{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:01:00Z","timestamp":1780635660169,"version":"3.54.1"},"reference-count":137,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondation de l\u2019Ataxie Charlevoix-Saguenay"},{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"crossref","award":["RC26"],"award-info":[{"award-number":["RC26"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Hereditary cerebellar ataxias are progressive neurodegenerative disorders for which disease-modifying treatments remain lacking. Although these conditions have traditionally been investigated from a neuron-centered perspective, evidence from several ataxia models indicates that changes in the cerebellar immune microenvironment can arise before overt neuronal loss and may contribute to early circuit dysfunction. This review examines hereditary cerebellar ataxias through the lens of early neuroimmune regulation, with particular attention to the region-specific properties of cerebellar microglia and their roles in synaptic refinement, inflammatory tone modulation and circuit homeostasis. We further discuss zebrafish as a useful experimental system for this question, because they combine in vivo imaging, genetic manipulation, and scalable functional assays in an intact vertebrate model. In this context, flavonoids\u2014and especially naringenin\u2014are not considered as immediate therapeutic candidates, but as mechanistically informative experimental probes to investigate how modulation of neuroimmune signaling affects disease-relevant phenotypes in vivo. By integrating genetic ataxia models with dynamic neuroimmune readouts, functional behavioral assays, and circuit-level analyses, zebrafish-based approaches can help identify early windows during which neuroimmune signaling influences cerebellar resilience and disease progression and can guide subsequent validation in mammalian systems.<\/jats:p>","DOI":"10.3390\/cells15111014","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T08:09:16Z","timestamp":1780301356000},"page":"1014","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Neuroimmune Modulation in Hereditary Cerebellar Ataxias: Experimental Opportunities in Zebrafish Models"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4941-635X","authenticated-orcid":false,"given":"Valentina","family":"Naef","sequence":"first","affiliation":[{"name":"Neurobiology and Molecular Medicine Units, IRCCS Fondazione Stella Maris, 56128 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8498-7889","authenticated-orcid":false,"given":"Michela","family":"Giacich","sequence":"additional","affiliation":[{"name":"Neurobiology and Molecular Medicine Units, IRCCS Fondazione Stella Maris, 56128 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2962-6296","authenticated-orcid":false,"given":"Devid","family":"Damiani","sequence":"additional","affiliation":[{"name":"Neurobiology and Molecular Medicine Units, IRCCS Fondazione Stella Maris, 56128 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo Maria","family":"Santorelli","sequence":"additional","affiliation":[{"name":"Neurobiology and Molecular Medicine Units, IRCCS Fondazione Stella Maris, 56128 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","article-title":"Hallmarks of Neurodegenerative Diseases","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Dom\u00ednguez, M. (2025). Neuroinflammation: Mechanisms, Dual Roles, and Therapeutic Strategies in Neurological Disorders. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47060417"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Bernardi, E., L\u00f3pez-Lombard\u00eda, \u00d3., Olmedo-Saura, G., Pagonabarraga, J., Kulisevsky, J., and P\u00e9rez-P\u00e9rez, J. (2026). Hereditary Ataxias: From Pathogenesis and Clinical Features to Neuroimaging, Fluid, and Digital Biomarkers\u2014A Scoping Review. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27020881"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s00415-022-11383-6","article-title":"The Inherited Cerebellar Ataxias: An Update","volume":"270","author":"Coarelli","year":"2023","journal-title":"J. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/gim.2013.28","article-title":"Hereditary Ataxias: Overview","volume":"15","author":"Jayadev","year":"2013","journal-title":"Genet. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s12311-015-0664-x","article-title":"Consensus Paper: Neuroimmune Mechanisms of Cerebellar Ataxias","volume":"15","author":"Mitoma","year":"2016","journal-title":"Cerebellum"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1016\/j.jmb.2019.01.016","article-title":"Role of Microglia in Ataxias","volume":"431","author":"Ferro","year":"2019","journal-title":"J. Mol. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4780","DOI":"10.1093\/hmg\/ddv202","article-title":"Loss of MyD88 Alters Neuroinflammatory Response and Attenuates Early Purkinje Cell Loss in a Spinocerebellar Ataxia Type 6 Mouse Model","volume":"24","author":"Aikawa","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.nbd.2018.08.022","article-title":"Lysosomal Dysfunction and Early Glial Activation Are Involved in the Pathogenesis of Spinocerebellar Ataxia Type 21 Caused by Mutant Transmembrane Protein 240","volume":"120","author":"Seki","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Shen, Y., McMackin, M.Z., Shan, Y., Raetz, A., David, S., and Cortopassi, G. (2016). Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation That Is Rescued by PJ34. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0151026"},{"key":"ref_11","first-page":"109","article-title":"A Rat Model of Ataxia-Telangiectasia: Evidence for a Neurodegenerative Phenotype","volume":"26","author":"Quek","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.neuroscience.2015.01.003","article-title":"Early Activation of Microglia and Astrocytes in Mouse Models of Spinocerebellar Ataxia Type 1","volume":"289","author":"Cvetanovic","year":"2015","journal-title":"Neuroscience"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Parvez, M.S.A., and Ohtsuki, G. (2022). Acute Cerebellar Inflammation and Related Ataxia: Mechanisms and Pathophysiology. Brain Sci., 12.","DOI":"10.3390\/brainsci12030367"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/glia.24122","article-title":"Dysfunction of Cerebellar Microglia in Ataxia-telangiectasia","volume":"70","author":"Levi","year":"2022","journal-title":"Glia"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"113622","DOI":"10.1016\/j.celrep.2023.113622","article-title":"ATM-Deficiency-Induced Microglial Activation Promotes Neurodegeneration in Ataxia-Telangiectasia","volume":"43","author":"Lai","year":"2024","journal-title":"Cell Rep."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Apolloni, S., Milani, M., and D\u2019Ambrosi, N. (2022). Neuroinflammation in Friedreich\u2019s Ataxia. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23116297"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41467-025-66710-y","article-title":"Microgliopathy as a Primary Mediator of Neuronal Death in Models of Friedreich\u2019s Ataxia","volume":"17","author":"Pernaci","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/mds.28825","article-title":"Neuroinflammation in the Cerebellum and Brainstem in Friedreich Ataxia: An [18F]-FEMPA PET Study","volume":"37","author":"Khan","year":"2022","journal-title":"Mov. Disord."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Hampe, C.S., and Mitoma, H. (2022). A Breakdown of Immune Tolerance in the Cerebellum. Brain Sci., 12.","DOI":"10.3390\/brainsci12030328"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"156","DOI":"10.4103\/NRR.NRR-D-24-00550","article-title":"Cerebellar Microglia: On the Edge between Neuroinflammation and Neuroregulation","volume":"21","author":"Dukhinova","year":"2026","journal-title":"Neural Regen. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"106773","DOI":"10.1016\/j.phrs.2023.106773","article-title":"Proinflammatory Activation of Microglia in the Cerebellum Hyperexcites Purkinje Cells to Trigger Ataxia","volume":"191","author":"Xie","year":"2023","journal-title":"Pharmacol. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1016\/j.celrep.2019.07.078","article-title":"Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar Inflammation","volume":"28","author":"Yamamoto","year":"2019","journal-title":"Cell Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"11589","DOI":"10.1038\/s41598-018-29786-9","article-title":"TNF-\u03b1 Increases the Intrinsic Excitability of Cerebellar Purkinje Cells through Elevating Glutamate Release in Bergmann Glia","volume":"8","author":"Shim","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"272","DOI":"10.2174\/1568026620666200221172619","article-title":"The Role of Microglia in Neurodevelopmental Disorders and Their Therapeutics","volume":"20","author":"Coomey","year":"2020","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00281-024-01017-6","article-title":"The Role of Microglia in Early Neurodevelopment and the Effects of Maternal Immune Activation","volume":"46","author":"Mastenbroek","year":"2024","journal-title":"Semin. Immunopathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/glia.23083","article-title":"Identification of a Conserved and Acute Neurodegeneration-specific Microglial Transcriptome in the Zebrafish","volume":"65","author":"Oosterhof","year":"2017","journal-title":"Glia"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.cell.2008.04.037","article-title":"Live Imaging of Neuronal Degradation by Microglia Reveals a Role for V0-ATPase A1 in Phagosomal Fusion In Vivo","volume":"133","author":"Peri","year":"2008","journal-title":"Cell"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1182\/blood-2010-10-314120","article-title":"Mpeg1 Promoter Transgenes Direct Macrophage-Lineage Expression in Zebrafish","volume":"117","author":"Ellett","year":"2011","journal-title":"Blood"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Mastrogiovanni, M., Mart\u00ednez-Navarro, F.J., Bowman, T.V., and Cayuela, M.L. (2024). Inflammation in Development and Aging: Insights from the Zebrafish Model. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25042145"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1038\/s41593-020-0703-x","article-title":"Live-Imaging of Astrocyte Morphogenesis and Function in Zebrafish Neural Circuits","volume":"23","author":"Chen","year":"2020","journal-title":"Nat. Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"111549","DOI":"10.1016\/j.isci.2024.111549","article-title":"Zebrafish Glial-Vascular Interactions Progressively Expand over the Course of Brain Development","volume":"28","author":"Gall","year":"2025","journal-title":"iScience"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Quelle-Regaldie, A., Sobrido-Came\u00e1n, D., Barreiro-Iglesias, A., Sobrido, M.J., and S\u00e1nchez, L. (2021). Zebrafish Models of Autosomal Recessive Ataxias. Cells, 10.","DOI":"10.3390\/cells10040836"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Quelle-Regaldie, A., Sobrido-Came\u00e1n, D., Barreiro-Iglesias, A., Sobrido, M.J., and S\u00e1nchez, L. (2021). Zebrafish Models of Autosomal Dominant Ataxias. Cells, 10.","DOI":"10.3390\/cells10020421"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"101195","DOI":"10.1016\/j.jpha.2025.101195","article-title":"Zebrafish as a Vertebrate Model for High-Throughput Drug Toxicity Screening: Mechanisms, Novel Techniques, and Future Perspectives","volume":"15","author":"Wang","year":"2025","journal-title":"J. Pharm. Anal."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.reprotox.2011.06.121","article-title":"Zebrafish Embryos as an Alternative to Animal Experiments\u2014A Commentary on the Definition of the Onset of Protected Life Stages in Animal Welfare Regulations","volume":"33","author":"Scholz","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Allen, C., and Mocho, J.-P. (2024). The 3Rs in Zebrafish Research. Zebrafish, CABI.","DOI":"10.1079\/9781800629431.0001"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e70080","DOI":"10.1002\/bies.70080","article-title":"Zebrafish: A Versatile and Powerful Model for Biomedical Research","volume":"47","author":"Siddiqui","year":"2025","journal-title":"BioEssays"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/JLB.3MR1021-531R","article-title":"Microglial Activation in Alzheimer\u2019s Disease: The Role of Flavonoids and microRNAs","volume":"112","author":"Secundino","year":"2022","journal-title":"J. Leukoc. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"114537","DOI":"10.1016\/j.yexcr.2025.114537","article-title":"Flavonoids in the Regulation of Microglial-Mediated Neuroinflammation; Focus on Fisetin, Rutin, and Quercetin","volume":"447","author":"Jasim","year":"2025","journal-title":"Exp. Cell Res."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Dos Santos, B.L., Dos Santos, C.C., Soares, J.R.P., Da Silva, K.C., De Oliveira, J.V.R., Pereira, G.S., De Ara\u00fajo, F.M., Costa, M.D.F.D., David, J.M., and Da Silva, V.D.A. (2023). The Flavonoid Agathisflavone Directs Brain Microglia\/Macrophages to a Neuroprotective Anti-Inflammatory and Antioxidant State via Regulation of NLRP3 Inflammasome. Pharmaceutics, 15.","DOI":"10.1016\/j.ibneur.2023.08.474"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Chen, Y., Peng, F., Xing, Z., Chen, J., Peng, C., and Li, D. (2022). Beneficial Effects of Natural Flavonoids on Neuroinflammation. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1006434"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Yang, G., Xu, X., Gao, W., Wang, X., Zhao, Y., and Xu, Y. (2025). Microglia-Orchestrated Neuroinflammation and Synaptic Remodeling: Roles of pro-Inflammatory Cytokines and Receptors in Neurodegeneration. Front. Cell. Neurosci., 19.","DOI":"10.3389\/fncel.2025.1700692"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Zhang, B., Wei, Y.-Z., Wang, G.-Q., Li, D.-D., Shi, J.-S., and Zhang, F. (2019). Targeting MAPK Pathways by Naringenin Modulates Microglia M1\/M2 Polarization in Lipopolysaccharide-Stimulated Cultures. Front. Cell. Neurosci., 12.","DOI":"10.3389\/fncel.2018.00531"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1007\/s12035-014-9042-9","article-title":"Naringenin Suppresses Neuroinflammatory Responses Through Inducing Suppressor of Cytokine Signaling 3 Expression","volume":"53","author":"Wu","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_45","first-page":"204","article-title":"Naringenin Attenuates the Release of Pro-Inflammatory Mediators from Lipopolysaccharide-Stimulated BV2 Microglia by Inactivating Nuclear Factor-\u03baB and Inhibiting Mitogen-Activated Protein Kinases","volume":"30","author":"Park","year":"2012","journal-title":"Int. J. Mol. Med."