{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:29:04Z","timestamp":1785414544795,"version":"3.56.0"},"reference-count":68,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"U.S. National Science Foundation","doi-asserted-by":"publisher","award":["EF-20121785"],"award-info":[{"award-number":["EF-20121785"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"award":["EF-20121785"],"award-info":[{"award-number":["EF-20121785"]}],"id":[{"id":"https:\/\/ror.org\/021nxhr62","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell'universit\u00e0 e della ricerca","doi-asserted-by":"crossref","award":["2022LB4"],"award-info":[{"award-number":["2022LB4"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"crossref"}]},{"award":["2022LB4"],"award-info":[{"award-number":["2022LB4"]}],"id":[{"id":"https:\/\/ror.org\/0341vw408","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>\u201cImmature\u201d or \u201clate-maturing\u201d neurons exist in layer II of the cerebral cortex (cortical immature neurons; cINs) and within the amygdaloid complex (subcortical immature neurons; scINs). These cells remain in a prolonged state of arrested development yet retain the ability to resume maturation and to functionally integrate into neural circuits. Both cINs and scINs are abundant in large-brained mammals with respect to small-brained, lissencephalic rodents. In previous reports, using a comparable method for quantification in diverse mammals, including mice, chimpanzees, and other species, we showed positive correlation of immature neuron cell density with brain size and gyrencephaly. Here, we quantified the cINs and scINs in the cerebral cortex and amygdala of young adult rhesus macaques to determine how they compare to phylogenetic variation. Our results further demonstrate the existence of covariance between cIN density and both increasing brain size and neocortical expansion, as well as the specialized increase of scINs in the amygdala of primates. These findings support the emerging view that immature neurons may represent a reservoir of undifferentiated (stem cell-independent) neuronal cells for the widely expanded cortices and amygdala of mammals endowed with high-order cognitive functions and complex sociality. The detailed mapping of cortical and subcortical immature neurons in a primate often used in translational research sets the foundation for deeper, functional studies aimed at understanding human brain plasticity.<\/jats:p>","DOI":"10.3390\/cells15131158","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:37:55Z","timestamp":1782391075000},"page":"1158","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative and Phylogenetic Analyses of Immature Neurons in Cortical Layer II and Amygdala of Macaque Monkeys"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1913-2466","authenticated-orcid":false,"given":"Alessia","family":"Pattaro","sequence":"first","affiliation":[{"name":"Neuroscience Institute Cavalieri Ottolenghi, 10043 Orbassano, Italy"},{"name":"Department of Veterinary Sciences, University of Turin, 10095 Grugliasco, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0296-8280","authenticated-orcid":false,"given":"Marco","family":"Ghibaudi","sequence":"additional","affiliation":[{"name":"Neuroscience Institute Cavalieri Ottolenghi, 10043 Orbassano, Italy"},{"name":"Department of Veterinary Sciences, University of Turin, 10095 Grugliasco, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline","family":"Bramel","sequence":"additional","affiliation":[{"name":"Department of Anthropology and Center for the Advanced Study of Human Paleobiology, The George Washington University, Washington, DC 20052, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6711-449X","authenticated-orcid":false,"given":"Chet C.","family":"Sherwood","sequence":"additional","affiliation":[{"name":"Department of Anthropology and Center for the Advanced Study of Human Paleobiology, The George Washington University, Washington, DC 20052, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1469-8898","authenticated-orcid":false,"given":"Luca","family":"Bonfanti","sequence":"additional","affiliation":[{"name":"Neuroscience Institute Cavalieri Ottolenghi, 10043 Orbassano, Italy"},{"name":"Department of Veterinary Sciences, University of Turin, 10095 Grugliasco, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1093\/cercor\/bhm255","article-title":"A