{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:20:01Z","timestamp":1787721601092,"version":"build-2784847793"},"reference-count":257,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Nanomedicine has yielded clinically useful platforms, including liposomes, albumin-bound nanoparticles, and lipid nanoparticles; yet, many systems translate poorly because of nonspecific biodistribution, limited target-site accumulation, inefficient cellular uptake and intracellular delivery, immune clearance, and off-target toxicity. These bottlenecks are often shaped at cell membrane interfaces, where therapeutic materials are recognized, retained, internalized, or cleared and may elicit unsafe responses. Here, we frame cell membrane biophysics as a therapeutic interface for nanomedicine. We examine how lipid organization and fluidity, mechanics, electrochemical state, glycocalyx architecture, and membrane protein identity shape recognition, adhesion, endocytosis, fusion, trafficking, immune responses, and drug release. We assess how disease-associated membrane remodeling can create candidate therapeutic entry points and delivery barriers across cancer, neurodegeneration, inflammation, infection, and vascular disease. We then analyze receptor-mediated targeting, lipid-domain-associated uptake, membrane-coated nanocarriers, engineered extracellular vesicles, and hybrid platforms, with explicit context-of-use definitions and design boundaries. Finally, we propose translational qualification through function-linked critical quality attributes, mechanism-relevant potency assays, context-matched models, in vivo pharmacology and immune safety, scalable manufacturing, and regulatory evaluation. Progress will depend less on descriptive membrane mimicry than on measurable, reproducible, and qualified membrane-dependent functions.<\/jats:p>","DOI":"10.3390\/cells15171525","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:20:28Z","timestamp":1787592028000},"page":"1525","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cell Membrane Biophysics as a Therapeutic Interface for Nanomedicine: From Disease-Associated Remodeling to Translational Qualification"],"prefix":"10.3390","volume":"15","author":[{"given":"Yueming","family":"Yin","sequence":"first","affiliation":[{"name":"School of Engineering, Dali University, Dali 671003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Engineering, Dali University, Dali 671003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"An","sequence":"additional","affiliation":[{"name":"School of Engineering, Dali University, Dali 671003, China"},{"name":"Precision Medicine Translational Research Center, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Engineering, Dali University, Dali 671003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaling","family":"Liu","sequence":"additional","affiliation":[{"name":"Precision Medicine Translational Research Center, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Department of Bioengineering, Lehigh University, Bethlehem, PA 18015, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1038\/s41565-024-01754-7","article-title":"A Translational Framework to DELIVER Nanomedicines to the Clinic","volume":"19","author":"Joyce","year":"2024","journal-title":"Nat. Nanotechnol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","article-title":"Engineering Precision Nanoparticles for Drug Delivery","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"eads5249","DOI":"10.1126\/sciadv.ads5249","article-title":"Leveraging Nature\u2019s Nanocarriers: Translating Insights from Extracellular Vesicles to Biomimetic Synthetic Vesicles for Biomedical Applications","volume":"11","author":"Chen","year":"2025","journal-title":"Sci. Adv."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nbt.3330","article-title":"Principles of Nanoparticle Design for Overcoming Biological Barriers to Drug Delivery","volume":"33","author":"Blanco","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nmat2442","article-title":"Understanding Biophysicochemical Interactions at the Nano\u2013Bio Interface","volume":"8","author":"Nel","year":"2009","journal-title":"Nat. Mater."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1021\/mp9000662","article-title":"Biophysical Interactions with Model Lipid Membranes: Applications in Drug Discovery and Drug Delivery","volume":"6","author":"Peetla","year":"2009","journal-title":"Mol. Pharm."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1126\/science.175.4023.720","article-title":"The Fluid Mosaic Model of the Structure of Cell Membranes","volume":"175","author":"Singer","year":"1972","journal-title":"Science"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/nature04394","article-title":"Membranes Are More Mosaic than Fluid","volume":"438","author":"Engelman","year":"2005","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/42408","article-title":"Functional Rafts in Cell Membranes","volume":"387","author":"Simons","year":"1997","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"M\u00f6ckl, L. (2020). The Emerging Role of the Mammalian Glycocalyx in Functional Membrane Organization and Immune System Regulation. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.00253"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1146\/annurev-biophys-090721-072718","article-title":"Lipid\u2013Protein Interactions in Plasma Membrane Organization and Function","volume":"51","author":"Sych","year":"2022","journal-title":"Annu. Rev. Biophys."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.tcb.2006.08.009","article-title":"Biophysical Properties of Lipids and Dynamic Membranes","volume":"16","author":"Janmey","year":"2006","journal-title":"Trends Cell Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1146\/annurev-cellbio-100809-151736","article-title":"Dynamic Organizing Principles of the Plasma Membrane That Regulate Signal Transduction: Commemorating the Fortieth Anniversary of Singer and Nicolson\u2019s Fluid-Mosaic Model","volume":"28","author":"Kusumi","year":"2012","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrm2330","article-title":"Membrane Lipids: Where They Are and How They Behave","volume":"9","author":"Voelker","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nrm2977","article-title":"Revitalizing Membrane Rafts: New Tools and Insights","volume":"11","author":"Simons","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ceb.2020.04.001","article-title":"Pay Attention to Membrane Tension: Mechanobiology of the Cell Surface","volume":"66","author":"Sitarska","year":"2020","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1021\/nl072053l","article-title":"Modeling the Thermodynamics of the Interaction of Nanoparticles with Cell Membranes","volume":"7","author":"Ginzburg","year":"2007","journal-title":"Nano Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jconrel.2010.01.036","article-title":"Endocytosis of Nanomedicines","volume":"145","author":"Sahay","year":"2010","journal-title":"J. Control. Release"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nnano.2007.223","article-title":"Immunological Properties of Engineered Nanomaterials","volume":"2","author":"Dobrovolskaia","year":"2007","journal-title":"Nat. Nanotechnol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jconrel.2012.12.013","article-title":"Biocompatibility of Engineered Nanoparticles for Drug Delivery","volume":"166","author":"Naahidi","year":"2013","journal-title":"J. Control. Release"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.cell.2019.04.018","article-title":"The Lateral Organization and Mobility of Plasma Membrane Components","volume":"177","author":"Jacobson","year":"2019","journal-title":"Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"102308","DOI":"10.1016\/j.ceb.2023.102308","article-title":"Lipid Nanodomains and Receptor Signaling: From Actin-Based Organization to Membrane Mechanics","volume":"86","author":"Li","year":"2024","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e2104826118","DOI":"10.1073\/pnas.2104826118","article-title":"Stiffness of Targeted Layer-by-Layer Nanoparticles Impacts Elimination Half-Life, Tumor Accumulation, and Tumor Penetration","volume":"118","author":"Kong","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6996","DOI":"10.1021\/acsnano.5b01326","article-title":"Surface