{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:55:38Z","timestamp":1792605338663,"version":"4.5.0"},"reference-count":194,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T00:00:00Z","timestamp":1400803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Transient receptor potential vanilloid 1 (TRPV1) is an ion channel present on sensory neurons which is activated by heat, protons, capsaicin and a variety of endogenous lipids termed endovanilloids. As such, TRPV1 serves as a multimodal sensor of noxious stimuli which could trigger counteractive measures to avoid pain and injury. Activation of TRPV1 has been linked to chronic inflammatory pain conditions and peripheral neuropathy, as observed in diabetes. Expression of TRPV1 is also observed in non-neuronal sites such as the epithelium of bladder and lungs and in hair cells of the cochlea. At these sites, activation of TRPV1 has been implicated in the pathophysiology of diseases such as cystitis, asthma and hearing loss. Therefore, drugs which could modulate TRPV1 channel activity could be useful for the treatment of conditions ranging from chronic pain to hearing loss. This review describes the roles of TRPV1 in the normal physiology and pathophysiology of selected organs of the body and highlights how drugs targeting this channel could be important clinically.<\/jats:p>","DOI":"10.3390\/cells3020517","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T12:46:27Z","timestamp":1400849187000},"page":"517-545","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":161,"title":["TRPV1: A Potential Drug Target for Treating Various Diseases"],"prefix":"10.3390","volume":"3","author":[{"given":"Rafael","family":"Brito","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Neuroscience, Southern Illinois University School of Medicine, Springfield, IL 62702, USA"},{"name":"Department of Neurobiology and Program of Neurosciences, Institute of Biology, Fluminense Federal University, Niteroi 24020141, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6570-8120","authenticated-orcid":false,"given":"Sandeep","family":"Sheth","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Neuroscience, Southern Illinois University School of Medicine, Springfield, IL 62702, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debashree","family":"Mukherjea","sequence":"additional","affiliation":[{"name":"Department of Surgery (Otoloryngalogy), Southern Illinois University School of Medicine, Springfield, IL 62702, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Rybak","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Neuroscience, Southern Illinois University School of Medicine, Springfield, IL 62702, USA"},{"name":"Department of Surgery (Otoloryngalogy), Southern Illinois University School of Medicine, Springfield, IL 62702, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickram","family":"Ramkumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Neuroscience, Southern Illinois University School of Medicine, Springfield, IL 62702, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev.neuro.24.1.487","article-title":"The vanilloid receptor: A molecular gateway to the pain pathway","volume":"24","author":"Caterina","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0031-6997(25)06664-5","article-title":"Capsaicin: Cellular targets, mechanisms of action, and selectivity for thin sensory neurons","volume":"43","author":"Holzer","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: A heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1073\/pnas.97.7.3655","article-title":"Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human","volume":"97","author":"Mezey","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.brainres.2003.10.001","article-title":"[3H]Resiniferatoxin autoradiography in the CNS of wild-type and TRPV1 null mice defines TRPV1 (VR-1) protein distribution","volume":"995","author":"Roberts","year":"2004","journal-title":"Brain Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1111\/j.1432-1033.2004.04081.x","article-title":"Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels","volume":"271","year":"2004","journal-title":"Eur. J. Biochem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/22761","article-title":"Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide","volume":"400","author":"Zygmunt","year":"1999","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/sj.bjp.0705467","article-title":"Anandamide and vanilloid TRPV1 receptors","volume":"140","author":"Ross","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1124\/jpet.102.043893","article-title":"Endocannabinoids induce ileitis in rats via the capsaicin receptor (VR1)","volume":"304","author":"McVey","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1046\/j.1471-4159.2003.01595.x","article-title":"Compounds acting at the endocannabinoid and\/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington\u2019s disease","volume":"84","author":"Makriyannis","year":"2003","journal-title":"J. Neurochem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/syn.10054","article-title":"Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington\u2019s disease","volume":"44","author":"Hansen","year":"2002","journal-title":"Synapse"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.lfs.2007.12.022","article-title":"Actions of 3-methyl-N-oleoyldopamine, 4-methyl-N-oleoyldopamine and N-oleoylethanolamide on the rat TRPV1 receptor in vitro and in vivo","volume":"82","author":"Almasi","year":"2008","journal-title":"Life Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1113\/jphysiol.2004.081844","article-title":"Oleoylethanolamide excites vagal sensory neurones, induces visceral pain and reduces short-term food intake in mice via capsaicin receptor TRPV1","volume":"564","author":"Wang","year":"2005","journal-title":"J. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0024-3205(03)00310-2","article-title":"Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat","volume":"73","author":"Toth","year":"2003","journal-title":"Life Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"8400","DOI":"10.1073\/pnas.122196999","article-title":"An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors","volume":"99","author":"Huang","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0014-2999(03)02114-9","article-title":"Capsaicin-like effects of N-arachidonoyl-dopamine in the isolated guinea pig bronchi and urinary bladder","volume":"475","author":"Harrison","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"13633","DOI":"10.1074\/jbc.M211231200","article-title":"N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia","volume":"278","author":"Chu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainresrev.2006.02.002","article-title":"Cyclooxygenases, lipoxygenases, and epoxygenasesin CNS: Their role and involvement in neurological disorders","volume":"52","author":"Phillis","year":"2006","journal-title":"Brain Res. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"6155","DOI":"10.1073\/pnas.97.11.6155","article-title":"Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances","volume":"97","author":"Hwang","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"10150","DOI":"10.1073\/pnas.152002699","article-title":"Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia","volume":"99","author":"Shin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"6721","DOI":"10.1073\/pnas.1110460109","article-title":"Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors","volume":"109","author":"Gregus","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1113\/jphysiol.2013.251751","article-title":"The role of endogenous molecules in modulating pain through transient receptor potential vanilloid 1 (TRPV1)","volume":"591","author":"Simon","year":"2013","journal-title":"J. Physiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1124\/mol.109.055624","article-title":"Pharmacology of vanilloid transient receptor potential cation channels","volume":"75","author":"Vriens","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.neuron.2007.05.027","article-title":"The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity","volume":"54","author":"Lishko","year":"2007","journal-title":"Neuron"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/35050121","article-title":"Induction of vanilloid receptor channel activity by protein kinase C","volume":"408","author":"Premkumar","year":"2000","journal-title":"Nature"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"6951","DOI":"10.1073\/pnas.111025298","article-title":"Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia","volume":"98","author":"Tominaga","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/35093019","article-title":"Molecular mechanisms of nociception","volume":"413","author":"Julius","year":"2001","journal-title":"Nature"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1523\/JNEUROSCI.4901-08.2009","article-title":"TRPV1 is activated by both acidic and basic pH","volume":"29","author":"Dhaka","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"8991","DOI":"10.1074\/jbc.M513429200","article-title":"Polyamines are potent ligands for the capsaicin receptor TRPV1","volume":"281","author":"Ahern","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1152\/jn.1978.41.2.509","article-title":"Comparison of responses of warm and nociceptive C-fiber afferents in monkey with human judgments of thermal pain","volume":"41","author":"LaMotte","year":"1978","journal-title":"J. Neurophysiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1113\/jphysiol.1995.sp020766","article-title":"Response of C fibre nociceptors in the anaesthetized monkey to heat stimuli: Estimates of receptor depth and threshold","volume":"485Pt 3","author":"Tillman","year":"1995","journal-title":"J. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"15435","DOI":"10.1073\/pnas.93.26.15435","article-title":"A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin","volume":"93","author":"Cesare","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"7006","DOI":"10.1073\/pnas.94.13.7006","article-title":"Heat transduction in rat sensory neurons by calcium-dependent activation of a cation channel","volume":"94","author":"Reichling","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0896-6273(00)80564-4","article-title":"The cloned capsaicin receptor integrates multiple pain-producing stimuli","volume":"21","author":"Tominaga","year":"1998","journal-title":"Neuron"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/cne.20794","article-title":"Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta\/c-fibers and colocalization with trk receptors","volume":"493","author":"Kobayashi","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1126\/science.288.5464.306","article-title":"Impaired nociception and pain sensation in mice lacking the capsaicin receptor","volume":"288","author":"Caterina","year":"2000","journal-title":"Science"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/35012076","article-title":"Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia","volume":"405","author":"Davis","year":"2000","journal-title":"Nature"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/j.pain.2012.04.034","article-title":"TRPV1 is important for mechanical and heat sensitivity in uninjured animals and development of heat hypersensitivity after muscle inflammation","volume":"153","author":"Walder","year":"2012","journal-title":"Pain"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"17160","DOI":"10.1523\/JNEUROSCI.1048-13.2013","article-title":"Dynamic and permissive roles of TRPV1 and TRPV4 channels for thermosensation in mouse supraoptic magnocellular neurosecretory neurons","volume":"33","author":"Sudbury","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1002\/jcp.22514","article-title":"Thermosensitive transient receptor potential channels in human corneal epithelial cells","volume":"226","author":"Mergler","year":"2011","journal-title":"J. Cell Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0079-6123(08)61084-5","article-title":"Modification of nociceptor responses by inflammatory mediators and second messengers implicated in their action\u2014A study in canine testicular polymodal receptors","volume":"113","author":"Mizumura","year":"1996","journal-title":"Prog. Brain Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0959-437X(99)80049-5","article-title":"Pain","volume":"9","author":"Wood","year":"1999","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1126\/science.288.5472.1765","article-title":"Neuronal plasticity: Increasing the gain in pain","volume":"288","author":"Woolf","year":"2000","journal-title":"Science"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1523\/JNEUROSCI.5679-03.2004","article-title":"Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia","volume":"24","author":"Amadesi","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1523\/JNEUROSCI.0454-04.2004","article-title":"Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain","volume":"24","author":"Dai","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1744-8069-1-3","article-title":"Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins","volume":"1","author":"Moriyama","year":"2005","journal-title":"Mol. Pain"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.1523\/JNEUROSCI.23-14-06058.2003","article-title":"Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity","volume":"23","author":"Moriyama","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1152\/jn.2002.88.1.544","article-title":"Bradykinin lowers the threshold temperature for heat activation of vanilloid receptor 1","volume":"88","author":"Sugiura","year":"2002","journal-title":"J. Neurophysiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"12480","DOI":"10.1073\/pnas.2032100100","article-title":"Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)","volume":"100","author":"Bhave","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"13375","DOI":"10.1074\/jbc.C200104200","article-title":"Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues","volume":"277","author":"Numazaki","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"14709","DOI":"10.1523\/JNEUROSCI.1634-12.2012","article-title":"Cyclin-dependent kinase 5 controls TRPV1 membrane trafficking and the heat sensitivity of nociceptors through KIF13B","volume":"32","author":"Xing","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"7279","DOI":"10.1074\/jbc.M111.305045","article-title":"Heteromeric heat-sensitive transient receptor potential channels exhibit distinct temperature and chemical response","volume":"287","author":"Cheng","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/978-3-540-79090-7_9","article-title":"Acid-sensitive ion channels and receptors","volume":"194","author":"Holzer","year":"2009","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev-cellbio-101011-155833","article-title":"TRP channels and pain","volume":"29","author":"Julius","year":"2013","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.neuroscience.2005.12.020","article-title":"The role of the capsaicin receptor TRPV1 and acid-sensing ion channels (ASICS) in proton sensitivity of subpopulations of primary nociceptive neurons in rats and mice","volume":"139","author":"Leffler","year":"2006","journal-title":"Neuroscience"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"C1768","DOI":"10.1152\/ajpcell.00440.2006","article-title":"Mouse colon sensory neurons detect extracellular acidosis via TRPV1","volume":"292","author":"Sugiura","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1161\/01.RES.0000238388.79295.4c","article-title":"Sustained currents through ASIC3 ion channels at the modest pH changes that occur during myocardial ischemia","volume":"99","author":"Yagi","year":"2006","journal-title":"Circ. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00424-005-1423-5","article-title":"Functional aspects and mechanisms of TRPV1 involvement in neurogenic inflammation that leads to thermal hyperalgesia","volume":"451","year":"2005","journal-title":"Pflugers Arch."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1046\/j.0953-816x.2001.01591.x","article-title":"VR1 protein expression increases in undamaged DRG neurons after partial nerve injury","volume":"13","author":"Hudson","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0896-6273(02)00908-X","article-title":"p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia","volume":"36","author":"Ji","year":"2002","journal-title":"Neuron"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/366072a0","article-title":"Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice","volume":"366","author":"Tisch","year":"1993","journal-title":"Nature"},{"key":"ref_62","first-page":"140","article-title":"Genetic and immunological basis of autoimmune diabetes in the NOD mouse","volume":"2","author":"Yoshida","year":"2000","journal-title":"Rev. Immunogenet."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.4049\/jimmunol.166.4.2831","article-title":"Type I diabetes and multiple sclerosis patients target islet plus central nervous system autoantigens; nonimmunized nonobese diabetic mice can develop autoimmune encephalitis","volume":"166","author":"Winer","year":"2001","journal-title":"J. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/nm818","article-title":"Autoimmune islet destruction in spontaneous type 1 diabetes is not beta-cell exclusive","volume":"9","author":"Winer","year":"2003","journal-title":"Nat. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/270741a0","article-title":"Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones","volume":"270","author":"Jancso","year":"1977","journal-title":"Nature"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.cell.2006.10.038","article-title":"TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes","volume":"127","author":"Razavi","year":"2006","journal-title":"Cell"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"5120","DOI":"10.1073\/pnas.0407780102","article-title":"Immunological role of neuronal receptor vanilloid receptor 1 expressed on dendritic cells","volume":"102","author":"Basu","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.febslet.2013.03.027","article-title":"Transient receptor potential vanilloid-2 mediates the effects of transient heat shock on endocytosis of human monocyte-derived dendritic cells","volume":"587","author":"Szollosi","year":"2013","journal-title":"FEBS Lett."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.febslet.2009.04.031","article-title":"Transient receptor potential vanilloid-1 signaling inhibits differentiation and activation of human dendritic cells","volume":"583","author":"Toth","year":"2009","journal-title":"FEBS Lett."