{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:58:43Z","timestamp":1785430723550,"version":"3.56.0"},"reference-count":63,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research, Development and Innovation Office","award":["NKFIH-142939"],"award-info":[{"award-number":["NKFIH-142939"]}]},{"name":"National Research, Development and Innovation Office","award":["NKFIH-152378"],"award-info":[{"award-number":["NKFIH-152378"]}]},{"award":["NKFIH-142939"],"award-info":[{"award-number":["NKFIH-142939"]}],"id":[{"id":"https:\/\/ror.org\/03g2am276","id-type":"ROR","asserted-by":"publisher"}]},{"award":["NKFIH-152378"],"award-info":[{"award-number":["NKFIH-152378"]}],"id":[{"id":"https:\/\/ror.org\/03g2am276","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Hungarian Academy of Sciences","doi-asserted-by":"crossref","award":["BO\/00227\/23"],"award-info":[{"award-number":["BO\/00227\/23"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003825","name":"Hungarian Academy of Sciences","doi-asserted-by":"crossref","award":["BO\/000687\/23\/7"],"award-info":[{"award-number":["BO\/000687\/23\/7"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"crossref"}]},{"award":["BO\/00227\/23"],"award-info":[{"award-number":["BO\/00227\/23"]}],"id":[{"id":"https:\/\/ror.org\/02ks8qq67","id-type":"ROR","asserted-by":"publisher"}]},{"award":["BO\/000687\/23\/7"],"award-info":[{"award-number":["BO\/000687\/23\/7"]}],"id":[{"id":"https:\/\/ror.org\/02ks8qq67","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009232","name":"University of Debrecen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009232","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/02xf66n48","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Childhood obesity may be associated with an accelerated loss of thermogenic adipocytes, increasing the risk of progressive lipid accumulation and metabolic deterioration. Early detection of the loss of thermogenic adipocytes would allow improved intervention to abrogate childhood obesity, yet reliable markers of human thermogenic adipocytes remain limited. We previously identified expression of FAM153A (family with sequence similarity 153 member A) in the developing human adipose tissue. Here, we investigated the expression pattern and potential association of FAM153A with the thermogenic transcriptional program in the adipose tissue of infants, children, and adolescents. We found that adipocyte FAM153A expression was triggered by beta adrenergic receptor stimulation, a key signal of adipocyte thermogenesis. FAM153A protein was confined to preadipocyte and adipocyte nuclei, and FAM153A mRNA expression positively correlated with the mRNA levels of canonical thermogenic adipocyte markers including uncoupling protein 1 (UCP1), myogenic differentiation 1 (MYOD1), type II iodothyronine deiodinase (DIO2), transmembrane protein 26 (TMEM26), Lim Homeobox 8 (LHX8), beta adrenergic receptor 2 (ADRB2), and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A). Importantly, FAM153A expression was positively associated not only with the expression of individual thermogenic genes but also with their coordinated co-expression. Collectively, our findings identify FAM153A as a novel mRNA biomarker of human thermogenic adipocytes that serves as a robust indicator of the thermogenic transcriptional network.<\/jats:p>","DOI":"10.3390\/cells15151321","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T07:36:13Z","timestamp":1784878573000},"page":"1321","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["FAM153A Is a Novel Biomarker of Human Thermogenic Adipocytes"],"prefix":"10.3390","volume":"15","author":[{"given":"Katalin","family":"Gyurina","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4440-2460","authenticated-orcid":false,"given":"Krist\u00f3f Levente","family":"Korp\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Bajusz-R\u00e1cz","sequence":"additional","affiliation":[{"name":"Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, 1117 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5907-2725","authenticated-orcid":false,"given":"\u00c1d\u00e1m","family":"Radv\u00e1nyi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Sasi-Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"M\u00e9hes","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1903-7922","authenticated-orcid":false,"given":"Tam\u00e1s","family":"R\u00f6szer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S2213-8587(24)00342-5","article-title":"Associations of obesity with co-morbidities in early adult life","volume":"13","year":"2025","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41572-023-00435-4","article-title":"Child and adolescent obesity","volume":"9","author":"Lister","year":"2023","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0140-6736(25)01906-3","article-title":"Childhood obesity: A global health crisis","volume":"406","year":"2025","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cell.2019.03.028","article-title":"Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood","volume":"177","author":"Khera","year":"2019","journal-title":"Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1159\/000543467","article-title":"Epigenetics of Childhood Obesity","volume":"99","author":"Keller","year":"2026","journal-title":"Horm. Res. Paediatr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1038\/s41591-025-03931-0","article-title":"Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities","volume":"31","author":"Chami","year":"2025","journal-title":"Nat. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Saba, L., Acosta, A.J., Kelly, A.S., and Kumar, S. (2026). Obesity Phenotyping in Children and Adolescents: Next Steps Towards Precision Medicine in Pediatric Obesity. Nutrients, 18.","DOI":"10.3390\/nu18020303"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.2337\/dbi24-0044","article-title":"Adipose Tissue as a Target for Precision Medicine Approaches in Childhood Obesity","volume":"74","author":"Cartwright","year":"2025","journal-title":"Diabetes"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/s41366-024-01599-z","article-title":"Precision medicine for obesity: Current evidence and insights for personalization of obesity pharmacotherapy","volume":"49","author":"Anazco","year":"2025","journal-title":"Int. J. Obes."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Alcal\u00e1, M., Calderon-Dominguez, M., Serra, D., Herrero, L., and Viana, M. (2019). Mechanisms of Impaired Brown Adipose Tissue Recruitment in Obesity. Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.00094"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/pr.2012.141","article-title":"Relevance of brown adipose tissue in infancy and adolescence","volume":"73","author":"Gilsanz","year":"2013","journal-title":"Pediatr. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1159\/000518353","article-title":"Brown Adipose Tissue in Children and Its Metabolic Function","volume":"95","author":"Tews","year":"2022","journal-title":"Horm. Res. Paediatr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/MOP.0b013e32833a8d6e","article-title":"The role and importance of brown adipose tissue in energy homeostasis","volume":"22","author":"Cypess","year":"2010","journal-title":"Curr. Opin. Pediatr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"8649","DOI":"10.1073\/pnas.1705287114","article-title":"Mapping of human brown adipose tissue in lean and obese young men","volume":"114","author":"Leitner","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Gyurina, K., Yarmak, M., Sasi-Szab\u00f3, L., Moln\u00e1r, S., M\u00e9hes, G., and R\u00f6szer, T. (2023). Loss of Uncoupling Protein 1 Expression in the Subcutaneous Adipose Tissue Predicts Childhood Obesity. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242316706"},{"key":"ref_16","unstructured":"Sinclair, J.C. (1978). Temperature Regulation and Energy Metabolism in the Newborn (Monographs in Neonatalogy), Grune & Stratton."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.jpeds.2011.09.035","article-title":"Changes in brown adipose tissue in boys and girls during childhood and puberty","volume":"160","author":"Gilsanz","year":"2012","journal-title":"J. Pediatr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1042\/cs0710291","article-title":"Brown adipose tissue uncoupling protein content in human infants, children and adults","volume":"71","author":"Lean","year":"1986","journal-title":"Clin. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.jpeds.2010.11.020","article-title":"Functional brown adipose tissue is related to muscle volume in children and adolescents","volume":"158","author":"Gilsanz","year":"2011","journal-title":"J. Pediatr."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Rockstroh, D., Landgraf, K., Wagner, I.V., Gesing, J., Tauscher, R., Lakowa, N., Kiess, W., B\u00fchligen, U., Wojan, M., and Till, H. (2015). Direct evidence of brown adipocytes in different fat depots in children. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0117841"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1172\/JCI125646","article-title":"Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages","volume":"129","author":"Yu","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Kozak, L.P. (2011). The genetics of brown adipocyte induction in white fat depots. Front. Endocrinol., 2.","DOI":"10.3389\/fendo.2011.00064"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"E314","DOI":"10.1152\/ajpendo.2000.279.2.E314","article-title":"Evidence of UCP1-independent regulation of norepinephrine-induced thermogenesis in brown fat","volume":"279","author":"Ribeiro","year":"2000","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"E1085","DOI":"10.1152\/ajpendo.00023.2015","article-title":"A stringent validation of mouse adipose tissue identity markers","volume":"308","author":"Larsson","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/ijo.2014.185","article-title":"Inflammatory characteristics of adipose tissue collected by surgical excision vs needle aspiration","volume":"39","author":"Santosa","year":"2015","journal-title":"Int. J. Obes."