{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T08:22:26Z","timestamp":1787559746955,"version":"build-2736575974"},"reference-count":158,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Major Project for the Prevention and Treatment of Cancer, Cardiovascular, Respiratory and Metabolic Diseases","award":["2025ZD0547700"],"award-info":[{"award-number":["2025ZD0547700"]}]},{"name":"National Health Commission Scientific Research Fund\u2013Zhejiang Provincial Major Health Science and Technology Plan Project","award":["WKJ-ZJ-2405"],"award-info":[{"award-number":["WKJ-ZJ-2405"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270515"],"award-info":[{"award-number":["82270515"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["82270515"],"award-info":[{"award-number":["82270515"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Advances in anticancer therapies have substantially improved cancer survival but have also highlighted the growing challenge of cancer therapy-related cardiac dysfunction. Ferroptosis, an iron-dependent form of regulated cell death characterized by iron dysregulation, lipid peroxidation, and impaired antioxidant defense, has emerged as a promising strategy for eliminating therapy-resistant tumors. However, the lack of tissue specificity in ferroptosis regulation raises concerns regarding its potential contribution to cardiovascular injury during anticancer treatment. This review summarizes the dual roles of ferroptosis in cancer biology and cardio-oncology. We first discuss the molecular mechanisms governing ferroptosis, including iron metabolism, lipid peroxidation, and antioxidant defense systems. We then highlight the context-dependent roles of ferroptosis in tumor progression, immune regulation, and metabolic adaptation. Furthermore, we systematically review how chemotherapy, targeted therapy, immunotherapy, and radiotherapy contribute to ferroptosis-associated cardiovascular toxicity. Finally, we discuss emerging approaches to minimize cardiac injury, including tissue-specific ferroptosis-targeting and cardioprotective strategies. Understanding tissue-specific ferroptosis regulation may facilitate the development of safer and more precise therapeutic approaches in cardio-oncology.<\/jats:p>","DOI":"10.3390\/cells15171507","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T08:03:41Z","timestamp":1787558621000},"page":"1507","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular Toxicity in Cancer Therapy: Potential Mechanisms of Ferroptosis and Treatment Strategies"],"prefix":"10.3390","volume":"15","author":[{"given":"Jiani","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China"},{"name":"State Key Laboratory of Transvascular Implantation Devices, Hangzhou 310009, China"},{"name":"Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou 310009, China"},{"name":"Transvascular Implantation Devices Research Institute, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China"},{"name":"State Key Laboratory of Transvascular Implantation Devices, Hangzhou 310009, China"},{"name":"Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou 310009, China"},{"name":"Transvascular Implantation Devices Research Institute, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunna","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China"},{"name":"State Key Laboratory of Transvascular Implantation Devices, Hangzhou 310009, China"},{"name":"Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou 310009, China"},{"name":"Transvascular Implantation Devices Research Institute, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuguang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China"},{"name":"State Key Laboratory of Transvascular Implantation Devices, Hangzhou 310009, China"},{"name":"Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou 310009, China"},{"name":"Transvascular Implantation Devices Research Institute, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3175-0213","authenticated-orcid":false,"given":"Yao","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China"},{"name":"State Key Laboratory of Transvascular Implantation Devices, Hangzhou 310009, China"},{"name":"Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou 310009, China"},{"name":"Transvascular Implantation Devices Research Institute, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7508-2432","authenticated-orcid":false,"given":"Liangliang","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China"},{"name":"State Key Laboratory of Transvascular Implantation Devices, Hangzhou 310009, China"},{"name":"Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou 310009, China"},{"name":"Transvascular Implantation Devices Research Institute, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixiang","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China"},{"name":"State Key Laboratory of Transvascular Implantation Devices, Hangzhou 310009, China"},{"name":"Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou 310009, China"},{"name":"Transvascular Implantation Devices Research Institute, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/s41569-020-0348-1","article-title":"Adverse cardiac effects of cancer therapies: Cardiotoxicity and arrhythmia","volume":"17","author":"Herrmann","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_2","first-page":"900","article-title":"Shared Risk Factors for Cardiovascular Disease and Cancer: Implications for Preventive Health and Clinical Care in Oncology Patients","volume":"32","author":"Johnson","year":"2016","journal-title":"Can. J. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jaccao.2025.07.001","article-title":"Cancer and Cardiovascular Disease: Shared Risk Factors, Mechanisms, and Clinical Implications: JACC: CardioOncology State-of-the-Art Review","volume":"7","author":"Alhuneafat","year":"2025","journal-title":"JACC CardioOncol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"117217","DOI":"10.1016\/j.biopha.2024.117217","article-title":"Ferroptosis: A novel therapeutic target of natural products against doxorubicin-induced cardiotoxicity","volume":"178","author":"Yi","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2147\/DDDT.S443107","article-title":"Understanding Sorafenib-Induced Cardiovascular Toxicity: Mechanisms and Treatment Implications","volume":"18","author":"Li","year":"2024","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"166586","DOI":"10.1016\/j.bbadis.2022.166586","article-title":"Inhibition of YAP by lenvatinib in endothelial cells increases blood pressure through ferroptosis","volume":"1869","author":"Liang","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e70357","DOI":"10.1002\/mco2.70357","article-title":"Programmed Cell Death in Cancer","volume":"6","author":"Wei","year":"2025","journal-title":"MedComm"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"101288","DOI":"10.1016\/j.drup.2025.101288","article-title":"Drug resistance in breast cancer: Mechanisms and strategies for management","volume":"83","author":"Wu","year":"2025","journal-title":"Drug Resist. Updat."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.2147\/DDDT.S469331","article-title":"Cardiotoxicity of Anticancer Drugs: Molecular Mechanisms, Clinical Management and Innovative Treatment","volume":"18","author":"Gao","year":"2024","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"118328","DOI":"10.1016\/j.biopha.2025.118328","article-title":"From iron-driven cell death to clot formation: The emerging role of ferroptosis in thrombogenesis","volume":"189","author":"Rafiei","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1016\/j.tjnut.2025.06.016","article-title":"Nutritional Landscape of Iron in Cardiovascular Disease","volume":"155","author":"Shen","year":"2025","journal-title":"J. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5079","DOI":"10.7150\/ijbs.107402","article-title":"Activation of sphingosine-1-phosphate receptors can relieve myocardial ischemia-reperfusion injury by mitigating oxidative stress and ferroptosis in cardiomyocytes","volume":"21","author":"Xu","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00204-023-03665-3","article-title":"The role of ferroptosis in cardio-oncology","volume":"98","author":"Hou","year":"2024","journal-title":"Arch. Toxicol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1152\/physrev.00031.2024","article-title":"Ferroptosis: When metabolism meets cell death","volume":"105","author":"Zheng","year":"2025","journal-title":"Physiol. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","article-title":"Glutaminolysis and Transferrin Regulate Ferroptosis","volume":"59","author":"Gao","year":"2015","journal-title":"Mol. Cell"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1182\/blood.2019002907","article-title":"Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis","volume":"136","author":"Yu","year":"2020","journal-title":"Blood"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41419-023-06151-x","article-title":"Publisher Correction: Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer","volume":"14","author":"Wang","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.bbrc.2020.07.032","article-title":"NEDD4L-mediated LTF protein degradation limits ferroptosis","volume":"531","author":"Wang","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.tem.2021.04.010","article-title":"Ferritinophagy and ferroptosis in the management of metabolic diseases","volume":"32","author":"Ajoolabady","year":"2021","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1080\/15548627.2025.2504792","article-title":"SENP2-mediated deSUMOylation of NCOA4 protects against ferritinophagy-dependent ferroptosis in myocardial ischemia-reperfusion injury","volume":"21","author":"Xue","year":"2025","journal-title":"Autophagy"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1161\/CIRCRESAHA.120.316509","article-title":"Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis","volume":"127","author":"Fang","year":"2020","journal-title":"Circ. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"102555","DOI":"10.1016\/j.redox.2022.102555","article-title":"Ferritin light chain deficiency-induced ferroptosis is involved in preeclampsia pathophysiology by disturbing uterine spiral artery remodelling","volume":"58","author":"Yang","year":"2022","journal-title":"Redox Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.cmet.2015.09.006","article-title":"Ironing out Ferroportin","volume":"22","author":"Drakesmith","year":"2015","journal-title":"Cell Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5686","DOI":"10.1038\/s41467-020-19458-6","article-title":"Structural basis of ion transport and inhibition in ferroportin","volume":"11","author":"Pan","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e70049","DOI":"10.1002\/mco2.70049","article-title":"H3K14la drives endothelial dysfunction in sepsis-induced ARDS by promoting SLC40A1\/transferrin-mediated