Population of Prenatally Generated Cells in the Rat Paleocortex Maintains an Immature Neuronal Phenotype into Adulthood","volume":"18","author":"Varea","year":"2008","journal-title":"Cereb. Cortex"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2012.05.002","article-title":"New Scenarios for Neuronal Structural Plasticity in Non-neurogenic Brain Parenchyma: The Case of Cortical Layer II Immature Neurons","volume":"98","author":"Bonfanti","year":"2012","journal-title":"Prog. Neurobiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11515-016-1403-5","article-title":"Distribution and Fate of DCX\/PSA-NCAM Expressing Cells in the Adult Mammalian Cortex: A Local Reservoir for Adult Cortical Neuroplasticity?","volume":"11","author":"Benedetti","year":"2016","journal-title":"Front. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1093\/cercor\/bhy087","article-title":"Cellular Plasticity in the Adult Murine Piriform Cortex: Continuous Maturation of Dormant Precursors into Excitatory Neurons","volume":"28","author":"Rotheneichner","year":"2018","journal-title":"Cereb. Cortex"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"La Rosa, C., Parolisi, R., and Bonfanti, L. (2020). Brain Structural Plasticity: From Adult Neurogenesis to Immature Neurons. Front. Neurosci., 14.","DOI":"10.3389\/fnins.2020.00075"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1093\/cercor\/bhz181","article-title":"Functional Integration of Neuronal Precursors in the Adult Murine Piriform Cortex","volume":"30","author":"Benedetti","year":"2020","journal-title":"Cereb. Cortex"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e13974","DOI":"10.1111\/acel.13974","article-title":"The Awakening of Dormant Neuronal Precursors in the Adult and Aged Brain","volume":"22","author":"Benedetti","year":"2023","journal-title":"Aging Cell"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"877167","DOI":"10.3389\/fnins.2022.877167","article-title":"Why Would the Brain Need Dormant Neuronal Precursors?","volume":"16","author":"Benedetti","year":"2022","journal-title":"Front. Neurosci."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Bonfanti, L., and Seki, T. (2021). The PSA-NCAM-positive \u201cImmature\u201d Neurons: An Old Discovery Providing New Vistas on Brain Structural Plasticity. Cells, 10.","DOI":"10.3390\/cells10102542"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0896-6273(00)80778-3","article-title":"Doublecortin is a Microtubule-Associated Protein and is Expressed Widely by Migrating Neurons","volume":"23","author":"Gleeson","year":"1999","journal-title":"Neuron"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neuroscience.2012.03.040","article-title":"Revisiting the Hippocampal-Amygdala Pathway in Primates: Association with Immature-appearing Neurons","volume":"212","author":"Fudge","year":"2012","journal-title":"Neuroscience"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/dev.21493","article-title":"Maternal Deprivation Alters Expression of Neural Maturation Gene tbr1 in the Amygdala Paralaminar Nucleus in Infant Female Macaques","volume":"59","author":"Cameron","year":"2017","journal-title":"Dev. Psychobiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1523\/JNEUROSCI.1781-17.2017","article-title":"Non-newly Generated, \u201cImmature\u201d Neurons in the Sheep Brain Are Not Restricted to Cerebral Cortex","volume":"38","author":"Piumatti","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1038\/s41467-019-10765-1","article-title":"Immature Excitatory Neurons Develop During Adolescence in the Human Amygdala","volume":"10","author":"Sorrells","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e55456","DOI":"10.7554\/eLife.55456","article-title":"Phylogenetic Variation in Cortical Layer II Immature Neuron Reservoir of Mammals","volume":"9","author":"Cavallo","year":"2020","journal-title":"eLife"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00429-025-02981-x","article-title":"Phylogenetic Variation of Layer II Cortical Immature Neurons in Dog and Horse Confirms Covariance with Brain Size and Neocortical Surface","volume":"230","author":"Pattaro","year":"2025","journal-title":"Brain Struct. Funct."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ghibaudi, M., La Rosa, C., Telitsyn, N., Gra\u00efc, J.