Functionalization of Nanoparticles with Polyethylene Glycol: Effects on Protein Adsorption and Cellular Uptake","volume":"9","author":"Pelaz","year":"2015","journal-title":"ACS Nano"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nnano.2012.237","article-title":"Transferrin-Functionalized Nanoparticles Lose Their Targeting Capabilities When a Biomolecule Corona Adsorbs on the Surface","volume":"8","author":"Salvati","year":"2013","journal-title":"Nat. Nanotechnol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e70143","DOI":"10.1002\/agt2.70143","article-title":"Illuminating the Unseen and Targeting the Untreatable: Aggregation-Induced Emission Nanoparticles as Intelligent, Immune-Compatible Tools for Precision Cancer Theranostics","volume":"6","author":"Shubhra","year":"2025","journal-title":"Aggregate"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.biomaterials.2017.02.041","article-title":"Cell Membrane-Derived Nanomaterials for Biomedical Applications","volume":"128","author":"Fang","year":"2017","journal-title":"Biomaterials"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e70074","DOI":"10.1002\/bmm2.70074","article-title":"Mimic, Target, and Adapt: Cell Membrane-coated Nanoplatforms for Precision and Immune-guided Cancer Treatment","volume":"4","author":"Alam","year":"2026","journal-title":"BMEMat"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41392-025-02312-w","article-title":"Extracellular Vesicle-Based Drug Overview: Research Landscape, Quality Control and Nonclinical Evaluation Strategies","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"076602","DOI":"10.1088\/0034-4885\/77\/7\/076602","article-title":"The Fundamental Role of Mechanical Properties in the Progression of Cancer Disease and Inflammation","volume":"77","author":"Mierke","year":"2014","journal-title":"Rep. Prog. Phys."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrd.2015.5","article-title":"Targeting Voltage-Gated Calcium Channels in Neurological and Psychiatric Diseases","volume":"15","author":"Zamponi","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev-virology-111821-093413","article-title":"Viral Membrane Fusion: A Dance Between Proteins and Lipids","volume":"10","author":"White","year":"2023","journal-title":"Annu. Rev. Virol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s41392-025-02264-1","article-title":"Pattern Recognition Receptors: Function, Regulation and Therapeutic Potential","volume":"10","author":"Chen","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.addr.2020.06.007","article-title":"Engineering the Drug Carrier Biointerface to Overcome Biological Barriers to Drug Delivery","volume":"167","author":"Finbloom","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"215712","DOI":"10.1016\/j.ccr.2024.215712","article-title":"At the Crossroad of Nanotechnology and Cancer Cell Membrane Coating: Expanding Horizons with Engineered Nanoplatforms for Advanced Cancer Therapy Harnessing Homologous Tumor Targeting","volume":"506","author":"Pan","year":"2024","journal-title":"Coord. Chem. Rev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/s41589-020-0529-6","article-title":"Plasma Membranes Are Asymmetric in Lipid Unsaturation, Packing and Protein Shape","volume":"16","author":"Lorent","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1016\/j.bpj.2012.10.033","article-title":"Acyl Chain Length and Saturation Modulate Interleaflet Coupling in Asymmetric Bilayers: Effects on Dynamics and Structural Order","volume":"103","author":"Chiantia","year":"2012","journal-title":"Biophys. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrd.2016.230","article-title":"A Comprehensive Map of Molecular Drug Targets","volume":"16","author":"Santos","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41580-019-0134-2","article-title":"Integrins as Biomechanical Sensors of the Microenvironment","volume":"20","author":"Kechagia","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41580-022-00524-4","article-title":"Regulation of Membrane Protein Structure and Function by Their Lipid Nano-Environment","volume":"24","author":"Levental","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1021\/jm3011433","article-title":"Ion Channels as Therapeutic Targets: A Drug Discovery Perspective","volume":"56","author":"Bagal","year":"2013","journal-title":"J. Med. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41565-021-00858-8","article-title":"Key Principles and Methods for Studying the Endocytosis of Biological and Nanoparticle Therapeutics","volume":"16","author":"Rennick","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5397","DOI":"10.1039\/D0CS01127D","article-title":"Understanding Nanoparticle Endocytosis to Improve Targeting Strategies in Nanomedicine","volume":"50","author":"Susnik","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1210\/en.2009-1082","article-title":"Minireview: Nanoparticles and the Immune System","volume":"151","author":"Zolnik","year":"2010","journal-title":"Endocrinology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/s41565-025-01974-5","article-title":"Limiting Endosomal Damage Sensing Reduces Inflammation Triggered by Lipid Nanoparticle Endosomal Escape","volume":"20","author":"Wang","year":"2025","journal-title":"Nat. Nanotechnol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41565-023-01507-y","article-title":"Multivalent Insulin Receptor Activation Using Insulin\u2013DNA Origami Nanostructures","volume":"19","author":"Spratt","year":"2024","journal-title":"Nat. Nanotechnol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1021\/acs.langmuir.8b02707","article-title":"Kinetics of Nanoparticle\u2013Membrane Adhesion Mediated by Multivalent Interactions","volume":"35","author":"Lanfranco","year":"2019","journal-title":"Langmuir"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev-biophys-030822-030629","article-title":"Single-Cell Mechanics: Structural Determinants and Functional Relevance","volume":"53","author":"Urbanska","year":"2024","journal-title":"Annu. Rev. Biophys."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"098101","DOI":"10.1103\/PhysRevLett.107.098101","article-title":"Cellular Uptake of Elastic Nanoparticles","volume":"107","author":"Yi","year":"2011","journal-title":"Phys. Rev. Lett."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"103128","DOI":"10.1016\/j.copbio.2024.103128","article-title":"Does the Surface Charge of the Nanoparticles Drive Nanoparticle\u2013Cell Membrane Interactions?","volume":"87","author":"Balog","year":"2024","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1039\/D3AN01423A","article-title":"A Review of Electrochemical Impedance as a Tool for Examining Cell Biology and Subcellular Mechanisms: Merits, Limits, and Future Prospects","volume":"149","author":"Arman","year":"2024","journal-title":"Analyst"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41392-024-01886-1","article-title":"Glycosylation: Mechanisms, Biological Functions and Clinical Implications","volume":"9","author":"He","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/s41423-023-01074-1","article-title":"Immune Regulatory Networks Coordinated by Glycans and Glycan-Binding Proteins in Autoimmunity and Infection","volume":"20","author":"Pinho","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.immuni.2024.03.004","article-title":"Decoding Toll-like Receptors: Recent Insights and Perspectives in Innate Immunity","volume":"57","author":"Kawai","year":"2024","journal-title":"Immunity"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Sushnitha, M., Evangelopoulos, M., Tasciotti, E., and Taraballi, F. (2020). Cell Membrane-Based Biomimetic Nanoparticles and the Immune System: Immunomodulatory Interactions to Therapeutic Applications. Front. Bioeng. Biotechnol., 8.","DOI":"10.3389\/fbioe.2020.00627"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/s41578-023-00552-2","article-title":"The Protein Corona from Nanomedicine to Environmental Science","volume":"8","author":"Mahmoudi","year":"2023","journal-title":"Nat. Rev. Mater."