{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T05:04:43Z","timestamp":1789275883712,"version":"build-2803163510"},"reference-count":155,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R00 HL146951"],"award-info":[{"award-number":["R00 HL146951"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"award":["R00 HL146951"],"award-info":[{"award-number":["R00 HL146951"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["941138"],"award-info":[{"award-number":["941138"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["26BCDA1622754"],"award-info":[{"award-number":["26BCDA1622754"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"award":["941138"],"award-info":[{"award-number":["941138"]}],"id":[{"id":"https:\/\/ror.org\/013kjyp64","id-type":"ROR","asserted-by":"publisher"}]},{"award":["26BCDA1622754"],"award-info":[{"award-number":["26BCDA1622754"]}],"id":[{"id":"https:\/\/ror.org\/013kjyp64","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2340666"],"award-info":[{"award-number":["2340666"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"award":["2340666"],"award-info":[{"award-number":["2340666"]}],"id":[{"id":"https:\/\/ror.org\/021nxhr62","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007268","name":"Washington University in St. Louis","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007268","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/01yc7t268","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Perivascular adipose tissue (PVAT) has emerged as a central regulator of vascular homeostasis in large arteries, with its dysfunction driving the pathogenesis of atherosclerosis, hypertension, and metabolic diseases. In the past, our understanding of PVAT was limited by bulk omics approaches that obscured the tissue\u2019s profound spatial, cellular, and functional heterogeneity. Here, we review how multimodal single-cell technologies, including single-cell RNA sequencing, spatial transcriptomics, and AI integration, are now decoding the PVAT ecosystem with unprecedented resolution. These approaches have generated an integrated atlas that reveals depot-specific cellular architectures, dynamic phenotypic plasticity, and spatially organized crosstalk between biological circuits that drive vasculopathy. We highlight novel biomarkers and actionable therapies emerging from these insights, such as Dpp4+ preadipocytes and BMP4-induced browning. Finally, we propose a translational roadmap that prioritizes human PVAT biobanking, CRISPR-based lineage tracing, and AI-driven modeling to transform these mechanistic discoveries into precision interventions. Ultimately, by establishing PVAT as a central orchestrator of vascular homeostasis, these single-cell insights provide the mechanistic foundation to therapeutically intercept cardiometabolic disease at its cellular source.<\/jats:p>","DOI":"10.3390\/cells15181645","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T08:17:42Z","timestamp":1789114662000},"page":"1645","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Decoding PVAT Complexity in Vascular Remodeling: Multimodal Single-Cell Technologies Unveil Novel Therapeutic Targets"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7770-2138","authenticated-orcid":false,"given":"Yujun","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering & Materials Science, Washington University in St. Louis, St. Louis, MO 63130, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1848-4165","authenticated-orcid":false,"given":"Matthew R.","family":"Bersi","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering & Materials Science, Washington University in St. Louis, St. Louis, MO 63130, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1161\/ATVBAHA.114.303029","article-title":"Perivascular Adipose Tissue in Vascular Function and Disease: A Review of Current Research and Animal Models","volume":"34","author":"Brown","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s12933-018-0777-x","article-title":"Perivascular Adipose Tissue (PVAT) in Atherosclerosis: A Double-Edged Sword","volume":"17","author":"Qi","year":"2018","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/CS20110151","article-title":"Perivascular Adipose Tissue: More than Just Structural Support","volume":"122","author":"Szasz","year":"2011","journal-title":"Clin. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"107269","DOI":"10.1016\/j.phrs.2024.107269","article-title":"Integrins Play a Role in Stress Relaxation of Perivascular Adipose Tissue","volume":"206","author":"Watts","year":"2024","journal-title":"Pharmacol. Res."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Horimatsu, T., Kim, H.W., and Weintraub, N.L. (2017). The Role of Perivascular Adipose Tissue in Non-Atherosclerotic Vascular Disease. Front. Physiol., 8.","DOI":"10.3389\/fphys.2017.00969"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Stanek, A., Bro\u017cyna-Tkaczyk, K., and My\u015bli\u0144ski, W. (2021). The Role of Obesity-Induced Perivascular Adipose Tissue (PVAT) Dysfunction in Vascular Homeostasis. Nutrients, 13.","DOI":"10.3390\/nu13113843"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/eurheartj\/ehz856","article-title":"Adipocytes Promote Interleukin-18 Binding to Its Receptors during Abdominal Aortic Aneurysm Formation in Mice","volume":"41","author":"Liu","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/s42255-021-00380-0","article-title":"Defining the Lineage of Thermogenic Perivascular Adipose Tissue","volume":"3","author":"Angueira","year":"2021","journal-title":"Nat. Metab."