-M., Faulkes, C.G., Sherwood, C.C., and Bonfanti, L. (2025). Multispecies Characterization of Immature Neurons in the Mammalian Amygdala Reveals their Expansion in Primates. PLoS Biol., 23.","DOI":"10.1371\/journal.pbio.3003322"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"633","DOI":"10.4103\/1673-5374.230282","article-title":"Do Large Brains of Long-living Mammals Prefer Non-newly Generated, Immature Neurons?","volume":"13","author":"Palazzo","year":"2018","journal-title":"Neural Regen. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s00429-023-02717-9","article-title":"Adult Neurogenesis and \u201cImmature\u201d Neurons in Mammals: An Evolutionary Trade-off in Plasticity?","volume":"229","author":"Bonfanti","year":"2024","journal-title":"Brain Struct. Funct."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.4103\/NRR.NRR-D-24-01438","article-title":"Brain Structural Plasticity in Large-brained Mammals: Not Only Narrowing Roads","volume":"21","author":"Ghibaudi","year":"2026","journal-title":"Neural Regen. Res."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"La Rosa, C., Ghibaudi, M., and Bonfanti, L. (2019). Newly Generated and Non-Newly Generated \u201cImmature\u201d Neurons in the Mammalian Brain: A Possible Reservoir of Young Cells to Prevent Brain Aging and Disease?. J. Clin. Med., 8.","DOI":"10.3390\/jcm8050685"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"101961","DOI":"10.1016\/j.pneurobio.2020.101961","article-title":"The Environmental Sculpting Hypothesis of Juvenile and Adult Hippocampal Neurogenesis","volume":"199","author":"Cushman","year":"2021","journal-title":"Prog. Neurobiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"101133","DOI":"10.1016\/j.dcn.2022.101133","article-title":"Immature Excitatory Neurons in the Amygdala Come of Age During Puberty","volume":"56","author":"Page","year":"2022","journal-title":"Dev. Cogn. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1007\/s12035-023-03261-7","article-title":"Doublecortin Expressing Neurons in Human Cerebral Cortex Layer II and Amygdala from Infancy to 100 Year-old","volume":"60","author":"Li","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Coviello, S., Gramuntell, Y., Klimczak, P., Varea, E., Blasco-Iba\u00f1ez, J.M., Crespo, C., Gutierrez, A., and Nacher, J. (2022). Phenotype and Distribution of Immature Neurons in the Human Cerebral Cortex Layer II. Front. Neuroanat., 16.","DOI":"10.3389\/fnana.2022.851432"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Pattaro, A., Zanone, A., Sherwood, C.C., Bonfanti, L., and Ghibaudi, M. (2026). Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains. J. Vis. Exp., e69446.","DOI":"10.3791\/69446"},{"key":"ref_27","unstructured":"Wilson, D.E., and Reeder, D.M. (2005). Mammal Species of the World: A Taxonomic and Geographic Reference, Johns Hopkins University Press. [3rd ed.]."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/S0140-6736(08)60489-4","article-title":"Contributions of Non-human Primates to Neuroscience Research","volume":"371","author":"Capitanio","year":"2008","journal-title":"Lancet"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/ajp.22281","article-title":"Why Primate Models Matter","volume":"76","author":"Phillips","year":"2014","journal-title":"Am. J. Primatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1177\/0300985815620628","article-title":"Age-associated Pathology in Rhesus Macaques (Macaca mulatta)","volume":"53","author":"Simmons","year":"2016","journal-title":"Vet. Pathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/ilar\/ilx033","article-title":"Nonhuman Primates and Translational Research: Progress, Opportunities, and Challenges","volume":"58","author":"Harding","year":"2017","journal-title":"ILAR J."},{"key":"ref_32","unstructured":"Saleem, K.S., and Logothetis, N.K. (2012). A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates, Academic Press. [2nd ed.]."},{"key":"ref_33","unstructured":"Paxinos, G., Petrides, M., Huang, X., and Toga, A.W. (2008). The Rhesus Monkey Brain in Stereotaxic Coordinates, Academic Press. [2nd ed.]."