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Rashid, S.M., James, A.W., Shehjar, F., Yousuf, S., and Shah, Z.A. (2026). Naringenin Ameliorates LPS-Induced Neuroinflammation Through NF-\u03baB Signaling in Human Microglia and Protects Neuronal Cells. Brain Sci., 16.","DOI":"10.20944\/preprints202601.1082.v1"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"119700","DOI":"10.1016\/j.ecoenv.2026.119700","article-title":"Naringenin Protects Zebrafish Larvae from BMAA-Induced Neuromuscular Toxicity by Regulating Myogenic and Inflammatory Pathways","volume":"309","author":"Cao","year":"2026","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Thayumanavan, G., Jeyabalan, S., Fuloria, S., Sekar, M., Ravi, M., Selvaraj, L.K., Bala, L., Chidambaram, K., Gan, S.H., and Rani, N.N.I.M. (2022). Silibinin and Naringenin against Bisphenol A-Induced Neurotoxicity in Zebrafish Model\u2014Potential Flavonoid Molecules for New Drug Design, Development, and Therapy for Neurological Disorders. Molecules, 27.","DOI":"10.3390\/molecules27082572"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.neuron.2018.10.010","article-title":"Spatial and Temporal Organization of the Individual Human Cerebellum","volume":"100","author":"Marek","year":"2018","journal-title":"Neuron"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"7554","DOI":"10.1523\/JNEUROSCI.1451-23.2023","article-title":"Cognitive-Affective Functions of the Cerebellum","volume":"43","author":"Rudolph","year":"2023","journal-title":"J. Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1093\/brain\/awv066","article-title":"Roles of Microglia in Brain Development, Tissue Maintenance and Repair","volume":"138","author":"Touil","year":"2015","journal-title":"Brain J. Neurol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"La Sala, G., and Farini, D. (2025). Glial Cells and Aging: From the CNS to the Cerebellum. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26157553"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/dneu.22572","article-title":"Cerebellar Microglia Are Dynamically Unique and Survey Purkinje Neurons In Vivo","volume":"78","author":"Stowell","year":"2018","journal-title":"Dev. Neurobiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nn.4222","article-title":"Microglial Brain Region\u2212dependent Diversity and Selective Regional Sensitivities to Aging","volume":"19","author":"Grabert","year":"2016","journal-title":"Nat. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"ENEURO.0036-15.2015","DOI":"10.1523\/ENEURO.0036-15.2015","article-title":"Morphological and Phagocytic Profile of Microglia in the Developing Rat Cerebellum","volume":"2","author":"VanRyzin","year":"2015","journal-title":"eneuro"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/s41593-018-0192-3","article-title":"Epigenetic Regulation of Brain Region-Specific Microglia Clearance Activity","volume":"21","author":"Ayata","year":"2018","journal-title":"Nat. Neurosci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s12311-017-0904-3","article-title":"The Molecular Pathway Regulating Bergmann Glia and Folia Generation in the Cerebellum","volume":"17","author":"Leung","year":"2018","journal-title":"Cerebellum"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.neuron.2016.05.037","article-title":"Purkinje Cell Collaterals Enable Output Signals from the Cerebellar Cortex to Feed Back to Purkinje Cells and Interneurons","volume":"91","author":"Witter","year":"2016","journal-title":"Neuron"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e2514663122","DOI":"10.1073\/pnas.2514663122","article-title":"Essential New Insights into Human Cerebellar Purkinje Cell Biology from Studies of Essential Tremor","volume":"122","author":"Millen","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.conb.2008.05.010","article-title":"Cerebellar Development and Disease","volume":"18","author":"Millen","year":"2008","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1080\/14734220600724569","article-title":"Interactions between Purkinje Neurones and Bergmann Glia","volume":"5","author":"Bellamy","year":"2006","journal-title":"Cerebellum"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/s42003-025-07566-2","article-title":"Maternal Immune Activation Followed by Peripubertal Stress Combinedly Produce Reactive Microglia and Confine Cerebellar Cognition","volume":"8","author":"Hikosaka","year":"2025","journal-title":"Commun. Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s12311-009-0142-4","article-title":"Cerebellar Disorders\u2014At the Crossroad of Molecular Pathways and Diagnosis","volume":"8","author":"Manto","year":"2009","journal-title":"Cerebellum"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Deus, C.M., Tavares, H., Beatriz, M., Mota, S., and Lopes, C. (2022). Mitochondrial Damage-Associated Molecular Patterns Content in Extracellular Vesicles Promotes Early Inflammation in Neurodegenerative Disorders. Cells, 11.","DOI":"10.20944\/preprints202207.0078.v2"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"116480","DOI":"10.1016\/j.celrep.2025.116480","article-title":"Autonomous STING Signaling in Purkinje Cells Drives Neurodegeneration Independent of Type I Interferon","volume":"44","author":"Yang","year":"2025","journal-title":"Cell Rep."