chen, E.Y., Tan, C.M., Kou, Y., Duan, Q., Wang, Z., Meirelles, G.V., Clark, N.R., and Ma\u2019ayan, A. (2013). Enrichr: Interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinform., 14.","DOI":"10.1186\/1471-2105-14-128"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"D1040","DOI":"10.1093\/nar\/gks1215","article-title":"Interferome v2.0: An updated database of annotated interferon-regulated genes","volume":"41","author":"Rusinova","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1126\/science.275.5298.343","article-title":"An information-intensive approach to the molecular pharmacology of cancer","volume":"275","author":"Weinstein","year":"1997","journal-title":"Science"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: Protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"8044","DOI":"10.1039\/C5CC01088H","article-title":"Mitochondria-targeted fluorescent thermometer monitors intracellular temperature gradient","volume":"51","author":"Arai","year":"2015","journal-title":"Chem. Commun."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Lane, N. (2018). Hot mitochondria?. PLoS Biol., 16.","DOI":"10.1371\/journal.pbio.2005113"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e397","DOI":"10.1038\/tp.2014.44","article-title":"Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression","volume":"4","author":"Karabatsiakis","year":"2014","journal-title":"Transl. Psychiatry"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1002\/stem.2635","article-title":"CD36 Is a Marker of Human Adipocyte Progenitors with Pronounced Adipogenic and Triglyceride Accumulation Potential","volume":"35","author":"Gao","year":"2017","journal-title":"Stem Cells"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0022-2275(20)41129-0","article-title":"Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes","volume":"36","author":"Dwyer","year":"1995","journal-title":"J. Lipid Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41586-018-0801-z","article-title":"Thermal stress induces glycolytic beige fat formation via a myogenic state","volume":"565","author":"Chen","year":"2019","journal-title":"Nature"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/s41390-024-03465-0","article-title":"Using weight-for-age as a screening tool for metabolic syndrome in apparently healthy adolescents","volume":"97","author":"Oselka","year":"2025","journal-title":"Pediatr. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1172\/JCI125646","article-title":"Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages","volume":"129","author":"Yu","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1101\/gad.348762.121","article-title":"Cold-responsive adipocyte progenitors couple adrenergic signaling to immune cell activation to promote beige adipocyte accrual","volume":"35","author":"Shan","year":"2021","journal-title":"Genes. Dev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.cmet.2020.07.005","article-title":"Human Brown Adipocyte Thermogenesis Is Driven by \u03b22-AR Stimulation","volume":"32","author":"Blondin","year":"2020","journal-title":"Cell Metab."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.bbrc.2009.12.107","article-title":"Caspase 3 inactivates biologically active full length interleukin-33 as a classical cytokine but does not prohibit nuclear translocation","volume":"391","author":"Ali","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/s41366-024-01522-6","article-title":"Genetic evidence for involvement of \u03b22-adrenergic receptor in brown adipose tissue thermogenesis in humans","volume":"48","author":"Ishida","year":"2024","journal-title":"Int. J. Obes."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1172\/JCI119444","article-title":"In vivo resistance of lipolysis to epinephrine. A new feature of childhood onset obesity","volume":"99","author":"Stunff","year":"1997","journal-title":"J. Clin. Investig."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e139160","DOI":"10.1172\/jci.insight.139160","article-title":"\u03b23-Adrenergic receptors regulate human brown\/beige adipocyte lipolysis and thermogenesis","volume":"6","author":"Cero","year":"2021","journal-title":"JCI Insight"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"100942","DOI":"10.1016\/j.xcrm.2023.100942","article-title":"Stimulation of the beta-2-adrenergic receptor with salbutamol activates human brown adipose tissue","volume":"4","author":"Straat","year":"2023","journal-title":"Cell Rep. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1172\/JCI116191","article-title":"Tissue distribution of beta 3-adrenergic receptor mRNA in man","volume":"91","author":"Krief","year":"1993","journal-title":"J. Clin. Investig."