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuroimage.2006.11.053","article-title":"Internet-enabled high-resolution brain mapping and virtual microscopy","volume":"35","author":"Mikula","year":"2007","journal-title":"Neuroimage"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s12021-014-9258-x","article-title":"The Scalable Brain Atlas: Instant web-based access to public brain atlases and related content","volume":"13","author":"Bakker","year":"2015","journal-title":"Neuroinformatics"},{"key":"ref_36","unstructured":"Dubach, M.F., and Bowden, D.M. (2009). BrainInfo Online 3D Macaque Brain Atlas: A Database in the Shape of a Brain. Society for Neuroscience Annual Meeting, McCormick Place Convention Center. Abstract No. 199.5."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Rohlfing, T., Kroenke, C.D., Sullivan, E.V., Dubach, M.F., Bowden, D.M., Grant, K.A., and Pfefferbaum, A. (2012). The INIA19 Template and NeuroMaps Atlas for Primate Brain Image Parcellation and Spatial Normalization. Front. Neuroinform., 6.","DOI":"10.3389\/fninf.2012.00027"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1093\/molbev\/msx116","article-title":"TimeTree: A Resource for Timelines, Timetrees, and Divergence Times","volume":"34","author":"Kumar","year":"2017","journal-title":"Mol. Biol. Evol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1093\/cercor\/bhn145","article-title":"DCX and PSA-NCAM Expression Identifies a Population of Neurons Preferentially Distributed in Associative Areas of Different Pallial Derivatives and Vertebrate Species","volume":"19","author":"Luzzati","year":"2009","journal-title":"Cereb. Cortex"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.neuron.2023.11.010","article-title":"Delayed Maturation and Migration of Excitatory Neurons in the Juvenile Mouse Paralaminar Amygdala","volume":"112","author":"Alderman","year":"2024","journal-title":"Neuron"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5194\/asr-5-11-2010","article-title":"Ethics of Primate Use","volume":"5","author":"Prescott","year":"2010","journal-title":"Adv. Sci. Res."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Aguilera, B., Perez Gomez, J., and DeGrazia, D. (2021). Should Biomedical Research with Great Apes be Restricted? A Systematic Review of Reasons. BMC Med. Ethics, 22.","DOI":"10.1186\/s12910-021-00580-z"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Ghibaudi, M., Marchetti, N., Vergnano, E., La Rosa, C., Benedetti, B., Couillard-Despres, S., Farioli-Vecchioli, S., and Bonfanti, L. (2023). Age-related Changes in Layer II Immature Neurons of the Murine Piriform Cortex. Front. Cell. Neurosci., 17.","DOI":"10.3389\/fncel.2023.1205173"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s00429-025-03008-1","article-title":"Postnatal Plasticity in the Olfactory System of the Juvenile Swine Brain","volume":"230","author":"Freixes","year":"2025","journal-title":"Brain Struct. Funct."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00429-026-03106-8","article-title":"Postnatal Plasticity in the Paralaminar Nucleus of the Pallial Amygdala in Juvenile Swine Brain","volume":"231","author":"Freixes","year":"2026","journal-title":"Brain Struct. Funct."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e70155","DOI":"10.1002\/cne.70155","article-title":"Immature Excitatory Neurons in the Postnatal Ferret Paralaminar Nuclei and Their Relationship to the Amygdala Across Species","volume":"534","author":"Ghibaudi","year":"2026","journal-title":"J. Comp. Neurol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"DeFelipe, J. (2011). The Evolution of the Brain, the Human Nature of Cortical Circuits, and Intellectual Creativity. Front. Neuroanat., 5, Erratum in Front. Neuroanat. 2013, 7, 10.","DOI":"10.3389\/fnana.2013.00010"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.tins.2013.01.006","article-title":"Development of Cortical Folding During Evolution and Ontogeny","volume":"36","author":"Zilles","year":"2013","journal-title":"Trends Neurosci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"102981","DOI":"10.1016\/j.conb.2025.102981","article-title":"Large Brains: Big Unknowns in Cellular Neuroscience","volume":"91","author":"Brecht","year":"2025","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/cne.23896","article-title":"Brain Size and Limits to Adult Neurogenesis","volume":"524","author":"Paredes","year":"2016","journal-title":"J. Comp. Neurol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Parolisi, R., Cozzi, B., and Bonfanti, L. (2018). Humans and Dolphins: Decline and Fall of Adult Neurogenesis. Front. Neurosci., 12.","DOI":"10.3389\/fnins.2018.00497"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Pattaro, A., Ghibaudi, M., Zanone, A., Cerrato, V., Sherwood, C.C., and