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Fujita, Y., and Yamashita, T. (2021). Alterations in Chromatin Structure and Function in the Microglia. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.626541"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"9912686","DOI":"10.1155\/2021\/9912686","article-title":"Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases","volume":"2021","author":"Wang","year":"2021","journal-title":"Neural Plast."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"103838","DOI":"10.1016\/j.mcn.2023.103838","article-title":"Transcriptional and Epigenetic Regulation of Microglia in Substance Use Disorders","volume":"125","author":"Vilca","year":"2023","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Ferro, A., Qu, W., Lukowicz, A., Svedberg, D., Johnson, A., and Cvetanovic, M. (2018). Inhibition of NF-\u03baB Signaling in IKK\u03b2F\/F;LysM Cre Mice Causes Motor Deficits but Does Not Alter Pathogenesis of Spinocerebellar Ataxia Type 1. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0200013"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Pansera, L., Mhalhel, K., Cavallaro, M., Aragona, M., Laur\u00e0, R., Levanti, M., Guerrera, M.C., Abbate, F., German\u00e0, A., and Montalbano, G. (2025). Zebrafish as an Integrative Model for Central Nervous System Research: Current Advances and Translational Perspectives. Life, 15.","DOI":"10.3390\/life15111751"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.celrep.2012.08.015","article-title":"High-Throughput Screening for Bioactive Molecules Using Primary Cell Culture of Transgenic Zebrafish Embryos","volume":"2","author":"Huang","year":"2012","journal-title":"Cell Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"bio058513","DOI":"10.1242\/bio.058513","article-title":"A Versatile, Automated and High-Throughput Drug Screening Platform for Zebrafish Embryos","volume":"10","author":"Lubin","year":"2021","journal-title":"Biol. Open"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"RP97614","DOI":"10.7554\/eLife.97614","article-title":"Cerebellar Purkinje Cells Control Posture in Larval Zebrafish (Danio rerio)","volume":"13","author":"Auer","year":"2025","journal-title":"Elife"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00018-023-04879-5","article-title":"Development, Circuitry, and Function of the Zebrafish Cerebellum","volume":"80","author":"Schramm","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1440-169X.2012.01348.x","article-title":"Development and Evolution of Cerebellar Neural Circuits","volume":"54","author":"Hashimoto","year":"2012","journal-title":"Dev. Growth Differ."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1179069519880515","DOI":"10.1177\/1179069519880515","article-title":"Neurological Disease Modelling for Spinocerebellar Ataxia Using Zebrafish","volume":"13","author":"Namikawa","year":"2019","journal-title":"J. Exp. Neurosci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/dneu.20875","article-title":"Development of the Cerebellum and Cerebellar Neural Circuits","volume":"72","author":"Hibi","year":"2012","journal-title":"Dev. Neurobiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1002\/glia.23849","article-title":"Radial Glia in the Zebrafish Brain: Functional, Structural, and Physiological Comparison with the Mammalian Glia","volume":"68","author":"Yaksi","year":"2020","journal-title":"Glia"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"116509","DOI":"10.1016\/j.celrep.2025.116509","article-title":"Radial Astroglia Cooperate with Microglia to Clear Neuronal Cell Bodies during Zebrafish Optic Tectum Development","volume":"44","author":"Barber","year":"2025","journal-title":"Cell Rep."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/glia.22780","article-title":"Immune Cell Dynamics in the CNS: Learning from the Zebrafish","volume":"63","author":"Oosterhof","year":"2015","journal-title":"Glia"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.phrs.2017.08.017","article-title":"Zebrafish: A Promising in Vivo Model for Assessing the Delivery of Natural Products, Fluorescence Dyes and Drugs across the Blood-Brain Barrier","volume":"125","author":"Li","year":"2017","journal-title":"Pharmacol. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"ENEURO.0507-20.2021","DOI":"10.1523\/ENEURO.0507-20.2021","article-title":"Involvement of Cerebellar Neural Circuits in Active Avoidance Conditioning in Zebrafish","volume":"8","author":"Koyama","year":"2021","journal-title":"eneuro"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.modgep.2006.04.006","article-title":"GFAP Transgenic Zebrafish","volume":"6","author":"Bernardos","year":"2006","journal-title":"Gene Expr. Patterns"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Mazzolini, J., Chia, K., and Sieger, D. (2018). Isolation and RNA Extraction of Neurons, Macrophages and Microglia from Larval Zebrafish Brains. J. Vis. Exp., e57431.","DOI":"10.3791\/57431"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1523\/JNEUROSCI.1862-18.2019","article-title":"Modeling Neurodegenerative Spinocerebellar Ataxia Type 13 in Zebrafish Using a Purkinje Neuron Specific Tunable Coexpression System","volume":"39","author":"Namikawa","year":"2019","journal-title":"J. Neurosci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"11846","DOI":"10.1073\/pnas.1403105111","article-title":"Functional Regionalization of the Teleost Cerebellum Analyzed In Vivo","volume":"111","author":"Matsui","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2014.09.030","article-title":"Establishment of Gal4 Transgenic Zebrafish Lines for Analysis of Development of Cerebellar Neural Circuitry","volume":"397","author":"Takeuchi","year":"2015","journal-title":"Dev. Biol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Walton, E.M., Cronan, M.R., Beerman, R.W., and Tobin, D.M. (2015). The Macrophage-Specific Promoter Mfap4 Allows Live, Long-Term Analysis of Macrophage Behavior during Mycobacterial Infection in Zebrafish. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0138949"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s00018-024-05538-z","article-title":"Genetic Modeling of Degenerative Diseases and Mechanisms of Neuronal Regeneration in the Zebrafish Cerebellum","volume":"82","author":"Namikawa","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.15252\/embj.201593350","article-title":"Loss of C9ORF72 Impairs Autophagy and Synergizes with polyQ Ataxin-2 to Induce Motor Neuron Dysfunction and Cell Death","volume":"35","author":"Sellier","year":"2016","journal-title":"EMBO J."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Yanicostas, C., Barbieri, E., Hibi, M., Brice, A., Stevanin, G., and Soussi-Yanicostas, N. (2012). Requirement for Zebrafish Ataxin-7 in Differentiation of Photoreceptors and Cerebellar Neurons. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0050705"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1152\/jn.00839.2011","article-title":"Touch Responsiveness in Zebrafish Requires Voltage-Gated Calcium Channel 2.1b","volume":"108","author":"Low","year":"2012","journal-title":"J. Neurophysiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"7384","DOI":"10.1523\/JNEUROSCI.5839-12.2013","article-title":"Zebrafish Calls for Reinterpretation for the Roles of P\/Q Calcium Channels in Neuromuscular Transmission","volume":"33","author":"Wen","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"7782","DOI":"10.1523\/JNEUROSCI.1142-17.2017","article-title":"Calpain Inhibition Is Protective in Machado\u2013Joseph Disease Zebrafish Due to Induction of Autophagy","volume":"37","author":"Watchon","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"106793","DOI":"10.1016\/j.nbd.2025.106793","article-title":"Modeling Sacsin Depletion in Danio Rerio Offers New Insight on Retinal Defects in ARSACS","volume":"205","author":"Naef","year":"2025","journal-title":"Neurobiol. Dis."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Naef, V., Marchese, M., Ogi, A., Fichi, G., Galatolo, D., Licitra, R., Doccini, S., Verri, T., Argenton, F., and Morani, F. (2021). Efficient Neuroprotective Rescue of Sacsin-Related Disease Phenotypes in Zebrafish. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22168401"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"13779","DOI":"10.1021\/acs.analchem.4c07095","article-title":"Stable Isotope Labeling in Bacteria Enables Characterization and Quantification of Frataxin Protein in a Friedreich\u2019s Ataxia Zebrafish Model","volume":"97","author":"Rojsajjakul","year":"2025","journal-title":"Anal. Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1002\/acn3.52094","article-title":"SCAR32: Functional Characterization and Expansion of the Clinical-genetic Spectrum","volume":"11","author":"Naef","year":"2024","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"6019","DOI":"10.1038\/s41467-025-60775-5","article-title":"RFC1 Regulates the Expansion of Neural Progenitors in the Developing Zebrafish Cerebellum","volume":"16","author":"Nobilleau","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Chen, K., Wang, P., Chen, J., Ying, Y., Chen, Y., Gilson, E., Lu, Y., and Ye, J. (2022). Loss of Atm in Zebrafish as a Model of Ataxia\u2013Telangiectasia Syndrome. Biomedicines, 10.","DOI":"10.3390\/biomedicines10020392"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1017\/jns.2016.41","article-title":"Flavonoids: An Overview","volume":"5","author":"Panche","year":"2016","journal-title":"J. Nutr. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"100217","DOI":"10.1016\/j.crphar.2025.100217","article-title":"Anti-Inflammatory Potential of Quercetin: From Chemistry and Mechanistic Insight to Nanoformulations","volume":"8","author":"Aggarwal","year":"2025","journal-title":"Curr. Res. Pharmacol. Drug Discov."