{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:28:04Z","timestamp":1789975684560,"version":"4.0.1"},"reference-count":72,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Voltage-gated calcium channels (VGCCs) are widely distributed within the central nervous system (CNS) and presumed to play an important role in the pathophysiology of a broad spectrum of CNS disorders including Alzheimer\u2019s and Parkinson\u2019s disease as well as multiple sclerosis. Several calcium channel blockers have been in clinical practice for many years so that their toxicity and side effects are well studied. However, these drugs are primarily used for the treatment of cardiovascular diseases and most if not all effects on brain functions are secondary to peripheral effects on blood pressure and circulation. While the use of calcium channel antagonists for the treatment of CNS diseases therefore still heavily depends on the development of novel strategies to specifically target different channels and channel subunits, this review is meant to provide an impulse to further emphasize the importance of future research towards this goal.<\/jats:p>","DOI":"10.3390\/cells6040043","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T11:13:35Z","timestamp":1510744415000},"page":"43","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Danger: High Voltage\u2014The Role of Voltage-Gated Calcium Channels in Central Nervous System Pathology"],"prefix":"10.3390","volume":"6","author":[{"given":"Andrea","family":"Schampel","sequence":"first","affiliation":[{"name":"Institute of Anatomy and Cell Biology, University of W\u00fcrzburg, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6119-605X","authenticated-orcid":false,"given":"Stefanie","family":"Kuerten","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Cell Biology, Friedrich-Alexander University Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,11,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4816","DOI":"10.2174\/092986712803341430","article-title":"L-type voltage-dependent calcium channels as therapeutic targets for neurodegenerative diseases","volume":"19","author":"Yagami","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.biolcel.2003.10.007","article-title":"Calcium signal communication in the central nervous system","volume":"96","author":"Braet","year":"2004","journal-title":"Biol. Cell"},{"key":"ref_3","first-page":"S9","article-title":"Role of calcium in central nervous system injuries","volume":"9","author":"Young","year":"1992","journal-title":"J. Neurotrauma"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1124\/pr.57.4.5","article-title":"International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels","volume":"57","author":"Catterall","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2174\/1874205X01610010099","article-title":"Cav2.3 R-type voltage-gated Ca2+ channels\u2014Functional implications in convulsive and non-convulsive seizure activity","volume":"10","author":"Wormuth","year":"2016","journal-title":"Open Neurol. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.2174\/0929867311320100005","article-title":"Ion channels as drug targets in central nervous system disorders","volume":"20","author":"Waszkielewicz","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.neuroscience.2010.02.037","article-title":"Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons","volume":"167","author":"Schlick","year":"2010","journal-title":"Neuroscience"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/0166-2236(96)10048-5","article-title":"Calcium signalling in glial cells","volume":"19","author":"Verkhratsky","year":"1996","journal-title":"Trends Neurosci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1002\/ajmg.b.31122","article-title":"L-type calcium channels and psychiatric disorders: A brief review","volume":"153B","author":"Casamassima","year":"2010","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2007.01.016","article-title":"Calcium channel antagonists: Clinical uses\u2014Past, present and future","volume":"74","author":"Triggle","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0006-8993(98)01272-4","article-title":"Activation of microglial cells by PrP and beta-amyloid fragments raises intracellular calcium through L-type voltage sensitive calcium channels","volume":"818","author":"Silei","year":"1999","journal-title":"Brain Res."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Seitter, H., and Koschak, A. (2017). Relevance of tissue specific subunit expression in channelopathies. Neuropharmacology.","DOI":"10.1016\/j.neuropharm.2017.06.029"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1100\/tsw.2010.219","article-title":"Ca2+ signalling in B cells","volume":"10","author":"Lyubchenko","year":"2010","journal-title":"Sci. World J."