ferroptosis","volume":"6","author":"Gong","year":"2025","journal-title":"MedComm"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/s41419-024-06902-4","article-title":"Erianin induces ferroptosis in GSCs via REST\/LRSAM1 mediated SLC40A1 ubiquitination to overcome TMZ resistance","volume":"15","author":"Mansuer","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"414","DOI":"10.7150\/ijbs.89368","article-title":"Elevated SLC40A1 impairs cardiac function and exacerbates mitochondrial dysfunction, oxidative stress, and apoptosis in ischemic myocardia","volume":"20","author":"Feng","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/MOL.0000000000000820","article-title":"The expanding role of lyso-phosphatidylcholine acyltransferase-3 (LPCAT3), a phospholipid remodeling enzyme, in health and disease","volume":"33","author":"Lagrost","year":"2022","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41556-019-0305-6","article-title":"ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway","volume":"21","author":"Chu","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Kagan, V.E., Tyurina, Y.Y., Vlasova, I.I., Kapralov, A.A., Amoscato, A.A., Anthonymuthu, T.S., Tyurin, V.A., Shrivastava, I.H., Cinemre, F.B., and Lamade, A. (2020). Redox Epiphospholipidome in Programmed Cell Death Signaling: Catalytic Mechanisms and Regulation. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.628079"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/ana.25356","article-title":"N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E(2) to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice","volume":"84","author":"Karuppagounder","year":"2018","journal-title":"Ann. Neurol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"23746","DOI":"10.1021\/acsnano.3c07555","article-title":"Biomimetic Macrophage Membrane-Camouflaged Nanoparticles Induce Ferroptosis by Promoting Mitochondrial Damage in Glioblastoma","volume":"17","author":"Cao","year":"2023","journal-title":"ACS Nano"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1021\/ar200024c","article-title":"Free radical oxidation of polyunsaturated lipids: New mechanistic insights and the development of peroxyl radical clocks","volume":"44","author":"Pratt","year":"2011","journal-title":"Acc. Chem. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5944","DOI":"10.1021\/cr200084z","article-title":"Free radical lipid peroxidation: Mechanisms and analysis","volume":"111","author":"Yin","year":"2011","journal-title":"Chem. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41589-019-0434-z","article-title":"Publisher Correction: The chemical basis of ferroptosis","volume":"16","author":"Conrad","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1021\/acscentsci.7b00589","article-title":"Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis","volume":"4","author":"Shah","year":"2018","journal-title":"ACS Cent. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cell.2017.11.048","article-title":"Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis","volume":"172","author":"Ingold","year":"2018","journal-title":"Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"103672","DOI":"10.1016\/j.redox.2025.103672","article-title":"Hsp90 C-terminal domain inhibition enhances ferroptosis by disrupting GPX4-VDAC1 interaction to increase HMOX1 release from oligomerized VDAC1 channels","volume":"85","author":"Li","year":"2025","journal-title":"Redox Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1158\/0008-5472.CAN-16-1979","article-title":"HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells","volume":"77","author":"Zhu","year":"2017","journal-title":"Cancer Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1080\/15548627.2023.2165323","article-title":"Copper-dependent autophagic degradation of GPX4 drives ferroptosis","volume":"19","author":"Xue","year":"2023","journal-title":"Autophagy"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13045-020-01016-8","article-title":"Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells","volume":"14","author":"Ding","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.freeradbiomed.2022.01.009","article-title":"Bufotalin induces ferroptosis in non-small cell lung cancer cells by facilitating the ubiquitination and degradation of GPX4","volume":"180","author":"Zhang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.molmed.2023.05.013","article-title":"FSP1: A key regulator of ferroptosis","volume":"29","author":"Li","year":"2023","journal-title":"Trends Mol. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1093\/nar\/gkg537","article-title":"Prediction of lipid posttranslational modifications and localization signals from protein sequences: Big-Pi, NMT and PTS1","volume":"31","author":"Eisenhaber","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Schneider","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1021\/acscentsci.9b01063","article-title":"GTP Cyclohydrolase 1\/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling","volume":"6","author":"Kraft","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/s41589-020-0613-y","article-title":"Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers","volume":"16","author":"Soula","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"E18","DOI":"10.1038\/s41586-019-1459-x","article-title":"Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer","volume":"572","author":"Cronin","year":"2019","journal-title":"Nature"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s13046-022-02527-7","article-title":"Correction: CircLRFN5 inhibits the progression of glioblastoma via PRRX2\/GCH1 mediated ferroptosis","volume":"41","author":"Jiang","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41586-021-03539-7","article-title":"DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer","volume":"593","author":"Mao","year":"2021","journal-title":"Nature"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"103788","DOI":"10.1016\/j.redox.2025.103788","article-title":"DHODH-mediated mitochondrial redox homeostasis: A novel ferroptosis regulator and promising therapeutic target","volume":"85","author":"Cao","year":"2025","journal-title":"Redox Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.jhep.2025.06.034","article-title":"Mevalonate pathway promotes liver cancer by suppressing ferroptosis through CoQ10 production and selenocysteine-tRNA modification","volume":"83","author":"Chen","year":"2025","journal-title":"J. Hepatol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1158\/1535-7163.MCT-25-0667","article-title":"Lipophilic Statins Deplete GPX4 to Promote Ferroptosis and Sensitize Cancer Cells to Immune Checkpoint Blockade","volume":"25","author":"Talty","year":"2026","journal-title":"Mol. Cancer Ther."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: The role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41392-023-01347-1","article-title":"Targeting p53 pathways: Mechanisms, structures, and advances in therapy","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/s41420-023-01517-8","article-title":"Ferroptosis and the bidirectional regulatory factor p53","volume":"9","author":"Xu","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Pasino, M., Speciale, A., Ravera, S., Cutrona, G., Massara, R., Bertola, N., Viale, M., Velkova, I., Mazzarello, A.N., and Fais, F. (2025). Targeting the p53\/xCT\/GSH Axis with PRIMA-1(Met) Combined with Sulfasalazine Shows Therapeutic Potential in Chronic Lymphocytic Leukemia. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26125559"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"113436","DOI":"10.1016\/j.intimp.2024.113436","article-title":"ANP32E promotes esophageal cancer progression and paclitaxel resistance via P53\/SLC7A11 axis-regulated ferroptosis","volume":"144","author":"Sun","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2174\/0115680096284068240506095417","article-title":"Silencing HEATR1 Rescues Cisplatin Resistance of Non-small Cell Lung Cancer by Inducing Ferroptosis via the p53\/SAT1\/ALOX15 Axis","volume":"25","author":"Ma","year":"2025","journal-title":"Curr. Cancer Drug Targets"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"118305","DOI":"10.1016\/j.lfs.2020.118305","article-title":"LncRNA PVT1 regulates ferroptosis through miR-214-mediated TFR1 and p53","volume":"260","author":"Lu","year":"2020","journal-title":"Life Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.celrep.2017.12.077","article-title":"p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells","volume":"22","author":"Tarangelo","year":"2018","journal-title":"Cell Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.freeradbiomed.2023.12.047","article-title":"P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability","volume":"212","author":"Zheng","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"eadk1835","DOI":"10.1126\/sciadv.adk1835","article-title":"Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo","volume":"10","author":"Dibra","year":"2024","journal-title":"Sci. Adv."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s13046-023-02865-0","article-title":"TMEM147 aggravates the progression of HCC by modulating cholesterol homeostasis, suppressing ferroptosis, and promoting the M2 polarization of tumor-associated macrophages","volume":"42","author":"Huang","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1080\/15548627.2020.1714209","article-title":"Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein","volume":"16","author":"Dai","year":"2020","journal-title":"Autophagy"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1016\/j.ccell.2024.10.010","article-title":"Itaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistance","volume":"42","author":"Lin","year":"2024","journal-title":"Cancer Cell"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/s42255-024-01019-6","article-title":"Fatty acid binding protein 5 suppression attenuates obesity-induced hepatocellular carcinoma by promoting ferroptosis and intratumoral immune rewiring","volume":"6","author":"Sun","year":"2024","journal-title":"Nat. Metab."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ccell.2022.02.003","article-title":"CD8(+) T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4","volume":"40","author":"Liao","year":"2022","journal-title":"Cancer Cell"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/mc.23861","article-title":"HMGB3 Contributes to Anti-PD-1 Resistance by Inhibiting IFN-\u03b3-Driven Ferroptosis in TNBC","volume":"64","author":"Luo","year":"2025","journal-title":"Mol. Carcinog."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41556-020-0461-8","article-title":"Energy-stress-mediated AMPK activation inhibits ferroptosis","volume":"22","author":"Lee","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrc3110","article-title":"Dysregulated pH: A perfect storm for cancer progression","volume":"11","author":"Webb","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"108487","DOI":"10.1016\/j.celrep.2020.108487","article-title":"HCAR1\/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications","volume":"33","author":"Zhao","year":"2020","journal-title":"Cell Rep."