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1016\/j.febslet.2005.08.023","article-title":"Dendritic cells do not transduce inflammatory stimuli via the capsaicin receptor TRPV1","volume":"579","author":"Pingle","year":"2005","journal-title":"FEBS Lett."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.bbrc.2004.06.149","article-title":"Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet beta cells modulates insulin secretion in rats","volume":"321","author":"Akiba","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_72","first-page":"17","article-title":"Sensitization and translocation of TRPV1 by insulin and IGF-I","volume":"1","author":"Bhat","year":"2005","journal-title":"Mol. Pain"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1074\/jbc.M408500200","article-title":"Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1","volume":"280","author":"Hong","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1744-8069-4-9","article-title":"Influence of TRPV1 on diabetes-induced alterations in thermal pain sensitivity","volume":"4","author":"Pabbidi","year":"2008","journal-title":"Mol. Pain"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1365-2559.2007.02851.x","article-title":"Epidermal transient receptor potential vanilloid 1 in idiopathic small nerve fibre disease, diabetic neuropathy and healthy human subjects","volume":"51","author":"Ong","year":"2007","journal-title":"Histopathology"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2377-7-11","article-title":"Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy","volume":"7","author":"Facer","year":"2007","journal-title":"BMC Neurol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1161\/01.CIR.102.1.42","article-title":"Chronic subclinical inflammation as part of the insulin resistance syndrome: The Insulin Resistance Atherosclerosis Study (IRAS)","volume":"102","author":"Festa","year":"2000","journal-title":"Circulation"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/aje\/155.1.65","article-title":"Associations of serum C-reactive protein with fasting insulin, glucose, and glycosylated hemoglobin: The Third National Health and Nutrition Examination Survey, 1988\u20131994","volume":"155","author":"Wu","year":"2002","journal-title":"Am. J. Epidemiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1089\/dia.2007.0204","article-title":"Indicators for the efficacy of pioglitazone before and during treatment in Japanese patients with type 2 diabetes","volume":"9","author":"Tajiri","year":"2007","journal-title":"Diabetes Technol. Ther."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1530\/eje.1.02046","article-title":"Plasma calcitonin gene-related peptide is increased prior to obesity, and sensory nerve desensitization by capsaicin improves oral glucose tolerance in obese Zucker rats","volume":"153","author":"Gram","year":"2005","journal-title":"Eur. J. Endocrinol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/j.1550-8528.1995.tb00159.x","article-title":"Resistance to aging-associated obesity in capsaicin-desensitized rats one year after treatment","volume":"3","author":"Melnyk","year":"1995","journal-title":"Obes. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1210\/endo-119-2-865","article-title":"Calcitonin gene-related peptide: Occurrence in pancreatic islets in the mouse and the rat and inhibition of insulin secretion in the mouse","volume":"119","author":"Pettersson","year":"1986","journal-title":"Endocrinology"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1460-9568.2006.05261.x","article-title":"Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes","volume":"25","author":"Gram","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/sj.ijo.0802862","article-title":"Sensory and gastrointestinal satiety effects of capsaicin on food intake","volume":"29","author":"Smeets","year":"2005","journal-title":"Int. J. Obes."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/sj.ijo.0803351","article-title":"Body fat loss achieved by stimulation of thermogenesis by a combination of bioactive food ingredients: A placebo-controlled, double-blind 8-week intervention in obese subjects","volume":"31","author":"Belza","year":"2007","journal-title":"Int. J. Obes."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/sj.ki.5002434","article-title":"Ototoxicity","volume":"72","author":"Rybak","year":"2007","journal-title":"Kidney Int."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1097\/00005537-199911000-00003","article-title":"Application of antioxidants and other agents to prevent cisplatin ototoxicity","volume":"109","author":"Rybak","year":"1999","journal-title":"Laryngoscope"},{"key":"ref_88","first-page":"559","article-title":"Use of organotypic cultures of Corti\u2019s organ to study the protective effects of antioxidant molecules on cisplatin-induced damage of auditory hair cells","volume":"18","author":"Kopke","year":"1997","journal-title":"Am. J. Otol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1152\/jn.00919.2002","article-title":"Vanilloid receptors in hearing: Altered cochlear sensitivity by vanilloids and expression of TRPV1 in the organ of corti","volume":"90","author":"Zheng","year":"2003","journal-title":"J. Neurophysiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.neuroscience.2003.12.030","article-title":"Co-localization of the vanilloid capsaicin receptor and substance P in sensory nerve fibers innervating cochlear and vertebro-basilar arteries","volume":"124","author":"Vass","year":"2004","journal-title":"Neuroscience"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.heares.2010.10.010","article-title":"Effect of capsaicin on potassium conductance and electromotility of the guinea pig outer hair cell","volume":"272","author":"Wu","year":"2011","journal-title":"Hear. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.heares.2006.02.013","article-title":"Effect of intracochlear perfusion of vanilloids on cochlear neural activity in the guinea pig","volume":"218","author":"Zhou","year":"2006","journal-title":"Hear. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"4054","DOI":"10.1523\/JNEUROSCI.23-10-04054.2003","article-title":"Lighting up the senses: FM1\u201343 loading of sensory cells through nonselective ion channels","volume":"23","author":"Meyers","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.heares.2005.02.005","article-title":"TRPV1 regulators mediate gentamicin penetration of cultured kidney cells","volume":"204","author":"Myrdal","year":"2005","journal-title":"Hear. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1038\/emm.2013.25","article-title":"Different uptake of gentamicin through TRPV1 and TRPV4 channels determines cochlear hair cell vulnerability","volume":"45","author":"Lee","year":"2013","journal-title":"Exp. Mol. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"13056","DOI":"10.1523\/JNEUROSCI.1307-08.2008","article-title":"Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat","volume":"28","author":"Mukherjea","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1089\/ars.2010.3497","article-title":"NOX3 NADPH oxidase couples transient receptor potential vanilloid 1 to signal transducer and activator of transcription 1-mediated inflammation and hearing loss","volume":"14","author":"Mukherjea","year":"2011","journal-title":"Antioxid Redox Signal."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.heares.2004.09.007","article-title":"Changes in transient receptor potential cation channel superfamily V (TRPV) mRNA expression in the mouse inner ear ganglia after kanamycin challenge","volume":"201","author":"Kitahara","year":"2005","journal-title":"Hear. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1080\/00016480802032835","article-title":"Changes in transient receptor potential vanilloid (TRPV) 1, 2, 3 and 4 expression in mouse inner ear following gentamicin challenge","volume":"129","author":"Ishibashi","year":"2009","journal-title":"Acta Oto-Laryngol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.neuroscience.2009.11.048","article-title":"Behavioral assessment and identification of a molecular marker in a salicylate-induced tinnitus in rats","volume":"165","author":"Kizawa","year":"2010","journal-title":"Neuroscience"},{"key":"ref_101","first-page":"21","article-title":"Acoustic injury and TRPV1 expression in the cochlear spiral ganglion","volume":"13","author":"Bauer","year":"2007","journal-title":"Int. Tinnitus J."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e180","DOI":"10.1038\/cddis.2011.63","article-title":"Short interfering RNA against STAT1 attenuates cisplatin-induced ototoxicity in the rat by suppressing inflammation","volume":"2","author":"Kaur","year":"2011","journal-title":"Cell Death. Dis."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-0115(01)00285-3","article-title":"Tachykinins as modulators of the micturition reflex in the central and peripheral nervous system","volume":"101","author":"Lecci","year":"2001","journal-title":"Regul. Pept."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1046\/j.1464-410x.2001.02190.x","article-title":"Capsaicin receptor VR1 and ATP-gated ion channel P2X3 in human urinary bladder","volume":"87","author":"Yiangou","year":"2001","journal-title":"BJU Int."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0022-5347(17)38701-3","article-title":"Cystometric evidence that capsaicin-sensitive nerves modulate the afferent branch of micturition reflex in humans","volume":"142","author":"Maggi","year":"1989","journal-title":"J. Urol."},{"key":"ref_106","first-page":"77","article-title":"The dual function of capsaicin-sensitive sensory nerves in the bladder and urethra","volume":"151","author":"Maggi","year":"1990","journal-title":"Ciba. Found. Symp."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"PL221","DOI":"10.1016\/0024-3205(93)90051-4","article-title":"Characterization of a peripheral vanilloid (capsaicin) receptor in the urinary bladder of the rat","volume":"52","author":"Szallasi","year":"1993","journal-title":"Life Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0306-4522(01)00496-1","article-title":"Vanilloid receptor 1 expression in the rat urinary tract","volume":"109","author":"Avelino","year":"2002","journal-title":"Neuroscience"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"13396","DOI":"10.1073\/pnas.231243698","article-title":"Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells","volume":"98","author":"Birder","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.urology.2004.10.007","article-title":"Capsaicin receptor TRPV1 in urothelium of neurogenic human bladders and effect of intravesical resiniferatoxin","volume":"65","author":"Apostolidis","year":"2005","journal-title":"Urology"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1111\/j.1464-410X.2009.08658.x","article-title":"Sex differences in the expression profile of acid-sensing ion channels in the mouse urinary bladder: A possible involvement in irritative bladder symptoms","volume":"104","author":"Kobayashi","year":"2009","journal-title":"BJU Int."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.eururo.2005.05.018","article-title":"Transient receptor potential vanilloid type 1 (TRPV1) expression changes from normal urothelium to transitional cell carcinoma of human bladder","volume":"48","author":"Lazzeri","year":"2005","journal-title":"Eur. Urol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"F396","DOI":"10.1152\/ajprenal.00127.2013","article-title":"Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium","volume":"305","author":"Shabir","year":"2013","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"F49","DOI":"10.1152\/ajprenal.00349.2010","article-title":"Expression and distribution of transient receptor potential (TRP) channels in bladder epithelium","volume":"300","author":"Yu","year":"2011","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0022-5347(05)64910-5","article-title":"Topography of the vanilloid receptor in the human bladder: More than just the nerve fibers","volume":"168","author":"Ost","year":"2002","journal-title":"J. Urol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1097\/01.ju.0000108120.28291.eb","article-title":"Electrical characteristics of suburothelial cells isolated from the human bladder","volume":"171","author":"Sui","year":"2004","journal-title":"J. Urol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"F692","DOI":"10.1152\/ajprenal.00599.2009","article-title":"Functional characterization of transient receptor potential channels in mouse urothelial cells","volume":"298","author":"Everaerts","year":"2010","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1369\/jhc.2008.951962","article-title":"Differential localizations of the transient receptor potential channels TRPV4 and TRPV1 in the mouse urinary bladder","volume":"57","author":"Yamada","year":"2009","journal-title":"J. Histochem. Cytochem."