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12929-021-00720-y","article-title":"PPAR\u03b3 Activation Improves the Microenvironment of Perivascular Adipose Tissue and Attenuates Aortic Stiffening in Obesity","volume":"28","author":"Chen","year":"2021","journal-title":"J. Biomed. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"H1003","DOI":"10.1152\/ajpheart.00574.2021","article-title":"Aortic Stiffness Is Lower When PVAT Is Included: A Novel Ex Vivo Mechanics Study","volume":"322","author":"Tuttle","year":"2022","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1038\/s41598-020-58368-x","article-title":"A New Function for Perivascular Adipose Tissue (PVAT): Assistance of Arterial Stress Relaxation","volume":"10","author":"Watts","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ejphar.2015.09.012","article-title":"Human Perivascular Adipose Tissue Dysfunction as a Cause of Vascular Disease: Focus on Vascular Tone and Wall Remodeling","volume":"766","author":"Ozen","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1515\/hmbci-2014-0048","article-title":"The Role of Perivascular Adipose Tissue in Vasoconstriction, Arterial Stiffness, and Aneurysm","volume":"21","author":"Villacorta","year":"2015","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/ATVBAHA.120.312464","article-title":"Perivascular Adipose Tissue Regulates Vascular Function by Targeting Vascular Smooth Muscle Cells","volume":"40","author":"Chang","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"107459","DOI":"10.1016\/j.carpath.2022.107459","article-title":"The Pathobiology of Perivascular Adipose Tissue (PVAT), the Fourth Layer of the Blood Vessel Wall","volume":"61","author":"Gotlieb","year":"2022","journal-title":"Cardiovasc. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ahmed, A., Bibi, A., Valoti, M., and Fusi, F. (2023). Perivascular Adipose Tissue and Vascular Smooth Muscle Tone: Friends or Foes?. Cells, 12.","DOI":"10.3390\/cells12081196"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s11906-016-0692-z","article-title":"A Clinical Perspective: Contribution of Dysfunctional Perivascular Adipose Tissue (PVAT) to Cardiovascular Risk","volume":"18","author":"Lian","year":"2016","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_18","first-page":"402053","article-title":"Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity","volume":"2013","author":"Aranguez","year":"2013","journal-title":"Int. J. Endocrinol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5117","DOI":"10.1038\/s41467-022-32658-6","article-title":"Beiging of Perivascular Adipose Tissue Regulates Its Inflammation and Vascular Remodeling","volume":"13","author":"Adachi","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.atherosclerosis.2010.05.034","article-title":"Perivascular Adipose Tissue as a Cause of Atherosclerosis","volume":"214","author":"Verhagen","year":"2011","journal-title":"Atherosclerosis"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Zhang, S., Jiang, J., Luo, Y., Liu, G., Hu, S., Wan, S., Luo, C., Li, H., Li, N., and da Gra\u00e7a Esp\u00edrito Santo Vasconcelos, J. (2025). Molecular Crosstalk in Perivascular Adipose Tissue: Mechanisms of Inflammation, Metabolic Dysregulation, and Therapeutic Opportunities in Cardiovascular Disease. Front. Cardiovasc. Med., 12.","DOI":"10.3389\/fcvm.2025.1613900"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1476-5381.2011.01430.x","article-title":"Vasodilator Signals from Perivascular Adipose Tissue","volume":"165","author":"Gollasch","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1093\/eurheartj\/ehad484","article-title":"Perivascular Adipose Tissue as a Source of Therapeutic Targets and Clinical Biomarkers: A Clinical Consensus Statement from the European Society of Cardiology Working Group on Coronary Pathophysiology and Micro-Circulation","volume":"44","author":"Antoniades","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Adachi, Y., Ueda, K., and Takimoto, E. (2023). Perivascular Adipose Tissue in Vascular Pathologies\u2014A Novel Therapeutic Target for Atherosclerotic Disease?. Front. Cardiovasc. Med., 10.","DOI":"10.3389\/fcvm.2023.1151717"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s42255-019-0152-6","article-title":"Single-Cell Analysis of Human Adipose Tissue Identifies Depot- and Disease-Specific Cell Types","volume":"2","author":"Vijay","year":"2020","journal-title":"Nat. Metab."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41576-019-0093-7","article-title":"Integrative Single-Cell Analysis","volume":"20","author":"Stuart","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1161\/ATVBAHA.123.319828","article-title":"Single-Cell RNA Sequencing of Coronary Perivascular Adipose Tissue From End-Stage Heart Failure Patients Identifies SPP1+ Macrophage Subpopulation as a Target for Alleviating Fibrosis","volume":"43","author":"Fu","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11427-023-2561-0","article-title":"Single-Cell Omics: Experimental Workflow, Data Analyses and Applications","volume":"68","author":"Sun","year":"2025","journal-title":"Sci. China Life Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2400444","DOI":"10.1002\/advs.202400444","article-title":"Single-Nucleus Multiomic Analyses Identifies Gene Regulatory Dynamics of Phenotypic Modulation in Human Aneurysmal Aortic Root","volume":"11","author":"Liu","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Li, Y., Wang, S., Zhang, R., Gong, Y., Che, Y., Li, K., and Pan, Z. (2025). Single-Cell and Spatial Analysis Reveals the Interaction between ITLN1+ Foam Cells and SPP1+ Macrophages in Atherosclerosis. Front. Cardiovasc. Med., 12.","DOI":"10.3389\/fcvm.2025.1510082"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/s41588-021-00778-2","article-title":"Characterizing the Molecular Regulation of Inhibitory Immune Checkpoints with Multimodal Single-Cell Screens","volume":"53","author":"Papalexi","year":"2021","journal-title":"Nat. Genet."