{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:00:56Z","timestamp":1790866856379,"version":"4.1.0"},"reference-count":44,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005297","name":"Medical University of Bialystok","doi-asserted-by":"publisher","award":["B.SUB.25.398"],"award-info":[{"award-number":["B.SUB.25.398"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005297","name":"Medical University of Bialystok","doi-asserted-by":"publisher","award":["B.SUB.25.390"],"award-info":[{"award-number":["B.SUB.25.390"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]},{"award":["B.SUB.25.398"],"award-info":[{"award-number":["B.SUB.25.398"]}],"id":[{"id":"https:\/\/ror.org\/00y4ya841","id-type":"ROR","asserted-by":"publisher"}]},{"award":["B.SUB.25.390"],"award-info":[{"award-number":["B.SUB.25.390"]}],"id":[{"id":"https:\/\/ror.org\/00y4ya841","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Adipose-derived mesenchymal stem cells (ADMSCs) are a crucial source of new adipocytes and play a significant role in regulating adipose tissue physiology. Interestingly, mature adipocytes differentiated from the ADMSCs maintain some characteristic features of their respective depots as well as the metabolic status of the donor patients. The above is true with respect to the cells\u2019 secretory profile and their glycerolipid and sphingolipid composition. In the current paper, we focused our attention on the phospholipid profile of the adipocytes derived from ADMSCs, with a particular emphasis placed on how obesity and metabolic syndrome affect their composition. Surprisingly, the cells displayed a significantly greater (even up to 10-fold) overall phospholipid concentration when compared with the primary human adipocytes described in the literature. The phenomenon may be explained by a geometrical property known as surface-to-volume ratio, which dictates that the total surface area of many small cells (our adipocytes) is greater than the total area of less numerous but more voluminous cells in vivo. Interestingly, also a donor\u2019s metabolic status can influence the characteristics of these fat cells. The study found that subcutaneous adipocytes, when derived from patients with obesity and metabolic syndrome, had an increased concentration of phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), and sphingomyelin (SM). The above-mentioned changes often reflect the ones found in vivo and may well be the early metabolic disarrangements that occur in the progress of obesity.<\/jats:p>","DOI":"10.3390\/cells15191725","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:45:10Z","timestamp":1790865910000},"page":"1725","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Significant Alterations in Phospholipid Content and Composition Contributing to Metabolic Dysfunction in ADMSC-Derived Adipocytes"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4954-3431","authenticated-orcid":false,"given":"Bart\u0142omiej","family":"\u0141ukaszuk","sequence":"first","affiliation":[{"name":"Department of Physiology, Medical University of Bialystok, Mickiewicza 2C, 15-222 Bia\u0142ystok, 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Metab."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Mik\u0142osz, A., \u0141ukaszuk, B., Supruniuk, E., Grubczak, K., Starosz, A., Kusaczuk, M., Naumowicz, M., and Chabowski, A. (2022). The Phenotype of the Adipocytes Derived from Subcutaneous and Visceral Admscs Is Altered When They Originate from Morbidly Obese Women: Is There a Memory Effect?. Cells, 11.","DOI":"10.3390\/cells11091435"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"116158","DOI":"10.1016\/j.bcp.2024.116158","article-title":"Adipose Tissue Place of Origin and Obesity Influence Sphingolipid Signaling Pathway in the Adipocytes Differentiated from Admscs Isolated from Morbidly Obese Women","volume":"223","author":"Supruniuk","year":"2024","journal-title":"Biochem. 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Control Release"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s00018-025-05825-3","article-title":"The Oily Nucleus- Role of Phospholipids in Genome Biology: Membrane-Directed Roles and Signaling in the Nucleoplasm","volume":"82","author":"Umair","year":"2025","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1016\/j.tjnut.2024.07.015","article-title":"How Membrane Phospholipids Containing Long-Chain Polyunsaturated Fatty Acids and Their Oxidation Products Orchestrate Lipid Raft Dynamics to Control Inflammation","volume":"154","author":"Virk","year":"2024","journal-title":"J. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Dai, Y., Tang, H., and Pang, S. (2021). The Crucial Roles of Phospholipids in Aging and Lifespan Regulation. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.775648"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"E736","DOI":"10.1152\/ajpendo.2000.279.4.E736","article-title":"Adipocyte Membrane Phospholipids and Ppar-Gamma Expression in Obese Women: Relationship to Hyperinsulinemia","volume":"279","author":"Zeghari","year":"2000","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"818945","DOI":"10.1155\/2009\/818945","article-title":"Cross-Talk Between Ppargamma and Insulin Signaling and Modulation of Insulin Sensitivity","volume":"2009","author":"Leonardini","year":"2009","journal-title":"PPAR Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1039\/D3SC04523D","article-title":"The Intricate Link Between Membrane Lipid Structure and Composition and Membrane Structural Properties in Bacterial Membranes","volume":"15","author":"Lee","year":"2024","journal-title":"Chem. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Mik\u0142osz, A., \u0141ukaszuk, B., Supruniuk, E., Grubczak, K., Moniuszko, M., Choroma\u0144ska, B., My\u015bliwiec, P., and Chabowski, A. (2021). Does Tbc1d4 (As160) or Tbc1d1 Deficiency Affect the Expression of Fatty Acid Handling Proteins in the Adipocytes Differentiated from Human Adipose-Derived Mesenchymal Stem Cells (Admscs) Obtained from Subcutaneous and Visceral Fat Depots?. Cells, 10.","DOI":"10.3390\/cells10061515"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A Simple Method for the Isolation and Purification of Total Lipides from Animal Tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1038\/s41598-022-07700-8","article-title":"The Influence of the pH on the Incorporation of Caffeic Acid into Biomimetic Membranes and Cancer Cells","volume":"12","author":"Naumowicz","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0009-3084(93)90069-F","article-title":"Surface-Modified Liposomes: Assessment and Characterization for Increased Stability and Prolonged Blood Circulation","volume":"64","author":"Woodle","year":"1993","journal-title":"Chem. Phys. Lipids"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.bioelechem.2018.07.010","article-title":"The Effect of Quercetin on the Electrical Properties of Model Lipid Membranes and Human Glioblastoma Cells","volume":"124","author":"Kruszewski","year":"2018","journal-title":"Bioelectrochemistry"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Palavicini, J.P., Chavez-Velazquez, A., Fourcaudot, M., Tripathy, D., Pan, M., Norton, L., DeFronzo, R.A., and Shannon, C.E. (2021). The Insulin-Sensitizer Pioglitazone Remodels Adipose Tissue Phospholipids in Humans. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.784391"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1074\/mcp.M800258-MCP200","article-title":"Comparative Proteomic Phenotyping of Cell Lines and Primary Cells to Assess Preservation of Cell Type-Specific Functions","volume":"8","author":"Pan","year":"2009","journal-title":"Mol. Cell. Proteom."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1074\/mcp.M114.044222","article-title":"Deep Proteomics of Mouse Skeletal Muscle Enables Quantitation of Protein Isoforms, Metabolic Pathways, and Transcription Factors","volume":"14","author":"Deshmukh","year":"2015","journal-title":"Mol. Cell. Proteom."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e3631","DOI":"10.21769\/BioProtoc.3631","article-title":"Mouse Adipose Tissue Protein Extraction","volume":"10","author":"An","year":"2020","journal-title":"Bio Protoc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"100222","DOI":"10.1016\/j.jlr.2022.100222","article-title":"Adaptations of the 3T3-L1 Adipocyte Lipidome to Defective Ether Lipid Catabolism Upon Agmo Knockdown","volume":"63","author":"Sailer","year":"2022","journal-title":"J. Lipid Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1038\/s41366-021-00883-6","article-title":"A Distribution-Centered Approach for Analyzing Human Adipocyte Size Estimates and Their Association with Obesity-Related Traits and Mitochondrial Function","volume":"45","author":"Honecker","year":"2021","journal-title":"Int. J. Obes."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.tim.2018.04.008","article-title":"Surface Area to Volume Ratio: A Natural Variable for Bacterial Morphogenesis","volume":"26","author":"Harris","year":"2018","journal-title":"Trends Microbiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1194\/jlr.M091173","article-title":"Rosiglitazone Remodels the Lipid Droplet and Britens Human Visceral and Subcutaneous Adipocytes Ex Vivo","volume":"60","author":"Lee","year":"2019","journal-title":"J. Lipid Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"21630","DOI":"10.1002\/jcp.28821","article-title":"Impact of Different Ectopic Fat Depots on Cardiovascular and Metabolic Diseases","volume":"234","author":"Ferrara","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/oby.23177","article-title":"Association of Visceral Adipose Tissue and Insulin Resistance with Incident Metabolic Syndrome Independent of Obesity Status: The Iras Family Study","volume":"29","author":"Hairston","year":"2021","journal-title":"Obesity"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/joim.13435","article-title":"Human White Adipose Tissue: A Highly Dynamic Metabolic Organ","volume":"291","author":"Arner","year":"2022","journal-title":"J. Intern. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/ijo.2015.223","article-title":"GM3 Ganglioside and Phosphatidylethanolamine-Containing Lipids Are Adipose Tissue Markers of Insulin Resistance in Obese Women","volume":"40","author":"Wentworth","year":"2016","journal-title":"Int. J. Obes."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Kim, J.-Y., Kwon, M.-S., Son, J., Kang, S.-W., and Song, Y. (2017). Selective Effect of Phosphatidylcholine on the Lysis of Adipocytes. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0176722"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.2337\/db23-0317","article-title":"Inhibiting Phosphatidylcholine Remodeling in Adipose Tissue Increases Insulin Sensitivity","volume":"72","author":"He","year":"2023","journal-title":"Diabetes"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1042\/bj3190179","article-title":"Lipid Mediators of Insulin Resistance: Ceramide Signalling down-Regulates Glut4 Gene Transcription in 3T3-L1 Adipocytes","volume":"319","author":"Long","year":"1996","journal-title":"Biochem. J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4631","DOI":"10.2147\/DMSO.S280146","article-title":"Development of Obesity: The Driver and the Passenger","volume":"13","author":"Kopp","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4112","DOI":"10.1038\/s41598-022-08125-z","article-title":"PET\/Mri-Evaluated Brown Adipose Tissue Activity May Be Related to Dietary Mufa and Omega-6 Fatty Acids Intake","volume":"12","author":"Maliszewska","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"106622","DOI":"10.1016\/j.prostaglandins.2022.106622","article-title":"EPA\/Dha and Linseed Oil Have Different Effects on Liver and Adipose Tissue in Rats Fed with a High-Fat Diet","volume":"159","author":"Dias","year":"2022","journal-title":"Prostaglandins Other Lipid Mediat."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/19\/1725\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:48:54Z","timestamp":1790866134000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/19\/1725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":44,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["cells15191725"],"URL":"https:\/\/doi.org\/10.3390\/cells15191725","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,22]]}}}