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1113\/jphysiol.2007.139147","article-title":"Bladder afferent sensitivity in wild-type and TRPV1 knockout mice","volume":"583","author":"Daly","year":"2007","journal-title":"J. Physiol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.juro.2009.03.085","article-title":"Selective pharmacological blockade of the TRPV1 receptor suppresses sensory reflexes of the rodent bladder","volume":"182","author":"Cefalu","year":"2009","journal-title":"J. Urol."},{"key":"ref_121","first-page":"R786","article-title":"Effect of capsaicin on the micturition reflex in normal and chronic spinal cord-injured cats","volume":"277","author":"Cheng","year":"1999","journal-title":"Am. J. Physiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0006-8993(95)00212-9","article-title":"Effect of capsaicin on micturition and associated reflexes in chronic spinal rats","volume":"678","author":"Cheng","year":"1995","journal-title":"Brain Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.autneu.2011.09.005","article-title":"Rat detrusor overactivity induced by chronic spinalization can be abolished by a transient receptor potential vanilloid 1 (TRPV1) antagonist","volume":"166","author":"Charrua","year":"2012","journal-title":"Autono. Neurosci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/00005392-199907000-00002","article-title":"Intravesical capsaicin and resiniferatoxin therapy: Spicing up the ways to treat the overactive bladder","volume":"162","author":"Chancellor","year":"1999","journal-title":"J. Urol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1748-1716.2012.02462.x","article-title":"Alteration in TRPV1 and Muscarinic (M3) receptor expression and function in idiopathic overactive bladder urothelial cells","volume":"207","author":"Birder","year":"2013","journal-title":"Acta Physiol. (Oxf.)"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/bph.12467","article-title":"Role of CXCR2 and TRPV1 in functional, inflammatory and behavioural changes in the rat model of cyclophosphamide-induced haemorrhagic cystitis","volume":"171","author":"Dornelles","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.pain.2008.03.020","article-title":"Lack of TRPV1 inhibits cystitis-induced increased mechanical sensitivity in mice","volume":"139","author":"Wang","year":"2008","journal-title":"Pain"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1152\/jn.00945.2012","article-title":"Cyclophosphamide-induced cystitis reduces ASIC channel but enhances TRPV1 receptor function in rat bladder sensory neurons","volume":"110","author":"Dang","year":"2013","journal-title":"J. Neurophysiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/j.juro.2013.05.049","article-title":"Increased mRNA expression of genes involved in pronociceptive inflammatory reactions in bladder tissue of interstitial cystitis","volume":"190","author":"Homma","year":"2013","journal-title":"J. Urol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.neuroscience.2006.04.073","article-title":"Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system","volume":"141","author":"Watanabe","year":"2006","journal-title":"Neuroscience"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1007\/s12272-012-1016-8","article-title":"Quantitative analysis of TRP channel genes in mouse organs","volume":"35","author":"Jang","year":"2012","journal-title":"Arch. Pharm. Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/1471-2164-7-159","article-title":"Tissue-specific expression of TRP channel genes in the mouse and its variation in three different mouse strains","volume":"7","author":"Bisping","year":"2006","journal-title":"BMC Genomics"},{"key":"ref_133","first-page":"A6410","article-title":"The role of TRPV1 in tobacco smoke induced airway inflammatiom","volume":"185","author":"Baxter","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1465-9921-13-26","article-title":"Transient receptor potential genes, smoking, occupational exposures and cough in adults","volume":"13","author":"Smit","year":"2012","journal-title":"Respir. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"27532","DOI":"10.1074\/jbc.C110.159491","article-title":"Loss of function of transient receptor potential vanilloid 1 (TRPV1) genetic variant is associated with lower risk of active childhood asthma","volume":"285","author":"Gonzalez","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1745-9974-2-10","article-title":"TRPV1 antagonists attenuate antigen-provoked cough in ovalbumin sensitized guinea pigs","volume":"2","author":"McLeod","year":"2006","journal-title":"Cough"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1136\/thx.2003.012930","article-title":"Antitussive activity of iodo-resiniferatoxin in guinea pigs","volume":"59","author":"Trevisani","year":"2004","journal-title":"Thorax"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1124\/jpet.107.127258","article-title":"Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs","volume":"323","author":"Bhattacharya","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1152\/jappl.1995.79.4.1082","article-title":"Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs","volume":"79","author":"Lalloo","year":"1995","journal-title":"J. Appl. Physiol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1136\/thorax.55.8.643","article-title":"Capsaicin responsiveness and cough in asthma and chronic obstructive pulmonary disease","volume":"55","author":"Doherty","year":"2000","journal-title":"Thorax"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2332\/allergolint.55.149","article-title":"Cough sensitivity in pure cough variant asthma elicited using continuous capsaicin inhalation","volume":"55","author":"Nakajima","year":"2006","journal-title":"Allergol. Int."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0954-6111(96)90099-2","article-title":"Capsaicin cough sensitivity increases during upper respiratory infection","volume":"90","author":"Thomas","year":"1996","journal-title":"Respir. Med."