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.cmet.2017.09.002","article-title":"Lipolysis in brown adipocytes is not essential for cold-induced thermogenesis in mice","volume":"26","author":"Shin","year":"2017","journal-title":"Cell Metab."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1038\/s41467-022-31525-8","article-title":"Lipolysis regulates major transcriptional programs in brown adipocytes","volume":"13","author":"Markussen","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/sj.ijo.0800789","article-title":"Catecholamine-induced lipolysis in obesity","volume":"23","author":"Arner","year":"1999","journal-title":"Int. J. Obes. Relat. Metab. Disord. J. Int. Assoc. Study Obes."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1210\/jcem.84.11.6145","article-title":"Resistance to the lipolytic action of epinephrine: A new feature of protein Gs deficiency","volume":"84","author":"Carel","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1152\/japplphysiol.01072.2005","article-title":"Reduced exercise-associated response of the GH-IGF-I axis and catecholamines in obese children and adolescents","volume":"100","author":"Eliakim","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.2337\/db14-0744","article-title":"Evidence of early alterations in adipose tissue biology and function and its association with obesity-related inflammation and insulin resistance in children","volume":"64","author":"Landgraf","year":"2015","journal-title":"Diabetes"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e1146","DOI":"10.1002\/cti2.1146","article-title":"Interleukin (IL)-33: An orchestrator of immunity from host defence to tissue homeostasis","volume":"9","author":"Zhou","year":"2020","journal-title":"Clin. Transl. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/imr.12619","article-title":"Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family","volume":"281","author":"Cayrol","year":"2018","journal-title":"Immunol. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Misawa, T., Wagner, M., and Koyasu, S. (2022). ILC2s and Adipose Tissue Homeostasis: Progress to Date and the Road Ahead. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.876029"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"R\u00f6szer, T. (2020). M2 Macrophages in the Metabolic Organs and in the Neuroendocrine System. The M2 Macrophage, Springer International Publishing.","DOI":"10.1007\/978-3-030-50480-9_9"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.bbi.2019.06.019","article-title":"STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI","volume":"81","author":"Holl","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1161\/CIRCRESAHA.110.218867","article-title":"Interleukin-33 Induces Protective Effects in Adipose Tissue Inflammation During Obesity in Mice","volume":"107","author":"Miller","year":"2010","journal-title":"Circ. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.immuni.2024.04.002","article-title":"Adipose-tissue Treg cells restrain differentiation of stromal adipocyte precursors to promote insulin sensitivity and metabolic homeostasis","volume":"57","author":"Wang","year":"2024","journal-title":"Immunity"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.cell.2014.12.011","article-title":"Activated type 2 innate lymphoid cells regulate beige fat biogenesis","volume":"160","author":"Lee","year":"2015","journal-title":"Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"eabg9698","DOI":"10.1126\/sciimmunol.abg9698","article-title":"The chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte\/IL-33\/type 2 innate immunity circuit","volume":"6","author":"Lin","year":"2021","journal-title":"Sci. Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1530\/JOE-16-0229","article-title":"IL-33-driven ILC2\/eosinophil axis in fat is induced by sympathetic tone and suppressed by obesity","volume":"231","author":"Ding","year":"2016","journal-title":"J. Endocrinol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1016\/j.cmet.2021.08.004","article-title":"IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2","volume":"33","author":"Goldberg","year":"2021","journal-title":"Cell Metab."