},{"key":"ref_14","first-page":"7297","article-title":"Anti-Ig-induced calcium influx in rat B lymphocytes mediated by cGMP through a dihydropyridine-sensitive channel","volume":"13","author":"Willmott","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fphys.2015.00019","article-title":"Functional role of voltage gated Ca(2+) channels in heart automaticity","volume":"6","author":"Mesirca","year":"2015","journal-title":"Front. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0304-3940(02)00469-X","article-title":"Calpain-dependent neurofilament breakdown in anoxic and ischemic rat central axons","volume":"328","author":"Stys","year":"2002","journal-title":"Neurosci. Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.bbrc.2003.12.034","article-title":"Study of drug effects of calcium channel blockers on retinal degeneration of rd mouse","volume":"313","author":"Takano","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0376-8716(93)90024-K","article-title":"Calcium agonists and antagonists of the dihydropyridine type: Effect on nicotine-induced antinociception and hypomotility","volume":"32","author":"Damaj","year":"1993","journal-title":"Drug Alcohol Depend."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1352458507080111","article-title":"Oxidative stress and excitotoxicity: A therapeutic issue in multiple sclerosis?","volume":"14","author":"Gonsette","year":"2008","journal-title":"Mult. Scler. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nrn2023","article-title":"Axonal conduction and injury in multiple sclerosis: The role of sodium channels","volume":"7","author":"Waxman","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1093\/brain\/awr110","article-title":"Increased mitochondrial content in remyelinated axons: Implications for multiple sclerosis","volume":"134","author":"Zambonin","year":"2011","journal-title":"Brain"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jneuroim.2006.03.027","article-title":"Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases","volume":"176","author":"Arnold","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/ana.20736","article-title":"Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients","volume":"59","author":"Dutta","year":"2006","journal-title":"Ann. Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1096\/fasebj.9.2.7781924","article-title":"Calcium-mediated cell injury and cell death","volume":"9","author":"Trump","year":"1995","journal-title":"FASEB J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.clim.2013.10.011","article-title":"Differential aspects of immune cell infiltration and neurodegeneration in acute and relapse experimental autoimmune encephalomyelitis","volume":"149","author":"Soellner","year":"2013","journal-title":"Clin. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.pneurobio.2015.09.002","article-title":"Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders","volume":"134","author":"Heyes","year":"2015","journal-title":"Prog. Neurobiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/ana.21937","article-title":"L-type calcium channel blockers and Parkinson disease in Denmark","volume":"67","author":"Ritz","year":"2010","journal-title":"Ann. Neurol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.bbrc.2016.08.168","article-title":"Calcium and Parkinson\u2019s disease","volume":"483","author":"Surmeier","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/0006-8993(94)90041-8","article-title":"Amyloid beta-peptide (A beta P) potentiates a nimodipine-sensitive L-type barium conductance in N1E-115 neuroblastoma cells","volume":"643","author":"Davidson","year":"1994","journal-title":"Brain Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1111\/j.1471-4159.2006.03960.x","article-title":"Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels","volume":"98","author":"Fu","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10059-011-0075-x","article-title":"Effects of amyloid-beta peptides on voltage-gated L-type Ca(V)1.2 and Ca(V)1.3 Ca (2+) channels","volume":"32","author":"Kim","year":"2011","journal-title":"Mol. Cells"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0006-8993(02)03547-3","article-title":"Modulation of Ca2+ channel currents in primary cultures of rat cortical neurones by amyloid beta protein (1\u201340) is dependent on solubility status","volume":"956","author":"Ramsden","year":"2002","journal-title":"Brain Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1096\/fj.04-2659fje","article-title":"Alzheimer\u2019s amyloid peptides mediate hypoxic up-regulation of L-type Ca2+ channels","volume":"19","author":"Scragg","year":"2005","journal-title":"FASEB J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1046\/j.1471-4159.1997.68010265.x","article-title":"Amyloid beta protein potentiates Ca2+ influx through L-type voltage-sensitive Ca2+ channels: A possible involvement of free