{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:08:56Z","timestamp":1782731336448,"version":"3.54.5"},"reference-count":334,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013362","name":"Swiss Cancer Research","doi-asserted-by":"publisher","award":["KFS-3409-02-2014"],"award-info":[{"award-number":["KFS-3409-02-2014"]}],"id":[{"id":"10.13039\/501100013362","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Werner and Hedy Berger-Janser Foundation of Cancer Research","award":["none"],"award-info":[{"award-number":["none"]}]},{"name":"Conseil R\u00e9gional d\u2019Aquitaine","award":["none"],"award-info":[{"award-number":["none"]}]},{"name":"INCa-DGOS-Inserm","award":["6046"],"award-info":[{"award-number":["6046"]}]},{"DOI":"10.13039\/501100007622","name":"Bernese Cancer League","doi-asserted-by":"publisher","award":["none"],"award-info":[{"award-number":["none"]}],"id":[{"id":"10.13039\/501100007622","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UniBE Initiator grant","award":["none"],"award-info":[{"award-number":["none"]}]},{"name":"Tumor Forschung Bern","award":["none"],"award-info":[{"award-number":["none"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovative Programme under the Marie Sklodowska-Curie grant","award":["675712"],"award-info":[{"award-number":["675712"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Haematopoiesis is a tightly orchestrated process where a pool of hematopoietic stem and progenitor cells (HSPCs) with high self-renewal potential can give rise to both lymphoid and myeloid lineages. The HSPCs pool is reduced with ageing resulting in few HSPC clones maintaining haematopoiesis thereby reducing blood cell diversity, a phenomenon called clonal haematopoiesis. Clonal expansion of HSPCs carrying specific genetic mutations leads to increased risk for haematological malignancies. Therefore, it comes as no surprise that hematopoietic tumours develop in higher frequency in elderly people. Unfortunately, elderly patients with leukaemia or lymphoma still have an unsatisfactory prognosis compared to younger ones highlighting the need to develop more efficient therapies for this group of patients. Growing evidence indicates that macroautophagy (hereafter referred to as autophagy) is essential for health and longevity. This review is focusing on the role of autophagy in normal haematopoiesis as well as in leukaemia and lymphoma development. Attenuated autophagy may support early hematopoietic neoplasia whereas activation of autophagy in later stages of tumour development and in response to a variety of therapies rather triggers a pro-tumoral response. Novel insights into the role of autophagy in haematopoiesis will be discussed in light of designing new autophagy modulating therapies in hematopoietic cancers.<\/jats:p>","DOI":"10.3390\/cells8020103","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T10:58:27Z","timestamp":1548845907000},"page":"103","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Therapeutic Modulation of Autophagy in Leukaemia and Lymphoma"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4893-6505","authenticated-orcid":false,"given":"Mojgan","family":"Djavaheri-Mergny","sequence":"first","affiliation":[{"name":"INSERM U1218, Universit\u00e9 de Bordeaux, 33076 Bordeaux, France"},{"name":"INSERM U1138, 75006 Paris, France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, 75006 Paris, France"},{"name":"Universit\u00e9 Pierre et Marie Curie, Sorbonne Universit\u00e9, 75006 Paris, France"},{"name":"Cell Biology and Metabolomics Platforms, Gustave Roussy Cancer Campus, 94800 Villejuif, France"},{"name":"TRANSAUTOPHAGY: European Network for Multidisciplinary Research and Translation of Autophagy Knowledge, COST Action CA15138"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Giuriato","sequence":"additional","affiliation":[{"name":"TRANSAUTOPHAGY: European Network for Multidisciplinary Research and Translation of Autophagy Knowledge, COST Action CA15138"},{"name":"INSERM, UMR1037 CRCT, F-31000 Toulouse, France"},{"name":"Universit\u00e9 Toulouse III-Paul Sabatier, UMR1037 CRCT, F-31000 Toulouse, France"},{"name":"CNRS, ERL5294 CRCT, F-31000 Toulouse, France"},{"name":"Department of Pathology, Boston Children\u2019s Hospital and Harvard Medical School, Boston, MA 02115, USA"},{"name":"European Research Initiative on ALK-related malignancies (ERIA), F-31000 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5897-3647","authenticated-orcid":false,"given":"Mario P.","family":"Tschan","sequence":"additional","affiliation":[{"name":"TRANSAUTOPHAGY: European Network for Multidisciplinary Research and Translation of Autophagy Knowledge, COST Action CA15138"},{"name":"Institute of Pathology, Division of Experimental Pathology, University of Bern, Murtenstrasse 31, CH-3008 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3820-0297","authenticated-orcid":false,"given":"Magali","family":"Humbert","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Division of Experimental Pathology, University of Bern, Murtenstrasse 31, CH-3008 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1159\/000351979","article-title":"The mechanism and physiological function of macroautophagy","volume":"5","author":"Klionsky","year":"2013","journal-title":"J. Innate Immun."