{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:59:57Z","timestamp":1785214797124,"version":"3.55.0"},"reference-count":74,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Pseudoexfoliation glaucoma (PXG) is a unique cause of open-angle glaucoma with a more severe clinical course and higher intraocular pressure (IOP) than primary open-angle glaucoma (POAG). This reflects progressive structural failure of the trabecular meshwork (TM) driven by pseudoexfoliation (PXF) fibrillar material deposition, distinguishing PXG from POAG pathogenically. The TM, an active load-bearing filtration sieve, regulates IOP and is most affected by XFM deposition and extracellular matrix (ECM) dysregulation in PXG. Despite extensive research, the mechanism of trabecular dysfunction remains unclear, with both mechanical obstruction and ischemic\/oxidative stress implicated. This narrative review amalgamates evidence across TM biology, PXF material science, and glaucoma pathophysiology to propose a five-stage framework for TM failure in PXG.<\/jats:p>","DOI":"10.3390\/cells15151329","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T01:26:23Z","timestamp":1785115583000},"page":"1329","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Load-Bearing Tissue to Failed Filter: A Conceptual Framework for Trabecular Meshwork Breakdown in Pseudoexfoliation Glaucoma"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8120-8740","authenticated-orcid":false,"given":"Aparna","family":"Rao","sequence":"first","affiliation":[{"name":"Faculty Glaucoma Services, ICARE Eye Hospital and PG Institute, Noida 201301, UP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.4274\/tjo.galenos.2023.76300","article-title":"Pseudoexfoliation glaucoma: Clinical presentation and therapeutic options","volume":"53","year":"2023","journal-title":"Turk. J. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S1350-9462(99)00019-1","article-title":"Exfoliation syndrome and exfoliation glaucoma","volume":"19","author":"Vesti","year":"2000","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/bs.apcsb.2021.03.004","article-title":"Proteomics of pseudoexfoliation materials in the anterior eye segment","volume":"127","author":"Morris","year":"2021","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/ICU.0b013e3282f49cda","article-title":"The molecular pathophysiology of pseudoexfoliation glaucoma","volume":"19","author":"Lee","year":"2008","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Tomczyk-Socha, M., Tomczak, W., Winkler-Lach, W., and Turno-Kr\u0119cicka, A. (2023). Pseudoexfoliation syndrome: Clinical characteristics of most common cause of secondary glaucoma. J. Clin. Med., 12.","DOI":"10.3390\/jcm12103580"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.1097\/IJG.0000000000000924","article-title":"Clinical and laboratory biomarkers for pseudoexfoliation syndrome","volume":"27","author":"Kamel","year":"2018","journal-title":"J. Glaucoma"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/iub.2606","article-title":"Pseudoexfoliation syndrome: The critical role of the extracellular matrix in pathogenesis and treatment","volume":"74","author":"Mastronikolis","year":"2022","journal-title":"IUBMB Life"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/ICU.0000000000000736","article-title":"Pseudoexfoliation syndrome and glaucoma: From genes to disease mechanisms","volume":"32","author":"Khor","year":"2021","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e217","DOI":"10.1016\/j.jfo.2020.05.002","article-title":"The trabecular meshwork: Structure, function and clinical implications. A review of the literature","volume":"43","author":"Buffault","year":"2020","journal-title":"J. Fr. Ophtalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.exer.2009.02.007","article-title":"The trabecular meshwork outflow pathways: Structural and functional aspects","volume":"88","author":"Tamm","year":"2009","journal-title":"Exp. Eye Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/s41598-024-83834-1","article-title":"Trabecular meshwork ultrastructural changes in primary and secondary glaucoma","volume":"15","author":"Rao","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Izzotti, A., Longobardi, M., Cartiglia, C., and Sacc\u00e0, S.C. (2011). Mitochondrial damage in the trabecular meshwork occurs only in primary open-angle glaucoma and in pseudoexfoliative glaucoma. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0014567"},{"key":"ref_13","first-page":"320","article-title":"The role of Schlemm\u2019s canal in aqueous outflow from the human eye","volume":"24","author":"Johnson","year":"1983","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.exer.2016.07.009","article-title":"The many faces of the trabecular meshwork cell","volume":"158","author":"Stamer","year":"2017","journal-title":"Exp. Eye Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/IJG.0b013e31815f52a8","article-title":"Stress response of the trabecular meshwork","volume":"17","author":"Liton","year":"2008","journal-title":"J. Glaucoma"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.exer.2008.11.025","article-title":"Structural changes of the trabecular meshwork in different kinds of glaucoma","volume":"88","author":"Tektas","year":"2009","journal-title":"Exp. Eye Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1089\/jop.2013.0185","article-title":"Intraocular pressure homeostasis: Maintaining balance in a high-pressure environment","volume":"30","author":"Acott","year":"2014","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.matbio.2014.03.007","article-title":"The role of matricellular proteins in glaucoma","volume":"37","author":"Wallace","year":"2014","journal-title":"Matrix Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e881","DOI":"10.1111\/aos.15027","article-title":"Schlemm\u2019s canal: The outflow \u2018vessel\u2019","volume":"100","author":"Lewczuk","year":"2022","journal-title":"Acta Ophthalmol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.preteyeres.2016.12.004","article-title":"Aqueous outflow\u2014A continuum from trabecular meshwork to episcleral veins","volume":"57","author":"Carreon","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"108473","DOI":"10.1016\/j.visres.2024.108473","article-title":"Mechanosensitive ion channels in glaucoma pathophysiology","volume":"223","author":"Lin","year":"2024","journal-title":"Vis. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.survophthal.2025.07.001","article-title":"Trabecular meshwork: A pivotal target for evolving glaucoma treatments","volume":"70","author":"Wan","year":"2025","journal-title":"Surv. Ophthalmol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1097\/IJG.0000000000000106","article-title":"The trabecular meshwork in normal eyes and in exfoliation glaucoma","volume":"23","author":"Rasmussen","year":"2014","journal-title":"J. Glaucoma"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.exer.2009.01.005","article-title":"Modulation of extracellular matrix turnover in the trabecular meshwork","volume":"88","author":"Fuchshofer","year":"2009","journal-title":"Exp. Eye Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.exer.2008.08.008","article-title":"The role of the actomyosin system in regulating trabecular fluid outflow","volume":"88","author":"Tian","year":"2009","journal-title":"Exp. Eye Res."},{"key":"ref_26","first-page":"288","article-title":"Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow","volume":"11","author":"Rao","year":"2005","journal-title":"Mol. Vis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.preteyeres.2013.05.002","article-title":"Rho-associated kinase inhibitors: A novel glaucoma therapy","volume":"37","author":"Inoue","year":"2013","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Chakraborty, M., Sahay, P., and Rao, A. (2021). Primary human trabecular meshwork model for pseudoexfoliation. Cells, 10.","DOI":"10.3390\/cells10123448"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.exer.2008.08.012","article-title":"Molecular pathology of pseudoexfoliation syndrome\/glaucoma\u2014New insights from LOXL1 gene associations","volume":"88","year":"2009","journal-title":"Exp. Eye Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"BIO106","DOI":"10.1167\/iovs.17-21723","article-title":"Functional activity of matrix metalloproteinases 2 and 9 in tears of patients with glaucoma","volume":"58","author":"Sahay","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_31","first-page":"e27129","article-title":"Role of mitochondrial mutations in ocular aggregopathy","volume":"14","author":"Chakraborty","year":"2022","journal-title":"Cureus"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Sahay, P., Chakraborty, M., and Rao, A. (2022). Global and comparative proteome signatures in the lens capsule, trabecular meshwork, and iris of patients with pseudoexfoliation glaucoma. Front. Mol. Biosci., 9.","DOI":"10.3389\/fmolb.2022.877250"},{"key":"ref_33","first-page":"579","article-title":"Elevated levels of aqueous TGF-\u03b21 versus TGF-\u03b22 in pseudoexfoliation versus primary open-angle glaucoma","volume":"19","author":"Imanishi","year":"2010","journal-title":"J. Glaucoma"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"107820","DOI":"10.1016\/j.exer.2019.107820","article-title":"Thrombospondin-2 is up-regulated by TGF\u03b22 and increases fibronectin expression in human trabecular meshwork cells","volume":"189","author":"Kennedy","year":"2019","journal-title":"Exp. Eye Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00441-011-1274-7","article-title":"The role of TGF-\u03b2 in the pathogenesis of primary open-angle glaucoma","volume":"347","author":"Fuchshofer","year":"2012","journal-title":"Cell