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e353","DOI":"10.1038\/emm.2017.70","article-title":"Induction of thermogenic adipocytes: Molecular targets and thermogenic small molecules","volume":"49","author":"Song","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1172\/JCI86080","article-title":"IRF3 promotes adipose inflammation and insulin resistance and represses browning","volume":"126","author":"Kumari","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"E485","DOI":"10.1152\/ajpendo.00505.2012","article-title":"Interferon regulatory factor 7 deficiency prevents diet-induced obesity and insulin resistance","volume":"305","author":"Wang","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.15252\/embj.201695588","article-title":"PRDM16 represses the type I interferon response in adipocytes to promote mitochondrial and thermogenic programing","volume":"36","author":"Kissig","year":"2017","journal-title":"EMBO J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"113285","DOI":"10.1016\/j.intimp.2024.113285","article-title":"Interleukin-33: Expression, regulation and function in adipose tissues","volume":"143","author":"Chen","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Joshi, A.D., Oak, S.R., Hartigan, A.J., Finn, W.G., Kunkel, S.L., Duffy, K.E., Das, A., and Hogaboam, C.M. (2010). Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages. BMC Immunol., 11.","DOI":"10.1186\/1471-2172-11-52"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/ijo.2012.118","article-title":"Severe obesity increases adipose tissue expression of interleukin-33 and its receptor ST2, both predominantly detectable in endothelial cells of human adipose tissue","volume":"37","author":"Zeyda","year":"2013","journal-title":"Int. J. Obes."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"156080","DOI":"10.1016\/j.cyto.2022.156080","article-title":"Interleukin-33 inhibits glucose uptake in human adipocytes and its expression in adipose tissue is elevated in insulin resistance and type 2 diabetes","volume":"161","author":"Pereira","year":"2023","journal-title":"Cytokine"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.2337\/dbi20-0036","article-title":"Viral and Nonviral Transfer of Genetic Materials to Adipose Tissues: Toward a Gold Standard Approach","volume":"69","author":"Romanelli","year":"2020","journal-title":"Diabetes"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.tem.2025.03.010","article-title":"Adipose tissue-targeting nanomedicines for obesity pharmacotherapy","volume":"36","author":"Wang","year":"2025","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/s41434-024-00471-z","article-title":"Preclinical evaluation of tissue-selective gene therapies for congenital generalised lipodystrophy","volume":"31","author":"Tiwari","year":"2024","journal-title":"Gene Ther."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/1520-7560(200005\/06)16:3<202::AID-DMRR116>3.0.CO;2-#","article-title":"Lipid metabolism in the fetus and the newborn","volume":"16","author":"Herrera","year":"2000","journal-title":"Diabetes\/Metab. Res. Rev."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Draper, H.H. (1990). Energy Metabolism of the Newborn Infant. Advances in Nutritional Research, Springer.","DOI":"10.1007\/978-1-4613-0611-5"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1399-6576.1974.tb00706.x","article-title":"Carbohydrate and Lipid Metabolism in the Newborn Infant","volume":"18","author":"Persson","year":"1974","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-3782(84)90106-3","article-title":"The chronology of adipose tissue appearance and distribution in the human fetus","volume":"10","author":"Poissonnet","year":"1984","journal-title":"Early Hum. Dev."},{"key":"ref_77","unstructured":"Badr, M.Z. (2019). Isolation and Characterization of Adipose Tissue Macrophages. Nuclear Receptors: Methods and Experimental Protocols, Springer."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Hoang, A.C., Yu, H., and R\u00f6szer, T. (2021). Transcriptional Landscaping Identifies a Beige Adipocyte Depot in the Newborn Mouse. Cells, 10.","DOI":"10.3390\/cells10092368"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Radv\u00e1nyi, \u00c1., Gyurina, K., R\u00e1cz, E., Kov\u00e1cs, I., M\u00e9hes, G., and R\u00f6szer, T. (2024). Adipose Tissue Macrophages of the Human Fetus. Cells, 13.","DOI":"10.3390\/cells13211787"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"E1085","DOI":"10.1152\/ajpendo.00023.2015","article-title":"A stringent validation of mouse adipose tissue identity markers","volume":"308","author":"Larsson","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/11\/1000\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:23:14Z","timestamp":1780633394000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/11\/1000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":80,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["cells15111000"],"URL":"https:\/\/doi.org\/10.3390\/cells15111000","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]}}}