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"156846","DOI":"10.1016\/j.cyto.2024.156846","article-title":"Kaempferol: Unveiling Its Anti-Inflammatory Properties for Therapeutic Innovation","volume":"186","author":"Herrera","year":"2025","journal-title":"Cytokine"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Liu, Y., Shi, X., Tian, Y., Zhai, S., Liu, Y., Xiong, Z., and Chu, S. (2023). An Insight into Novel Therapeutic Potentials of Taxifolin. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1173855"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1753-4887.2010.00336.x","article-title":"Can Consuming Flavonoids Restore Old Microglia to Their Youthful State?","volume":"68","author":"Jang","year":"2010","journal-title":"Nutr. Rev."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"105895","DOI":"10.1016\/j.jddst.2024.105895","article-title":"Naringenin-Loaded Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate)-Based Devices Have an Anti-Inflammatory Activity on Microglia","volume":"98","author":"Pecorini","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1007\/s10787-025-01729-7","article-title":"Flavonoids Regulating NLRP3 Inflammasome: A Promising Approach in Alleviating Diabetic Peripheral Neuropathy","volume":"33","author":"Khanna","year":"2025","journal-title":"Inflammopharmacology"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mam.2011.10.016","article-title":"Neuroinflammation: Modulation by Flavonoids and Mechanisms of Action","volume":"33","author":"Spencer","year":"2012","journal-title":"Mol. Asp. Med."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Al-Khayri, J.M., Sahana, G.R., Nagella, P., Joseph, B.V., Alessa, F.M., and Al-Mssallem, M.Q. (2022). Flavonoids as Potential Anti-Inflammatory Molecules: A Review. Molecules, 27.","DOI":"10.3390\/molecules27092901"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Abbate, F., Maugeri, A., Laur\u00e0, R., Levanti, M., Navarra, M., Cirmi, S., and German\u00e0, A. (2021). Zebrafish as a Useful Model to Study Oxidative Stress-Linked Disorders: Focus on Flavonoids. Antioxidants, 10.","DOI":"10.3390\/antiox10050668"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Mhalhel, K., Sicari, M., Pansera, L., Chen, J., Levanti, M., Diotel, N., Rastegar, S., German\u00e0, A., and Montalbano, G. (2023). Zebrafish: A Model Deciphering the Impact of Flavonoids on Neurodegenerative Disorders. Cells, 12.","DOI":"10.3390\/cells12020252"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3945\/an.114.007500","article-title":"Flavonoid-Based Therapies in the Early Management of Neurodegenerative Diseases","volume":"6","author":"Solanki","year":"2015","journal-title":"Adv. Nutr."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"107836","DOI":"10.1016\/j.phrs.2025.107836","article-title":"Naringenin and SMER28 Target Lysosomal Reformation and Rescue SPG11 and SPG15 Hereditary Spastic Paraplegia Phenotypes","volume":"218","author":"Vantaggiato","year":"2025","journal-title":"Pharmacol. Res."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Napoli, B., Gumeni, S., Forgiarini, A., Fantin, M., De Filippis, C., Panzeri, E., Vantaggiato, C., and Orso, G. (2019). Naringenin Ameliorates Drosophila ReepA Hereditary Spastic Paraplegia-Linked Phenotypes. Front. Neurosci., 13.","DOI":"10.3389\/fnins.2019.01202"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1021\/acs.jnatprod.8b00366","article-title":"In Vivo Anti-Inflammatory and Antiallergic Activity of Pure Naringenin, Naringenin Chalcone, and Quercetin in Mice","volume":"82","year":"2019","journal-title":"J. Nat. Prod."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Lai, Z., Ke, L., and Zhao, W. (2025). Naringenin as a Neurotherapeutic Agent in Alzheimer\u2019s Disease: Epigenetic Signatures, Gut Microbiota Alterations, and Molecular Neuroprotection. Front. Aging Neurosci., 17.","DOI":"10.3389\/fnagi.2025.1647967"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/s42003-024-06615-6","article-title":"Naringenin Ameliorates Amyloid-\u03b2 Pathology and Neuroinflammation in Alzheimer\u2019s Disease","volume":"7","author":"Zhu","year":"2024","journal-title":"Commun. Biol."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Salehi, B., Fokou, P.V.T., Sharifi-Rad, M., Zucca, P., Pezzani, R., Martins, N., and Sharifi-Rad, J. (2019). The Therapeutic Potential of Naringenin: A Review of Clinical Trials. Pharmaceuticals, 12.","DOI":"10.3390\/ph12010011"},{"key":"ref_119","first-page":"3492058","article-title":"Naringin Regulates Microglia BV-2 Activation and Inflammation via the JAK\/STAT3 Pathway","volume":"2022","author":"Li","year":"2022","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"20138","DOI":"10.1038\/s41598-023-47540-8","article-title":"Anti-Inflammatory Reprogramming of Microglia Cells by Metabolic Modulators to Counteract Neurodegeneration; a New Role for Ranolazine","volume":"13","author":"Piano","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.neuint.2012.07.025","article-title":"Naringenin Ameliorates Alzheimer\u2019s Disease (AD)-Type Neurodegeneration with Cognitive Impairment (AD-TNDCI) Caused by the Intracerebroventricular-Streptozotocin in Rat Model","volume":"61","author":"Khan","year":"2012","journal-title":"Neurochem. Int."