Tissue Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1167\/iovs.05-0249","article-title":"Differential gene expression in pseudoexfoliation syndrome","volume":"46","author":"Zenkel","year":"2005","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.exger.2005.06.005","article-title":"Cellular senescence in the glaucomatous outflow pathway","volume":"40","author":"Liton","year":"2005","journal-title":"Exp. Gerontol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: Bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1167\/iovs.10-6342","article-title":"Elastic modulus determination of normal and glaucomatous human trabecular meshwork","volume":"52","author":"Last","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_40","first-page":"2435","article-title":"Correlation of pseudoexfoliative material and optic nerve damage in pseudoexfoliation syndrome","volume":"38","author":"Gottanka","year":"1997","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"C403","DOI":"10.1152\/ajpcell.00295.2024","article-title":"TRPV4 and chloride channels mediate volume sensing in trabecular meshwork cells","volume":"327","author":"Baumann","year":"2024","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e2022461118","DOI":"10.1073\/pnas.2022461118","article-title":"Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma","volume":"118","author":"Patel","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1126\/science.1146554","article-title":"Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma","volume":"317","author":"Thorleifsson","year":"2007","journal-title":"Science"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.ajo.2007.09.034","article-title":"LOXL1 mutations are associated with exfoliation syndrome in patients from the United States","volume":"144","author":"Fingert","year":"2007","journal-title":"Am. J. Ophthalmol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"107818","DOI":"10.1016\/j.exer.2019.107818","article-title":"The role of lysyl oxidase-like 1 (LOXL1) in exfoliation syndrome and glaucoma","volume":"189","author":"Zenkel","year":"2019","journal-title":"Exp. Eye Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/ahg.12128","article-title":"Ethnicity-based differences in the association of LOXL1 polymorphisms with pseudoexfoliation\/pseudoexfoliative glaucoma: A meta-analysis","volume":"79","author":"Founti","year":"2015","journal-title":"Ann. Hum. Genet."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.exer.2016.03.013","article-title":"Biological effect of LOXL1 coding variants associated with pseudoexfoliation syndrome","volume":"146","author":"Sharma","year":"2016","journal-title":"Exp. Eye Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"8488","DOI":"10.1167\/iovs.11-8361","article-title":"Regulation of lysyl oxidase-like 1 (LOXL1) and elastin-related genes by pathogenic factors associated with pseudoexfoliation syndrome","volume":"52","author":"Zenkel","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"15466","DOI":"10.1038\/ncomms15466","article-title":"Pseudoexfoliation syndrome-associated genetic variants affect transcription factor binding and alternative splicing of LOXL1","volume":"8","author":"Pasutto","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Thomas, M.N., Skopi\u0144ski, P., Roberts, H., and Woronkowicz, M. (2025). The ocular surface and the anterior segment of the eye in the pseudoexfoliation syndrome: A comprehensive review. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26020532"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/BF00186513","article-title":"Blood-aqueous barrier in pseudoexfoliation syndrome: Evaluation by immunohistochemical staining of endogenous albumin","volume":"234","author":"Vinores","year":"1996","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1001\/archopht.122.1.29","article-title":"Factors associated with long-term progression in newly diagnosed patients with exfoliation glaucoma","volume":"122","author":"Konstas","year":"2004","journal-title":"Arch. Ophthalmol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0161-6420(98)96020-1","article-title":"Pseudoexfoliation syndrome for the comprehensive ophthalmologist. Intraocular and systemic manifestations","volume":"105","author":"Naumann","year":"1998","journal-title":"Ophthalmology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0039-6257(00)00196-X","article-title":"Exfoliation syndrome","volume":"45","author":"Ritch","year":"2001","journal-title":"Surv. Ophthalmol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/IJG.0000000000000119","article-title":"Ocular and systemic manifestations of exfoliation syndrome","volume":"23","author":"Ritch","year":"2014","journal-title":"J. Glaucoma"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1097\/IJG.0000000000000123","article-title":"The composition of exfoliation material and the cells that produce