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"a041409","DOI":"10.1101\/cshperspect.a041409","article-title":"Beyond Fluidity: The Role of Lipid Unsaturation in Membrane Function","volume":"15","author":"Harayama","year":"2023","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1038\/s41467-022-29272-x","article-title":"Membrane Thickness, Lipid Phase and Sterol Type Are Determining Factors in the Permeability of Membranes to Small Solutes","volume":"13","author":"Frallicciardi","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.bbamem.2012.08.013","article-title":"Effect of Oxidative Stress on Plasma Membrane Fluidity of THP-1 Induced Macrophages","volume":"1828","author":"Palacio","year":"2013","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e70011","DOI":"10.1002\/dmrr.70011","article-title":"Evaluating Red Blood Cells\u2019 Membrane Fluidity in Diabetes: Insights, Mechanisms, and Future Aspects","volume":"41","author":"Pitocco","year":"2025","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"7752","DOI":"10.1039\/D2SM00693F","article-title":"Modulation of Lipid Vesicle\u2013Membrane Interactions by Cholesterol","volume":"18","author":"Chng","year":"2022","journal-title":"Soft Matter"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.jcis.2024.07.220","article-title":"Resolving the Interactions between Hydrophilic CdTe Quantum Dots and Positively Charged Membranes at the Nanoscale","volume":"677","author":"Villanueva","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s43246-026-01073-5","article-title":"Engineering the Biophysical Properties of Lipid Nanostructures for Drug Delivery","volume":"7","author":"Menge","year":"2026","journal-title":"Commun. Mater."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e12844","DOI":"10.1002\/smll.202512844","article-title":"Glassy Dynamics as a Predictive Framework for Lipid Exchange Across Membranes","volume":"22","author":"Wang","year":"2026","journal-title":"Small"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"11875","DOI":"10.1073\/pnas.1301766110","article-title":"Plasma Membrane Tension Orchestrates Membrane Trafficking, Cytoskeletal Remodeling, and Biochemical Signaling during Phagocytosis","volume":"110","author":"Masters","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"102401","DOI":"10.1016\/j.ceb.2024.102401","article-title":"Roles of Membrane Mechanics-Mediated Feedback in Membrane Traffic","volume":"89","author":"Liu","year":"2024","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"14467","DOI":"10.1073\/pnas.1105845108","article-title":"Temporary Increase in Plasma Membrane Tension Coordinates the Activation of Exocytosis and Contraction during Cell Spreading","volume":"108","author":"Gauthier","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/ncb3162","article-title":"Feedback Regulation between Plasma Membrane Tension and Membrane-Bending Proteins Organizes Cell Polarity during Leading Edge Formation","volume":"17","author":"Tsujita","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cell.2011.10.050","article-title":"Membrane Tension Maintains Cell Polarity by Confining Signals to the Leading Edge during Neutrophil Migration","volume":"148","author":"Houk","year":"2012","journal-title":"Cell"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"384003","DOI":"10.1088\/0957-4484\/19\/38\/384003","article-title":"AFM-Based Analysis of Human Metastatic Cancer Cells","volume":"19","author":"Cross","year":"2008","journal-title":"Nanotechnology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s44341-024-00007-x","article-title":"Mechanical Signatures in Cancer Metastasis","volume":"2","author":"Agrawal","year":"2025","journal-title":"npj Biol. Phys. Mech."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1093\/cvr\/cvad076","article-title":"Endothelial Mechanobiology in Atherosclerosis","volume":"119","author":"Wang","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"H157","DOI":"10.1152\/ajpheart.00457.2014","article-title":"Role of TRP Channels in the Cardiovascular System","volume":"308","author":"Yue","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41572-024-00538-6","article-title":"Cystic Fibrosis","volume":"10","author":"Mall","year":"2024","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"9737","DOI":"10.1021\/jacs.3c01451","article-title":"A Benzohydrazide-Based Artificial Ion Channel That Modulates Chloride Ion Concentration in Cancer Cells and Induces Apoptosis by Disruption of Autophagy","volume":"145","author":"Mondal","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"100090","DOI":"10.1016\/j.pharmr.2025.100090","article-title":"Recent Advances in the Pharmacology of Voltage-Gated Ion Channels","volume":"77","author":"Harris","year":"2025","journal-title":"Pharmacol. Rev."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Magar, H.S., Hassan, R.Y.A., and Mulchandani, A. (2021). Electrochemical Impedance Spectroscopy (EIS): Principles, Construction, and Biosensing Applications. Sensors, 21.","DOI":"10.3390\/s21196578"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/s41563-024-01808-0","article-title":"Immunoengineering Can Overcome the Glycocalyx Armour of Cancer Cells","volume":"23","author":"Park","year":"2024","journal-title":"Nat. Mater."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s43018-023-00702-z","article-title":"Lipids as Mediators of Cancer Progression and Metastasis","volume":"5","author":"Vogel","year":"2024","journal-title":"Nat. Cancer"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41392-024-01899-w","article-title":"Therapeutic Advances of Targeting Receptor Tyrosine Kinases in Cancer","volume":"9","author":"Tomuleasa","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e012391","DOI":"10.1136\/jitc-2025-012391","article-title":"Tumor Glyco-Immunology, Glyco-Immune Checkpoints and Immunotherapy","volume":"13","author":"Pinho","year":"2025","journal-title":"J. Immunother. Cancer"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1046\/j.1471-4159.2002.00997.x","article-title":"Substantial Sulfatide Deficiency and Ceramide Elevation in Very Early Alzheimer\u2019s Disease: Potential Role in Disease Pathogenesis","volume":"82","author":"Han","year":"2002","journal-title":"J. Neurochem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e2106210118","DOI":"10.1073\/pnas.2106210118","article-title":"Amyloid-\u03b2 Peptide Dimers Undergo a Random Coil to \u03b2-Sheet Transition in the Aqueous Phase but Not at the Neuronal Membrane","volume":"118","author":"Fatafta","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13024-025-00803-6","article-title":"Lipidome Disruption in Alzheimer\u2019s Disease Brain: Detection, Pathological Mechanisms, and Therapeutic Implications","volume":"20","author":"He","year":"2025","journal-title":"Mol. Neurodegener."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1146\/annurev-biophys-062823-023436","article-title":"Cholesterol and Lipid Rafts in the Biogenesis of Amyloid-\u03b2 Protein and Alzheimer\u2019s Disease","volume":"53","author":"Pantelopulos","year":"2024","journal-title":"Annu. Rev. Biophys."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41392-023-01486-5","article-title":"Role of Neuroinflammation in Neurodegeneration Development","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1152\/physrev.00050.2017","article-title":"Blood-Brain Barrier: From Physiology to Disease and Back","volume":"99","author":"Sweeney","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1038\/jcbfm.2012.126","article-title":"Drug Transport across the Blood\u2013Brain Barrier","volume":"32","author":"Pardridge","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1182\/blood-2014-07-588590","article-title":"ST3Gal-4 Is the Primary Sialyltransferase Regulating the Synthesis of E-, P-, and L-Selectin Ligands on Human Myeloid Leukocytes","volume":"125","author":"Mondal","year":"2015","journal-title":"Blood"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1146\/annurev-biochem-032620-104745","article-title":"Endothelial Glycocalyx Turnover in Vascular Health and Disease: Rethinking Endothelial Dysfunction","volume":"94","author":"Golden","year":"2025","journal-title":"Annu. Rev. Biochem."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Zhang, J., Huang, S., Zhu, Z., Gatt, A., and Liu, J. (2024). E-selectin in Vascular Pathophysiology. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1401399"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nri2171","article-title":"Evolving Functions of Endothelial Cells in Inflammation","volume":"7","author":"Pober","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e00957-20","DOI":"10.1128\/JVI.00957-20","article-title":"Replication of Severe Acute Respiratory Syndrome Coronavirus 2 in Human Respiratory Epithelium","volume":"94","author":"Milewska","year":"2020","journal-title":"J. Virol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"5498","DOI":"10.1038\/s41467-021-25729-7","article-title":"A CRISPR\/Cas9 Genetically Engineered Organoid Biobank Reveals Essential Host Factors for Coronaviruses","volume":"12","author":"Beumer","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41580-021-00418-x","article-title":"Mechanisms of SARS-CoV-2 Entry into Cells","volume":"23","author":"Jackson","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_96","first-page":"1","article-title":"Sialic Acid Receptors of Viruses","volume":"Volume 367","author":"Delannoy","year":"2013","journal-title":"SialoGlyco Chemistry and Biology II"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.atherosclerosis.2022.11.019","article-title":"Spatial Metabolomics Identifies Lipid Profiles of Human Carotid Atherosclerosis","volume":"364","author":"Li","year":"2023","journal-title":"Atherosclerosis"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1126\/science.1217815","article-title":"Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels","volume":"337","author":"Korin","year":"2012","journal-title":"Science"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"eadw1731","DOI":"10.1126\/sciadv.adw1731","article-title":"Enhanced Immunocompatibility and Hemocompatibility of Nanomedicines across Multiple Species Using Complement Pathway Inhibitors","volume":"11","author":"Li","year":"2025","journal-title":"Sci. Adv."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"115216","DOI":"10.1016\/j.addr.2024.115216","article-title":"The Interaction between Particles and Vascular Endothelium in Blood Flow","volume":"207","author":"Li","year":"2024","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.tibs.2023.08.004","article-title":"Membrane Homeostasis beyond Fluidity: Control of Membrane Compressibility","volume":"48","author":"Renne","year":"2023","journal-title":"Trends Biochem. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1080\/10715762.2016.1231403","article-title":"Fatty Acid-Related Modulations of Membrane Fluidity in Cells: Detection and Implications","volume":"50","author":"Maulucci","year":"2016","journal-title":"Free Radic. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1038\/s12276-023-01071-4","article-title":"Lipid Remodeling of Adipose Tissue in Metabolic Health and Disease","volume":"55","author":"Cho","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"178152","DOI":"10.1016\/j.ejphar.2025.178152","article-title":"Spotlight on Membrane Fluidity of Normal and Cancer Cells: Implications for Cancer Diagnosis and Treatment","volume":"1006","author":"Canaparo","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1016\/j.bbagen.2017.09.003","article-title":"Multi-Scale Mechanical Characterization of Prostate Cancer Cell Lines: Relevant Biological Markers to Evaluate the Cell Metastatic Potential","volume":"1861","author":"Zouaoui","year":"2017","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1186\/s12964-024-01876-4","article-title":"Lipid Rafts, Caveolae, and Epidermal Growth Factor Receptor Family: Friends or Foes?","volume":"22","author":"Ruzzi","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1194\/jlr.TR119000439","article-title":"Lipid Rafts as Signaling Hubs in Cancer Cell Survival\/Death and Invasion: Implications in Tumor Progression and Therapy: Thematic Review Series: Biology of Lipid Rafts","volume":"61","author":"Mollinedo","year":"2020","journal-title":"J. Lipid Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"5134","DOI":"10.1021\/acs.langmuir.0c00262","article-title":"Membrane Fluidity as a New Means to Selectively Target Cancer Cells with Fusogenic Lipid Carriers","volume":"36","author":"Bompard","year":"2020","journal-title":"Langmuir"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.7150\/thno.82189","article-title":"Perturbing Plasma Membrane Lipid: A New Paradigm for Tumor Nanotherapeutics","volume":"13","author":"Fei","year":"2023","journal-title":"Theranostics"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13041-024-01118-1","article-title":"The Duality of Amyloid-\u03b2: Its Role in Normal and Alzheimer\u2019s Disease States","volume":"17","author":"Azargoonjahromi","year":"2024","journal-title":"Mol. Brain"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12944-025-02563-0","article-title":"Lipid Rafts: Novel Therapeutic Targets for Metabolic, Neurodegenerative, Oncological, and Cardiovascular Diseases","volume":"24","author":"Warda","year":"2025","journal-title":"Lipids Health Dis."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1161\/ATVBAHA.122.318006","article-title":"Differential Expression of Inflammarafts in Macrophage Foam Cells and in Nonfoamy Macrophages in Atherosclerotic Lesions\u2014Brief Report","volume":"43","author":"Choi","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/MOL.0000000000000888","article-title":"Macrophage Inflammarafts in Atherosclerosis","volume":"34","author":"Li","year":"2023","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/s41419-023-06206-z","article-title":"Macrophage Polarization and Metabolism in Atherosclerosis","volume":"14","author":"Hou","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1016\/j.cell.2024.04.006","article-title":"Mechanobiology: Shaping the Future of Cellular Form and Function","volume":"187","author":"Nelson","year":"2024","journal-title":"Cell"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ccr.2005.08.010","article-title":"Tensional Homeostasis and the Malignant Phenotype","volume":"8","author":"Paszek","year":"2005","journal-title":"Cancer Cell"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.cell.2009.10.027","article-title":"Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling","volume":"139","author":"Levental","year":"2009","journal-title":"Cell"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in Mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.actbio.2022.10.016","article-title":"Extracellular Matrix Mechanobiology in Cancer Cell Migration","volume":"163","author":"Vasudevan","year":"2023","journal-title":"Acta Biomater."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1038\/s41388-023-02844-x","article-title":"Biophysics in Tumor Growth and Progression: From Single Mechano-Sensitive Molecules to Mechanomedicine","volume":"42","author":"Xin","year":"2023","journal-title":"Oncogene"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/s41551-019-0405-4","article-title":"The Softness of Tumour-Cell-Derived Microparticles Regulates Their Drug-Delivery Efficiency","volume":"3","author":"Liang","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/s41467-018-03705-y","article-title":"Progress and Challenges towards Targeted Delivery of Cancer Therapeutics","volume":"9","author":"Rosenblum","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41577-022-00761-w","article-title":"Tuning Immunity through Tissue Mechanotransduction","volume":"23","author":"Du","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"eabp8964","DOI":"10.1126\/science.abp8964","article-title":"The Extracellular Matrix and the Immune System: A Mutually Dependent Relationship","volume":"379","author":"Sutherland","year":"2023","journal-title":"Science"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"eadj9559","DOI":"10.1126\/sciadv.adj9559","article-title":"Modeling Mechanical Activation of Macrophages during Pulmonary Fibrogenesis for Targeted Anti-Fibrosis Therapy","volume":"10","author":"Xu","year":"2024","journal-title":"Sci. Adv."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e1602536","DOI":"10.1126\/sciadv.1602536","article-title":"Mechanical Deformation Induces Depolarization of Neutrophils","volume":"3","author":"Ekpenyong","year":"2017","journal-title":"Sci. Adv."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.bpj.2017.06.033","article-title":"Stiff Substrates Increase Inflammation-Induced Endothelial Monolayer Tension and Permeability","volume":"113","author":"Urbano","year":"2017","journal-title":"Biophys. J."