radicals","volume":"68","author":"Ueda","year":"1997","journal-title":"J. Neurochem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.neurobiolaging.2005.02.002","article-title":"Amyloid peptides mediate hypoxic increase of L-type Ca2+ channels in central neurons","volume":"27","author":"Webster","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1046\/j.1471-4159.1994.62010372.x","article-title":"Ca2+ channel blockers attenuate beta-amyloid peptide toxicity to cortical neurons in culture","volume":"62","author":"Weiss","year":"1994","journal-title":"J. Neurochem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0197-4580(99)00068-8","article-title":"L-type calcium channels in the hippocampus and cerebellum of Alzheimer\u2019s disease brain tissue","volume":"20","author":"Coon","year":"1999","journal-title":"Neurobiol. Aging"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1126\/science.272.5264.1017","article-title":"Increase in single L-type calcium channels in hippocampal neurons during aging","volume":"272","author":"Thibault","year":"1996","journal-title":"Science"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.neurobiolaging.2008.03.026","article-title":"Hippocampal \u2018zipper\u2019 slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging","volume":"31","author":"Norris","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1523\/JNEUROSCI.18-09-03171.1998","article-title":"Reversal of age-related alterations in synaptic plasticity by blockade of L-type Ca2+ channels","volume":"18","author":"Norris","year":"1998","journal-title":"J. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1152\/jn.1992.68.6.2100","article-title":"Nimodipine increases excitability of rabbit CA1 pyramidal neurons in an age- and concentration-dependent manner","volume":"68","author":"Moyer","year":"1992","journal-title":"J. Neurophysiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1126\/science.2916127","article-title":"Nimodipine facilitates associative learning in aging rabbits","volume":"243","author":"Deyo","year":"1989","journal-title":"Science"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0169-328X(02)00643-5","article-title":"Age-related working memory impairment is correlated with increases in the L-type calcium channel protein alpha1D (Cav1.3) in area CA1 of the hippocampus and both are ameliorated by chronic nimodipine treatment","volume":"110","author":"Veng","year":"2003","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.bbadis.2012.01.004","article-title":"Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer\u2019s disease","volume":"1822","author":"Thibault","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"6761","DOI":"10.1523\/JNEUROSCI.2946-16.2017","article-title":"Lower affinity of isradipine for L-Type Ca2+ channels during substantia nigra dopamine neuron-like activity: Implications for neuroprotection in Parkinson's disease","volume":"37","author":"Ortner","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"E3295","DOI":"10.1073\/pnas.1620052114","article-title":"Nimodipine fosters remyelination in a mouse model of multiple sclerosis and induces microglia-specific apoptosis","volume":"114","author":"Schampel","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"8089","DOI":"10.1073\/pnas.0502506102","article-title":"Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations","volume":"102","author":"Splawski","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1101\/lm.886208","article-title":"Role of L-type Ca2+ channel isoforms in the extinction of conditioned fear","volume":"15","author":"Busquet","year":"2008","journal-title":"Learn. Mem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.biopsych.2010.06.019","article-title":"Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans","volume":"68","author":"Dao","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/bdi.12143","article-title":"Pilot investigation of isradipine in the treatment of bipolar depression motivated by genome-wide association","volume":"16","author":"Ostacher","year":"2014","journal-title":"Bipolar Disord."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"9920","DOI":"10.1523\/JNEUROSCI.5482-12.2013","article-title":"Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures","volume":"33","author":"Radzicki","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Roca-Lapirot, O., Radwani, H., Aby, F., Nagy, F., Landry, M., and Fossat, P. (2017). Calcium signalling through L-type calcium channels: Role in pathophysiology of spinal nociceptive transmission. Br. J. Pharmacol.","DOI":"10.1111\/bph.13747"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"6607","DOI":"10.1113\/JP272725","article-title":"Cav1.2 and Cav1.3 L-type calcium channels independently control short- and long-term sensitization to pain","volume":"594","author":"Radwani","year":"2016","journal-title":"J. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1007\/s00424-015-1725-1","article-title":"Analgesic effect of a broad-spectrum dihydropyridine inhibitor of voltage-gated calcium channels","volume":"467","author":"Gadotti","year":"2015","journal-title":"Pflugers Arch."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/ng.2742","article-title":"Genome-wide association analysis identifies 13 new risk loci for schizophrenia","volume":"45","author":"Ripke","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00232-005-0854-4","article-title":"Structure and function of the hair cell ribbon synapse","volume":"209","author":"Nouvian","year":"2006","journal-title":"J. Membr. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0092-8674(00)00013-1","article-title":"Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channels","volume":"102","author":"Platzer","year":"2000","journal-title":"Cell"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/19336950.2015.1048936","article-title":"L-type calcium channels as drug targets in CNS disorders","volume":"10","author":"Orthner","year":"2016","journal-title":"Channels"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.bbrc.2004.08.039","article-title":"L-type Ca2+ channels in Ca2+ channelopathies","volume":"322","author":"Striessnig","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/947","article-title":"Loss-of-function mutations in a calcium-channel \u03b11 subunit gene in Xp11.23 cause incomplete X-linked congenital stationary night blindness","volume":"19","author":"Naylor","year":"1998","journal-title":"Nat. Genet."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s00415-014-7310-2","article-title":"Episodic ataxia type 2: Phenotype characteristics of a novel CACNA1A mutation and review of the literature","volume":"261","author":"Nachbauer","year":"2014","journal-title":"J. Neurol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1749-6632.2002.tb02832.x","article-title":"Genetics of familial episodic vertigo and ataxia","volume":"956","author":"Baloh","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0896-6273(04)00085-6","article-title":"A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression","volume":"41","author":"Pietrobon","year":"2004","journal-title":"Neuron"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1093\/hmg\/6.8.1283","article-title":"Molecular features of the CAG repeats of spinocerebellar ataxia 6 (SCA6)","volume":"6","author":"Matsuyama","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/ng0197-62","article-title":"Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the alpha 1A-voltage-dependent calcium channel","volume":"15","author":"Zhuchenko","year":"1997","journal-title":"Nat. Genet."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuron.2011.02.042","article-title":"Cav2.3 channels are critical for oscillatory burst discharges in the reticular thalamus and absence epilepsy","volume":"70","author":"Zaman","year":"2011","journal-title":"Neuron"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"6132","DOI":"10.1073\/pnas.100124197","article-title":"Altered pain responses in mice lacking \u03b11E subunit of the voltage-dependent Ca2+ channel","volume":"97","author":"Saegusa","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1523\/JNEUROSCI.2081-08.2009","article-title":"Genetic enhancement of thalamocortical network activity by elevating \u03b11G-mediated low-voltage-activated calcium current induces pure absence epilepsy","volume":"29","author":"Ernst","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/2040-2392-3-18","article-title":"Support for calcium channel gene defects in autism spectrum disorders","volume":"3","author":"Lu","year":"2012","journal-title":"Mol. Autism"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1097\/j.pain.0000000000000469","article-title":"T-type channels in neuropathic pain","volume":"127","author":"Bourinet","year":"2016","journal-title":"Pain"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1172\/JCI46482","article-title":"Modulation of subthalamic T-type Ca2+ channels remedies locomotor deficits in a rat model of Parkinson disease","volume":"121","author":"Tai","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/bph.12240","article-title":"Calcium channel blockers and dementia","volume":"169","author":"Nimrich","year":"2013","journal-title":"Br. J. Pharmacol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/6\/4\/43\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:49:40Z","timestamp":1760208580000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/6\/4\/43"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,15]]},"references-count":72,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["cells6040043"],"URL":"https:\/\/doi.org\/10.3390\/cells6040043","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,15]]}}}