it","volume":"23","author":"Zenkel","year":"2014","journal-title":"J. Glaucoma"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/S0002-9394(14)77871-7","article-title":"Pseudoexfoliative fibrillopathy in the skin of patients with ocular pseudoexfoliation","volume":"110","author":"Streeten","year":"1990","journal-title":"Am. J. Ophthalmol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.2147\/OPTH.S431723","article-title":"Visual field progression after glaucoma surgery in pseudoexfoliation versus primary glaucoma","volume":"17","author":"Rao","year":"2023","journal-title":"Clin. Ophthalmol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1167\/iovs.05-1060","article-title":"TGF\u03b22-induced changes in human trabecular meshwork: Implications for intraocular pressure","volume":"47","author":"Fleenor","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/ng.3226","article-title":"A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome","volume":"47","author":"Aung","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_61","first-page":"714","article-title":"Age-related changes in trabecular meshwork cellularity","volume":"21","author":"Alvarado","year":"1981","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1016\/j.ajpath.2012.02.030","article-title":"Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork","volume":"180","author":"Junglas","year":"2012","journal-title":"Am. J. Pathol."},{"key":"ref_63","first-page":"1604","article-title":"Peak intraocular pressure and glaucomatous progression in primary open-angle glaucoma and exfoliative glaucoma","volume":"32","author":"Konstas","year":"2010","journal-title":"Clin. Ther."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/eye.1987.38","article-title":"Age-related depletion of the cell population in the human trabecular meshwork","volume":"1","author":"Grierson","year":"1987","journal-title":"Eye"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S0161-6420(84)34248-8","article-title":"Trabecular meshwork cellularity in primary open-angle glaucoma and nonglaucomatous normals","volume":"91","author":"Alvarado","year":"1984","journal-title":"Ophthalmology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/08820538.2011.626356","article-title":"Diurnal curve after phacoemulsification in patients with pseudoexfoliation syndrome and cataract","volume":"27","author":"Rao","year":"2012","journal-title":"Semin. Ophthalmol."},{"key":"ref_67","first-page":"197","article-title":"Clinical and optical coherence tomography features in unilateral versus bilateral pseudoexfoliation syndrome","volume":"7","author":"Rao","year":"2012","journal-title":"J. Ophthalmic Vis. Res."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Rao, A., and Padhy, D. (2014). Pattern of pseudoexfoliation deposits on the lens and their clinical correlation\u2014Clinical study and review of literature. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0113329"},{"key":"ref_69","first-page":"169","article-title":"Specific Biomarkers in the Aqueous Humour of Glaucoma Patients","volume":"239","author":"Reinehr","year":"2022","journal-title":"Klin. Monbl. Augenheilkd."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1136\/bjo.87.3.353","article-title":"8-Isoprostaglandin E2 and ascorbic acid concentration in the aqueous humour of patients with exfoliation syndrome or glaucoma","volume":"87","author":"Koliakos","year":"2003","journal-title":"Br. J. Ophthalmol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Vernazza, S., Tirendi, S., Bassi, A.M., Traverso, C.E., and Sacc\u00e0, S.C. (2020). Neuroinflammation in Primary Open-Angle Glaucoma. J. Clin. Med., 9.","DOI":"10.3390\/jcm9103172"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"S562","DOI":"10.4103\/IJO.IJO_2685_23","article-title":"Risk factors for exfoliation glaucoma\u2014Current evidence and perspectives","volume":"72","author":"Rao","year":"2024","journal-title":"Indian J. Ophthalmol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.3390\/cimb44030078","article-title":"Alternate causes for pathogenesis of exfoliation glaucoma, a multifactorial elastotic disorder: A literature review","volume":"44","author":"Chakraborty","year":"2022","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/s41467-020-20851-4","article-title":"Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with distinct functions of diverse signal enrichment","volume":"12","author":"Gharahkhani","year":"2021","journal-title":"Nat. Commun."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/15\/1329\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:15:49Z","timestamp":1785212149000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/15\/1329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":74,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["cells15151329"],"URL":"https:\/\/doi.org\/10.3390\/cells15151329","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]}}}