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1152\/physrev.00053.2021","article-title":"Vascular Mechanotransduction","volume":"103","author":"Davis","year":"2023","journal-title":"Physiol. Rev."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-physiol-042022-030946","article-title":"Mechanosensing by Vascular Endothelium","volume":"86","author":"Lim","year":"2024","journal-title":"Annu. Rev. Physiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41569-024-01103-0","article-title":"Extracellular Matrix in Vascular Homeostasis and Disease","volume":"22","author":"Zhang","year":"2025","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1172\/JCI86387","article-title":"Vascular Stiffness Mechanoactivates YAP\/TAZ-Dependent Glutaminolysis to Drive Pulmonary Hypertension","volume":"126","author":"Bertero","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-physiol-042022-031925","article-title":"Arterial Stiffness: From Basic Primers to Integrative Physiology","volume":"86","author":"Regnault","year":"2024","journal-title":"Annu. Rev. Physiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"100557","DOI":"10.1016\/j.xgen.2024.100557","article-title":"The Landscape of Cancer-Rewired GPCR Signaling Axes","volume":"4","author":"Arora","year":"2024","journal-title":"Cell Genom."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.addr.2012.09.041","article-title":"Targeting Receptor-Mediated Endocytotic Pathways with Nanoparticles: Rationale and Advances","volume":"65","author":"Xu","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41392-023-01536-y","article-title":"Nanomedicine in Cancer Therapy","volume":"8","author":"Fan","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41392-023-01464-x","article-title":"TRP (Transient Receptor Potential) Ion Channel Family: Structures, Biological Functions and Therapeutic Interventions for Diseases","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1152\/physrev.00022.2023","article-title":"Recent Insights into Channelopathies","volume":"104","author":"Harraz","year":"2024","journal-title":"Physiol. Rev."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1126\/science.1712984","article-title":"Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity","volume":"253","author":"Anderson","year":"1991","journal-title":"Science"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"e148517","DOI":"10.1172\/JCI148517","article-title":"Nasal Ciliated Cells Are Primary Targets for SARS-CoV-2 Replication in the Early Stage of COVID-19","volume":"131","author":"Ahn","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/s41567-018-0186-9","article-title":"Physical Biology of the Cancer Cell Glycocalyx","volume":"14","author":"Kuo","year":"2018","journal-title":"Nat. Phys."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"101893","DOI":"10.1016\/j.smim.2024.101893","article-title":"Sialic Acid and Siglec Receptors in Tumor Immunity and Immunotherapy","volume":"74\u201375","author":"Mantuano","year":"2024","journal-title":"Semin. Immunol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"189274","DOI":"10.1016\/j.bbcan.2025.189274","article-title":"Modulation of N-Glycosylation in the PD-1: PD-L1 Axis as a Strategy to Enhance Cancer Immunotherapies","volume":"1880","author":"Granica","year":"2025","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Kapetanakis, N.-I., and Busson, P. (2023). Galectins as Pivotal Components in Oncogenesis and Immune Exclusion in Human Malignancies. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1145268"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"11275","DOI":"10.1038\/s41467-025-66169-x","article-title":"Endothelial Glycosylation and Its Emerging Role in Pulmonary Vascular Health and Disease","volume":"16","author":"Nazaire","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Radovani, B., and Gudelj, I. (2022). N-Glycosylation and Inflammation; the Not-So-Sweet Relation. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.893365"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.immuni.2024.03.005","article-title":"Myeloid C-type Lectin Receptors in Innate Immune Recognition","volume":"57","author":"Yamasaki","year":"2024","journal-title":"Immunity"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"101887","DOI":"10.1016\/j.smim.2024.101887","article-title":"Siglecs as Modulators of Macrophage Phenotype and Function","volume":"73","author":"Kukan","year":"2024","journal-title":"Semin. Immunol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"17080","DOI":"10.1021\/acsnano.1c03800","article-title":"Cell Membrane-Coated Mimics: A Methodological Approach for Fabrication, Characterization for Therapeutic Applications, and Challenges for Clinical Translation","volume":"15","author":"Chugh","year":"2021","journal-title":"ACS Nano"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2308646","DOI":"10.1002\/smll.202308646","article-title":"Recent Advances of Engineered Cell Membrane-Based Nanotherapeutics to Combat Inflammatory Diseases","volume":"20","author":"Ma","year":"2024","journal-title":"Small"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/s41565-018-0254-4","article-title":"Neutrophil Membrane-Coated Nanoparticles Inhibit Synovial Inflammation and Alleviate Joint Damage in Inflammatory Arthritis","volume":"13","author":"Zhang","year":"2018","journal-title":"Nat. Nanotechnol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"6340","DOI":"10.1021\/acsnano.0c06836","article-title":"Membrane Nanoparticles Derived from ACE2-Rich Cells Block SARS-CoV-2 Infection","volume":"15","author":"Wang","year":"2021","journal-title":"ACS Nano"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1152\/physrev.00044.2016","article-title":"Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?","volume":"98","author":"Prevarskaya","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.pbiomolbio.2024.07.005","article-title":"Bioelectric Pharmacology of Cancer: A Systematic Review of Ion Channel Drugs Affecting the Cancer Phenotype","volume":"191","author":"Kofman","year":"2024","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/mt.2013.54","article-title":"Endocytosis of Gene Delivery Vectors: From Clathrin-Dependent to Lipid Raft-Mediated Endocytosis","volume":"21","author":"Harashima","year":"2013","journal-title":"Mol. Ther."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1073\/pnas.1912012117","article-title":"Selective Targeting of Nanomedicine to Inflamed Cerebral Vasculature to Enhance the Blood\u2013Brain Barrier","volume":"117","author":"Greineder","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"2304110","DOI":"10.1002\/advs.202304110","article-title":"Nanotechnology and Cancer Bioelectricity: Bridging the Gap Between Biology and Translational Medicine","volume":"11","author":"Moreddu","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1021\/acs.jpclett.5b01739","article-title":"Clathrin to Lipid Raft-Endocytosis via Controlled Surface Chemistry and Efficient Perinuclear Targeting of Nanoparticle","volume":"6","author":"Chakraborty","year":"2015","journal-title":"J. Phys. Chem. Lett."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"159140","DOI":"10.1016\/j.bbalip.2022.159140","article-title":"Lipid Rafts as Viral Entry Routes and Immune Platforms: A Double-Edged Sword in SARS-CoV-2 Infection?","volume":"1867","author":"Roncato","year":"2022","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"e12290","DOI":"10.1002\/jev2.12290","article-title":"Cell-specific Targeting of Extracellular Vesicles through Engineering the Glycocalyx","volume":"11","author":"Zheng","year":"2022","journal-title":"J. Extracell. Vesicles"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1039\/C5SM01793A","article-title":"The Role of Membrane Curvature for the Wrapping of Nanoparticles","volume":"12","author":"Bahrami","year":"2016","journal-title":"Soft Matter"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"e1982","DOI":"10.1002\/wnan.1982","article-title":"Manipulation of Protein Corona for Nanomedicines","volume":"16","author":"Li","year":"2024","journal-title":"WIREs Nanomed. Nanobiotechnol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"e2214757120","DOI":"10.1073\/pnas.2214757120","article-title":"Nanoparticle Elasticity Regulates the Formation of Cell Membrane-Coated Nanoparticles and Their Nano-Bio Interactions","volume":"120","author":"Zou","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Cybulski, P., Bravo, M., Chen, J.J.