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Pincu, Y., Yoel, U., Haim, Y., Makarenkov, N., Maixner, N., Shaco-Levy, R., Bashan, N., Dicker, D., and Rudich, A. (2022). Assessing Obesity-Related Adipose Tissue Disease (OrAD) to Improve Precision Medicine for Patients Living with Obesity. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.860799"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/978-1-59745-245-8_15","article-title":"Isolation and culture of preadipocytes from rodent white adipose tissue","volume":"456","author":"Hausman","year":"2008","journal-title":"Methods Mol. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Untergasser, A., Ruijter, J.M., Benes, V., and van den Hoff, M.J.B. (2021). Web-based LinRegPCR: Application for the visualization and analysis of (RT)-qPCR amplification and melting data. BMC Bioinform., 22.","DOI":"10.1186\/s12859-021-04306-1"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1002\/stem.2635","article-title":"CD36 Is a Marker of Human Adipocyte Progenitors with Pronounced Adipogenic and Triglyceride Accumulation Potential","volume":"35","author":"Gao","year":"2017","journal-title":"Stem Cells"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0022-2275(20)41129-0","article-title":"Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes","volume":"36","author":"Dwyer","year":"1995","journal-title":"J. Lipid Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1073\/pnas.0610615104","article-title":"Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages","volume":"104","author":"Timmons","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Sharp, L.Z., Shinoda, K., Ohno, H., Scheel, D.W., Tomoda, E., Ruiz, L., Hu, H., Wang, L., Pavlova, Z., and Gilsanz, V. (2012). Human BAT possesses molecular signatures that resemble beige\/brite cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0049452"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cmet.2007.06.001","article-title":"Transcriptional control of brown fat determination by PRDM16","volume":"6","author":"Seale","year":"2007","journal-title":"Cell Metab."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.cmet.2020.07.005","article-title":"Human Brown Adipocyte Thermogenesis Is Driven by \u03b22-AR Stimulation","volume":"32","author":"Blondin","year":"2020","journal-title":"Cell Metab."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.cmet.2013.04.011","article-title":"A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans","volume":"17","author":"Jespersen","year":"2013","journal-title":"Cell Metab."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Gyurina, K., Radv\u00e1nyi, \u00c1., Sasi-Szab\u00f3, L., Felszeghy, E., R\u00e1cz, E., M\u00e9hes, G., K\u00e1d\u00e1r, A., Fekete, C., and R\u00f6szer, T. (2026). Lim Homeobox 8 Is Essential for Beta Adrenergic Stimulation of Thermogenesis in Human Adipocytes. Cells, 15.","DOI":"10.3390\/cells15111000"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.cmet.2017.09.004","article-title":"Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue","volume":"26","author":"Schreiber","year":"2017","journal-title":"Cell Metab."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"8039","DOI":"10.1038\/s41467-023-43606-3","article-title":"A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence","volume":"14","author":"Jiang","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Wen, X., Kleinman, K., Gillman, M.W., Rifas-Shiman, S.L., and Taveras, E.M. (2012). Childhood body mass index trajectories: Modeling, characterizing, pairwise correlations and socio-demographic predictors of trajectory characteristics. BMC Med. Res. Methodol., 12.","DOI":"10.1186\/1471-2288-12-38"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13052-024-01671-4","article-title":"Early adiposity rebound: Predictors and outcomes","volume":"50","author":"Pomi","year":"2024","journal-title":"Ital. J. Pediatr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ecl.2020.02.008","article-title":"Sex Differences in Adipose Tissue Function","volume":"49","author":"Gavin","year":"2020","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: Protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.jnutbio.2009.11.012","article-title":"mRNA transcripts as molecular biomarkers in medicine and nutrition","volume":"21","author":"Sunde","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3934\/molsci.2026010","article-title":"Application of qPCR testing in clinical diagnostics: A brief review of its history, challenges and perspectives","volume":"13","author":"Rodrigues","year":"2026","journal-title":"AIMS Mol. Sci."},{"key":"ref_45","unstructured":"Centers for Disease Control and Prevention (CDC) (2026, June 10). Information on Rapid Molecular Assays, RT-PCR, and Other Molecular Assays for Diagnosis of Influenza Virus Infection, Available online: https:\/\/www.cdc.gov\/flu\/hcp\/testing-methods\/molecular-assays.html."