{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:00:22Z","timestamp":1792789222972,"version":"4.5.0"},"reference-count":72,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Carl-Zeiss foundation"},{"name":"European Commission","award":["211696"],"award-info":[{"award-number":["211696"]}],"id":[{"id":"https:\/\/ror.org\/00k4n6c32","id-type":"ROR","asserted-by":"crossref"}]},{"award":["211696"],"award-info":[{"award-number":["211696"]}],"id":[{"id":"https:\/\/ror.org\/00k4n6c32","id-type":"ROR","asserted-by":"publisher"}]},{"name":"EU Joint Program\u2014Neuro-degenerative Disease Research"},{"name":"BMBF grants Multi-Memo","award":["01ED2306"],"award-info":[{"award-number":["01ED2306"]}]},{"name":"EURO-FINGERS","award":["01ED2003"],"award-info":[{"award-number":["01ED2003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Cannabidiol (CBD) is increasingly discussed in relation to neurodegenerative disorders, including Alzheimer\u2019s disease (AD), yet its effects on cellular lipid profiles remain poorly understood. Using targeted lipidomics, we investigated whether CBD alters the lipidome of SH-SY5Y wildtype (wt) cells and whether the principal phosphatidylcholine response is also observed in cells expressing amyloid precursor protein with the Swedish mutation (APPswe). CBD induced a broad, class-specific lipid response. Total diacyl and ether-linked phosphatidylcholines increased. Within these classes, many species with lower degrees of unsaturation increased, whereas several highly polyunsaturated ether-linked phosphatidylcholines declined. Lysophosphatidylcholines were broadly reduced, total sphingomyelin abundance declined, free carnitine decreased, and most measured acylcarnitine species also declined. Together, in wt cells, these changes are consistent with a relative shift toward a less polyunsaturated lipid profile. CBD-associated changes in both phosphatidylcholine classes were also observed in stably APPswe-expressing SH-SY5Y cells. Because the affected lipid classes have been implicated in AD-related lipid dysregulation, these findings link CBD exposure to an AD-relevant lipid context and provide a rationale for investigating the functional consequences of this response in more complex neurodegeneration-relevant models.<\/jats:p>","DOI":"10.3390\/cells15181714","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:01:38Z","timestamp":1789981298000},"page":"1714","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lipidomic Evidence for Cannabidiol-Induced Remodeling of Cellular Lipid Composition in SH-SY5Y Cells"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2695-4525","authenticated-orcid":false,"given":"Oliver","family":"Walzer","sequence":"first","affiliation":[{"name":"Experimental Neurology, Saarland University, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Vincent Konrad Johannes","family":"Erhardt","sequence":"additional","affiliation":[{"name":"Experimental Neurology, Saarland University, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Jill Sven Ren\u00e9","family":"Z\u00fcgner","sequence":"additional","affiliation":[{"name":"Experimental Neurology, Saarland University, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Natalya V.","family":"Izarova","sequence":"additional","affiliation":[{"name":"Experimental Neurology, Saarland University, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1099-8287","authenticated-orcid":false,"given":"Kristina","family":"Endres","sequence":"additional","affiliation":[{"name":"Faculty of Computer Sciences and Microsystems Technology Kaiserslautern, University of Applied Sciences, 66482 Zweibr\u00fccken, Germany"},{"name":"Department of Psychiatry and Psychotherapy, University Medical Center, Johannes Gutenberg University Mainz, 55122 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"given":"Heike Sabine","family":"Grimm","sequence":"additional","affiliation":[{"name":"Experimental Neurology, Saarland University, 66421 Homburg, Germany"},{"name":"Nutrition Therapy and Counseling, Campus Rheinland, SRH University of Applied Health Sciences, 51377 Leverkusen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7481-6430","authenticated-orcid":false,"given":"Tobias","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Experimental Neurology, Saarland University, 66421 Homburg, Germany"},{"name":"Deutsches Institut f\u00fcr Demenzpr\u00e4vention (DIDP), Saarland University, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4160-6506","authenticated-orcid":false,"given":"Marcus Otto Walter","family":"Grimm","sequence":"additional","affiliation":[{"name":"Experimental Neurology, Saarland University, 66421 Homburg, Germany"},{"name":"Nutrition Therapy and Counseling, Campus