-K., Van Zundert, I., Krzyzowska, S., Taemaitree, F., Uji-i, H., Hofkens, J., Rocha, S., and Fortuni, B. (2025). Nanoparticle Accumulation and Penetration in 3D Tumor Models: The Effect of Size, Shape, and Surface Charge. Front. Cell Dev. Biol., 12.","DOI":"10.3389\/fcell.2024.1520078"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/brv.12928","article-title":"Interaction between Nanomaterials and the Innate Immune System across Evolution","volume":"98","author":"Boraschi","year":"2023","journal-title":"Biol. Rev."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"10980","DOI":"10.1073\/pnas.1106634108","article-title":"Erythrocyte Membrane-Camouflaged Polymeric Nanoparticles as a Biomimetic Delivery Platform","volume":"108","author":"Hu","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1126\/science.288.5473.2051","article-title":"Role of CD47 as a Marker of Self on Red Blood Cells","volume":"288","author":"Oldenborg","year":"2000","journal-title":"Science"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nnano.2013.54","article-title":"A Biomimetic Nanosponge That Absorbs Pore-Forming Toxins","volume":"8","author":"Hu","year":"2013","journal-title":"Nat. Nanotechnol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"2301361","DOI":"10.1002\/advs.202301361","article-title":"Study on the Role of an Erythrocyte Membrane-Coated Nanotheranostic System in Targeted Immune Regulation of Alzheimer\u2019s Disease","volume":"10","author":"Su","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jconrel.2024.07.013","article-title":"From Bench to Bedside: Platelet Biomimetic Nanoparticles as a Promising Carriers for Personalized Drug Delivery","volume":"373","author":"Safdar","year":"2024","journal-title":"J. Control. Release"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.nano.2018.08.002","article-title":"Platelet Membrane-Coated Nanoparticle-Mediated Targeting Delivery of Rapamycin Blocks Atherosclerotic Plaque Development and Stabilizes Plaque in Apolipoprotein E-Deficient (ApoE\u2212\/\u2212) Mice","volume":"15","author":"Song","year":"2019","journal-title":"Nanomedicine"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"9845459","DOI":"10.34133\/2022\/9845459","article-title":"Platelet Membrane-Coated Nanocarriers Targeting Plaques to Deliver Anti-CD47 Antibody for Atherosclerotic Therapy","volume":"2022","author":"Chen","year":"2022","journal-title":"Research"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"21438","DOI":"10.1021\/acsami.3c18402","article-title":"Platelet Membrane-Coated r-SAK Improves Thrombolytic Efficacy by Targeting Thrombus","volume":"16","author":"Hua","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"eaau5898","DOI":"10.1126\/scitranslmed.aau5898","article-title":"Platelet Decoys Inhibit Thrombosis and Prevent Metastatic Tumor Formation in Preclinical Models","volume":"11","author":"Papa","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jconrel.2024.03.030","article-title":"Anti-Inflammatory Mechanisms of Neutrophil Membrane-Coated Nanoparticles without Drug Loading","volume":"369","author":"Zhang","year":"2024","journal-title":"J. Control. Release"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1038\/s41467-020-16439-7","article-title":"Treatment of Atherosclerosis by Macrophage-Biomimetic Nanoparticles via Targeted Pharmacotherapy and Sequestration of Proinflammatory Cytokines","volume":"11","author":"Gao","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/s41565-024-01618-0","article-title":"Photothermal Therapy of Tuberculosis Using Targeting Pre-Activated Macrophage Membrane-Coated Nanoparticles","volume":"19","author":"Li","year":"2024","journal-title":"Nat. Nanotechnol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41571-022-00699-x","article-title":"Targeting Drugs to Tumours Using Cell Membrane-Coated Nanoparticles","volume":"20","author":"Fang","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jcis.2023.01.068","article-title":"Design and Synthesis of Cancer-Cell-Membrane-Camouflaged Hemoporfin-Cu9S8 Nanoagents for Homotypic Tumor-Targeted Photothermal-Sonodynamic Therapy","volume":"637","author":"Zhao","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"16620","DOI":"10.1021\/acsnano.3c02724","article-title":"Cancer Cell Membrane-Coated Nanoparticle Co-Loaded with Photosensitizer and Toll-like Receptor 7 Agonist for the Enhancement of Combined Tumor Immunotherapy","volume":"17","author":"Chen","year":"2023","journal-title":"ACS Nano"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"7941","DOI":"10.1021\/acs.nanolett.3c01775","article-title":"Cancer Cell Membrane Nanodiscs for Antitumor Vaccination","volume":"23","author":"Guo","year":"2023","journal-title":"Nano Lett."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"2300473","DOI":"10.1002\/sstr.202300473","article-title":"Hybrid Cell Membrane-Coated Nanoparticles for Biomedical Applications","volume":"5","author":"Yu","year":"2024","journal-title":"Small Struct."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1606209","DOI":"10.1002\/adma.201606209","article-title":"Erythrocyte\u2013Platelet Hybrid Membrane Coating for Enhanced Nanoparticle Functionalization","volume":"29","author":"Dehaini","year":"2017","journal-title":"Adv. Mater."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"5241","DOI":"10.1021\/acsnano.7b08355","article-title":"Erythrocyte\u2013Cancer Hybrid Membrane Camouflaged Hollow Copper Sulfide Nanoparticles for Prolonged Circulation Life and Homotypic-Targeting Photothermal\/Chemotherapy of Melanoma","volume":"12","author":"Wang","year":"2018","journal-title":"ACS Nano"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"26614","DOI":"10.1021\/acsnano.4c04814","article-title":"Platelet and Erythrocyte Membranes Coassembled Biomimetic Nanoparticles for Heart Failure Treatment","volume":"18","author":"Li","year":"2024","journal-title":"ACS Nano"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"e12404","DOI":"10.1002\/jev2.12404","article-title":"Minimal Information for Studies of Extracellular Vesicles (MISEV2023): From Basic to Advanced Approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J. Extracell. Vesicles"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/s44222-026-00405-x","article-title":"The Status of Extracellular Vesicles as Drug Carriers and Therapeutics","volume":"4","author":"Chaudhari","year":"2026","journal-title":"Nat. Rev. Bioeng."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"eaau6977","DOI":"10.1126\/science.aau6977","article-title":"The Biology, Function, and Biomedical Applications of Exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-Mediated Transfer of mRNAs and microRNAs Is a Novel Mechanism of Genetic Exchange between Cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jconrel.2015.03.033","article-title":"Exosomes as Drug Delivery Vehicles for Parkinson\u2019s Disease Therapy","volume":"207","author":"Haney","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nbt.1807","article-title":"Delivery of siRNA to the Mouse Brain by Systemic Injection of Targeted Exosomes","volume":"29","author":"Seow","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1021\/bc500291r","article-title":"Surface Functionalization of Exosomes Using Click Chemistry","volume":"25","author":"Smyth","year":"2014","journal-title":"Bioconjug. Chem."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1038\/s41551-024-01214-6","article-title":"Antibody-Displaying Extracellular Vesicles for Targeted Cancer Therapy","volume":"8","author":"Wiklander","year":"2024","journal-title":"Nat. Biomed. Eng."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"12277","DOI":"10.1038\/ncomms12277","article-title":"Exosome Engineering for Efficient Intracellular Delivery of Soluble Proteins Using Optically Reversible Protein\u2013Protein Interaction Module","volume":"7","author":"Yim","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1038\/s41467-023-40453-0","article-title":"Identification of Scaffold Proteins for Improved Endogenous Engineering of Extracellular Vesicles","volume":"14","author":"Zheng","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1038\/s41467-025-59377-y","article-title":"Engineering of Extracellular Vesicles for Efficient Intracellular Delivery of Multimodal Therapeutics Including Genome Editors","volume":"16","author":"Liang","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13770-023-00610-4","article-title":"Engineering of Cell Derived-Nanovesicle as an Alternative to Exosome Therapy","volume":"21","author":"Jang","year":"2024","journal-title":"Tissue Eng. Regen. Med."