{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:24:44Z","timestamp":1760243084181,"version":"build-2065373602"},"reference-count":110,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2015,7,13]],"date-time":"2015-07-13T00:00:00Z","timestamp":1436745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Dentate-gyral granule cells in the hippocampus plus dentate gyrus  memory-recording\/retrieving machine, unlike most other neurons in the brain, are continuously being generated in the adult brain with the important task of separating overlapping patterns of data streaming in from the outside world via the entorhinal cortex. This \u201cadult neurogenesis\u201d is driven by tools in the mature granule cell\u2019s cilium. Here we report our discovery of leptin\u2019s LepRb receptor in this cilium. In addition, we discuss how ciliary LepRb signaling might be involved with ciliary p75NTR and SSTR3 receptors in adult neurogenesis and memory formation as well as attenuation of Alzheimer\u2019s neuropathology by reducing the production of its toxic amyloid-\u03b2-derived drivers.<\/jats:p>","DOI":"10.3390\/cells4030253","type":"journal-article","created":{"date-parts":[[2015,7,13]],"date-time":"2015-07-13T10:38:10Z","timestamp":1436783890000},"page":"253-274","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Possible Roles of the Dentate Granule Cell\u2019s Leptin and Other Ciliary Receptors in Alzheimer\u2019s Neuropathology"],"prefix":"10.3390","volume":"4","author":[{"given":"James","family":"Whitfield","sequence":"first","affiliation":[{"name":"Human Health Therapeutics, National Research Council of Canada, Ottawa, ON K1A 0R6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Chiarini","sequence":"additional","affiliation":[{"name":"Histology & Embryology Unit, Department of Life & Reproduction Sciences, University of Verona Medical School, 8 Strada Le Grazie, Verona, Venetia 37134, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Dal Pr\u00e0","sequence":"additional","affiliation":[{"name":"Histology & Embryology Unit, Department of Life & Reproduction Sciences, University of Verona Medical School, 8 Strada Le Grazie, Verona, Venetia 37134, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ubaldo","family":"Armato","sequence":"additional","affiliation":[{"name":"Histology & Embryology Unit, Department of Life & Reproduction Sciences, University of Verona Medical School, 8 Strada Le Grazie, Verona, Venetia 37134, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balu","family":"Chakravarthy","sequence":"additional","affiliation":[{"name":"Human Health Therapeutics, National Research Council of Canada, Ottawa, ON K1A 0R6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,7,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Duvernoy, H., Cattin, F., and Risold, P.Y. 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