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s41586-022-04518-2","article-title":"A Single-Cell Atlas of Human and Mouse White Adipose Tissue","volume":"603","author":"Emont","year":"2022","journal-title":"Nature"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.cell.2019.05.054","article-title":"Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner","volume":"178","author":"Jaitin","year":"2019","journal-title":"Cell"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s41590-021-00922-4","article-title":"Single-Cell Sequencing of Human White Adipose Tissue Identifies New Cell States in Health and Obesity","volume":"22","author":"Hildreth","year":"2021","journal-title":"Nat. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s11658-024-00668-5","article-title":"Single-Cell View and a Novel Protective Macrophage Subset in Perivascular Adipose Tissue in T2DM","volume":"29","author":"Li","year":"2024","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1038\/s41366-022-01135-x","article-title":"Macrophages in Obesity Are Characterised by Increased IL-1\u03b2 Response to Calcium-Sensing Receptor Signals","volume":"46","author":"Thrum","year":"2022","journal-title":"Int. J. Obes."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1038\/s41467-020-16019-9","article-title":"Single-Cell Transcriptional Networks in Differentiating Preadipocytes Suggest Drivers Associated with Tissue Heterogeneity","volume":"11","author":"Ramirez","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1038\/s41467-023-36983-2","article-title":"An Integrated Single Cell and Spatial Transcriptomic Map of Human White Adipose Tissue","volume":"14","author":"Massier","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/s42255-025-01296-9","article-title":"Towards a Consensus Atlas of Human and Mouse Adipose Tissue at Single-Cell Resolution","volume":"7","author":"Loft","year":"2025","journal-title":"Nat. Metab."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1161\/ATVBAHA.119.312732","article-title":"Single-Cell RNA-Sequencing and Metabolomics Analyses Reveal the Contribution of Perivascular Adipose Tissue Stem Cells to Vascular Remodeling","volume":"39","author":"Gu","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e31510","DOI":"10.1002\/jcp.31510","article-title":"Stearoyl-CoA Desaturase 1 Regulates Metabolism and Inflammation in Mouse Perivascular Adipose Tissue in Response to a High-Fat Diet","volume":"240","author":"Sowka","year":"2025","journal-title":"J. Cell. Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.metabol.2014.07.002","article-title":"Thermogenic Adipocytes: From Cells to Physiology and Medicine","volume":"63","author":"Diaz","year":"2014","journal-title":"Metabolism"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"101979","DOI":"10.1016\/j.redox.2021.101979","article-title":"BMP4-Mediated Browning of Perivascular Adipose Tissue Governs an Anti-Inflammatory Program and Prevents Atherosclerosis","volume":"43","author":"Mu","year":"2021","journal-title":"Redox Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cell.2021.12.016","article-title":"Adipose Tissue Plasticity in Health and Disease","volume":"185","author":"Sakers","year":"2022","journal-title":"Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e018905","DOI":"10.1161\/JAHA.120.018905","article-title":"Antiatherosclerotic Phenotype of Perivascular Adipose Tissue Surrounding the Saphenous Vein in Coronary Artery Bypass Grafting","volume":"10","author":"Mikami","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.jare.2025.03.003","article-title":"From Inflammation to Remodelling: A Novel BASP1+ Monocyte Subset as a Catalyst for Acute Aortic Dissection","volume":"78","author":"He","year":"2025","journal-title":"J. Adv. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1161\/CIRCRESAHA.124.325269","article-title":"LRP1 Repression by SNAIL Results in ECM Remodeling in Genetic Risk for Vascular Diseases","volume":"135","author":"Liu","year":"2024","journal-title":"Circ. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"105235","DOI":"10.1016\/j.phrs.2020.105235","article-title":"Nox1\/4 Inhibition Exacerbates Age Dependent Perivascular Inflammation and Fibrosis in a Model of Spontaneous Hypertension","volume":"161","author":"Nosalski","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_49","first-page":"cvae079","article-title":"NLRP3 Inflammasome-Mediated Premature Immunosenescence Drives Diabetic Vascular Aging Dependent on the Induction of Perivascular Adipose Tissue Dysfunction","volume":"121","author":"Tai","year":"2024","journal-title":"Cardiovasc. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.stem.2020.12.008","article-title":"Pathologic HIF1\u03b1 Signaling Drives Adipose Progenitor Dysfunction in Obesity","volume":"28","author":"Shao","year":"2021","journal-title":"Cell Stem Cell"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1186\/s12933-024-02549-9","article-title":"Perivascular Adipose Tissue: A Central Player in the Triad of Diabetes, Obesity, and Cardiovascular Health","volume":"23","author":"Queiroz","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"eaav2501","DOI":"10.1126\/science.aav2501","article-title":"Identification of a Mesenchymal Progenitor Cell Hierarchy in Adipose Tissue","volume":"364","author":"Merrick","year":"2019","journal-title":"Science"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"eaau0964","DOI":"10.1126\/science.aau0964","article-title":"Two Distinct Interstitial Macrophage Populations Coexist across Tissues in Specific Subtissular Niches","volume":"363","author":"Chakarov","year":"2019","journal-title":"Science"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.cmet.2020.11.008","article-title":"Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity","volume":"33","author":"Brestoff","year":"2021","journal-title":"Cell Metab."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"6592","DOI":"10.1038\/s41467-022-34469-1","article-title":"JAK2V617F Mutation Drives Vascular Resident Macrophages toward a Pathogenic Phenotype and Promotes Dissecting Aortic Aneurysm","volume":"13","author":"Vandestienne","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41569-023-00964-1","article-title":"Immune and Inflammatory Mechanisms in Hypertension","volume":"21","author":"Guzik","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1161\/CIRCRESAHA.124.324366","article-title":"L-Wnk1 Deletion in Smooth Muscle Cells Causes Aortitis and Inflammatory Shift","volume":"135","author":"Quelquejay","year":"2024","journal-title":"Circ. Res."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Xiong, J., Li, Z., Tang, H., Duan, Y., Ban, X., Xu, K., Guo, Y., and Tu, Y. (2023). Bulk and Single-Cell Characterisation of the Immune Heterogeneity of Atherosclerosis Identifies Novel Targets for Immunotherapy. BMC Biol., 21.","DOI":"10.1186\/s12915-023-01540-2"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/ATVBAHA.120.312137","article-title":"Heterogeneity of T Cells in Atherosclerosis Defined by Single-Cell RNA-Sequencing and Cytometry by Time of Flight","volume":"41","author":"Winkels","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"eadg1128","DOI":"10.1126\/science.adg1128","article-title":"Septal LYVE1+ Macrophages Control Adipocyte Stem Cell Adipogenic Potential","volume":"389","author":"Yu","year":"2025","journal-title":"Science"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1172\/JCI93558","article-title":"The Perivascular Origin of Pathological Fibroblasts","volume":"128","author":"Peduto","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1038\/s41591-019-0512-5","article-title":"Atheroprotective Roles of Smooth Muscle Cell Phenotypic Modulation and the TCF21 Disease Gene as Revealed by Single-Cell Analysis","volume":"25","author":"Wirka","year":"2019","journal-title":"Nat. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41392-022-01259-6","article-title":"Targeting Integrin Pathways: Mechanisms and Advances in Therapy","volume":"8","author":"Pang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Rendon, C.J., Sempere, L., Lauver, A., Watts, S.W., and Contreras, G.A. (2024). Anatomical Location, Sex, and Age Modulate Adipocyte Progenitor Populations in Perivascular Adipose Tissues. Front. Physiol., 15.","DOI":"10.3389\/fphys.2024.1411218"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"112869","DOI":"10.1016\/j.celrep.2023.112869","article-title":"Sox10 Escalates Vascular Inflammation by Mediating Vascular Smooth Muscle Cell Transdifferentiation and Pyroptosis in Neointimal Hyperplasia","volume":"42","author":"Xu","year":"2023","journal-title":"Cell Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e174639","DOI":"10.1172\/jci.insight.174639","article-title":"Smooth Muscle\u2013Derived Adventitial Progenitor Cells Direct Atherosclerotic Plaque Composition Complexity in a Klf4-Dependent Manner","volume":"8","author":"Dubner","year":"2023","journal-title":"JCI Insight"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1161\/CIRCULATIONAHA.123.063332","article-title":"Epigenetic Induction of Smooth Muscle Cell Phenotypic Alterations in Aortic Aneurysms and Dissections","volume":"148","author":"Chakraborty","year":"2023","journal-title":"Circulation"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.cmet.2018.05.025","article-title":"Deconstructing Adipogenesis Induced by \u03923-Adrenergic Receptor Activation with Single-Cell Expression Profiling","volume":"28","author":"Burl","year":"2018","journal-title":"Cell Metab."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/s41401-022-00959-7","article-title":"Thoracic Perivascular Adipose Tissue Inhibits VSMC Apoptosis and Aortic Aneurysm Formation in Mice via the Secretome of Browning Adipocytes","volume":"44","author":"Huang","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s12195-025-00864-z","article-title":"Paracrine Signaling by Distinct Adipose Tissue Depots Regulate Fibroblast Mechanobiology and Functional Heterogeneity","volume":"18","author":"Xu","year":"2025","journal-title":"Cell. Mol. Bioeng."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Shi, H., Goo, B., Kim, D., Kress, T.C., Ogbi, M., Mintz, J., Wu, H., Belin de Chantem\u00e8le, E.J., Stepp, D., and Long, X. (2023). Perivascular Adipose Tissue Promotes Vascular Dysfunction in Murine Lupus. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1095034"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1161\/HYPERTENSIONAHA.123.22057","article-title":"Atlas of Cell Repertoire Within Neointimal Lesions Is Metabolically Altered in Hypertensive Rats","volume":"81","author":"Sun","year":"2024","journal-title":"Hypertension"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/j.cmet.2021.07.018","article-title":"Spatial Mapping Reveals Human Adipocyte Subpopulations with Distinct Sensitivities to Insulin","volume":"33","author":"Massier","year":"2021","journal-title":"Cell Metab."