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Although accumulating evidence has implicated BAP31 in tumor progression and immune regulation, its role in immune evasion in cervical cancer remains poorly understood. In this study, we found that BAP31 was significantly upregulated in cervical cancer tissues and that elevated BAP31 expression was associated with poor patient prognosis. Functional assays demonstrated that BAP31 silencing restored the immune activity of dendritic cells. Mechanistically, BAP31 was found to regulate TGF-\u03b2 at the post-transcriptional level and to facilitate its transport from the endoplasmic reticulum to the Golgi apparatus through an interaction involving the Asn-381 residue, thereby affecting its intracellular maturation and extracellular secretion. Additional functional analyses showed that exogenous TGF-\u03b2 impaired dendritic cell maturation and migration while enhancing phagocytic activity. Collectively, these findings indicate that BAP31 regulation of TGF-\u03b2 contributes to dendritic cell dysfunction and the establishment of an immunosuppressive microenvironment in cervical cancer.<\/jats:p>","DOI":"10.3390\/cells15191765","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T08:18:46Z","timestamp":1790583526000},"page":"1765","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["BAP31 Facilitates TGF-\u03b2 Trafficking and Secretion and Promotes Dendritic Cell Dysfunction in Cervical Cancer"],"prefix":"10.3390","volume":"15","author":[{"given":"Lin","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Immunology, Air Force Medical University, No. 169 Changle West Road, Xi\u2019an 710032, China"},{"name":"Yan\u2019an Key Laboratory of Microbial Drug Innovation and Transformation, School of Basic Medicine, Yan\u2019an University, Yan\u2019an 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