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6991","DOI":"10.1038\/s41598-023-34220-w","article-title":"Commercially available SARS-CoV-2 RT-qPCR diagnostic tests need obligatory internal validation","volume":"13","author":"Linkowska","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e01606-23","DOI":"10.1128\/spectrum.01606-23","article-title":"A Two-Step Real-Time PCR Method To Identify Mycobacterium tuberculosis Infections and Six Dominant Nontuberculous Mycobacterial Infections from Clinical Specimens","volume":"11","author":"Park","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"ref_48","unstructured":"World Health Organization (2021). WHO Guideline for Screening and Treatment of Cervical Pre-Cancer Lesions for Cervical Cancer Prevention: Use of mRNA Tests for Human Papillomavirus (HPV), World Health Organization."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Lin, B., Han, C., Li, J.-H., and Wang, R. (2024). Evaluation of the performance of a qPCR-based assay for HIV-1 viral load determination. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0315579"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2353\/jmoldx.2007.060134","article-title":"Inter-laboratory comparison of chronic myeloid leukemia minimal residual disease monitoring: Summary and recommendations","volume":"9","author":"Zhang","year":"2007","journal-title":"J. Mol. Diagn. JMD"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s12033-024-01356-7","article-title":"Research Trends and Development Dynamics of qPCR-based Biomarkers: A Comprehensive Bibliometric Analysis","volume":"68","author":"Liu","year":"2026","journal-title":"Mol. Biotechnol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.2337\/db21-0799","article-title":"Impaired Cold-Stimulated Supraclavicular Brown Adipose Tissue Activity in Young Boys with Obesity","volume":"71","author":"Ahmed","year":"2022","journal-title":"Diabetes"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.molmet.2019.12.014","article-title":"Mechanisms of insulin resistance related to white, beige, and brown adipocytes","volume":"34","author":"Czech","year":"2020","journal-title":"Mol. Metab."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.cell.2015.09.035","article-title":"A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat","volume":"163","author":"Kazak","year":"2015","journal-title":"Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1073\/pnas.0308258100","article-title":"Rapid transformation of white adipocytes into fat-oxidizing machines","volume":"101","author":"Orci","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Pilkington, A.-C., Paz, H.A., and Wankhade, U.D. (2021). Beige Adipose Tissue Identification and Marker Specificity\u2014Overview. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.599134"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/oby.23948","article-title":"A newly identified compound activating UCP1 inhibits obesity and its related metabolic disorders","volume":"32","author":"Onodera","year":"2024","journal-title":"Obesity"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5","article-title":"Antigens recognized by autologous antibody in patients with renal-cell carcinoma","volume":"83","author":"Scanlan","year":"1999","journal-title":"Int. J. Cancer"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1007\/s12672-025-03241-4","article-title":"The complex role and molecular mechanism of family with sequence similarity genes in cancer: A comprehensive review","volume":"16","author":"Deng","year":"2025","journal-title":"Discov. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"12581","DOI":"10.3934\/mbe.2022587","article-title":"Family with sequence similarity 153 member B as a potential prognostic biomarker of gastric cancer","volume":"19","author":"Yang","year":"2022","journal-title":"Math. Biosci. Eng. MBE"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1073\/pnas.1720475115","article-title":"Family with sequence similarity 13, member A modulates adipocyte insulin signaling and preserves systemic metabolic homeostasis","volume":"115","author":"Wardhana","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/s41366-018-0222-y","article-title":"Obesity-associated family with sequence similarity 13, member A (FAM13A) is dispensable for adipose development and insulin sensitivity","volume":"43","author":"Tang","year":"2019","journal-title":"Int. J. Obes."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1038\/s41467-020-15291-z","article-title":"FAM13A affects body fat distribution and adipocyte function","volume":"11","author":"Fathzadeh","year":"2020","journal-title":"Nat. Commun."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/15\/1321\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T04:13:43Z","timestamp":1785039223000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/15\/1321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":63,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["cells15151321"],"URL":"https:\/\/doi.org\/10.3390\/cells15151321","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]}}}