},{"key":"ref_143","first-page":"557","article-title":"Cough reflex sensitivity testing in in seasonal allergic rhinitis patients and healthy volunteers","volume":"59","author":"Pecova","year":"2008","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_144","first-page":"289","article-title":"Testing of cough reflex sensitivity in children suffering from allergic rhinitis and common cold","volume":"57","author":"Plevkova","year":"2006","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1164\/rccm.200402-174OC","article-title":"Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough","volume":"170","author":"Groneberg","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/01902140590918803","article-title":"Expression and characterization of the intracellular vanilloid receptor (TRPV1) in bronchi from patients with chronic cough","volume":"31","author":"Mitchell","year":"2005","journal-title":"Exp. Lung Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1164\/ajrccm.165.8.2108065","article-title":"Expression of tachykinins in nonnociceptive vagal afferent neurons during respiratory viral infection in guinea pigs","volume":"165","author":"Carr","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.pupt.2006.12.001","article-title":"Animal models of cough: Literature review and presentation of a novel cigarette smoke-enhanced cough model in the guinea-pig","volume":"20","author":"Lewis","year":"2007","journal-title":"Pulm. Pharmacol. Ther."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"L941","DOI":"10.1152\/ajplung.00366.2011","article-title":"TRPV1 induction in airway vagal low-threshold mechanosensory neurons by allergen challenge and neurotrophic factors","volume":"302","author":"Lieu","year":"2012","journal-title":"Am. J. Physiol. Lung. Cell Mol. Physiol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"L775","DOI":"10.1152\/ajplung.00353.2001","article-title":"Allergic inflammation-induced neuropeptide production in rapidly adapting afferent nerves in guinea pig airways","volume":"282","author":"Myers","year":"2002","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3109\/01902148.2010.540768","article-title":"Cough reflex sensitivity is increased in guinea pigs with parainfluenza virus infection","volume":"37","author":"Ye","year":"2011","journal-title":"Exp. Lung Res."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.1113\/jphysiol.2008.161042","article-title":"Altered expression of TRPV1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway inflammation in the rat","volume":"586","author":"Zhang","year":"2008","journal-title":"J. Physiol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"569","DOI":"10.2165\/00003495-200767040-00006","article-title":"Diabetic painful neuropathy: Current and future treatment options","volume":"67","author":"Chong","year":"2007","journal-title":"Drugs"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"737","DOI":"10.2165\/00002512-200118100-00003","article-title":"Management of painful diabetic neuropathy","volume":"18","author":"Jensen","year":"2001","journal-title":"Drugs Aging"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"417","DOI":"10.2165\/00023210-200822050-00005","article-title":"An update on the pharmacological management of post-herpetic neuralgia and painful diabetic neuropathy","volume":"22","author":"Zin","year":"2008","journal-title":"CNS Drugs"},{"key":"ref_156","first-page":"S8","article-title":"Management strategies for herpes zoster and postherpetic neuralgia","volume":"107","author":"Galluzzi","year":"2007","journal-title":"J. Am. Osteopath. Assoc."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.2174\/156802608786264254","article-title":"Recent progress in the development of selective TRPV1 antagonists for pain","volume":"8","author":"Broad","year":"2008","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.2174\/138161209787581995","article-title":"Vanilloid receptor antagonists: Emerging class of novel anti-inflammatory agents for pain management","volume":"15","author":"Pal","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.brainresrev.2008.12.006","article-title":"Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks","volume":"60","author":"Wong","year":"2009","journal-title":"Brain Res. Rev."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1021\/jm00039a006","article-title":"The discovery of capsazepine, the first competitive antagonist of the sensory neuron excitants capsaicin and resiniferatoxin","volume":"37","author":"Walpole","year":"1994","journal-title":"J. Med. Chem."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/j.1476-5381.1992.tb12781.x","article-title":"Capsazepine: A competitive antagonist of the sensory neurone excitant capsaicin","volume":"107","author":"Bevan","year":"1992","journal-title":"Br. J. Pharmacol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0304-3940(97)00358-3","article-title":"Capsazepine, a vanilloid receptor antagonist, inhibits nicotinic acetylcholine receptors in rat trigeminal ganglia","volume":"228","author":"Liu","year":"1997","journal-title":"Neurosci. Lett."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/sj.bjp.0701272","article-title":"Capsazepine block of voltage-activated calcium channels in adult rat dorsal root ganglion neurones in culture","volume":"121","author":"Docherty","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1124\/mol.105.012146","article-title":"Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8","volume":"68","author":"Weil","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1124\/jpet.102.042010","article-title":"The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain","volume":"304","author":"Walker","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1016\/j.bmc.2007.06.041","article-title":"Alpha-substituted N-(4-tert-butylbenzyl)-N'-[4-(methylsulfonylamino) benzyl]thiourea analogues as potent and stereospecific TRPV1 antagonists","volume":"15","author":"Chung","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"5823","DOI":"10.1021\/jm0502790","article-title":"Novel potent antagonists of transient receptor potential channel, vanilloid subfamily member 1: Structure-activity relationship of 1,3-diarylalkyl thioureas possessing new vanilloid equivalents","volume":"48","author":"Suh","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.bcp.2009.02.014","article-title":"Analgesic