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s00109-023-02346-z","article-title":"Molecular therapy of cardiac ischemia-reperfusion injury based on mitochondria and ferroptosis","volume":"101","author":"Wang","year":"2023","journal-title":"J. Mol. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"15515","DOI":"10.1038\/s41598-023-42760-4","article-title":"Oxidative stress induces mitochondrial iron overload and ferroptotic cell death","volume":"13","author":"Chen","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"153230","DOI":"10.1016\/j.ijbiomac.2026.153230","article-title":"NOX4 promotes cardiomyocyte ferroptosis-related injury in septic cardiomyopathy in associated with mitochondrial dysfunction and impaired NRF2 nuclear translocation","volume":"373","author":"Qin","year":"2026","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1093\/eurheartj\/ehac244","article-title":"2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS)","volume":"43","author":"Lyon","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e2117396119","DOI":"10.1073\/pnas.2117396119","article-title":"Mitochondrial outer membrane protein FUNDC2 promotes ferroptosis and contributes to doxorubicin-induced cardiomyopathy","volume":"119","author":"Ta","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"103024","DOI":"10.1016\/j.redox.2023.103024","article-title":"Pharmacological activation of GPX4 ameliorates doxorubicin-induced cardiomyopathy","volume":"70","author":"Huang","year":"2024","journal-title":"Redox Biol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e2301136","DOI":"10.1002\/advs.202301136","article-title":"Use of Deep-Learning Assisted Assessment of Cardiac Parameters in Zebrafish to Discover Cyanidin Chloride as a Novel Keap1 Inhibitor Against Doxorubicin-Induced Cardiotoxicity","volume":"10","author":"Liu","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Menon, A.V., and Kim, J. (2022). Iron Promotes Cardiac Doxorubicin Retention and Toxicity Through Downregulation of the Mitochondrial Exporter ABCB8. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.817951"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00109-006-0068-y","article-title":"IRP1-independent alterations of cardiac iron metabolism in doxorubicin-treated mice","volume":"84","author":"Corna","year":"2006","journal-title":"J. Mol. Med."},{"key":"ref_88","first-page":"8422","article-title":"Doxorubicin irreversibly inactivates iron regulatory proteins 1 and 2 in cardiomyocytes: Evidence for distinct metabolic pathways and implications for iron-mediated cardiotoxicity of antitumor therapy","volume":"61","author":"Minotti","year":"2001","journal-title":"Cancer Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"111708","DOI":"10.1016\/j.biopha.2021.111708","article-title":"Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management","volume":"139","author":"Rawat","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e2206007","DOI":"10.1002\/advs.202206007","article-title":"The Imbalance of p53-Park7 Signaling Axis Induces Iron Homeostasis Dysfunction in Doxorubicin-Challenged Cardiomyocytes","volume":"10","author":"Pan","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s12012-007-0023-3","article-title":"Dexrazoxane: How it works in cardiac and tumor cells. Is it a prodrug or is it a drug?","volume":"7","author":"Hasinoff","year":"2007","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1172\/JCI72931","article-title":"Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation","volume":"124","author":"Ichikawa","year":"2014","journal-title":"J. Clin. Invest."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"103157","DOI":"10.1016\/j.redox.2024.103157","article-title":"Inhibition of METTL3 ameliorates doxorubicin-induced cardiotoxicity through suppression of TFRC-mediated ferroptosis","volume":"72","author":"Wu","year":"2024","journal-title":"Redox Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"153113","DOI":"10.1016\/j.tox.2022.153113","article-title":"ROS and iron homeostasis dependent ferroptosis play a vital role in 5-Fluorouracil induced cardiotoxicity in vitro and in vivo","volume":"468","author":"Li","year":"2022","journal-title":"Toxicology"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Fujii, K., Fujiwara-Tani, R., Nukaga, S., Ohmori, H., Luo, Y., Nishida, R., Sasaki, T., Miyagawa, Y., Nakashima, C., and Kawahara, I. (2024). Involvement of Ferroptosis Induction and Oxidative Phosphorylation Inhibition in the Anticancer-Drug-Induced Myocardial Injury: Ameliorative Role of Pterostilbene. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25053015"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"109241","DOI":"10.1016\/j.jnutbio.2022.109241","article-title":"Resveratrol alleviated 5-FU-induced cardiotoxicity by attenuating GPX4 dependent ferroptosis","volume":"112","author":"Li","year":"2023","journal-title":"J. Nutr. Biochem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1161\/01.CIR.0000114521.88547.5E","article-title":"Neuregulin-1 induces a negative inotropic effect in cardiac muscle: Role of nitric oxide synthase","volume":"109","author":"Lemmens","year":"2004","journal-title":"Circulation"},{"key":"ref_98","first-page":"22","article-title":"Mechanisms of trastuzumab induced cardiotoxicity-is exercise a potential treatment?","volume":"9","author":"Eaton","year":"2023","journal-title":"Cardiooncology"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3892\/ijmm.2021.5072","article-title":"Herceptin induces ferroptosis and mitochondrial dysfunction in H9c2 cells","volume":"49","author":"Sun","year":"2022","journal-title":"Int. J. Mol. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1200\/JCO.2002.20.5.1215","article-title":"Cardiac dysfunction in the trastuzumab clinical trials experience","volume":"20","author":"Seidman","year":"2002","journal-title":"J. Clin. Oncol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"177685","DOI":"10.1016\/j.ejphar.2025.177685","article-title":"Targeting mitochondrial dynamics emerges as an effective strategy of cardioprotection against trastuzumab-induced mitochondrial functional aberrations and cardiotoxicity in rats","volume":"999","author":"Maneechote","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.freeradbiomed.2023.06.019","article-title":"Trastuzumab-induced cardiomyopathy via ferroptosis-mediated mitochondrial dysfunction","volume":"206","author":"Ye","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Hu, Q., Zhong, B., Zheng, Y., and Zhou, H. (2026). Targeting the SP1\/ACSL4 axis attenuates ferroptosis in trastuzumab-induced cardiotoxicity. Drug Chem. Toxicol., 1\u201310.","DOI":"10.1080\/01480545.2025.2586862"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"e13158","DOI":"10.1111\/cpr.13158","article-title":"Sorafenib attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis via HIF-1\u03b1\/SLC7A11 pathway","volume":"55","author":"Yuan","year":"2022","journal-title":"Cell Prolif."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"106363","DOI":"10.1016\/j.biocel.2023.106363","article-title":"Protocadherin 20 promotes ferroptosis by suppressing the expression of Sirtuin 1 and promoting the acetylation of nuclear factor erythroid 2-related factor 2 in hepatocellular carcinoma","volume":"156","author":"Jun","year":"2023","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41420-020-00306-x","article-title":"Circular RNA cIARS regulates ferroptosis in HCC cells through interacting with RNA binding protein ALKBH5","volume":"6","author":"Liu","year":"2020","journal-title":"Cell Death Discov."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"111388","DOI":"10.1016\/j.cbi.2025.111388","article-title":"Sorafenib-induced cardiovascular toxicity: A cause for concern","volume":"410","author":"Deng","year":"2025","journal-title":"Chem. Biol. Interact."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1177\/2047487318755193","article-title":"Cardiovascular diseases in patients receiving small molecules with anti-vascular endothelial growth factor activity: A meta-analysis of approximately 29,000 cancer patients","volume":"25","author":"Totzeck","year":"2018","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ctrv.2016.12.002","article-title":"Cardiovascular toxicity of angiogenesis inhibitors in treatment of malignancy: A systematic review and meta-analysis","volume":"53","author":"Ethier","year":"2017","journal-title":"Cancer Treat. Rev."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.7150\/ijbs.86479","article-title":"Ferroptosis inhibitor alleviates sorafenib-induced cardiotoxicity by attenuating KLF11-mediated FSP1-dependent ferroptosis","volume":"20","author":"Li","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Li, Y., Yan, J., Zhao, Q., Zhang, Y., and Zhang, Y. (2022). ATF3 promotes ferroptosis in sorafenib-induced cardiotoxicity by suppressing Slc7a11 expression. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.904314"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.jacasi.2025.04.009","article-title":"Cancer Therapy-Related Cardiac Dysfunction in Patients Using Immune Checkpoint Inhibitors: A Multicenter Study","volume":"5","author":"Chang","year":"2025","journal-title":"JACC Asia"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/eurheartj\/ehaf682","article-title":"Incidence and risk factors of immune checkpoint inhibitor myocardial and muscle toxicity: A French nationwide study","volume":"47","author":"Salem","year":"2026","journal-title":"Eur. Heart J."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"e017454","DOI":"10.1161\/CIRCIMAGING.124.017454","article-title":"Imaging of the Acute and Chronic Cardiovascular Complications of Radiation Therapy","volume":"18","author":"Wilson","year":"2025","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/BF02144383","article-title":"The influence of lethal x-irradiation on trace metal uptake by the mitochondrion","volume":"24","author":"Decker","year":"1968","journal-title":"Experientia"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Su, X., Liang, F., Zeng, Y., Yang, Z.R., Deng, Y.Z., Xu, Y.H., and Cai, X.W. (2024). Radiation-Induced Endothelial Ferroptosis Accelerates Atherosclerosis via the DDHD2-Mediated Nrf2\/GPX4 Pathway. Biomolecules, 14.","DOI":"10.3390\/biom14070879"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"117537","DOI":"10.1016\/j.taap.2025.117537","article-title":"NFE2L2 protects against Sorafenib-induced Ferroptosis and cardiotoxicity by activating the HO1\/ferritin pathway","volume":"504","author":"Jiang","year":"2025","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.freeradbiomed.2026.01.065","article-title":"PGAM1-dependent VDAC1 oligomerization disrupts mitochondrial quality control to drive doxorubicin cardiotoxicity via the cGAS-STING-ferroptosis axis","volume":"247","author":"Li","year":"2026","journal-title":"Free Radic. Biol. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"e02726","DOI":"10.1002\/advs.202502726","article-title":"EBBP-Mediated Integrated Stress Response Attenuates Anthracycline-Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes","volume":"12","author":"Chen","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"150716","DOI":"10.1016\/j.bbrc.2024.150716","article-title":"Icariin alleviates cellular injury induced by cardiac ischemia-reperfusion injury by inhibiting IRE1\/JNK-induced ferroptosis","volume":"733","author":"Zhong","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"108029","DOI":"10.1016\/j.phrs.2025.108029","article-title":"ER stress sensor PERK drives ferroptosis by disrupting MAMs-mediated mitochondrial homeostasis and promoting mtROS accumulation in acute myocardial infarction","volume":"222","author":"Tao","year":"2025","journal-title":"Pharmacol. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1007\/s10495-025-02192-z","article-title":"The impact of lipid metabolism on ferroptosis in myocardial ischemia-reperfusion injury","volume":"30","author":"Li","year":"2025","journal-title":"Apoptosis"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"178608","DOI":"10.1016\/j.ejphar.2026.178608","article-title":"14,15-EET mitigates sepsis-induced cardiomyopathy by inhibiting cardiomyocyte ferroptosis via PPAR\u03b1 activation","volume":"1015","author":"Nan","year":"2026","journal-title":"Eur. J. Pharmacol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"e52280","DOI":"10.15252\/embr.202052280","article-title":"PPAR\u03b1 alleviates iron overload-induced ferroptosis in mouse liver","volume":"23","author":"Xing","year":"2022","journal-title":"EMBO Rep."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1007\/s12265-025-10628-9","article-title":"Hypoxia\/reoxygenation-induced Glycolysis Mediates Myocardial Ischemia-reperfusion Injury Through Promoting the Lactylation of GPX4","volume":"18","author":"Wang","year":"2025","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"115268","DOI":"10.1016\/j.intimp.2025.115268","article-title":"METTL3-mediated MSRB3 m6A modification accelerates hypoxia-induced cardiomyocyte ferroptosis by inhibiting mitochondrial oxidative phosphorylation","volume":"163","author":"Li","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Zhang, G., Yuan, C., Su, X., Zhang, J., Gokulnath, P., Vulugundam, G., Li, G., Yang, X., An, N., and Liu, C. (2022). Relevance of Ferroptosis to Cardiotoxicity Caused by Anthracyclines: Mechanisms to Target Treatments. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.896792"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s12012-026-10166-z","article-title":"Lapatinib Induces Ferroptosis in Cardiomyocytes by Regulating ATF4\/GPX4","volume":"26","author":"Sun","year":"2026","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"113280","DOI":"10.1016\/j.biopha.2022.113280","article-title":"ATF4 protects against sorafenib-induced cardiotoxicity by suppressing ferroptosis","volume":"153","author":"Jiang","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"110829","DOI":"10.1016\/j.cbi.2023.110829","article-title":"Sunitinib induces cardiotoxicity through modulating oxidative stress and Nrf2-dependent ferroptosis in vitro and in vivo","volume":"388","author":"Li","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.7150\/thno.19551","article-title":"Cardiac Metabolic Deregulation Induced by the Tyrosine Kinase Receptor Inhibitor Sunitinib is rescued by Endothelin Receptor Antagonism","volume":"7","author":"Sourdon","year":"2017","journal-title":"Theranostics"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/s41371-024-00982-7","article-title":"Angiotensin type 1 and type 2 receptors-induced mitochondrial dysfunction promotes ferroptosis in cardiomyocytes","volume":"39","author":"Fang","year":"2025","journal-title":"J. Hum. Hypertens."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"109379","DOI":"10.1016\/j.intimp.2022.109379","article-title":"LCZ696 protects against doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via AKT\/SIRT3\/SOD2 signaling pathway activation","volume":"113","author":"Liu","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Li, Y.C., and Cheng, M.L. (2024). Carvedilol Confers Ferroptosis Resistance in HL-1 Cells by Upregulating GPX4, FTH1, and FTL1 and Inducing Metabolic Remodeling Under Hypoxia\/Reoxygenation. Antioxidants, 14.","DOI":"10.3390\/antiox14010007"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"179142","DOI":"10.1016\/j.ejphar.2026.179142","article-title":"Carvedilol, an antihypertensive drug that reduces morbidity and mortality in heart failure, alleviates ferroptotic damage in cardiomyocytes and hepatocytes","volume":"1030","author":"Pan","year":"2026","journal-title":"Eur. J. Pharmacol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1007\/s11010-025-05294-z","article-title":"SGLT2i continuously prevents cardiac hypertrophy by reducing ferroptosis via AMPK up-regulation","volume":"480","author":"Zhao","year":"2025","journal-title":"Mol. Cell Biochem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"e70219","DOI":"10.1111\/bcpt.70219","article-title":"Vericiguat as a Novel Ferroptosis Inhibitor Alleviates Doxorubicin-Induced