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METTL14, an essential constituent of the N6-methyladenosine (m6A) methyltransferase complex, plays an important role in mammalian preadipocyte differentiation. However, its role in avian adipogenesis remains unclear. More importantly, the m6A mechanism by which METTL14 regulates preadipocyte differentiation has not been elucidated. Here, we found that the level of METTL14 expression was substantially elevated within the adipose tissue of the abdominal region of fat chickens relative to lean chickens. Knockdown of METTL14 inhibited preadipocyte differentiation, whereas overexpression of METTL14 promoted this process. Through the integration of MeRIP-seq and RNA-seq, we confirmed that chBMI1, chTMED3, and chMFAP2 were functionally essential targets of METTL14-dependent m6A modification in adipogenesis. METTL14-mediated chBMI1 mRNA stabilization and the degradation of chTMED3 and chMFAP2 mRNAs depend on IGF2BP1\/2 and YTHDF2, respectively. Overall, our findings establish that METTL14 promotes chicken preadipocyte differentiation by modulating the stability of target mRNAs through a dual-reader m6A mechanism.<\/jats:p>","DOI":"10.3390\/cells15191761","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T08:18:46Z","timestamp":1790583526000},"page":"1761","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["METTL14 Promotes Chicken Preadipocyte Differentiation by Modulating mRNA Stability via a Dual-Reader m6A Mechanism"],"prefix":"10.3390","volume":"15","author":[{"given":"Saibo","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Harbin 150030, China"},{"name":"Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China"},{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Harbin 150030, China"},{"name":"Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China"},{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"},{"name":"Key Laboratory of Exploration and Innovative Utilization of White Goose Germplasm Resources in the Cold Region of Heilongjiang Province, #2 Xinyang Road, New Development District, Daqing 163319, China"},{"name":"College of Animal Science and Technology, Heilongjiang Bayi Agricultural University, #2 Xinyang Road, New Development District, Daqing 163319, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Yawen","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Harbin 150030, China"},{"name":"Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China"},{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Harbin 150030, China"},{"name":"Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China"},{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"visualization","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4592-3326","authenticated-orcid":false,"given":"Fei","family":"Teng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Harbin 150030, China"},{"name":"Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China"},{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Shouzhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Harbin 150030, China"},{"name":"Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China"},{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"software","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6282-5559","authenticated-orcid":false,"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Harbin 150030, China"},{"name":"Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China"},{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5572-0150","authenticated-orcid":false,"given":"Bohan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Harbin 150030, China"},{"name":"Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China"},{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1172\/JCI129191","article-title":"Contribution of adipogenesis to healthy adipose tissue expansion in obesity","volume":"129","author":"Vishvanath","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nrm2066","article-title":"Adipocyte differentiation from the inside out","volume":"7","author":"Rosen","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.tem.2008.11.005","article-title":"New developments in adipogenesis","volume":"20","author":"Lefterova","year":"2009","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e00601-18","DOI":"10.1128\/MCB.00601-18","article-title":"Transcriptional and Epigenomic Regulation of Adipogenesis","volume":"39","author":"Lee","year":"2019","journal-title":"Mol. Cell. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.bbalip.2018.08.008","article-title":"FTO regulates adipogenesis by controlling cell cycle progression via m6A-YTHDF2 dependent mechanism","volume":"1863","author":"Wu","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrm.2016.132","article-title":"Post-transcriptional gene regulation by mRNA