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1161\/CIRCRESAHA.124.325750","article-title":"SM22\u03b1-Lineage Perivascular Stromal Cells Contribute to Abdominal Aortic Aneurysm","volume":"137","author":"Pan","year":"2025","journal-title":"Circ. Res."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Duerre, D.J., and Galmozzi, A. (2022). Deconstructing Adipose Tissue Heterogeneity One Cell at a Time. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.847291"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"20170327","DOI":"10.1098\/rsif.2017.0327","article-title":"Differential Cell-Matrix Mechanoadaptations and Inflammation Drive Regional Propensities to Aortic Fibrosis, Aneurysm or Dissection in Hypertension","volume":"14","author":"Bersi","year":"2017","journal-title":"J. R. Soc. Interface"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Kumar, R.K., Yang, Y., Contreras, A.G., Garver, H., Bhattacharya, S., Fink, G.D., Rockwell, C.E., and Watts, S.W. (2021). Phenotypic Changes in T Cell and Macrophage Subtypes in Perivascular Adipose Tissues Precede High-Fat Diet-Induced Hypertension. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.616055"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"zqae024","DOI":"10.1093\/function\/zqae024","article-title":"Sex-Specific Effects of Cholesteryl Ester Transfer Protein (CETP) on the Perivascular Adipose Tissue","volume":"5","author":"Lazaro","year":"2024","journal-title":"Function"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e70413","DOI":"10.1096\/fj.202401871R","article-title":"Sex-specific Characterization of Aortic Function and Inflammation in a New Diet-induced Mouse Model of Metabolic Syndrome","volume":"39","author":"Tran","year":"2025","journal-title":"FASEB J."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"060904","DOI":"10.1115\/1.4064965","article-title":"Primary Mouse Aortic Smooth Muscle Cells Exhibit Region- and Sex-Dependent Biological Responses In Vitro","volume":"146","author":"Karbasion","year":"2024","journal-title":"J. Biomech. Eng."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1161\/STROKEAHA.125.051754","article-title":"Aging and Sex Modify the Risk of Carotid Plaque Thrombosis Related to Dyslipidemic Profile","volume":"56","author":"Servadei","year":"2025","journal-title":"Stroke"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"106183","DOI":"10.1016\/j.phrs.2022.106183","article-title":"RNA Sequencing Reveals Perivascular Adipose Tissue Plasticity in Response to Angiotensin II","volume":"178","author":"Wang","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Shi, N., Xia, J., Wang, C., Zhou, J., Huang, J., Hu, M., and Liao, J. (2022). Aerobic Exercise Prevents Arterial Stiffness and Attenuates Hyperexcitation of Sympathetic Nerves in Perivascular Adipose Tissue of Mice after Transverse Aortic Constriction. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911189"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1093\/cvr\/cvae213","article-title":"Activation of \u03923-Adrenergic Receptor by Mirabegron Prevents Aortic Dissection\/Aneurysm by Promoting Lymphangiogenesis in Perivascular Adipose Tissue","volume":"120","author":"Zhang","year":"2024","journal-title":"Cardiovasc. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e49501","DOI":"10.7554\/eLife.49501","article-title":"Single Cell Analysis Reveals Immune Cell\u2013Adipocyte Crosstalk Regulating the Transcription of Thermogenic Adipocytes","volume":"8","author":"Rajbhandari","year":"2019","journal-title":"eLife"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Liu, X., Jiang, X., Hu, J., Ding, M., Lee, S.K., Korivi, M., Qian, Y., Li, T., Wang, L., and Li, W. (2024). Exercise Attenuates High-Fat Diet-Induced PVAT Dysfunction through Improved Inflammatory Response and BMP4-Regulated Adipose Tissue Browning. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1393343"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e12969","DOI":"10.1111\/acel.12969","article-title":"Perivascular Adipose Tissue-Derived Stromal Cells Contribute to Vascular Remodeling during Aging","volume":"18","author":"Pan","year":"2019","journal-title":"Aging Cell"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.2337\/db11-1508","article-title":"Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity","volume":"61","author":"Arner","year":"2012","journal-title":"Diabetes"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0014-5793(01)02264-5","article-title":"TNF-\u03b1 Inhibits UCP-1 Expression in Brown Adipocytes via ERKs: Opposite Effect of p38MAPK","volume":"493","author":"Valladares","year":"2001","journal-title":"FEBS Lett."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/s44161-023-00337-4","article-title":"Nuclear Smooth Muscle \u03b1-Actin Participates in Vascular Smooth Muscle Cell Differentiation","volume":"2","author":"Kwartler","year":"2023","journal-title":"Nat. Cardiovasc. Res."