potential of TRPV1 antagonists","volume":"78","author":"Kym","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nrd2280","article-title":"The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept","volume":"6","author":"Szallasi","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1124\/mol.62.4.947","article-title":"High affinity antagonists of the vanilloid receptor","volume":"62","author":"Wang","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1124\/jpet.105.084103","article-title":"A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid","volume":"314","author":"Surowy","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1124\/jpet.102.045674","article-title":"N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl) tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. In vitro characterization and pharmacokinetic properties","volume":"306","author":"Valenzano","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1021\/jm0495071","article-title":"Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist","volume":"48","author":"Swanson","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1016\/j.bmcl.2006.03.030","article-title":"Discovery of SB-705498: A potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development","volume":"16","author":"Rami","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0028-3908(03)00305-8","article-title":"Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1\/TRPV1) antagonist","volume":"46","author":"Gunthorpe","year":"2004","journal-title":"Neuropharmacology"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1124\/jpet.104.079855","article-title":"AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo [b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties","volume":"313","author":"Gavva","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.1016\/j.bmcl.2006.07.010","article-title":"From arylureas to biarylamides to aminoquinazolines: Discovery of a novel, potent TRPV1 antagonist","volume":"16","author":"Zheng","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1021\/jm060065y","article-title":"Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles","volume":"49","author":"Ognyanov","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/157015906775202995","article-title":"Physiology and pharmacology of the vanilloid receptor","volume":"4","author":"Messeguer","year":"2006","journal-title":"Curr. Neuropharmacol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"32552","DOI":"10.1074\/jbc.M002391200","article-title":"Identification of an aspartic residue in the P-loop of the vanilloid receptor that modulates pore properties","volume":"275","author":"Merino","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1124\/jpet.301.3.981","article-title":"The arginine-rich hexapeptide R4W2 is a stereoselective antagonist at the vanilloid receptor 1: A Ca2+ imaging study in adult rat dorsal root ganglion neurons","volume":"301","author":"Himmel","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ejphar.2004.10.005","article-title":"Methoctramine analogues inhibit responses to capsaicin and protons in rat dorsal root ganglion neurons","volume":"505","author":"Mellor","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"15544","DOI":"10.1021\/bi051494l","article-title":"An inhibitor of TRPV1 channels isolated from funnel Web spider venom","volume":"44","author":"Kitaguchi","year":"2005","journal-title":"Biochemistry"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1073\/pnas.022285899","article-title":"Attenuation of thermal nociception and hyperalgesia by VR1 blockers","volume":"99","author":"Humet","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/sj.bjp.0703918","article-title":"Pharmacological differences between the human and rat vanilloid receptor 1 (VR1)","volume":"132","author":"McIntyre","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1124\/jpet.105.083915","article-title":"A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats","volume":"314","author":"Honore","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1124\/jpet.102.046268","article-title":"N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine-1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vivo characterization in rat models of inflammatory and neuropathic pain","volume":"306","author":"Pomonis","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"9385","DOI":"10.1523\/JNEUROSCI.1246-06.2006","article-title":"TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists","volume":"26","author":"Cui","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0163-7258(84)90041-X","article-title":"Capsaicin and central control of thermoregulation","volume":"26","author":"Hori","year":"1984","journal-title":"Pharmacol. Ther."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1124\/jpet.107.125674","article-title":"Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade","volume":"323","author":"Gavva","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1523\/JNEUROSCI.4833-06.2007","article-title":"The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation","volume":"27","author":"Gavva","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"7459","DOI":"10.1523\/JNEUROSCI.1483-07.2007","article-title":"Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors","volume":"27","author":"Steiner","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.pain.2007.06.006","article-title":"The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans","volume":"132","author":"Chizh","year":"2007","journal-title":"Pain"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/j.1476-5381.2011.01601.x","article-title":"The thermo-TRP ion channel family: Properties and therapeutic implications","volume":"165","author":"Vay","year":"2012","journal-title":"Br. J. Pharmacol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/3\/2\/517\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:11:46Z","timestamp":1760217106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/3\/2\/517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,23]]},"references-count":194,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,6]]}},"alternative-id":["cells3020517"],"URL":"https:\/\/doi.org\/10.3390\/cells3020517","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,23]]}}}