modifications","volume":"18","author":"Zhao","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nchembio.1432","article-title":"A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation","volume":"10","author":"Liu","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/cr.2014.3","article-title":"Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase","volume":"24","author":"Ping","year":"2014","journal-title":"Cell Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nchembio.687","article-title":"N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO","volume":"7","author":"Jia","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.molcel.2012.10.015","article-title":"ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility","volume":"49","author":"Zheng","year":"2013","journal-title":"Mol. Cell"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/nature14234","article-title":"N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions","volume":"518","author":"Liu","year":"2015","journal-title":"Nature"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"12626","DOI":"10.1038\/ncomms12626","article-title":"YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex","volume":"7","author":"Du","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/cr.2014.151","article-title":"FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis","volume":"24","author":"Zhao","year":"2014","journal-title":"Cell Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.cell.2013.10.026","article-title":"RNA-methylation-dependent RNA processing controls the speed of the circadian clock","volume":"155","author":"Fustin","year":"2013","journal-title":"Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/cr.2017.15","article-title":"YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA","volume":"27","author":"Shi","year":"2017","journal-title":"Cell Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.cell.2015.08.011","article-title":"HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing Events","volume":"162","author":"Goodarzi","year":"2015","journal-title":"Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.molcel.2016.05.041","article-title":"Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases","volume":"63","author":"Wang","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e106309","DOI":"10.15252\/embj.2020106309","article-title":"m6 A deposition is regulated by PRMT1-mediated arginine methylation of METTL14 in its disordered C-terminal region","volume":"40","author":"Wang","year":"2021","journal-title":"EMBO J."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Li, X., Tian, G., and Wu, J. (2021). Novel circGFR\u03b11 Promotes Self-Renewal of Female Germline Stem Cells Mediated by m6A Writer METTL14. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.640402"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Yang, X., Mei, C., Ma, X., Du, J., Wang, J., and Zan, L. (2022). m6A Methylases Regulate Myoblast Proliferation.; Apoptosis and Differentiation. Animals, 12.","DOI":"10.3390\/ani12060773"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/cr.2017.117","article-title":"Mettl3-\/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis","volume":"27","author":"Lin","year":"2017","journal-title":"Cell Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"9096436","DOI":"10.1155\/2022\/9096436","article-title":"METTL14 Regulates Intestine Cellular Senescence through m6A Modification of Lamin B Receptor","volume":"2022","author":"Zhang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e18085","DOI":"10.1111\/jcmm.18085","article-title":"METTL14 promotes IL-6-induced viability.; glycolysis and inflammation in HaCaT cells via the m6A modification of TRIM27","volume":"28","author":"Chen","year":"2024","journal-title":"J. Cell. Mol. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"110979","DOI":"10.1016\/j.intimp.2023.110979","article-title":"CircMETTL14(11)S upregulated METTL14 and induced CXCR4 to aggravate endothelial inflammation and atherosclerosis","volume":"126","author":"Kang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"723","DOI":"10.4049\/jimmunol.2300339","article-title":"Glycolysis Induced by METTL14 Is Essential for Macrophage Phagocytosis and Phenotype in Cervical Cancer","volume":"212","author":"Wang","year":"2024","journal-title":"J. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e00116-18","DOI":"10.1128\/MCB.00116-18","article-title":"The RNA Methyltransferase Complex of WTAP.; METTL3.; and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis","volume":"38","author":"Kobayashi","year":"2018","journal-title":"Mol. Cell. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2476531","DOI":"10.1080\/10495398.2025.2476531","article-title":"METTL14 and WTAP play a crucial role in the regulation of bovine preadipocyte differentiation","volume":"36","author":"Liu","year":"2025","journal-title":"Anim. Biotechnol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1139\/gen-2020-0129","article-title":"The chicken model organism for epigenomic research","volume":"64","author":"Beacon","year":"2021","journal-title":"Genome"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.aninu.2023.05.001","article-title":"Effect of restricted feeding on hen performance.; egg quality and organ characteristics of individual laying hens","volume":"14","author":"Anene","year":"2023","journal-title":"Anim. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/ps\/86.2.267","article-title":"Genome-wide linkage analysis to identify chromosomal regions affecting phenotypic traits in the chicken. IV. Metabolic traits","volume":"86","author":"Zhou","year":"2007","journal-title":"Poult. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1530\/REP-22-0256","article-title":"Metformin improves ovarian function and increases egg production in broiler breeder hens","volume":"165","author":"Weaver","year":"2023","journal-title":"Reproduction"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"104875","DOI":"10.1016\/j.psj.2025.104875","article-title":"EGCG improve meat quality, restore lipid metabolism disorder and regulate intestinal flora in high-fat fed broilers","volume":"104","author":"Gao","year":"2025","journal-title":"Poult. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"101193","DOI":"10.1016\/j.isci.2020.101193","article-title":"Microevolutionary Dynamics of Chicken Genomes under Divergent Selection for Adiposity","volume":"23","author":"Zhang","year":"2020","journal-title":"iScience"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"skaa408","DOI":"10.1093\/jas\/skaa408","article-title":"Whole-genome bisulfite sequencing of abdominal adipose reveals DNA methylation pattern variations in broiler lines divergently selected for fatness","volume":"99","author":"Gong","year":"2021","journal-title":"J. Anim. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0022-2275(20)32341-5","article-title":"ADD-1\/SREBP-1 is a major determinant of tissue differential lipogenic capacity in mammalian and avian species","volume":"42","author":"Gondret","year":"2001","journal-title":"J. Lipid Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.3382\/ps.2010-00863","article-title":"Comparison of adipose tissue cellularity in chicken lines divergently selected for fatness","volume":"90","author":"Guo","year":"2011","journal-title":"Poult. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Wang, W., Zhang, T., Wu, C., Wang, S., Wang, Y., Li, H., and Wang, N. (2017). Immortalization of chicken preadipocytes by retroviral transduction of chicken TERT and TR. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0177348"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e00401","DOI":"10.1042\/BSR20160049","article-title":"Cocktail supplement with rosiglitazone.; a novel inducer for chicken preadipocyte differentiation in vitro","volume":"36","author":"Cheng","year":"2016","journal-title":"Biosci. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/BF00316069","article-title":"Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with Oil red O","volume":"97","year":"1992","journal-title":"Histochemistry"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Na, W., Wang, Y., Gong, P., Zhang, X., Zhang, K., Zhang, H., Wang, N., and Li, H. (2021). Screening of Reference Genes for RT-qPCR in Chicken Adipose Tissue and Adipocytes. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.676864"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ccell.2016.11.017","article-title":"FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase","volume":"31","author":"Li","year":"2017","journal-title":"Cancer Cell"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Liu, L., Wang, Y., Liang, X., Wu, X., Liu, J., Yang, S., Tao, C., Zhang, J., Tian, J., and Zhao, J. (2020). Stearoyl-CoA Desaturase is Essential for Porcine Adipocyte Differentiation. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072446"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/age.13131","article-title":"A genome-wide association study reveals additive and dominance effects on growth and fatness traits in large white pigs","volume":"52","author":"Yang","year":"2021","journal-title":"Anim. Genet."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"C1000","DOI":"10.1152\/ajpcell.00595.2020","article-title":"Pancreatic fat cells of humans with type 2 diabetes display reduced adipogenic and lipolytic activity","volume":"320","author":"Gerst","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.stemcr.2019.05.027","article-title":"Bmi1 Suppresses Adipogenesis in the Hematopoietic Stem Cell Niche","volume":"13","author":"Hu","year":"2019","journal-title":"Stem Cell Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.2337\/db13-1604","article-title":"The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGF-\u03b2","volume":"63","author":"Craft","year":"2014","journal-title":"Diabetes"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"115793","DOI":"10.1016\/j.taap.2021.115793","article-title":"TMED3 exerts a protumor function in non-small cell lung cancer by enhancing the Wnt\/\u03b2-catenin pathway via regulation of AKT","volume":"433","author":"Zhang","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e21957","DOI":"10.1096\/fj.202100691R","article-title":"Bone-derived sclerostin and Wnt\/\u03b2-catenin signaling regulate PDGFR\u03b1+ adipoprogenitor cell differentiation","volume":"35","author":"Kim","year":"2021","journal-title":"FASEB J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41556-018-0045-z","article-title":"Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation","volume":"20","author":"Huang","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41422-018-0040-8","article-title":"Dynamic transcriptomic m6A decoration.; writers.; erasers.; readers and functions in RNA metabolism","volume":"28","author":"Yang","year":"2018","journal-title":"Cell Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s12192-019-01002-1","article-title":"Maternal heat stress regulates the early fat deposition partly through modification of m6A RNA methylation in neonatal piglets","volume":"24","author":"Heng","year":"2019","journal-title":"Cell Stress Chaperones"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12986-019-0424-x","article-title":"Excessive BCAA regulates fat metabolism partially through the modification of m6A RNA methylation in weanling piglets","volume":"17","author":"Heng","year":"2020","journal-title":"Nutr. Metab."