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Callow, B., He, X., Juriga, N., Mangum, K.D., Joshi, A., Xing, X., Obi, A., Chattopadhyay, A., Milewicz, D.M., and O\u2019Riordan, M.X. (2025, May 06). Inhibition of Vascular Smooth Muscle Cell PERK\/ATF4 ER Stress Signaling Protects Against Abdominal Aortic Aneurysms. Available online: https:\/\/insight.jci.org\/articles\/view\/183959\/pdf.","DOI":"10.1172\/jci.insight.183959"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Zhang, R., Gao, Y., Zhao, X., Gao, M., Wu, Y., Han, Y., Qiao, Y., Luo, Z., Yang, L., and Chen, J. (2018). FSP1-Positive Fibroblasts Are Adipogenic Niche and Regulate Adipose Homeostasis. PLoS Biol., 16.","DOI":"10.1371\/journal.pbio.2001493"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"65","DOI":"10.33696\/Signaling.5.114","article-title":"Navigating the Adipocyte Precursor Niche: Cell-Cell Interactions, Regulatory Mechanisms and Implications for Adipose Tissue Homeostasis","volume":"5","author":"Kesharwani","year":"2024","journal-title":"J. Cell. Signal."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s42255-021-00509-1","article-title":"Identification of a Regulatory Pathway Inhibiting Adipogenesis via RSPO2","volume":"4","author":"Dong","year":"2022","journal-title":"Nat. Metab."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/dbi25-0017","article-title":"Mapping Macrophage-Fibroblast Interactions in Adipose Tissue Fibrosis","volume":"74","author":"Nahmgoong","year":"2025","journal-title":"Diabetes"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.2337\/db25-0337","article-title":"Deciphering Macrophage-Fibroblast Cross Talk in Obesity-Induced Adipose Tissue Fibrosis: Insights From Single-Cell and Spatial Transcriptomics","volume":"74","author":"Wu","year":"2025","journal-title":"Diabetes"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1161\/ATVBAHA.120.314360","article-title":"Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing","volume":"40","author":"Raddatz","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"7303","DOI":"10.1038\/s41467-022-34964-5","article-title":"Epigenetic Regulation of White Adipose Tissue Plasticity and Energy Metabolism by Nucleosome Binding HMGN Proteins","volume":"13","author":"Nanduri","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e2021073118","DOI":"10.1073\/pnas.2021073118","article-title":"DNMT1 Maintains Metabolic Fitness of Adipocytes through Acting as an Epigenetic Safeguard of Mitochondrial Dynamics","volume":"118","author":"Park","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1101\/gad.299644.117","article-title":"Pioneering EBF2 Remodels the Brown Fat Chromatin Landscape","volume":"31","author":"Wang","year":"2017","journal-title":"Genes Dev."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/ncb3590","article-title":"NFIA Co-Localizes with PPAR\u03b3 and Transcriptionally Controls the Brown Fat Gene Program","volume":"19","author":"Hiraike","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Jiang, N., Yang, M., Han, Y., Zhao, H., and Sun, L. (2022). PRDM16 Regulating Adipocyte Transformation and Thermogenesis: A Promising Therapeutic Target for Obesity and Diabetes. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.870250"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/s42003-022-03531-5","article-title":"Remodeling of Gene Regulatory Networks Underlying Thermogenic Stimuli-Induced Adipose Beiging","volume":"5","author":"Lee","year":"2022","journal-title":"Commun. Biol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"7249","DOI":"10.1038\/s41467-024-51030-4","article-title":"Macrophage ILF3 Promotes Abdominal Aortic Aneurysm by Inducing Inflammatory Imbalance in Male Mice","volume":"15","author":"Wang","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/s42255-024-01025-8","article-title":"A Spatiotemporal Proteomic Map of Human Adipogenesis","volume":"6","author":"Klingelhuber","year":"2024","journal-title":"Nat. Metab."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and Analysis of Cell-Cell Communication Using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41592-019-0667-5","article-title":"NicheNet: Modeling Intercellular Communication by Linking Ligands to Target Genes","volume":"17","author":"Browaeys","year":"2020","journal-title":"Nat. Methods"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2217\/clp.10.89","article-title":"Perivascular Adipose Tissue and Vascular Disease","volume":"6","author":"Britton","year":"2011","journal-title":"Clin. Lipidol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s10456-024-09933-9","article-title":"Site-Specific Genetic and Functional Signatures of Aortic Endothelial Cells at Aneurysm Predilection Sites in Healthy and AngII ApoE\u2212\/\u2212 Mice","volume":"27","author":"Brandtner","year":"2024","journal-title":"Angiogenesis"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.cmet.2023.02.002","article-title":"Adipose Tissue at Single-Cell Resolution","volume":"35","author":"Maniyadath","year":"2023","journal-title":"Cell Metab."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12967-020-02226-x","article-title":"C-Reactive Protein Derived from Perivascular Adipose Tissue Accelerates Injury-Induced Neointimal Hyperplasia","volume":"18","author":"Chen","year":"2020","journal-title":"J. Transl. Med."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Kim, E.N., Seok, H.Y., Lim, J.S., Koh, J., Bae, J.M., Kim, C.J., Ryu, G.-H., Ok, Y.J., Choi, J.-S., and Cho, C.-H. (2024). CRP Deposition in Human Abdominal Aortic Aneurysm Is Associated with Transcriptome Alterations toward Aneurysmal Pathogenesis: Insights from in Situ Spatial Whole Transcriptomic Analysis. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1475051"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.gendis.2023.03.021","article-title":"The Journey towards Physiology and Pathology: Tracing the Path of Neuregulin 4","volume":"11","author":"Chen","year":"2024","journal-title":"Genes Dis."