{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:12:39Z","timestamp":1791277959410,"version":"4.1.0"},"reference-count":47,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre","doi-asserted-by":"publisher","award":["MINI.A070.22.004"],"award-info":[{"award-number":["MINI.A070.22.004"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"National Science Centre","doi-asserted-by":"publisher","award":["SUBK.A410.26.021"],"award-info":[{"award-number":["SUBK.A410.26.021"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"award":["MINI.A070.22.004"],"award-info":[{"award-number":["MINI.A070.22.004"]}],"id":[{"id":"https:\/\/ror.org\/03ha2q922","id-type":"ROR","asserted-by":"publisher"}]},{"award":["SUBK.A410.26.021"],"award-info":[{"award-number":["SUBK.A410.26.021"]}],"id":[{"id":"https:\/\/ror.org\/03ha2q922","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy and is associated with profound metabolic reprogramming. This exploratory study aimed to characterize the metabolomic profiles of plasma and cerebrospinal fluid (CSF) in children with newly diagnosed pre-B-cell acute lymphoblastic leukemia (pre-B ALL) prior to therapy. Metabolomic analyses were performed using mass spectrometry-based platforms combined with multivariate statistical approaches (PCA, OPLS-DA, SVM-RFE, EBAM). In plasma, we identified 41 significantly altered metabolites (FDR &lt; 0.011), revealing a distinct signature that differentiated pre-B ALL patients from healthy controls. Specifically, patients exhibited elevated levels of hypoxanthine, xanthine, and phosphatidylcholine derivatives, alongside reduced concentrations of L-cysteine and prasterone sulfate, indicating systemic dysregulation of purine, lipid, and amino acid metabolism. In CSF, we observed a distinct metabolic profile characterized by coordinated disturbances in purine degradation, phospholipid metabolism, and sphingolipid pathways. Notably, correlation analysis between the two matrices suggested that systemic metabolic shifts, particularly in purine metabolism (e.g., hypoxanthine and xanthine levels), are mirrored within the central nervous system microenvironment. These findings indicate that children with pre-B ALL exhibit specific metabolic alterations in both compartments before treatment. This work serves as a proof-of-concept for applying metabolomics in pediatric oncology, highlighting the necessity for further validation in larger, prospective cohorts to assess the clinical utility of these profiles.<\/jats:p>","DOI":"10.3390\/cells15141255","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T07:28:27Z","timestamp":1783927707000},"page":"1255","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploratory Metabolomic Profiling of Plasma and Cerebrospinal Fluid in a Pilot Study of Children with Acute Lymphoblastic Leukemia"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9908-6921","authenticated-orcid":false,"given":"Andrzej","family":"Wasilewski","sequence":"first","affiliation":[{"name":"Student Scientific Association of Medical Chemistry and Immunochemistry, Wroclaw Medical University, ul. M. Sk\u0142odowskiej-Curie 48\/50, 59-369 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Czapor-Irzabek","sequence":"additional","affiliation":[{"name":"Laboratory of Elemental Analysis and Structural Research, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"\u015aciskalska","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9968-0948","authenticated-orcid":false,"given":"Adam","family":"El Idrissi","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Food and Nutrition (DiANA), Universit\u00e0 Cattolica del Sacro Cuore, Via Emilia Parmense, 84, 29122 Piacenza, PC, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2473-0302","authenticated-orcid":false,"given":"Fatima","family":"Chegdani","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Biology, Department of Biology, Faculty of Sciences A\u00efn Chock, Hassan II University of Casablanca, Route El Jadida, BP 5366 Maarif, Casablanca 20100, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1064-1237","authenticated-orcid":false,"given":"Agnieszka","family":"Matera-Witkiewicz","sequence":"additional","affiliation":[{"name":"Screening of Biological Activity Assays and Collection of Biological Material Laboratory, Wroclaw Medical University Biobank, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3043-4806","authenticated-orcid":false,"given":"Tomasz","family":"Zato\u0144ski","sequence":"additional","affiliation":[{"name":"Department and Clinic of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Po\u0142tyn-Zaradna","sequence":"additional","affiliation":[{"name":"Department of Social Medicine, Wroclaw Medical University, 50-345 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Brutkowski","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation, Pediatric Oncology and Hematology, Wroclaw Medical University, ul. Borowska 213, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6590-4420","authenticated-orcid":false,"given":"Aleksandra","family":"Klimczak","sequence":"additional","affiliation":[{"name":"Laboratory of Biology of Stem and Neoplastic Cells, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigla 12, 53-114 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernarda","family":"Kazanowska","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation, Pediatric Oncology and Hematology, Wroclaw Medical University, ul. Borowska 213, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2826-6623","authenticated-orcid":false,"given":"Agata","family":"Serrafi","sequence":"additional","affiliation":[{"name":"Division of Medical Biochemistry, Department of Biochemistry and Immunochemistry, Faculty of Medicine, Wroclaw Medical University, ul. Cha\u0142ubi\u0144skiego 10, 50-369 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Tseng, S., Lee, M.-E., and Lin, P.-C. (2023). A Review of Childhood Acute Myeloid Leukemia: Diagnosis and Novel Treatment. 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