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2919811","DOI":"10.1155\/2023\/2919811","article-title":"Naringin Prevents Cognitive Dysfunction in Aging Rats by Inhibiting Toll-Like Receptor 4 (TLR4)\/NF-\u03baB Pathway and Endoplasmic Reticulum Stress","volume":"2023","author":"Dai","year":"2023","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"100459","DOI":"10.1016\/j.prmcm.2024.100459","article-title":"Behavioral Rescue: Naringenin\u2019s Neuroprotective Effects against PTZ-Induced Seizures by Mitigating Oxidative Stress and Neuroinflammation in Zebrafish Larvae","volume":"12","author":"Manish","year":"2024","journal-title":"Pharmacol. Res.-Mod. Chin. Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"10924","DOI":"10.1080\/21655979.2021.1995994","article-title":"Naringenin Alleviates Myocardial Ischemia\/Reperfusion Injury by Regulating the Nuclear Factor-Erythroid Factor 2-Related Factor 2 (Nrf2)\/System Xc-\/Glutathione Peroxidase 4 (GPX4) Axis to Inhibit Ferroptosis","volume":"12","author":"Xu","year":"2021","journal-title":"Bioengineered"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"457","DOI":"10.4103\/ijp.IJP_18_20","article-title":"Anxiolytic Effects of Silibinin and Naringenin on Zebrafish Model: A Preclinical Study","volume":"53","author":"Nachammai","year":"2021","journal-title":"Indian J. Pharmacol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"108893","DOI":"10.1016\/j.cbpc.2020.108893","article-title":"Naringenin Alleviates 6-Hydroxydopamine Induced Parkinsonism in SHSY5Y Cells and Zebrafish Model","volume":"239","author":"Kesh","year":"2021","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.3892\/or.2017.5965","article-title":"Naringenin Inhibits Alcoholic Injury by Improving Lipid Metabolism and Reducing Apoptosis in Zebrafish Larvae","volume":"38","author":"Lin","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Sudhakaran, G., Chandran, A., Sreekutty, A.R., Madesh, S., Pachaiappan, R., Almutairi, B.O., Arokiyaraj, S., Kari, Z.A., Tellez-Isaias, G., and Guru, A. (2023). Ophthalmic Intervention of Naringenin Decreases Vascular Endothelial Growth Factor by Counteracting Oxidative Stress and Cellular Damage in In Vivo Zebrafish. Molecules, 28.","DOI":"10.3390\/molecules28145350"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1038\/s41467-018-05100-z","article-title":"Microglia Permit Climbing Fiber Elimination by Promoting GABAergic Inhibition in the Developing Cerebellum","volume":"9","author":"Nakayama","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2019.05.050","article-title":"Glia Accumulate Evidence That Actions Are Futile and Suppress Unsuccessful Behavior","volume":"178","author":"Mu","year":"2019","journal-title":"Cell"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"894597","DOI":"10.1155\/2015\/894597","article-title":"Protective Pleiotropic Effect of Flavonoids on NAD+ Levels in Endothelial Cells Exposed to High Glucose","volume":"2015","author":"Boesten","year":"2015","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Stachelska, M.A., Karpi\u0144ski, P., and Kruszewski, B. (2025). A Comprehensive Review of Biological Properties of Flavonoids and Their Role in the Prevention of Metabolic, Cancer and Neurodegenerative Diseases. Appl. Sci., 15.","DOI":"10.3390\/app151910840"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"105486","DOI":"10.1016\/j.neuint.2023.105486","article-title":"Structural Fingerprinting of Pleiotropic Flavonoids for Multifaceted Alzheimer\u2019s Disease","volume":"163","author":"Punmiya","year":"2023","journal-title":"Neurochem. Int."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Berga, M., Logviss, K., Lauberte, L., Paulausks, A., and Mohylyuk, V. (2023). Flavonoids in the Spotlight: Bridging the Gap between Physicochemical Properties and Formulation Strategies. Pharmaceuticals, 16.","DOI":"10.3390\/ph16101407"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"e24619","DOI":"10.1016\/j.heliyon.2024.e24619","article-title":"Regulatory Mechanism and Therapeutic Potentials of Naringin against Inflammatory Disorders","volume":"10","author":"Peng","year":"2024","journal-title":"Heliyon"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"e70066","DOI":"10.1002\/mnfr.70066","article-title":"Novel Insights Into Naringenin: A Multifaceted Exploration of Production, Synthesis, Health Effects, Nanodelivery Systems, and Molecular Simulation","volume":"69","author":"Jia","year":"2025","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Flores-Pe\u00f1a, R., Monroy-Ramirez, H.C., Caloca-Camarena, F., Arceo-Orozco, S., Salto-Sevilla, J.A., Galicia-Moreno, M., and Armendariz-Borunda, J. (2025). Naringin and Naringenin in Liver Health: A Review of Molecular and Epigenetic Mechanisms and Emerging Therapeutic Strategies. 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