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"107998","DOI":"10.1016\/j.celrep.2020.107998","article-title":"Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis","volume":"32","author":"Henriques","year":"2020","journal-title":"Cell Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"G990","DOI":"10.1152\/ajpgi.00296.2020","article-title":"NRG4-ErbB4 Signaling Represses Proinflammatory Macrophage Activity","volume":"320","author":"Schumacher","year":"2021","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e155478","DOI":"10.1172\/JCI155478","article-title":"Lymphangiogenesis Requires Ang2\/Tie\/PI3K Signaling for VEGFR3 Cell-Surface Expression","volume":"132","author":"Korhonen","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.cmet.2020.12.004","article-title":"Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus Resolution","volume":"33","author":"Hauwaert","year":"2021","journal-title":"Cell Metab."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"7073","DOI":"10.1113\/JP273061","article-title":"Obesity-induced Lymphatic Dysfunction Is Reversible with Weight Loss","volume":"594","author":"Nitti","year":"2016","journal-title":"J. Physiol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/s42255-021-00457-w","article-title":"Mesenteric Lymphatic Dysfunction Promotes Insulin Resistance and Represents a Potential Treatment Target in Obesity","volume":"3","author":"Cao","year":"2021","journal-title":"Nat. Metab."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Yeo, K.P., Lim, H.Y., and Angeli, V. (2021). Leukocyte Trafficking via Lymphatic Vessels in Atherosclerosis. Cells, 10.","DOI":"10.3390\/cells10061344"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.cell.2020.06.039","article-title":"The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease","volume":"182","author":"Oliver","year":"2020","journal-title":"Cell"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/s41574-023-00893-6","article-title":"The Evolving Functions of the Vasculature in Regulating Adipose Tissue Biology in Health and Obesity","volume":"19","author":"AlZaim","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Kral, M., van der Vorst, E.P.C., Weber, C., and D\u00f6ring, Y. (2024). (Multi-) Omics Studies of ILC2s in Inflammation and Metabolic Diseases. Front. Cell Dev. Biol., 12.","DOI":"10.3389\/fcell.2024.1473616"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Misawa, T., Wagner, M., and Koyasu, S. (2022). ILC2s and Adipose Tissue Homeostasis: Progress to Date and the Road Ahead. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.876029"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1126\/science.aam5809","article-title":"S1P-Dependent Interorgan Trafficking of Group 2 Innate Lymphoid Cells Supports Host Defense","volume":"359","author":"Huang","year":"2018","journal-title":"Science"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41392-023-01652-9","article-title":"Hypoxia-Induced Signaling in the Cardiovascular System: Pathogenesis and Therapeutic Targets","volume":"8","author":"Zhao","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"eabc8479","DOI":"10.1126\/science.abc8479","article-title":"Counteracting Age-Related VEGF Signaling Insufficiency Promotes Healthy Aging and Extends Life Span","volume":"373","author":"Grunewald","year":"2021","journal-title":"Science"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"eabi4822","DOI":"10.1126\/sciadv.abi4822","article-title":"Systematic Evaluation of the Association between Hemoglobin Levels and Metabolic Profile Implicates Beneficial Effects of Hypoxia","volume":"7","author":"Auvinen","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"114741","DOI":"10.1016\/j.celrep.2024.114741","article-title":"Integrated Metabolic-Transcriptomic Network Identifies Immunometabolic Modulations in Human Macrophages","volume":"43","author":"Chen","year":"2024","journal-title":"Cell Rep."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e39710","DOI":"10.1016\/j.heliyon.2024.e39710","article-title":"Regional Primary Preadipocyte Characteristics in Humans with Obesity and Type 2 Diabetes Mellitus","volume":"10","author":"Plissonneau","year":"2024","journal-title":"Heliyon"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e70448","DOI":"10.1096\/fj.202403227R","article-title":"SPP1 Macrophages across Diseases: A Call for Reclassification?","volume":"39","author":"Reggio","year":"2025","journal-title":"FASEB J."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.7150\/thno.65778","article-title":"Integrative Biology of Extracellular Vesicles in Diabetes Mellitus and Diabetic Complications","volume":"12","author":"Liu","year":"2022","journal-title":"Theranostics"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Fu, E., Pan, K., and Li, Z. (2024). Engineering Extracellular Vesicles for Targeted Therapeutics in Cardiovascular Disease. Front. Cardiovasc. Med., 11.","DOI":"10.3389\/fcvm.2024.1503830"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1172\/JCI123069","article-title":"Adipocyte-Secreted Exosomal microRNA-34a Inhibits M2 Macrophage Polarization to Promote Obesity-Induced Adipose Inflammation","volume":"129","author":"Pan","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Liu, S., Yang, Y., Jiang, S., Xu, H., Tang, N., Lobo, A., Zhang, R., Liu, S., Yu, T., and Xin, H. (2019). MiR-378a-5p Regulates Proliferation and Migration in Vascular Smooth Muscle Cell by Targeting CDK1. Front. Genet., 10, Correction in Front. Genet.