Rheinland, SRH University of Applied Health Sciences, 51377 Leverkusen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Martinez Naya, N., Kelly, J., Corna, G., Golino, M., Abbate, A., and Toldo, S. (2023). Molecular and Cellular Mechanisms of Action of Cannabidiol. Molecules, 28.","DOI":"10.3390\/molecules28165980"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s40263-020-00741-5","article-title":"Critical Aspects Affecting Cannabidiol Oral Bioavailability and Metabolic Elimination, and Related Clinical Implications","volume":"34","author":"Perucca","year":"2020","journal-title":"CNS Drugs"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00441-024-03867-w","article-title":"Entry of cannabidiol into the fetal, postnatal and adult rat brain","volume":"396","author":"Fitzpatrick","year":"2024","journal-title":"Cell Tissue Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1089\/can.2023.0214","article-title":"Cannabidiol Bioavailability Is Nonmonotonic with a Long Terminal Elimination Half-Life: A Pharmacokinetic Modeling-Based Analysis","volume":"10","author":"Kolli","year":"2025","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ejim.2018.01.004","article-title":"Practical considerations in medical cannabis administration and dosing","volume":"49","author":"MacCallum","year":"2018","journal-title":"Eur. J. Intern. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000531666","article-title":"Long-Term, Self-Dosing CBD Users: Indications, Dosage, and Self-Perceptions on General Health\/Symptoms and Drug Use","volume":"6","author":"Kaufmann","year":"2023","journal-title":"Med. Cannabis Cannabinoids"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1684\/epd.2020.1135","article-title":"The proposed mechanisms of action of CBD in epilepsy","volume":"22","author":"Gray","year":"2020","journal-title":"Epileptic Disord."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000521683","article-title":"Therapeutic Potential of Cannabis, Cannabidiol, and Cannabinoid-Based Pharmaceuticals","volume":"107","author":"Legare","year":"2022","journal-title":"Pharmacology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"104941","DOI":"10.1016\/j.neubiorev.2022.104941","article-title":"Cannabinoid treatments for anxiety: A systematic review and consideration of the impact of sleep disturbance","volume":"143","author":"Narayan","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"100791","DOI":"10.1016\/j.lanepe.2023.100791","article-title":"The use of cannabidiol (CBD) as an analgesic component","volume":"35","author":"Petersen","year":"2023","journal-title":"Lancet Reg. Health Eur."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.2174\/1570159X21666230322143401","article-title":"Update on Cannabidiol Clinical Toxicity and Adverse Effects: A Systematic Review","volume":"21","author":"Madeo","year":"2023","journal-title":"Curr. Neuropharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1080\/17512433.2022.2148655","article-title":"Cannabinoids and drug metabolizing enzymes: Potential for drug-drug interactions and implications for drug safety and efficacy","volume":"15","author":"Bardhi","year":"2022","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"110728","DOI":"10.1016\/j.biopha.2020.110728","article-title":"Biological effects of Cannabidiol on normal human healthy cell populations: Systematic review of the literature","volume":"132","author":"Pagano","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"20622","DOI":"10.1038\/s41598-020-77674-y","article-title":"Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma","volume":"10","author":"Go","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41582-019-0284-z","article-title":"Cannabinoids and the expanded endocannabinoid system in neurological disorders","volume":"16","author":"Cristino","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/sj.bjp.0707133","article-title":"Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro","volume":"150","author":"Thomas","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.1111\/bph.13250","article-title":"Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor","volume":"172","author":"Laprairie","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1111\/j.1471-4159.2007.05073.x","article-title":"5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid","volume":"104","author":"Massi","year":"2008","journal-title":"J. Neurochem."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Castillo-Arellano, J., Canseco-Alba, A., Cutler, S.J., and Leon, F. (2023). The Polypharmacological Effects of Cannabidiol. Molecules, 28.","DOI":"10.3390\/molecules28073271"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Ikeda, J., Ichiki, T., Takahara, Y., Kojima, H., Sankoda, C., Kitamoto, S., Tokunou, T., and Sunagawa, K. (2015). PPARgamma Agonists Attenuate Palmitate-Induced ER Stress through Up-Regulation of SCD-1 in Macrophages. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0128546"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"154771","DOI":"10.1016\/j.phymed.2023.154771","article-title":"Cannabidiol goes nuclear: The role of PPARgamma","volume":"114","author":"Khosropoor","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Esposito, G., Scuderi, C., Valenza, M., Togna, G.I., Latina, V., De Filippis, D., Cipriano, M., Carratu, M.R., Iuvone, T., and Steardo, L. (2011). Cannabidiol reduces Abeta-induced neuroinflammation and promotes hippocampal neurogenesis through PPARgamma involvement. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0028668"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"114910","DOI":"10.1016\/j.bcp.2022.114910","article-title":"Cannabidiol promotes adipogenesis of human and mouse mesenchymal stem cells via PPARgamma by inducing lipogenesis but not lipolysis","volume":"197","author":"Chang","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Wu, S., Rajiah, T., and Ali, A.B. (2025). Therapeutic Potential for Cannabidiol on Alzheimer\u2019s Disease-Related Neuroinflammation: A Systematic Review and Meta-Analysis. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262411963"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1038\/s41386-020-0667-2","article-title":"Adverse effects of cannabidiol: A systematic review and meta-analysis of randomized clinical trials","volume":"45","author":"Chesney","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1038\/s41380-024-02789-x","article-title":"Cannabidiol ameliorates cognitive decline in 5xFAD mouse model of Alzheimer\u2019s disease through potentiating the function of extrasynaptic glycine receptors","volume":"30","author":"Jin","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neulet.2006.01.047","article-title":"Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement","volume":"399","author":"Esposito","year":"2006","journal-title":"Neurosci. Lett."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.fitote.2016.11.010","article-title":"Target regulation of PI3K\/Akt\/mTOR pathway by cannabidiol in treatment of experimental multiple sclerosis","volume":"116","author":"Giacoppo","year":"2017","journal-title":"Fitoterapia"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s12035-021-02611-7","article-title":"Implications of Phosphoinositide 3-Kinase-Akt (PI3K-Akt) Pathway in the Pathogenesis of Alzheimer\u2019s Disease","volume":"59","author":"Kumar","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Kao, Y.C., Ho, P.C., Tu, Y.K., Jou, I.M., and Tsai, K.J. (2020). Lipids and Alzheimer\u2019s Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21041505"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.jalz.2017.01.008","article-title":"Dysregulation of lipids in Alzheimer\u2019s disease and their role as potential biomarkers","volume":"13","author":"Wong","year":"2017","journal-title":"Alzheimers Dement."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/nrn3012","article-title":"Linking lipids to Alzheimer\u2019s disease: Cholesterol and beyond","volume":"12","author":"Kim","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Branca, J.J., Morucci, G., Becatti, M., Carrino, D., Ghelardini, C., Gulisano, M., Di Cesare Mannelli, L., and Pacini, A. (2019). Cannabidiol Protects Dopaminergic Neuronal Cells from Cadmium. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16224420"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5434","DOI":"10.1038\/s41598-021-84879-2","article-title":"Cannabidiol induces autophagy via ERK1\/2 activation in neural cells","volume":"11","author":"Vrechi","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Theiss, E.L., Griebsch, L.V., Lauer, A.A., Janitschke, D., Erhardt, V.K.J., Haas, E.C., Kuppler, K.N., Radermacher, J., Walzer, O., and Portius, D. (2022). Vitamin B12 Attenuates Changes in Phospholipid Levels Related to Oxidative Stress in SH-SY5Y Cells. Cells, 11.","DOI":"10.3390\/cells11162574"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Kurokin, I., Lauer, A.A., Janitschke, D., Winkler, J., Theiss, E.L., Griebsch, L.V., Pilz, S.M., Matschke, V., van der Laan, M., and Grimm, H.S. (2021). Targeted Lipidomics of Mitochondria in a Cellular Alzheimer\u2019s Disease Model. Biomedicines, 9.","DOI":"10.3390\/biomedicines9081062"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"pdb-prot095497","DOI":"10.1101\/pdb.prot095497","article-title":"Analysis of Cell Viability by the Lactate Dehydrogenase Assay","volume":"2018","author":"Kumar","year":"2018","journal-title":"Cold Spring Harb. Protoc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1021\/ac103313x","article-title":"Reducing time and increasing sensitivity in sample preparation for adherent mammalian cell metabolomics","volume":"83","author":"Lorenz","year":"2011","journal-title":"Anal. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nprot.2014.198","article-title":"Fast sampling method for mammalian cell metabolic analyses using liquid chromatography-mass spectrometry","volume":"10","author":"Martano","year":"2015","journal-title":"Nat. Protoc."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"7713","DOI":"10.1016\/j.chroma.2011.07.073","article-title":"From brain to food: Analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin-plasmalogens derivates in Alzheimer\u2019s disease human post mortem brains and mice model via mass spectrometry","volume":"1218","author":"Grimm","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"15301","DOI":"10.1038\/s41598-021-94706-3","article-title":"Shotgun lipidomics of liver and brain tissue of Alzheimer\u2019s disease model mice treated with acitretin","volume":"11","author":"Lauer","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1194\/jlr.S120001025","article-title":"Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures","volume":"61","author":"Liebisch","year":"2020","journal-title":"J. Lipid Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"100138","DOI":"10.1016\/j.jlr.2021.100138","article-title":"Recommendations for good practice in MS-based lipidomics","volume":"62","author":"Ahrends","year":"2021","journal-title":"J. Lipid Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1039\/C1MB05350G","article-title":"LC-MS-based metabolomics","volume":"8","author":"Zhou","year":"2012","journal-title":"Mol. Biosyst."},{"key":"ref_46","first-page":"72","article-title":"Guidelines and considerations for the use of system suitability and quality control samples in mass spectrometry assays applied in untargeted clinical metabolomic studies","volume":"14","author":"Broadhurst","year":"2018","journal-title":"Metabolomics Off. J. Metabolomic Soc."},{"key":"ref_47","first-page":"70","article-title":"Quality assurance and quality control reporting in untargeted metabolic phenotyping: mQACC recommendations for analytical quality management","volume":"18","author":"Kirwan","year":"2022","journal-title":"Metabolomics Off. J. Metabolomic Soc."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"101177","DOI":"10.1016\/j.plipres.2022.101177","article-title":"Challenges and opportunities for prevention and removal of unwanted variation in lipidomic studies","volume":"87","author":"Olshansky","year":"2022","journal-title":"Prog. Lipid Res."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Luczaj, W., Dobrzynska, I., Wronski, A., Domingues, M.R., Domingues, P., and Skrzydlewska, E. (2020). Cannabidiol-Mediated Changes to the Phospholipid Profile of UVB-Irradiated Keratinocytes from Psoriatic Patients. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186592"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"112057","DOI":"10.1016\/j.biopha.2021.112057","article-title":"Cannabidiol\u2014A phytocannabinoid that widely affects sphingolipid metabolism under conditions of brain insulin resistance","volume":"142","author":"Charytoniuk","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Berk, K., Konstantynowicz-Nowicka, K., Charytoniuk, T., Harasim-Symbor, E., and Chabowski, A. (2022). Distinct Effects of Cannabidiol on Sphingolipid Metabolism in Subcutaneous and Visceral Adipose Tissues Derived from High-Fat-Diet-Fed Male Wistar Rats. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23105382"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"7844","DOI":"10.3168\/jds.2013-7105","article-title":"Peroxisome proliferator-activated receptor-gamma stimulates the synthesis of monounsaturated fatty acids in dairy goat mammary epithelial cells via the control of stearoyl-coenzyme A desaturase","volume":"96","author":"Shi","year":"2013","journal-title":"J. Dairy Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1210\/jc.2008-0782","article-title":"Stearoyl-coenzyme A desaturase 1 gene expression increases after pioglitazone treatment and is associated with peroxisomal proliferator-activated receptor-gamma responsiveness","volume":"93","author":"Rassouli","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"22027","DOI":"10.1074\/jbc.M110.126870","article-title":"Decrease in membrane phospholipid unsaturation induces unfolded protein response","volume":"285","author":"Ariyama","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1002\/1873-3468.12825","article-title":"Metabolism and functions of docosahexaenoic acid-containing membrane glycerophospholipids","volume":"591","author":"Hishikawa","year":"2017","journal-title":"FEBS Lett."