{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:56:11Z","timestamp":1785412571629,"version":"3.56.0"},"reference-count":139,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"NIA Clinical and Translational Predoctoral Training in Alzheimer\u2019s Disease and Related Dementias","doi-asserted-by":"publisher","award":["5T32AG061892-07"],"award-info":[{"award-number":["5T32AG061892-07"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH\/NIA","doi-asserted-by":"publisher","award":["1 R01 AG075900-01"],"award-info":[{"award-number":["1 R01 AG075900-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH\/NIA","doi-asserted-by":"publisher","award":["1 R01 AG074584-01"],"award-info":[{"award-number":["1 R01 AG074584-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH\/NIA","doi-asserted-by":"publisher","award":["1R21AG095654-01"],"award-info":[{"award-number":["1R21AG095654-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH\/NIA","doi-asserted-by":"publisher","award":["1R21AG093972-01"],"award-info":[{"award-number":["1R21AG093972-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"Department of Veterans Affairs","doi-asserted-by":"publisher","award":["5I50RX003000-07"],"award-info":[{"award-number":["5I50RX003000-07"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"award":["5I50RX003000-07"],"award-info":[{"award-number":["5I50RX003000-07"]}],"id":[{"id":"https:\/\/ror.org\/05rsv9s98","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The discovery of RNA in the late 19th century revolutionized the understanding of cell biology. Subsequent discoveries over the next six decades revealed a key role for RNA in protein synthesis. Nevertheless, today, the mechanisms driving RNA metabolism remain enigmatic. Given its fundamental cellular role, RNA alterations are strongly linked to disease, including devastating neurodegenerative disorders pathologically defined by the accumulation of RNA-binding proteins. For example, the mislocalization of TDP-43, an RNA-binding protein, is a pathological feature of amyotrophic lateral sclerosis and frontotemporal dementia TDP-43. Another group of more than 20 neurodegenerative disorders, called tauopathies, is characterized by the aberrant accumulation of the protein tau. Similarly, the emerging concept that tau binds RNA, facilitating the formation of pathological structures, highlights the importance of RNA stability in tauopathies. However, the dynamics and consequences of RNA\u2013tau interactions remain unclear. This review comprehensively catalogs key findings linking tau, RNA, and stress granules. These findings are important because they could offer novel opportunities to design therapeutic strategies.<\/jats:p>","DOI":"10.3390\/cells15151365","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T08:16:52Z","timestamp":1785313012000},"page":"1365","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Interactions of Tau, RNA, and Stress Granules in Neurodegenerative Disease: A Comprehensive Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1655-0085","authenticated-orcid":false,"given":"Tristyn N.","family":"Garza","sequence":"first","affiliation":[{"name":"Center for Translational Research in Neurodegenerative Disease (CTRND), University of Florida, Gainesville, FL 32610, USA"},{"name":"Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA"},{"name":"Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA"},{"name":"Brain Injury, Rehabilitation, and Neuroresilience (BRAIN) Center, University of Florida, Gainesville, FL 32610, USA"},{"name":"Genetics Institute, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6341-679X","authenticated-orcid":false,"given":"Jose F.","family":"Abisambra","sequence":"additional","affiliation":[{"name":"Center for Translational Research in Neurodegenerative Disease (CTRND), University of Florida, Gainesville, FL 32610, USA"},{"name":"Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA"},{"name":"Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA"},{"name":"Brain Injury, Rehabilitation, and Neuroresilience (BRAIN) Center, University of Florida, Gainesville, FL 32610, USA"},{"name":"Genetics Institute, University of Florida, Gainesville, FL 32610, USA"},{"name":"Brain Rehabilitation Research Center, Malcom Randall VA Medical Center, North Florida\/South Georgia Veterans Health System, Gainesville, FL 32608, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41419-021-03873-8","article-title":"Stress Granules, RNA-Binding Proteins and Polyglutamine Diseases: Too Much Aggregation?","volume":"12","author":"Marcelo","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"eady6859","DOI":"10.1126\/sciadv.ady6859","article-title":"Translation Landscape of Stress Granules","volume":"11","author":"Wu","year":"2025","journal-title":"Sci. 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