\u00a02019, 10, 193. https:\/\/doi.org\/10.3389\/fgene.2019.00193.","DOI":"10.3389\/fgene.2019.00193"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"115661","DOI":"10.1016\/j.biopha.2023.115661","article-title":"Finerenone Protects against Progression of Kidney and Cardiovascular Damage in a Model of Type 1 Diabetes through Modulation of Proinflammatory and Osteogenic Factors","volume":"168","author":"Somoza","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1056\/NEJMoa2025845","article-title":"Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes","volume":"383","author":"Bakris","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1161\/CIRCULATIONAHA.120.051898","article-title":"Finerenone and Cardiovascular Outcomes in Patients With Chronic Kidney Disease and Type 2 Diabetes","volume":"143","author":"Filippatos","year":"2021","journal-title":"Circulation"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1056\/NEJMoa2110956","article-title":"Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes","volume":"385","author":"Pitt","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Azul, L., Leandro, A., Sei\u00e7a, R., and Sena, C.M. (2024). Propagermanium as a Novel Therapeutic Approach for the Treatment of Endothelial Dysfunction in Type 2 Diabetes. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25158328"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1194\/jlr.D052787","article-title":"Xenotransplantation of Human Fetal Adipose Tissue: A Model of in Vivo Adipose Tissue Expansion and Adipogenesis","volume":"55","author":"Garcia","year":"2014","journal-title":"J. Lipid Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1530\/JOE-11-0201","article-title":"Functional Human to Mouse Adipose Tissue Xenotransplantation","volume":"212","author":"Ablamunits","year":"2012","journal-title":"J. Endocrinol."},{"key":"ref_144","unstructured":"(2026, August 07). Adipocyte-Derived Extracellular Vesicles Increase Insulin Secretion through Transport of Insulinotropic Protein Cargo|Nature Communications. Available online: https:\/\/www.nature.com\/articles\/s41467-023-36148-1."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"10252","DOI":"10.1021\/acsnano.3c00422","article-title":"A Liquid Biopsy-Based Approach to Isolate and Characterize Adipose Tissue-Derived Extracellular Vesicles from Blood","volume":"17","author":"Mishra","year":"2023","journal-title":"ACS Nano"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"101630","DOI":"10.1016\/j.mtbio.2025.101630","article-title":"GlycoRNA-Rich, Neutrophil Membrane-Coated, siMT1-Loaded Nanoparticles Mitigate Abdominal Aortic Aneurysm Progression by Inhibiting the Formation of Neutrophil Extracellular Traps","volume":"31","author":"Zhang","year":"2025","journal-title":"Mater. Today Bio"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"e200563","DOI":"10.1148\/ryct.2021200563","article-title":"Assessing Cardiovascular Risk by Using the Fat Attenuation Index in Coronary CT Angiography","volume":"3","author":"Oikonomou","year":"2021","journal-title":"Radiol. Cardiothorac. Imaging"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1016\/S0140-6736(24)00596-8","article-title":"Inflammatory Risk and Cardiovascular Events in Patients without Obstructive Coronary Artery Disease: The ORFAN Multicentre, Longitudinal Cohort Study","volume":"403","author":"Chan","year":"2024","journal-title":"Lancet"},{"key":"ref_149","first-page":"2677","article-title":"Standardized Measurement of Coronary Inflammation Using Cardiovascular Computed Tomography: Integration in Clinical Care as a Prognostic Medical Device","volume":"117","author":"Oikonomou","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/s42003-022-03175-5","article-title":"Deciphering Tissue Structure and Function Using Spatial Transcriptomics","volume":"5","author":"Walker","year":"2022","journal-title":"Commun. Biol."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Amor, M., Vila-Bedmar, R., Rodrigues-D\u00edez, R., Moreno-Carriles, R., Arcones, A.C., Cruces-Sande, M., Salaices, M., Mayor, F., Briones, A.M., and Murga, C. (2020). Myeloid GRK2 Regulates Obesity-Induced Endothelial Dysfunction by Modulating Inflammatory Responses in Perivascular Adipose Tissue. Antioxidants, 9.","DOI":"10.3390\/antiox9100953"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"111046","DOI":"10.1016\/j.celrep.2022.111046","article-title":"A Human Adipose Tissue Cell-Type Transcriptome Atlas","volume":"40","author":"Struck","year":"2022","journal-title":"Cell Rep."},{"key":"ref_153","unstructured":"Noutahi, E., Hartford, J., Tossou, P., Whitfield, S., Denton, A.K., Wognum, C., Ulicna, K., Craig, M., Hsu, J., and Cuccarese, M. (2025). Virtual Cells: Predict, Explain, Discover. arXiv."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41591-024-03434-4","article-title":"Artificial Intelligence in Drug Development","volume":"31","author":"Zhang","year":"2025","journal-title":"Nat. Med."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Wang, G., Liu, T., Zhao, J., Cheng, Y., and Zhao, H. (2024). Modeling and Predicting Single-Cell Multi-Gene Perturbation Responses with scLAMBDA. bioRxiv, 2024.12.04.626878.","DOI":"10.1101\/2024.12.04.626878"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/18\/1645\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T04:11:28Z","timestamp":1789272688000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/18\/1645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":155,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["cells15181645"],"URL":"https:\/\/doi.org\/10.3390\/cells15181645","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]}}}