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Sanchez-Campillo, M., Ruiz-Pastor, M.J., Gazquez, A., Marin-Munoz, J., Noguera-Perea, F., Ruiz-Alcaraz, A.J., Manzanares-Sanchez, S., Antunez, C., and Larque, E. (2019). Decreased Blood Level of MFSD2a as a Potential Biomarker of Alzheimer\u2019s Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010070"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1093\/advances\/nmaa024","article-title":"Perspective: The Potential Role of Circulating Lysophosphatidylcholine in Neuroprotection against Alzheimer Disease","volume":"11","author":"Semba","year":"2020","journal-title":"Adv. Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"106683","DOI":"10.1016\/j.phrs.2023.106683","article-title":"Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer","volume":"189","author":"Mahmoud","year":"2023","journal-title":"Pharmacol. Res."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Podinic, T., Limoges, L., Monaco, C., MacAndrew, A., Minhas, M., Nederveen, J., and Raha, S. (2024). Cannabidiol Disrupts Mitochondrial Respiration and Metabolism and Dysregulates Trophoblast Cell Differentiation. Cells, 13.","DOI":"10.3390\/cells13060486"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1089\/can.2022.0011","article-title":"Cannabidiol Impairs Brain Mitochondrial Metabolism and Neuronal Integrity","volume":"8","author":"Ahn","year":"2023","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.copbio.2015.02.003","article-title":"A roadmap for interpreting (13)C metabolite labeling patterns from cells","volume":"34","author":"Buescher","year":"2015","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.expneurol.2018.09.012","article-title":"Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP\/PS1 transgenic mice through promoting lysosomal degradation of BACE1","volume":"311","author":"Lu","year":"2019","journal-title":"Exp. Neurol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/s42003-022-04011-6","article-title":"Multi-Omic analyses characterize the ceramide\/sphingomyelin pathway as a therapeutic target in Alzheimer\u2019s disease","volume":"5","author":"Baloni","year":"2022","journal-title":"Commun. Biol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Chew, H., Solomon, V.A., and Fonteh, A.N. (2020). Involvement of Lipids in Alzheimer\u2019s Disease Pathology and Potential Therapies. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.00598"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e16244","DOI":"10.1111\/jnc.16244","article-title":"Circulating medium- and long-chain acylcarnitines are associated with plasma P-tau181 in cognitively normal older adults","volume":"169","author":"Sharmin","year":"2025","journal-title":"J. Neurochem."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Dong, R., Lu, Q., Kang, H., Suridjan, I., Kollmorgen, G., Wild, N., Deming, Y., Van Hulle, C.A., Anderson, R.M., and Zetterberg, H. (2023). CSF metabolites associated with biomarkers of Alzheimer\u2019s disease pathology. Front. Aging Neurosci., 15.","DOI":"10.3389\/fnagi.2023.1214932"},{"key":"ref_69","first-page":"e12623","article-title":"Circulating sphingolipids in relation to cognitive decline and incident dementia: The Cardiovascular Health Study","volume":"16","author":"Moseholm","year":"2024","journal-title":"Alzheimers Dement."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3233\/JAD-2011-110405","article-title":"Plasma sphingomyelins are associated with cognitive progression in Alzheimer\u2019s disease","volume":"27","author":"Mielke","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3233\/JAD-160925","article-title":"The Association Between Plasma Ceramides and Sphingomyelins and Risk of Alzheimer\u2019s Disease Differs by Sex and APOE in the Baltimore Longitudinal Study of Aging","volume":"60","author":"Mielke","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/s41398-021-01362-2","article-title":"Plasma lipidome is dysregulated in Alzheimer\u2019s disease and is associated with disease risk genes","volume":"11","author":"Liu","year":"2021","journal-title":"Transl. Psychiatry"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/18\/1714\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:21:55Z","timestamp":1790137315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/18\/1714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":72,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["cells15181714"],"URL":"https:\/\/doi.org\/10.3390\/cells15181714","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,21]]}}}