{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:43:20Z","timestamp":1785426200814,"version":"3.56.0"},"reference-count":53,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["1708442"],"award-info":[{"award-number":["1708442"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"award":["1708442"],"award-info":[{"award-number":["1708442"]}],"id":[{"id":"https:\/\/ror.org\/00hhkn466","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","award":["2022"],"award-info":[{"award-number":["2022"]}],"id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","award":["2023"],"award-info":[{"award-number":["2023"]}],"id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"award":["2022"],"award-info":[{"award-number":["2022"]}],"id":[{"id":"https:\/\/ror.org\/02y123g31","id-type":"ROR","asserted-by":"publisher"}]},{"award":["2023"],"award-info":[{"award-number":["2023"]}],"id":[{"id":"https:\/\/ror.org\/02y123g31","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013236","name":"MSD Life Science Foundation","doi-asserted-by":"publisher","award":["2025-2026"],"award-info":[{"award-number":["2025-2026"]}],"id":[{"id":"10.13039\/501100013236","id-type":"DOI","asserted-by":"publisher"}]},{"award":["2025-2026"],"award-info":[{"award-number":["2025-2026"]}],"id":[{"id":"https:\/\/ror.org\/03ym4q031","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008670","name":"Terumo","doi-asserted-by":"publisher","award":["2025-2026"],"award-info":[{"award-number":["2025-2026"]}],"id":[{"id":"10.13039\/501100008670","id-type":"DOI","asserted-by":"publisher"}]},{"award":["2025-2026"],"award-info":[{"award-number":["2025-2026"]}],"id":[{"id":"https:\/\/ror.org\/02kbe5v55","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Cervical cancer remains a major global health challenge and a leading cause of gynecological cancer-related mortality, particularly in developing countries. Although persistent human papillomavirus infection is the primary driver of cervical carcinogenesis, host factors such as immune dysregulation and microbiome dysbiosis may contribute to disease progression. Corisin is a microbiota-derived peptide implicated in epithelial injury and fibrosis, but its role in cervical neoplasia is unknown. To investigate its potential involvement, circulating corisin levels were measured in 27 women with cervical intraepithelial neoplasia (CIN) or cervical cancer and compared with those in 15 healthy women. Corisin localization in cervical carcinoma tissues was examined by immunohistochemistry, and its biological effects were evaluated in HeLa cells. Circulating corisin levels were significantly elevated in patients with CIN and cervical cancer, with the highest levels observed in CIN3 and cervical squamous cell carcinoma. Corisin was detected within cervical carcinoma tissues in intracellular and extracellular compartments adjacent to tumor cells. In HeLa cells, corisin accumulated in mitochondria, impaired cell-cycle progression, induced apoptosis, increased p21 expression, and promoted epithelial\u2013mesenchymal transition-like morphological changes. These findings suggest that corisin is elevated from the early stages of cervical neoplasia, is present within the cervical tumor microenvironment, and may contribute to pathogenic cellular processes associated with cervical cancer progression.<\/jats:p>","DOI":"10.3390\/cells15151358","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:07:33Z","timestamp":1785244053000},"page":"1358","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microbiota-Derived Corisin Is Elevated in Early Cervical Neoplasia and Drives Pathogenic Cellular Programs"],"prefix":"10.3390","volume":"15","author":[{"given":"Naoki","family":"Watashige","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty and Graduate School of Medicine, Mie University Hospital, Mie University, Tsu 514-8507, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3493-8753","authenticated-orcid":false,"given":"Michiko","family":"Kubo-Kaneda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty and Graduate School of Medicine, Mie University Hospital, Mie University, Tsu 514-8507, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Makino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty and Graduate School of Medicine, Mie University Hospital, Mie University, Tsu 514-8507, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty and Graduate School of Medicine, Mie University Hospital, Mie University, Tsu 514-8507, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kota","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty and Graduate School of Medicine, Mie University Hospital, Mie University, Tsu 514-8507, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty and Graduate School of Medicine, Mie University Hospital, Mie University, Tsu 514-8507, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Kotaka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty and Graduate School of Medicine, Mie University Hospital, Mie University, Tsu 514-8507, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Toda","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu 514-8507, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina N.","family":"D\u2019Alessandro-Gabazza","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu 514-8507, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Cann","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA"},{"name":"Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban C.","family":"Gabazza","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu 514-8507, Mie, Japan"},{"name":"Department of Animal Science, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Yasuma","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu 514-8507, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4755-3548","authenticated-orcid":false,"given":"Kenta","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty and Graduate School of Medicine, Mie University Hospital, Mie University, Tsu 514-8507, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9773-2520","authenticated-orcid":false,"given":"Eiji","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty and Graduate School of Medicine, Mie University Hospital, Mie University, Tsu 514-8507, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2026, June 01). Cervical Cancer. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cervical-cancer."},{"key":"ref_2","first-page":"e1756","article-title":"Global, Regional and National Burden, Incidence, and Mortality of Cervical Cancer","volume":"6","author":"Momenimovahed","year":"2023","journal-title":"Cancer Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S1470-2045(18)30836-2","article-title":"Impact of Scaled up Human Papillomavirus Vaccination and Cervical Screening and the Potential for Global Elimination of Cervical Cancer in 181 Countries, 2020\u201399: A Modelling Study","volume":"20","author":"Simms","year":"2019","journal-title":"Lancet Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e070115","DOI":"10.1136\/bmj-2022-070115","article-title":"Human Papillomavirus Vaccination and Cervical Cancer Risk","volume":"379","author":"Rahangdale","year":"2022","journal-title":"BMJ"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000511477","article-title":"Microbiome and Cervical Cancer","volume":"88","author":"Castanheira","year":"2021","journal-title":"Pathobiology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.ygyno.2008.07.045","article-title":"Natural History and Epidemiology of HPV Infection and Cervical Cancer","volume":"110","author":"Castellsague","year":"2008","journal-title":"Gynecol. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1111\/cas.70201","article-title":"Microbial and Metabolic Disorders in Cervical Cancer: Structural Insights, Biomarkers, Mechanisms, and Therapeutic Strategies","volume":"116","author":"Tao","year":"2025","journal-title":"Cancer Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0020-7292(92)90379-W","article-title":"Vaginal Microbial Flora as a Cofactor in the Pathogenesis of Uterine Cervical Intraepithelial Neoplasia","volume":"37","author":"Guijon","year":"1992","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_9","first-page":"7035","article-title":"Microbiota Dysbiosis Is Associated with Hpv-Induced Cervical Carcinogenesis","volume":"16","author":"Kwasniewski","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"385981","DOI":"10.1155\/2010\/385981","article-title":"Effects of Pregnancy and Bacterial Vaginosis on Proinflammatory Cytokine and Secretory Leukocyte Protease Inhibitor Concentrations in Vaginal Secretions","volume":"2010","author":"Balkus","year":"2010","journal-title":"J. Pregnancy"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s40168-022-01337-5","article-title":"Lactic Acid from Vaginal Microbiota Enhances Cervicovaginal Epithelial Barrier Integrity by Promoting Tight Junction Protein Expression","volume":"10","author":"Jesaveluk","year":"2022","journal-title":"Microbiome"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1038\/mi.2017.27","article-title":"Vaginal Lactic Acid Elicits an Anti-Inflammatory Response from Human Cervicovaginal Epithelial Cells and Inhibits Production of Pro-Inflammatory Mediators Associated with HIV Acquisition","volume":"10","author":"Hearps","year":"2017","journal-title":"Mucosal Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.2174\/1381612825666190215121712","article-title":"Oxidative Stress and Cancer","volume":"24","author":"Klaunig","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1177\/1933719115581000","article-title":"\u03b1-Amylase in Vaginal Fluid: Association with Conditions Favorable to Dominance of Lactobacillus","volume":"22","author":"Nasioudis","year":"2015","journal-title":"Reprod. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Torcia, M.G. (2019). Interplay among Vaginal Microbiome, Immune Response and Sexually Transmitted Viral Infections. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20020266"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ajog.2018.12.011","article-title":"Vaginal Dysbiosis and the Risk of Human Papillomavirus and Cervical Cancer: Systematic Review and Meta-Analysis","volume":"221","author":"Brusselaers","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/s41586-022-05435-0","article-title":"Effect of the Intratumoral Microbiota on Spatial and Cellular Heterogeneity in Cancer","volume":"611","author":"Wu","year":"2022","journal-title":"Nature"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1126\/science.aah5043","article-title":"Potential Role of Intratumor Bacteria in Mediating Tumor Resistance to the Chemotherapeutic Drug Gemcitabine","volume":"357","author":"Geller","year":"2017","journal-title":"Science"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/s41586-021-03368-8","article-title":"Identification of Bacteria-Derived HLA-Bound Peptides in Melanoma","volume":"592","author":"Kalaora","year":"2021","journal-title":"Nature"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/s41586-023-06081-w","article-title":"Microbial Peptides Activate Tumour-Infiltrating Lymphocytes in Glioblastoma","volume":"617","author":"Naghavian","year":"2023","journal-title":"Nature"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.aay9189","article-title":"The Human Tumor Microbiome Is Composed of Tumor Type-Specific Intracellular Bacteria","volume":"368","author":"Nejman","year":"2020","journal-title":"Science"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"eabc4552","DOI":"10.1126\/science.abc4552","article-title":"The Microbiome and Human Cancer","volume":"371","author":"Zitvogel","year":"2021","journal-title":"Science"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1038\/s41467-020-15344-3","article-title":"A Staphylococcus Pro-Apoptotic Peptide Induces Acute Exacerbation of Pulmonary Fibrosis","volume":"11","author":"Kobayashi","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1038\/s41467-022-29064-3","article-title":"Inhibition of Lung Microbiota-Derived Proapoptotic Peptides Ameliorates Acute Exacerbation of Pulmonary Fibrosis","volume":"13","author":"Yasuma","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7591","DOI":"10.1038\/s41467-025-61847-2","article-title":"Microbiota-Derived Corisin Accelerates Kidney Fibrosis by Promoting Cellular Aging","volume":"16","author":"Yasuma","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13099-023-00587-4","article-title":"Elevated Plasma and Bile Levels of Corisin, a Microbiota-Derived Proapoptotic Peptide, in Patients with Severe Acute Cholangitis","volume":"15","author":"Nishiwaki","year":"2023","journal-title":"Gut Pathog."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Saiki, H., Okano, Y., Yasuma, T., Toda, M., Takeshita, A., Abdel-Hamid, A.M., Fridman D\u2019Alessandro, V., Tsuruga, T., D\u2019Alessandro-Gabazza, C.N., and Katayama, K. (2021). A Microbiome-Derived Peptide Induces Apoptosis of Cells from Different Tissues. Cells, 10.","DOI":"10.3390\/cells10112885"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/j.jtha.2024.02.014","article-title":"Role of Microbiota-Derived Corisin in Coagulation Activation during SARS-CoV-2 Infection","volume":"22","author":"Tsuruga","year":"2024","journal-title":"J. Thromb. Haemost."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"549","DOI":"10.6004\/jnccn.2025.0057","article-title":"Cervical Cancer, Version 2.2026, NCCN Clinical Practice Guidelines in Oncology","volume":"23","author":"Campos","year":"2025","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.6004\/jnccn.2023.0062","article-title":"NCCN Guidelines\u00ae Insights: Cervical Cancer, Version 1.2024","volume":"21","author":"Yashar","year":"2023","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.3802\/jgo.2019.30.e40","article-title":"Multidisciplinary Perspectives on Newly Revised 2018 Figo Staging of Cancer of the Cervix Uteri","volume":"30","author":"Berek","year":"2019","journal-title":"J. Gynecol. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.tcb.2008.08.001","article-title":"Apoptosis-Induced Compensatory Proliferation. The Cell Is Dead. Long Live the Cell!","volume":"18","author":"Fan","year":"2008","journal-title":"Trends Cell Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s12943-024-02096-7","article-title":"Cellular Senescence and Sasp in Tumor Progression and Therapeutic Opportunities","volume":"23","author":"Dong","year":"2024","journal-title":"Mol. Cancer"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41420-020-0286-z","article-title":"Convergence of Therapy-Induced Senescence (TIS) and EMT in Multistep Carcinogenesis: Current Opinions and Emerging Perspectives","volume":"6","author":"Faheem","year":"2020","journal-title":"Cell Death Discov."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1111\/febs.16381","article-title":"The Role of Cellular Senescence and Sasp in Tumour Microenvironment","volume":"290","author":"Takasugi","year":"2023","journal-title":"FEBS J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1007\/s12672-025-04011-y","article-title":"Genes Associated with Epithelial Mesenchymal Transition (EMT) in Cervical Cancer Progression","volume":"16","author":"Kumari","year":"2025","journal-title":"Discov. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e2412574","DOI":"10.1002\/advs.202412574","article-title":"Radiotherapy-Associated Cellular Senescence and EMT Alterations Contribute to Distinct Disease Relapse Patterns in Locally Advanced Cervical Cancer","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Lin, S., Zhang, B., Lin, Y., Lin, Y., and Zuo, X. (2022). Dysbiosis of Cervical and Vaginal Microbiota Associated with Cervical Intraepithelial Neoplasia. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.767693"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Sekaran, K., Varghese, R.P., Gopikrishnan, M., Alsamman, A.M., El Allali, A., Zayed, H., and Doss, C.G. (2023). Unraveling the Dysbiosis of Vaginal Microbiome to Understand Cervical Cancer Disease Etiology\u2014An Explainable AI Approach. Genes, 14.","DOI":"10.3390\/genes14040936"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"So, K.A., Yang, E.J., Kim, N.R., Hong, S.R., Lee, J.H., Hwang, C.S., Shim, S.H., Lee, S.J., and Kim, T.J. (2020). Changes of Vaginal Microbiota during Cervical Carcinogenesis in Women with Human Papillomavirus Infection. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0238705"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s12223-018-0593-4","article-title":"Characterization of Multiple Antibiotic Resistant Clinical Strains of Staphylococcus Isolated from Pregnant Women Vagina","volume":"63","author":"Hetsa","year":"2018","journal-title":"Folia Microbiol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Oh, K.Y., Lee, S., Lee, M.S., Lee, M.J., Shim, E., Hwang, Y.H., Ha, J.G., Yang, Y.S., Hwang, I.T., and Park, J.S. (2021). Composition of Vaginal Microbiota in Pregnant Women with Aerobic Vaginitis. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.677648"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12088-018-0766-5","article-title":"Contraceptive Sperm Agglutinating Proteins Identified in Staphylococcus warneri, Natural Microflora of an Infertile Woman","volume":"59","author":"Pant","year":"2019","journal-title":"Indian J. Microbiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1258\/0956462054093999","article-title":"Staphylococcus sciuri: An Unusual Cause of Pelvic Inflammatory Disease","volume":"16","author":"Stepanovic","year":"2005","journal-title":"Int. J. STD AIDS"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Sun, M., Geng, H., Bai, J., Feng, J., Xu, N., Liu, Y., Liu, X., and Liu, G. (2022). Characterization of Cervical Canal and Vaginal Bacteria in Pregnant Women with Cervical Incompetence. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.986326"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1111\/j.1365-2672.2009.04485.x","article-title":"Probiotic Potential of Staphylococcus hominis Mbbl 2-9 as Anti-Staphylococcus aureus Agent Isolated from the Vaginal Microbiota of a Healthy Woman","volume":"108","author":"Sung","year":"2010","journal-title":"J. Appl. Microbiol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Zeng, M., Li, X., Jiao, X., Cai, X., Yao, F., Xu, S., Huang, X., Zhang, Q., and Chen, J. (2022). Roles of Vaginal Flora in Human Papillomavirus Infection, Virus Persistence and Clearance. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.1036869"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Agoni, L., Roselletti, E., Marasco, G., Martinelli, C., Pericolini, E., and De Seta, F. (2026). The Gut-Vagina Axis. Microorganisms, 14.","DOI":"10.3390\/microorganisms14061327"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of Cancer: New Dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/bs.ctdb.2015.07.013","article-title":"The Sound of Silence: Signaling by Apoptotic Cells","volume":"114","author":"Fogarty","year":"2015","journal-title":"Curr. Top. Dev. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/cdd.2017.47","article-title":"Killers Creating New Life: Caspases Drive Apoptosis-Induced Proliferation in Tissue Repair and Disease","volume":"24","author":"Fogarty","year":"2017","journal-title":"Cell Death Differ."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1007\/s10495-024-01958-1","article-title":"Understanding the Molecular Mechanism of Regeneration through Apoptosis-Induced Compensatory Proliferation Studies\u2014Updates and Future Aspects","volume":"29","author":"Rajagopalan","year":"2024","journal-title":"Apoptosis"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s10555-018-9736-y","article-title":"Novel Roles of Apoptotic Caspases in Tumor Repopulation, Epigenetic Reprogramming, Carcinogenesis, and Beyond","volume":"37","author":"Zhao","year":"2018","journal-title":"Cancer Metastasis Rev."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/15\/1358\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:21:38Z","timestamp":1785385298000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/15\/1358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":53,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["cells15151358"],"URL":"https:\/\/doi.org\/10.3390\/cells15151358","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]}}}