Bonfanti, L. (2026). Mixed Signals and Interspecies Variation in the Plasticity of Adult Mammal Brains. Cells, 15.","DOI":"10.3390\/cells15060520"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e70041","DOI":"10.1002\/bies.70041","article-title":"Reduced Adult Neurogenesis in Humans Results From a Tradeoff Rather Than Direct Negative Selection","volume":"47","author":"Morizet","year":"2025","journal-title":"BioEssays"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Aboitiz, F., and Montiel, J.F. (2015). Olfaction, Navigation, and the Origin of Isocortex. Front. Neurosci., 9.","DOI":"10.3389\/fnins.2015.00402"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/brv.12553","article-title":"Communicative Roots of Complex Sociality and Cognition","volume":"95","author":"Roberts","year":"2020","journal-title":"Biol. Rev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s42003-025-07505-1","article-title":"Cortical Areas Associated to Higher Cognition Drove Primate Brain Evolution","volume":"8","author":"Melchionna","year":"2025","journal-title":"Commun. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"bhae174","DOI":"10.1093\/cercor\/bhae174","article-title":"The Meso-connectomes of Mouse, Marmoset, and Macaque: Network Organization and the Emergence of Higher Cognition","volume":"34","author":"Magrou","year":"2024","journal-title":"Cereb. Cortex"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Stonebarger, G.A., Bimonte-Nelson, H.A., and Urbanski, H.F. (2021). The Rhesus Macaque as a Translational Model for Neurodegeneration and Alzheimer\u2019s Disease. Front. Aging Neurosci., 13.","DOI":"10.3389\/fnagi.2021.734173"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/ajp.20720","article-title":"The Unique Value of Primate Models in Translational Research","volume":"71","author":"Shively","year":"2009","journal-title":"Am. J. Primatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"20190612","DOI":"10.1098\/rstb.2019.0612","article-title":"Rhesus Macaques as a Tractable Physiological Model of Human Ageing","volume":"375","author":"Chiou","year":"2020","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1098\/rspb.2002.2276","article-title":"Evolutionary Coherence of the Mammalian Amygdala","volume":"270","author":"Barton","year":"2003","journal-title":"Proc. Biol. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1002\/cne.22677","article-title":"Stereological Analysis of the Rat and Monkey Amygdala","volume":"519","author":"Chareyron","year":"2011","journal-title":"J. Comp. Neurol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1037\/rev0000361","article-title":"Beyond Cortex: The Evolution of the Human Brain","volume":"130","author":"Chin","year":"2023","journal-title":"Psychol. Rev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s42003-023-05034-3","article-title":"Going Beyond Established Model Systems of Alzheimer\u2019s Disease: Companion Animals Provide Novel Insights into the Neurobiology of Aging","volume":"6","author":"Graff","year":"2023","journal-title":"Commun. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1749-6632.2009.04421.x","article-title":"In Search of a Unifying Theory of Complex Brain Evolution","volume":"1156","author":"Krubitzer","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev-anthro-102215-100009","article-title":"Brain Plasticity and Human Evolution","volume":"46","author":"Sherwood","year":"2017","journal-title":"Annu. Rev. Anthropol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/bs.irn.2020.12.003","article-title":"Social Processing by the Primate Medial Frontal Cortex","volume":"158","author":"Putnam","year":"2021","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41386-021-01076-5","article-title":"Evolution of Prefrontal Cortex","volume":"47","author":"Preuss","year":"2022","journal-title":"Neuropsychopharmacology"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/13\/1158\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:21:40Z","timestamp":1783398100000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/13\/1158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":68,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["cells15131158"],"URL":"https:\/\/doi.org\/10.3390\/cells15131158","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]}}}