{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:57:50Z","timestamp":1792180670395,"version":"4.4.0"},"reference-count":61,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Myocardial ischemia\u2013reperfusion injury (MIRI) represents a major contributor to morbidity and mortality in patients undergoing reperfusion therapy after acute myocardial infarction. Although timely restoration of coronary blood flow is essential for myocardial salvage, reperfusion paradoxically initiates a complex cascade of molecular and cellular events that may aggravate myocardial injury. Oxidative stress is considered one of the central mechanisms underlying MIRI, primarily through excessive production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), leading to mitochondrial dysfunction, calcium overload, endothelial injury, inflammatory activation, and cardiomyocyte death. This review summarizes the current understanding of the pathophysiological mechanisms involved in oxidative stress-mediated reperfusion injury, with emphasis on mitochondrial permeability transition pore opening, inflammasome activation, cytokine release, neutrophil extracellular trap formation, macrophage polarization, and interconnected cell death pathways including PANoptosis. Emerging evidence regarding immunometabolic regulation and epigenetic modulation in MIRI is also discussed. In addition, current pharmacological and non-pharmacological cardioprotective strategies targeting oxidative stress, mitochondrial dysfunction, and inflammatory signaling are reviewed, highlighting both promising experimental findings and the persistent challenges in clinical translation. A deeper understanding of the molecular interplay between oxidative stress and inflammatory pathways may facilitate the development of integrated therapeutic approaches aimed at improving myocardial recovery and long-term cardiovascular outcomes following reperfusion therapy.<\/jats:p>","DOI":"10.3390\/cells15131185","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:55:11Z","timestamp":1782780911000},"page":"1185","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oxidative Stress and Its Impact on Reperfused Myocardium: Pathophysiological Insights and Therapeutic Perspectives"],"prefix":"10.3390","volume":"15","author":[{"given":"Iris","family":"Bararu Bojan","sequence":"first","affiliation":[{"name":"Department of Morpho Functional Sciences, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5448-7761","authenticated-orcid":false,"given":"Carmen","family":"Plesoianu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Cristina","family":"Vladeanu","sequence":"additional","affiliation":[{"name":"Department of Morpho Functional Sciences, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Dobreanu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragos-Florin","family":"Tesoi","sequence":"additional","affiliation":[{"name":"Department of Morpho Functional Sciences, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Codruta","family":"Badescu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9989-1653","authenticated-orcid":false,"given":"Cezar Ilie","family":"Foia","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5836-1517","authenticated-orcid":false,"given":"Otilia Elena","family":"Frasinariu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Iliescu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Faculty of Medicine, Grigore T. 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Cells, 14.","DOI":"10.3390\/cells14191509"},{"key":"ref_3","first-page":"1","article-title":"The Canadian Cardiovascular Society Classification of Acute Atherothrombotic Myocardial Infarction Based on Stages of Tissue Injury Severity: An Expert Consensus Statement","volume":"40","author":"Kumar","year":"2024","journal-title":"Can. J. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s43044-025-00683-7","article-title":"Reperfusion injury in STEMI: A double-edged sword","volume":"77","author":"Thomas","year":"2025","journal-title":"Egypt. Heart J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1001\/jamacardio.2021.0676","article-title":"Calcium\/Calmodulin-dependent protein kinase II delta inhibition and ventricular remodeling after myocardial infarction: A randomized clinical trial","volume":"6","author":"Boyle","year":"2021","journal-title":"JAMA Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"116629","DOI":"10.1016\/j.biopha.2024.116629","article-title":"Construction of preclinical evidence for propofol in the treatment of reperfusion injury after acute myocardial infarction: A systematic review and meta-analysis","volume":"174","author":"Li","year":"2024","journal-title":"BioMed Pharmacother."