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Hernandez-Quiles, M., Broekema, M.F., and Kalkhoven, E. (2021). PPARgamma in Metabolism.; Immunity.; and Cancer.; Unified and Diverse Mechanisms of Action. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.624112"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"6410","DOI":"10.1016\/j.psj.2020.09.086","article-title":"Peroxisome proliferator-activated receptor \u03b3 isoforms differentially regulate preadipocyte proliferation.; apoptosis.; and differentiation in chickens","volume":"99","author":"Mu","year":"2020","journal-title":"Poult. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4161\/org.6.1.10226","article-title":"A chromatin perspective of adipogenesis","volume":"6","author":"Musri","year":"2010","journal-title":"Organogenesis"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s12020-019-02157-8","article-title":"Exogenous FABP4 interferes with differentiation, promotes lipolysis and inflammation in adipocytes","volume":"67","author":"Dou","year":"2020","journal-title":"Endocrine"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev.bi.64.070195.002021","article-title":"Transcriptional regulation of gene expression during adipocyte differentiation","volume":"64","author":"MacDougald","year":"1995","journal-title":"Annu. Rev. Biochem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1152\/physrev.1998.78.3.783","article-title":"Understanding adipocyte differentiation","volume":"78","author":"Gregoire","year":"1998","journal-title":"Physiol. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41556-021-00656-3","article-title":"m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype","volume":"23","author":"Liu","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.molcel.2022.02.006","article-title":"Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis","volume":"82","author":"Xu","year":"2022","journal-title":"Mol. Cell"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.molcel.2012.01.002","article-title":"PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes","volume":"45","author":"Gao","year":"2012","journal-title":"Mol. Cell"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e1953","DOI":"10.1038\/cddis.2015.255","article-title":"miR-300 mediates Bmi1 function and regulates differentiation in primitive cardiac progenitors","volume":"6","author":"Cruz","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1128\/MCB.00981-10","article-title":"BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair","volume":"31","author":"Ginjala","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1101\/gad.13.20.2678","article-title":"Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a\/ARF","volume":"13","author":"Jacobs","year":"1999","journal-title":"Genes Dev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1359\/jbmr.090812","article-title":"Defects in mesenchymal stem cell self-renewal and cell fate determination lead to an osteopenic phenotype in Bmi-1 null mice","volume":"25","author":"Zhang","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/embor.2011.165","article-title":"A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion","volume":"12","author":"Port","year":"2011","journal-title":"EMBO Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/0888-7543(95)80004-6","article-title":"Characterization of the human gene for microfibril-associated glycoprotein (MFAP2), assignment to chromosome 1p36.1-p35, and linkage to D1S170","volume":"25","author":"Faraco","year":"1995","journal-title":"Genomics"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2018.02.022","article-title":"Contribution of metabolic disease to bone fragility in MAGP1-deficient mice","volume":"67","author":"Turecamo","year":"2018","journal-title":"Matrix Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4394","DOI":"10.1111\/febs.14680","article-title":"MAGP-1 and fibronectin control EGFL7 functions by driving its deposition into distinct endothelial extracellular matrix locations","volume":"285","author":"Villain","year":"2018","journal-title":"FEBS J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1111\/jcmm.17884","article-title":"MFAP2 promotes HSCs activation through FBN1\/TGF-\u03b2\/Smad3 pathway","volume":"27","author":"Sun","year":"2023","journal-title":"J. Cell. Mol. Med."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Walji, T.A., Turecamo, S.E., Sanchez, A.C., Anthony, B.A., Abou-Ezzi, G., Scheller, E.L., Link, D.C., Mecham, R.P., and Craft, C.S. (2016). Marrow Adipose Tissue Expansion Coincides with Insulin Resistance in MAGP1-Deficient Mice. Front. Endocrinol., 7.","DOI":"10.3389\/fendo.2016.00087"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/19\/1761\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T08:30:59Z","timestamp":1790584259000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/19\/1761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,27]]},"references-count":71,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["cells15191761"],"URL":"https:\/\/doi.org\/10.3390\/cells15191761","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,27]]}}}