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"7698","DOI":"10.1021\/nn402232g","article-title":"Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors","volume":"7","author":"Jang","year":"2013","journal-title":"ACS Nano"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"e06162","DOI":"10.1002\/smll.202506162","article-title":"Microfluidic Generation of Exosome-Mimetic Nanoparticles for Scalable Production and Enhanced Therapeutic Efficacy","volume":"21","author":"Kim","year":"2025","journal-title":"Small"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1800161","DOI":"10.1002\/pmic.201800161","article-title":"Proteomic and Post-Translational Modification Profiling of Exosome-Mimetic Nanovesicles Compared to Exosomes","volume":"19","author":"Kastaniegaard","year":"2019","journal-title":"Proteomics"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"7248","DOI":"10.1007\/s12274-023-5374-3","article-title":"Comparison of Extruded Cell Nanovesicles and Exosomes in Their Molecular Cargos and Regenerative Potentials","volume":"16","author":"Wang","year":"2023","journal-title":"Nano Res."},{"key":"ref_201","first-page":"866","article-title":"Extruded Nanovesicles Derived from Umbilical Cord Mesenchymal Stem Cells Exhibit No Tumorigenic Potential","volume":"52","author":"Wang","year":"2025","journal-title":"Bioact. Mater."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"216107","DOI":"10.1016\/j.canlet.2023.216107","article-title":"Hybrid Extracellular Vesicles for Drug Delivery","volume":"558","author":"Ducrot","year":"2023","journal-title":"Cancer Lett."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"6830","DOI":"10.1021\/acsnano.8b02053","article-title":"Modification of Extracellular Vesicles by Fusion with Liposomes for the Design of Personalized Biogenic Drug Delivery Systems","volume":"12","author":"Piffoux","year":"2018","journal-title":"ACS Nano"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1700611","DOI":"10.1002\/advs.201700611","article-title":"Exosome\u2013Liposome Hybrid Nanoparticles Deliver CRISPR\/Cas9 System in MSCs","volume":"5","author":"Lin","year":"2018","journal-title":"Adv. Sci."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"e09636","DOI":"10.1002\/adfm.202509636","article-title":"Engineering Hybrid Extracellular Vesicles for Functional mRNA Delivery","volume":"36","author":"Louro","year":"2026","journal-title":"Adv. Funct. Mater."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1007\/s11095-024-03757-4","article-title":"Quality and Safety Considerations for Therapeutic Products Based on Extracellular Vesicles","volume":"41","author":"Takakura","year":"2024","journal-title":"Pharm. Res."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"113595","DOI":"10.1016\/j.jconrel.2025.113595","article-title":"Mechanisms of Receptor-Mediated Transcytosis at the Blood-Brain Barrier","volume":"381","author":"Baghirov","year":"2025","journal-title":"J. Control. Release"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/s41565-021-00923-2","article-title":"Cell-Mimicking Nanodecoys Neutralize SARS-CoV-2 and Mitigate Lung Injury in a Non-Human Primate Model of COVID-19","volume":"16","author":"Li","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"e2022769118","DOI":"10.1073\/pnas.2022769118","article-title":"Cell Membrane\u2013Camouflaged Liposomes for Tumor Cell\u2013Selective Glycans Engineering and Imaging in Vivo","volume":"118","author":"Liu","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.biomaterials.2015.10.046","article-title":"Targeted Drug Delivery to Circulating Tumor Cells via Platelet Membrane-Functionalized Particles","volume":"76","author":"Li","year":"2016","journal-title":"Biomaterials"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"39805","DOI":"10.1021\/acsnano.5c12658","article-title":"Natural Macrophage Membrane-Coated Nanoparticles as a Multifaceted Sepsis Therapeutic to Sequester Inflammatory and Toxic Mediators","volume":"19","author":"Hoffman","year":"2025","journal-title":"ACS Nano"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1080\/10717544.2020.1762262","article-title":"Brain Delivery of Quercetin-Loaded Exosomes Improved Cognitive Function in AD Mice by Inhibiting Phosphorylated Tau-Mediated Neurofibrillary Tangles","volume":"27","author":"Qi","year":"2020","journal-title":"Drug Deliv."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"7513","DOI":"10.1111\/jcmm.16787","article-title":"ADMSC Exo-MicroRNA-22 Improve Neurological Function and Neuroinflammation in Mice with Alzheimer\u2019s Disease","volume":"25","author":"Zhai","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jconrel.2021.11.019","article-title":"M2-Type Exosomes Nanoparticles for Rheumatoid Arthritis Therapy via Macrophage Re-Polarization","volume":"341","author":"Li","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"2300153","DOI":"10.1002\/adhm.202300153","article-title":"Tumor Therapy Strategies Based on Microenvironment-Specific Responsive Nanomaterials","volume":"12","author":"Zhang","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41392-024-01859-4","article-title":"Genetically Programmable Cell Membrane-Camouflaged Nanoparticles for Targeted Combination Therapy of Colorectal Cancer","volume":"9","author":"Yang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1038\/s41563-024-02114-5","article-title":"Blood\u2013Brain-Barrier-Crossing Lipid Nanoparticles for mRNA Delivery to the Central Nervous System","volume":"24","author":"Wang","year":"2025","journal-title":"Nat. Mater."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.bbi.2024.05.006","article-title":"Microglia-Targeted Inhibition of miR-17 via Mannose-Coated Lipid Nanoparticles Improves Pathology and Behavior in a Mouse Model of Alzheimer\u2019s Disease","volume":"119","author":"Badr","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"ref_219","first-page":"e70298","article-title":"Analysis of Protein and Lipid Dynamics Using Confocal Fluorescence Recovery After Photobleaching (FRAP)","volume":"62","author":"Day","year":"2012","journal-title":"Curr. Protoc. Cytom."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.bbamem.2008.08.021","article-title":"AFM for Structure and Dynamics of Biomembranes","volume":"1788","author":"Goksu","year":"2009","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1007\/s12551-026-01410-5","article-title":"Nuclear Magnetic Resonance Spectroscopy and Membrane Dynamics","volume":"17","author":"Brown","year":"2025","journal-title":"Biophys. Rev."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"8050","DOI":"10.1039\/D2TC00826B","article-title":"Understanding Electrochemical Properties of Supported Lipid Bilayers Interfaced with Organic Electronic Devices","volume":"10","author":"Lu","year":"2022","journal-title":"J. Mater. Chem. C"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3109\/07388551.2015.1128876","article-title":"Flow Cytometry: Basic Principles and Applications","volume":"37","author":"Adan","year":"2017","journal-title":"Crit. Rev. Biotechnol."},{"key":"ref_224","unstructured":"(2025). Q&A Translational Cancer Nanomedicine. Nat. Commun., 16, 8288."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"149641","DOI":"10.1016\/j.cej.2024.149641","article-title":"Bridging the Gaps in Cancer Photothermal Therapy through the Intersection of Nanotechnology and Cell Membrane Coating","volume":"484","author":"Yang","year":"2024","journal-title":"Chem. Eng. J."