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3892\/etm.2022.11357","article-title":"Myocardial ischemia\/reperfusion injury: Mechanisms of injury and implications for management (Review)","volume":"23","author":"He","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"101398","DOI":"10.1016\/j.cpcardiol.2022.101398","article-title":"Novel therapeutic strategies to reduce reperfusion injury after acute myocardial infarction","volume":"47","author":"Bauersachs","year":"2022","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.31083\/j.rcm2503105","article-title":"The Role of Microvascular Obstruction and Intra-Myocardial Hemorrhage in Reperfusion Cardiac Injury. Analysis of Clinical Data","volume":"25","author":"Ryabov","year":"2024","journal-title":"Rev. Cardiovasc. Med."},{"key":"ref_10","first-page":"133","article-title":"Redefining successful primary PCI","volume":"20","author":"McCartney","year":"2019","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/j.jacc.2009.12.054","article-title":"5-year prognostic value of no-reflow phenomenon after percutaneous coronary intervention in patients with acute myocardial infarction","volume":"55","author":"Ndrepepa","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1093\/ehjci\/jeac121","article-title":"Magnetic resonance imaging of cardiac metabolism in heart failure: How far have we come?","volume":"23","author":"Yurista","year":"2022","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e70918","DOI":"10.1111\/jcmm.70918","article-title":"The Promise of Exosomes in Cardiac Repair: When \u2019Best Things Come in Small Packages\u2019","volume":"29","author":"Yazbeck","year":"2025","journal-title":"J. Cell. Mol. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e000159","DOI":"10.1161\/JAHA.113.000159","article-title":"ROS-mediated PARP activity undermines mitochondrial function after permeability transition pore opening during myocardial ischemia-reperfusion","volume":"2","author":"Schriewer","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"110990","DOI":"10.1016\/j.biopha.2020.110990","article-title":"Uric acid aggravates myocardial ischemia-reperfusion injury via ROS\/NLRP3 pyroptosis pathway","volume":"133","author":"Shen","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2174\/15701611113119990003","article-title":"Cardiac oxidative stress and inflammatory cytokines response after myocardial infarction","volume":"13","author":"Neri","year":"2015","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Wu, J., Luo, J., Cai, H., Li, C., Lei, Z., Lu, Y., Ni, L., Cao, J., Cheng, B., and Hu, X. (2023). Expression Pattern and Molecular Mechanism of Oxidative Stress-Related Genes in Myocardial Ischemia\u2013Reperfusion Injury. J. Cardiovasc. Dev. Dis., 10.","DOI":"10.3390\/jcdd10020079"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1093\/cvr\/cvs116","article-title":"Calcium-mediated cell death during myocardial reperfusion","volume":"94","author":"Inserte","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1161\/01.RES.85.9.777","article-title":"The myocardial Na(+)-H(+) exchange: Structure, regulation, and its role in heart disease","volume":"85","author":"Karmazyn","year":"1999","journal-title":"Circ. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2454892","DOI":"10.1080\/13510002.2025.2454892","article-title":"M6a demethylase FTO regulates the oxidative stress, mitochondrial biogenesis of cardiomyocytes and PGC-1a stability in myocardial ischemia-reperfusion injury","volume":"30","author":"Jiang","year":"2025","journal-title":"Redox Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"155649","DOI":"10.1016\/j.phymed.2024.155649","article-title":"The pathological mechanisms and potential therapeutic drugs for myocardial ischemia reperfusion injury","volume":"129","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.molcel.2023.01.006","article-title":"RNA m6a methylation across the transcriptome","volume":"83","author":"Sendinc","year":"2023","journal-title":"Mol. Cell"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1161\/CIRCULATIONAHA.118.036146","article-title":"The N(6)-methyladenosine mRNA methylase METTL3 controls cardiac homeostasis and hypertrophy","volume":"139","author":"Dorn","year":"2019","journal-title":"Circulation"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Xu, Z.Y., Jing, X., and Xiong, X.D. (2023). Emerging role and mechanism of the FTO gene in cardiovascular diseases. Biomolecules, 13.","DOI":"10.3390\/biom13050850"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e2415205","DOI":"10.1002\/advs.202415205","article-title":"MMP9High Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia\/Reperfusion Injury","volume":"12","author":"Hu","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e232","DOI":"10.1161\/CIRCRESAHA.120.317200","article-title":"Dynamics of Cardiac Neutrophil Diversity in Murine Myocardial Infarction","volume":"127","author":"Vafadarnejad","year":"2020","journal-title":"Circ. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e2100752","DOI":"10.1002\/smtd.202100752","article-title":"Single-Cell RNA Sequencing Reveals the Temporal Diversity and Dynamics of Cardiac Immunity after Myocardial Infarction","volume":"6","author":"Jin","year":"2022","journal-title":"Small Methods"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e019019","DOI":"10.1161\/JAHA.120.019019","article-title":"SiglecF(HI) Marks Late-Stage Neutrophils of the Infarcted Heart: A Single-Cell Transcriptomic Analysis of Neutrophil Diversification","volume":"10","author":"Calcagno","year":"2021","journal-title":"Am. Heart Assoc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jare.2024.09.024","article-title":"Pharmacological upregulation of macrophage-derived itaconic acid by pubescenoside C attenuated myocardial ischemia-reperfusion injury","volume":"74","author":"Chen","year":"2025","journal-title":"J. Adv. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"820695","DOI":"10.1155\/2013\/820695","article-title":"The Cardioprotective Effects of Citric Acid and L-Malic Acid on Myocardial Ischemia\/Reperfusion Injury","volume":"2013","author":"Tang","year":"2013","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.cmet.2022.02.002","article-title":"Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages","volume":"34","author":"Runtsch","year":"2022","journal-title":"Cell Metab."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"154602","DOI":"10.1016\/j.phymed.2022.154602","article-title":"Formononetin improves cardiac function and depressive behaviours in myocardial infarction with depression by targeting GSK-3\u03b2 to regulate macrophage\/microglial polarization","volume":"109","author":"Yang","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.17219\/acem\/162578","article-title":"Effects of heat shock protein 90 on complement activation in myocardial ischemia\/reperfusion injury after pioglitazone preconditioning","volume":"32","author":"Wang","year":"2023","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Das, J., Sah, A.K., Choudhary, R.K., Elshaikh, R.H., Bhui, U., Chowdhury, S., Abbas, A.M., Shalabi, M.G., Siddique, N.A., and Alshammari, R.R. (2025). Network Pharmacology Approaches to Myocardial Infarction Reperfusion Injury: Exploring Mechanisms, Pathophysiology, and Novel Therapies. Biomedicines, 13.","DOI":"10.3390\/biomedicines13071532"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Sagris, M., Apostolos, A., Theofilis, P., Ktenopoulos, N., Katsaros, O., Tsalamandris, S., Tsioufis, K., Toutouzas, K., and Tousoulis, D. (2024). Myocardial Ischemia\u2013Reperfusion Injury: Unraveling Pathophysiology, Clinical Manifestations, and Emerging Prevention Strategies. Biomedicines, 12.","DOI":"10.3390\/biomedicines12040802"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"rbag040","DOI":"10.1093\/rb\/rbag040","article-title":"Mitochondria-targeted nanotechnology in cardiovascular diseases: A review of recent advances","volume":"13","author":"Sun","year":"2026","journal-title":"Regen. Biomater."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1161\/CIRCULATIONAHA.110.982777","article-title":"Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia\/reperfusion injury","volume":"123","author":"Kawaguchi","year":"2011","journal-title":"Circulation"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.bbrc.2015.12.051","article-title":"NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective","volume":"469","author":"Sandanger","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000455815","article-title":"Remote Ischaemic Preconditioning and Sevoflurane Postconditioning Synergistically Protect Rats from Myocardial Injury Induced by Ischemia and Reperfusion Partly via Inhibition TLR4\/MyD88\/NF-\u03baB Signaling Pathway","volume":"41","author":"Zhang","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_40","first-page":"5151","article-title":"Inhibition of MyD88 by a novel inhibitor reverses two-thirds of the infarct area in myocardial ischemia and reperfusion injury","volume":"12","author":"Miao","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"5178894","DOI":"10.1155\/cdr\/5178894","article-title":"Frontiers and Hotspot Evolution of NLRP3 Inflammasome in Myocardial Infarction Research: A Bibliometric Analysis from 2013 to 2024","volume":"2025","author":"Wu","year":"2025","journal-title":"Cardiovasc. Ther."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Chen, Y., Guan, B., Lu, J., Yan, X., Huang, C., Qiu, Y., Li, X., Sun, X., Chen, L., and Li, W. (2025). Gypensapogenin I alleviates PANoptosis, ferroptosis, and oxidative stress in myocardial ischemic\u2014Reperfusion injury by targeting the NOX2\/AMPK pathway. Front. Cell Dev. Biol., 13.","DOI":"10.3389\/fcell.2025.1623846"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e46750","DOI":"10.1097\/MD.0000000000046750","article-title":"Identification of PANoptosis-related biomarkers in myocardial infarction via bioinformatics and single-cell analyses","volume":"105","author":"Que","year":"2026","journal-title":"Medicine"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Wu, X., Wei, J., Zhang, W., Yi, Y., Wang, T., Gong, Q., Liu, X., Li, H., and Gao, J. (2024). Targeting the PANoptosis signaling pathway for myocardial protection: Therapeutic potential of Xian Ling Gu Bao capsule. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1391511"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"9929687","DOI":"10.1155\/2021\/9929687","article-title":"Ferroptosis: Opportunities and Challenges in Myocardial Ischemia-Reperfusion Injury","volume":"2021","author":"Zhao","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1001\/jamacardio.2017.0022","article-title":"Effect of Ischemic Postconditioning during Primary Percutaneous Coronary Intervention for Patients with ST-Segment Elevation Myocardial Infarction: A Randomized Clinical Trial","volume":"2","author":"Helqvist","year":"2017","journal-title":"JAMA Cardiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0140-6736(19)32039-2","article-title":"Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2\/ERIC-PPCI): A single-blind randomized controlled trial","volume":"394","author":"Hausenloy","year":"2019","journal-title":"Lancet"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Sch\u00e4fer, A., Akin, M., Diekmann, J., and K\u00f6nig, T. (2022). Intracoronary Application of Super-Saturated Oxygen to Reduce Infarct Size Following Myocardial Infarction. J. Clin. Med., 11.","DOI":"10.3390\/jcm11061509"},{"key":"ref_49","first-page":"882","article-title":"Evaluation of intracoronary hyperoxemic oxygen therapy in acute anterior myocardial infarction: The IC-HOT study","volume":"93","author":"David","year":"2019","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"El Farissi, M., Mast, T.P., van de Kar, M.R.D., Dillen, D.M.M., Demandt, J.P.A., Vervaat, F.E., Eerdekens, R., Dello, S.A.G., Keulards, D.C., and Zelis, J.M. (2022). Hypothermia for Cardioprotection in Patients with St-Elevation Myocardial Infarction: Do Not Give It the Cold Shoulder Yet!. J. Clin. Med., 11.","DOI":"10.3390\/jcm11041082"},{"key":"ref_51","first-page":"1285","article-title":"Sodium Thiosulfate in Acute Myocardial Infarction: A Randomized Clinical Trial","volume":"8","author":"Assa","year":"2023","journal-title":"J. Am. Coll. Cardiol. Basic Trans. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00395-021-00884-6","article-title":"Intravenous metoprolol during ongoing STEMI ameliorates markers of ischemic injury: A METOCARD-CNIC trial electrocardiographic study","volume":"116","author":"Pizarro","year":"2021","journal-title":"Basic Res. Cardiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/FJC.0000000000001174","article-title":"Isoform-Selective HDAC Inhibitor Mocetinostat (MGCD0103) Alleviates Myocardial Ischemia\/Reperfusion Injury via Mitochondrial Protection Through the HDACs\/CREB\/PGC-1\u03b1 Signaling Pathway","volume":"79","author":"Wang","year":"2022","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1001\/jama.2023.19524","article-title":"Traditional Chinese Medicine Compound (Tongxinluo) and Clinical Outcomes of Patients with Acute Myocardial Infarction: The CTS-AMI Randomized Clinical Trial","volume":"330","author":"Yang","year":"2023","journal-title":"JAMA"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Fernandez Rico, C., Konate, K., Josse, E., Nargeot, J., Barr\u00e8re-Lemaire, S., and Boisgu\u00e9rin, P. (2022). Therapeutic Peptides to Treat Myocardial Ischemia-Reperfusion Injury. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.792885"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1177\/1074248410362074","article-title":"Cyclosporine does not reduce myocardial infarct size in a porcine ischemia-reperfusion model","volume":"15","author":"Karlsson","year":"2010","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.lfs.2017.05.014","article-title":"Protective roles of bioactive peptides during ischemia-reperfusion injury: From bench to bedside","volume":"180","author":"Wu","year":"2017","journal-title":"Life Sci."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Bethke, A., Shanmuganathan, L., Shetelig, C., Swanson, D., Andersen, G.\u00d8., Eritsland, J., Kl\u00f8w, N.E., and Hoffmann, P. (2018). MR findings of microvascular perfusion in infarcted and remote myocardium early after successful primary PCI. PLoS ONE, 13, Erratum in PLoS ONE 2019, 14, e0213636. https:\/\/doi.org\/10.1371\/journal.pone.0213636.","DOI":"10.1371\/journal.pone.0213636"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Rozemeijer, S., Hemil\u00e4, H., van Baaren, M., and de Man, A.M.E. (2023). Vitamin C may reduce troponin and CKMB levels after PCI and CABG: A meta-analysis. BMC Cardiovasc. Disord., 23.","DOI":"10.1186\/s12872-023-03459-6"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1001\/jamacardio.2024.2298","article-title":"Prehospital Pulse-Dose Glucocorticoid in ST-Segment Elevation Myocardial Infarction: The PULSE-MI Randomized Clinical Trial","volume":"9","author":"Madsen","year":"2024","journal-title":"JAMA Cardiol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Medzikovic, L., Azem, T., Sun, W., Rejali, P., Esdin, L., Rahman, S., Dehghanitafti, A., Aryan, L., and Eghbali, M. (2023). Sex Differences in Therapies against Myocardial Ischemia-Reperfusion Injury: From Basic Science to Clinical Perspectives. 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