{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:06:23Z","timestamp":1760241983022,"version":"build-2065373602"},"reference-count":39,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Investigaci\u00f3n y Ciencias de Puerto del Rosario","award":["INIPRO 01\/14"],"award-info":[{"award-number":["INIPRO 01\/14"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Aquaporin 1 (AQP1) and aquaporin 4 (AQP4) have been identified in the eye as playing an essential role in the formation of the aqueous humor along with the Na+\/K+ ATPase pump. Different authors have described the relationship between blood pressure, aqueous humor production, and intraocular pressure with different conclusions, with some authors supporting a positive correlation between blood pressure and intraocular pressure while others disagree. The aim of this work was to study the effect of high blood pressure on the proteins involved in the production of aqueous humor in the ciliary body (CB) and iris. For this purpose, we used the eyes of spontaneously hypertensive rats (SHR) and their control Wistar-Kyoto rats (WKY). Immunofluorescence was performed in different eye structures to analyze the effects of hypertension in the expression of AQP1, AQP4, and the Na+\/K+ ATPase \u03b11 and \u03b12 subunits. The results showed an increase in AQP1 and Na+\/K+ ATPase \u03b11 and a decrease in AQP4 and Na+\/K+ ATPase \u03b12 in the CB of SHR, while an increase in AQP4 and no significant differences in AQP1 were found in the iris. Therefore, systemic hypertension produced changes in the proteins implicated in the movement of water in the CB and iris that could influence the production rate of aqueous humor, which would be affected depending on the duration of systemic hypertension.<\/jats:p>","DOI":"10.3390\/cells7110210","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T02:42:41Z","timestamp":1542163361000},"page":"210","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Systemic Hypertension Effects on the Ciliary Body and Iris. An Immunofluorescence Study with Aquaporin 1, Aquaporin 4, and Na+, K+ ATPase in Hypertensive Rats"],"prefix":"10.3390","volume":"7","author":[{"given":"Ibrahim","family":"Gonz\u00e1lez-Marrero","sequence":"first","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Ciencias de la Salud, Universidad de La Laguna, 38200 La Laguna, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6012-3553","authenticated-orcid":false,"given":"Luis G.","family":"Hern\u00e1ndez-Abad","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n y Ciencias de Puerto del Rosario, 35600 Puerto del Rosario, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilia M.","family":"Carmona-Calero","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Ciencias de la Salud, Universidad de La Laguna, 38200 La Laguna, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro","family":"Casta\u00f1eyra-Ruiz","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Ciencias de la Salud, Universidad de La Laguna, 38200 La Laguna, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"Abreu-Reyes","sequence":"additional","affiliation":[{"name":"Servicio de Oftalmolog\u00eda, Hospital Universitario de Canarias, 38200 La Laguna, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2472-0278","authenticated-orcid":false,"given":"Agust\u00edn","family":"Casta\u00f1eyra-Perdomo","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Ciencias de la Salud, Universidad de La Laguna, 38200 La Laguna, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,11,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1001\/archopht.119.12.1819","article-title":"The prevalence of glaucoma in a population-based study of Hispanic subjects: Proyecto VER","volume":"119","author":"Quigley","year":"2001","journal-title":"Arch. 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Int."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/7\/11\/210\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:29:24Z","timestamp":1760196564000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/7\/11\/210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,13]]},"references-count":39,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,11]]}},"alternative-id":["cells7110210"],"URL":"https:\/\/doi.org\/10.3390\/cells7110210","relation":{},"ISSN":["2073-4409"],"issn-type":[{"type":"electronic","value":"2073-4409"}],"subject":[],"published":{"date-parts":[[2018,11,13]]}}}