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"5726","DOI":"10.1038\/s41467-021-26052-x","article-title":"Cell Membrane Coating Integrity Affects the Internalization Mechanism of Biomimetic Nanoparticles","volume":"12","author":"Liu","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1016\/j.cell.2018.11.021","article-title":"Organoid Modeling of the Tumor Immune Microenvironment","volume":"175","author":"Neal","year":"2018","journal-title":"Cell"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41467-019-13896-7","article-title":"Microengineered Human Blood\u2013Brain Barrier Platform for Understanding Nanoparticle Transport Mechanisms","volume":"11","author":"Ahn","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41380-022-01892-1","article-title":"Microglia-Containing Human Brain Organoids for the Study of Brain Development and Pathology","volume":"28","author":"Zhang","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1161\/ATVBAHA.123.318233","article-title":"Engineering Organ-on-a-Chip Systems for Vascular Diseases","volume":"43","author":"Shakeri","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/s44222-023-00138-1","article-title":"Controlling the Biodistribution and Clearance of Nanomedicines","volume":"2","author":"Cabral","year":"2024","journal-title":"Nat. Rev. Bioeng."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.1038\/s41467-024-48838-5","article-title":"Rediscovery of Mononuclear Phagocyte System Blockade for Nanoparticle Drug Delivery","volume":"15","author":"Zelepukin","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"103046","DOI":"10.1016\/j.copbio.2023.103046","article-title":"Impact of Protein Coronas on Nanoparticle Interactions with Tissues and Targeted Delivery","volume":"85","author":"Chou","year":"2024","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1039\/D5NH00230C","article-title":"Influence of Hydrophilic Polymers on the Accelerated Blood Clearance of mRNA Lipid Nanoparticles upon Repeated Administration","volume":"10","author":"Hassanel","year":"2025","journal-title":"Nanoscale Horiz."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"103761","DOI":"10.1016\/j.cis.2025.103761","article-title":"The Surface-First Paradigm: Engineering Nanocarriers for Infection-Responsive Drug Delivery","volume":"349","author":"Shah","year":"2026","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1021\/acsnano.0c09873","article-title":"Selection of Fluorescent, Bioluminescent, and Radioactive Tracers to Accurately Reflect Extracellular Vesicle Biodistribution in Vivo","volume":"15","author":"Faruqu","year":"2021","journal-title":"ACS Nano"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1016\/j.xphs.2024.09.005","article-title":"Current State of Nanomedicine Drug Products: An Industry Perspective","volume":"113","author":"Clogston","year":"2024","journal-title":"J. Pharm. Sci."},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Sivanantham, A., and Jin, Y. (2022). Impact of Storage Conditions on EV Integrity\/Surface Markers and Cargos. Life, 12.","DOI":"10.3390\/life12050697"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"419","DOI":"10.2165\/00003088-200342050-00002","article-title":"Pharmacokinetics of Pegylated Liposomal Doxorubicin: Review of Animal and Human Studies","volume":"42","author":"Gabizon","year":"2003","journal-title":"Clin. Pharmacokinet."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jconrel.2012.03.020","article-title":"(Chezy) Doxil\u00ae\u2014The First FDA-Approved Nano-Drug: Lessons Learned","volume":"160","author":"Barenholz","year":"2012","journal-title":"J. Control. Release"},{"key":"ref_241","unstructured":"U.S. Food and Drug Administration (2026, August 18). NDA 050718\/S-064 Supplement Approval: DOXIL (Doxorubicin Hydrochloride Liposome Injection), Available online: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/appletter\/2026\/050718Orig1s064ltr.pdf."},{"key":"ref_242","unstructured":"U.S. Food and Drug Administration (2026, August 18). DOXIL (Doxorubicin Hydrochloride Liposome Injection): Prescribing Information, Available online: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2026\/050718s064lbl.pdf."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1021\/mp900015y","article-title":"The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic","volume":"6","author":"Davis","year":"2009","journal-title":"Mol. Pharm."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/nature08956","article-title":"Evidence of RNAi in Humans from Systemically Administered siRNA via Targeted Nanoparticles","volume":"464","author":"Davis","year":"2010","journal-title":"Nature"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"11449","DOI":"10.1073\/pnas.1411393111","article-title":"Correlating Animal and Human Phase Ia\/Ib Clinical Data with CALAA-01, a Targeted, Polymer-Based Nanoparticle Containing siRNA","volume":"111","author":"Zuckerman","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_246","unstructured":"ClinicalTrials.gov (2026, August 18). Safety Study of CALAA-01 to Treat Solid Tumor Cancers (NCT00689065), Available online: https:\/\/clinicaltrials.gov\/study\/NCT00689065."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"128ra39","DOI":"10.1126\/scitranslmed.3003651","article-title":"Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile","volume":"4","author":"Hrkach","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1158\/1078-0432.CCR-15-2548","article-title":"Phase I Study of PSMA-Targeted Docetaxel-Containing Nanoparticle BIND-014 in Patients with Advanced Solid Tumors","volume":"22","author":"Mita","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1001\/jamaoncol.2018.2168","article-title":"Safety and Efficacy of BIND-014, a Docetaxel Nanoparticle Targeting Prostate-Specific Membrane Antigen for Patients With Metastatic Castration-Resistant Prostate Cancer: A Phase 2 Clinical Trial","volume":"4","author":"Autio","year":"2018","journal-title":"JAMA Oncol."},{"key":"ref_250","unstructured":"BIND Therapeutics, Inc. (2026, August 18). Annual Report on Form 10-K for the Fiscal Year Ended December 31, 2015, Available online: https:\/\/www.sec.gov\/Archives\/edgar\/data\/1385228\/000156459016014829\/bind-10k_20151231.htm."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2012.04.008","article-title":"HER2-Targeted Liposomal Doxorubicin Displays Enhanced Anti-Tumorigenic Effects without Associated Cardiotoxicity","volume":"262","author":"Reynolds","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/s41416-018-0235-2","article-title":"Safety and Pharmacokinetics of MM-302, a HER2-Targeted Antibody\u2013Liposomal Doxorubicin Conjugate, in Patients with Advanced HER2-Positive Breast Cancer: A Phase 1 Dose-Escalation Study","volume":"119","author":"Munster","year":"2018","journal-title":"Br. J. Cancer"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1158\/1078-0432.CCR-16-3193","article-title":"64Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer","volume":"23","author":"Lee","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"ref_254","unstructured":"Merrimack Pharmaceuticals, Inc. (2026, August 18). Merrimack Stops the Phase 2 HERMIONE Trial of MM-302 in HER2-Positive Metastatic Breast Cancer Patients. Available online: https:\/\/www.prnewswire.com\/news-releases\/merrimack-stops-the-phase-2-hermione-trial-of-mm-302-in-her2-positive-metastatic-breast-cancer-patients-300382177.html."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"eabj7002","DOI":"10.1126\/sciadv.abj7002","article-title":"Exosome-Mediated Genetic Reprogramming of Tumor-Associated Macrophages by exoASO-STAT6 Leads to Potent Monotherapy Antitumor Activity","volume":"8","author":"Kamerkar","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_256","unstructured":"ClinicalTrials.gov (2026, August 18). Phase 1 Study of Macrophage Reprogramming Agent, exoASO-STAT6 (CDK-004), in Patients with Advanced Hepatocellular Carcinoma (HCC) and Patients with Liver Metastases from Either Primary Gastric Cancer or Colorectal Cancer (CRC) (NCT05375604), Available online: https:\/\/clinicaltrials.gov\/study\/NCT05375604."},{"key":"ref_257","unstructured":"Codiak BioSciences, Inc. (2026, August 18). Current Report on Form 8-K, Filed 27 March 2023, Available online: https:\/\/www.sec.gov\/Archives\/edgar\/data\/1659352\/000119312523079964\/d467120d8k.htm."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/17\/1525\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:25:58Z","timestamp":1787718358000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/17\/1525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":257,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["cells15171525"],"URL":"https:\/\/doi.org\/10.3390\/cells15171525","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,24]]}}}