Cardiotoxicity","volume":"138","author":"Han","year":"2026","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"155659","DOI":"10.1016\/j.metabol.2023.155659","article-title":"Ferroptosis, a new pathogenetic mechanism in cardiometabolic diseases and cancer: Is there a role for statin therapy?","volume":"146","author":"Sahebkar","year":"2023","journal-title":"Metabolism"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bbrc.2021.08.017","article-title":"Atorvastatin treatment ameliorates cardiac function and remodeling induced by isoproterenol attack through mitigation of ferroptosis","volume":"574","author":"Ning","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.freeradbiomed.2022.01.020","article-title":"Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6\/STAT3\/GPX4 signaling","volume":"181","author":"Zhang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.apsb.2021.10.005","article-title":"Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK\/NRF2 pathways","volume":"12","author":"Wang","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"117117","DOI":"10.1016\/j.bcp.2025.117117","article-title":"Herbacetin mitigates oxidative stress and ferroptosis to protect against doxorubicin-induced cardiotoxicity","volume":"240","author":"Yang","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"123609","DOI":"10.1016\/j.lfs.2025.123609","article-title":"Dexmedetomidine inhibits ferroptosis through the Akt\/GSK3\u03b2\/Nrf2 axis and alleviates adriamycin-induced cardiotoxicity","volume":"371","author":"Cao","year":"2025","journal-title":"Life Sci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2024.05.012","article-title":"Isoliquiritigenin alleviates myocardial ischemia-reperfusion injury by regulating the Nrf2\/HO-1\/SLC7a11\/GPX4 axis in mice","volume":"221","author":"Yao","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"112210","DOI":"10.1016\/j.cbi.2026.112210","article-title":"F-53B exacerbates doxorubicin-induced cardiotoxicity by impairing NRF2-dependent ferroptosis defense","volume":"436","author":"Yang","year":"2026","journal-title":"Chem. Biol. Interact."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Yu, J., Wang, J., Liu, X., Wang, C., Wu, L., and Zhang, Y. (2025). Bioinformatics analysis of ferroptosis-related biomarkers and potential drug predictions in doxorubicin-induced cardiotoxicity. Front. Cardiovasc. Med., 12.","DOI":"10.3389\/fcvm.2025.1566782"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.freeradbiomed.2026.03.068","article-title":"CDDO-Me alleviates doxorubicin\/lapatinib-induced cardiotoxicity by activating the NRF2\/GPX4 axis to inhibit oxidative stress and ferroptosis","volume":"250","author":"Chen","year":"2026","journal-title":"Free Radic. Biol. Med."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"eadw1720","DOI":"10.1126\/sciadv.adw1720","article-title":"BRD4770 protects against DOX-induced cardiotoxicity by inhibiting apoptosis and ferroptosis","volume":"11","author":"Shao","year":"2025","journal-title":"Sci. Adv."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Cha, Y.J., Jeon, S.B., Lee, C.J., Kim, H.J., Lee, S.H., Kim, H., Park, S.H., Chen, E.Z., Kim, J.W., and Park, S.W. (2025). Limitations of Ferroptosis Inhibitors on the Doxorubicin-Induced Cardiotoxicity. Antioxidants, 15.","DOI":"10.3390\/antiox15010027"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1200\/JCO.2016.70.5400","article-title":"Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline","volume":"35","author":"Armenian","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1161\/CIRCULATIONAHA.115.020406","article-title":"Shared Risk Factors in Cardiovascular Disease and Cancer","volume":"133","author":"Koene","year":"2016","journal-title":"Circulation"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Zhou, W., and Thiery, J.P. (2025). Ferroptosis-related LncRNAs in diseases. BMC Biol., 23.","DOI":"10.1186\/s12915-025-02268-x"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.2147\/IJN.S448715","article-title":"Advances in Ferroptosis-Inducing Agents by Targeted Delivery System in Cancer Therapy","volume":"19","author":"Xiang","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"e70626","DOI":"10.1002\/smtd.70626","article-title":"Correction to \u201cTriple Tumor Microenvironment-Responsive Ferroptosis Pathways Induced by Manganese-Based Imageable Nanoenzymes for Enhanced Breast Cancer Theranostics\u201d","volume":"10","author":"He","year":"2026","journal-title":"Small Methods"},{"key":"ref_157","first-page":"42","article-title":"Prevention of Heart Failure Induced by Doxorubicin with Early Administration of Dexrazoxane (PHOENIX Study): Dose response and time course of dexrazoxane-induced degradation of topoisomerase 2b","volume":"11","author":"Chang","year":"2025","journal-title":"Cardiooncology"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"4928","DOI":"10.1038\/s41467-025-60167-9","article-title":"Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection","volume":"16","author":"Karabanovich","year":"2025","journal-title":"Nat. Commun."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/17\/1507\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T08:09:22Z","timestamp":1787558962000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/17\/1507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,22]]},"references-count":158,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["cells15171507"],"URL":"https:\/\/doi.org\/10.3390\/cells15171507","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,22]]}}}