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.molcel.2010.09.023","article-title":"Autophagy and the Integrated Stress Response","volume":"40","author":"Kroemer","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e219625","DOI":"10.1155\/2012\/219625","article-title":"Autophagy: More Than a Nonselective Pathway","volume":"2012","author":"Reggiori","year":"2012","journal-title":"Int. J. Cell Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.1158\/1078-0432.CCR-15-0490","article-title":"Autophagy, Metabolism, and Cancer","volume":"21","author":"White","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: Renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1056\/NEJMra1205406","article-title":"Autophagy in human health and disease","volume":"368","author":"Choi","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev-cellbio-092910-154005","article-title":"The Role of Atg Proteins in Autophagosome Formation","volume":"27","author":"Mizushima","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_8","first-page":"207","article-title":"WIPI proteins: Essential PtdIns3P effectors at the nascent autophagosome","volume":"128","author":"Takacs","year":"2015","journal-title":"J. Cell Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.tcb.2015.08.010","article-title":"Ubiquitin-Dependent and Independent Signals in Selective Autophagy","volume":"26","author":"Khaminets","year":"2016","journal-title":"Trends Cell Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4161\/auto.7.3.14487","article-title":"Selective autophagy mediated by autophagic adapter proteins","volume":"7","author":"Johansen","year":"2011","journal-title":"Autophagy"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nature14506","article-title":"Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus","volume":"522","author":"Mochida","year":"2015","journal-title":"Nature"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/embor.2009.256","article-title":"Nix is a selective autophagy receptor for mitochondrial clearance","volume":"11","author":"Novak","year":"2010","journal-title":"EMBO Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.devcel.2008.08.012","article-title":"The role of autophagy in mammalian development: Cell makeover rather than cell death","volume":"15","author":"Cecconi","year":"2008","journal-title":"Dev. Cell"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1158\/1940-6207.CAPR-10-0387","article-title":"Role of Autophagy in Cancer Prevention","volume":"4","author":"Chen","year":"2011","journal-title":"Cancer Prev. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"384","DOI":"10.4161\/auto.27320","article-title":"Autophagy promotes BrafV600E-driven lung tumorigenesis by preserving mitochondrial metabolism","volume":"10","author":"Strohecker","year":"2014","journal-title":"Autophagy"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.4161\/auto.26123","article-title":"Autophagy is required for mitochondrial function, lipid metabolism, growth, and fate of KRAS(G12D)-driven lung tumors","volume":"9","author":"Guo","year":"2013","journal-title":"Autophagy"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ccr.2006.06.001","article-title":"Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis","volume":"10","author":"Degenhardt","year":"2006","journal-title":"Cancer Cell"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1101\/gad.2016311","article-title":"Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis","volume":"25","author":"Guo","year":"2011","journal-title":"Genes Dev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1124\/mol.114.091850","article-title":"Autophagy and cancer therapy","volume":"85","author":"Thorburn","year":"2014","journal-title":"Mol. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.bcp.2018.04.007","article-title":"Autophagy as a pharmacological target in hematopoiesis and hematological disorders","volume":"152","author":"Orsini","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.stem.2012.01.006","article-title":"Hematopoiesis: A human perspective","volume":"10","author":"Doulatov","year":"2012","journal-title":"Cell Stem Cell"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cell.2008.01.025","article-title":"Hematopoiesis: An evolving paradigm for stem cell biology","volume":"132","author":"Orkin","year":"2008","journal-title":"Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.tcb.2014.04.001","article-title":"Surviving change: The metabolic journey of hematopoietic stem cells","volume":"24","author":"Kohli","year":"2014","journal-title":"Trends Cell Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.4161\/cc.6.19.4759","article-title":"Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging","volume":"6","author":"Rossi","year":"2007","journal-title":"Cell Cycle"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1182\/blood.V81.11.2844.2844","article-title":"Differentiation and proliferation of hematopoietic stem cells","volume":"81","author":"Ogawa","year":"1993","journal-title":"Blood"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0301-472X(03)00088-2","article-title":"The role of stem cells in aging","volume":"31","author":"Liang","year":"2003","journal-title":"Exp. Hematol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/nm0996-1011","article-title":"The aging of hematopoietic stem cells","volume":"2","author":"Morrison","year":"1996","journal-title":"Nat. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1084\/jem.192.9.1273","article-title":"Age-associated characteristics of murine hematopoietic stem cells","volume":"192","author":"Sudo","year":"2000","journal-title":"J. Exp. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"9194","DOI":"10.1073\/pnas.0503280102","article-title":"Cell intrinsic alterations underlie hematopoietic stem cell aging","volume":"102","author":"Rossi","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Chambers, S.M., Shaw, C.A., Gatza, C., Fisk, C.J., Donehower, L.A., and Goodell, M.A. (2007). Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol., 5.","DOI":"10.1371\/journal.pbio.0050201"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1084\/jem.20101145","article-title":"The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance","volume":"208","author":"Mortensen","year":"2011","journal-title":"J. Exp. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1182\/blood-2010-06-288589","article-title":"FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells","volume":"116","author":"Liu","year":"2010","journal-title":"Blood"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature11895","article-title":"FOXO3A directs a protective autophagy program in haematopoietic stem cells","volume":"494","author":"Warr","year":"2013","journal-title":"Nature"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1089\/scd.2015.0176","article-title":"Autophagy Sustains Hematopoiesis Through Targeting Notch","volume":"24","author":"Cao","year":"2015","journal-title":"Stem Cells Dev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1080\/10245332.2016.1165446","article-title":"ROS functions as an upstream trigger for autophagy to drive hematopoietic stem cell differentiation","volume":"21","author":"Cao","year":"2016","journal-title":"Hematology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nature21388","article-title":"Autophagy maintains the metabolism and function of young and old stem cells","volume":"543","author":"Ho","year":"2017","journal-title":"Nature"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nri3801","article-title":"The early history of B cells","volume":"15","author":"Cooper","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1146\/annurev-cellbio-111315-125324","article-title":"TCR Signal Strength and T Cell Development","volume":"32","author":"Gascoigne","year":"2016","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.immuni.2007.05.009","article-title":"Commitment and developmental potential of extrathymic and intrathymic T cell precursors: Plenty to choose from","volume":"26","author":"Bhandoola","year":"2007","journal-title":"Immunity"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1084\/jem.20061303","article-title":"A critical role for the autophagy gene Atg5 in T cell survival and proliferation","volume":"204","author":"Pua","year":"2007","journal-title":"J. Exp. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"625","DOI":"10.4161\/auto.5.5.8133","article-title":"Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes","volume":"5","author":"Stephenson","year":"2009","journal-title":"Autophagy"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.4049\/jimmunol.177.8.5163","article-title":"Autophagy is induced in CD4+ T cells and important for the growth factor-withdrawal cell death","volume":"177","author":"Li","year":"2006","journal-title":"J. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.immuni.2012.04.008","article-title":"Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-\u03baB","volume":"36","author":"Paul","year":"2012","journal-title":"Immunity"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"16677","DOI":"10.1073\/pnas.0808597105","article-title":"FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells","volume":"105","author":"Bell","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/cdd.2008.113","article-title":"Autophagy in CD4+ T-cell immunity and tolerance","volume":"16","year":"2009","journal-title":"Cell Death Differ."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41467-017-00468-w","article-title":"Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells","volume":"8","author":"Cai","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/ni.3365","article-title":"Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis","volume":"17","author":"Wei","year":"2016","journal-title":"Nat. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.immuni.2014.06.005","article-title":"Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development","volume":"41","author":"Huang","year":"2014","journal-title":"Immunity"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1038\/s41467-018-05097-5","article-title":"TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival","volume":"9","author":"Zhu","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jaci.2013.01.046","article-title":"B-cell biology and development","volume":"131","author":"Pieper","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"309","DOI":"10.4161\/auto.5474","article-title":"The autophagy gene ATG5 plays an essential role in B lymphocyte development","volume":"4","author":"Miller","year":"2008","journal-title":"Autophagy"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/cdd.2015.149","article-title":"Autophagy is dispensable for B-cell development but essential for humoral autoimmune responses","volume":"23","author":"Arnold","year":"2016","journal-title":"Cell Death Differ."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nm.3521","article-title":"Essential role for autophagy in the maintenance of immunological memory against influenza infection","volume":"20","author":"Chen","year":"2014","journal-title":"Nat. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.4049\/jimmunol.1403001","article-title":"Requirement for autophagy in the long-term persistence but not initial formation of memory B cells","volume":"194","author":"Chen","year":"2015","journal-title":"J. Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1126\/science.aal3908","article-title":"A switch from canonical to noncanonical autophagy shapes B cell responses","volume":"355","author":"Maldonado","year":"2017","journal-title":"Science"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/ni.2524","article-title":"Plasma cells require autophagy for sustainable immunoglobulin production","volume":"14","author":"Pengo","year":"2013","journal-title":"Nat. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"11023","DOI":"10.1038\/ncomms11023","article-title":"FoxO1-mediated autophagy is required for NK cell development and innate immunity","volume":"7","author":"Wang","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1016\/j.celrep.2016.04.082","article-title":"Atg5 Is Essential for the Development and Survival of Innate Lymphocytes","volume":"15","author":"Geary","year":"2016","journal-title":"Cell Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrc.2015.5","article-title":"NK cells and cancer: You can teach innate cells new tricks","volume":"16","author":"Morvan","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1080\/15548627.2018.1427398","article-title":"Targeting autophagy blocks melanoma growth by bringing natural killer cells to the tumor battlefield","volume":"14","author":"Noman","year":"2018","journal-title":"Autophagy"},{"key":"ref_62","first-page":"04790","article-title":"Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia","volume":"2013","author":"Baginska","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1078\/0171-9335-00096","article-title":"Autophagy in embryonic erythroid cells: Its role in maturation","volume":"79","author":"Mukaida","year":"2000","journal-title":"Eur. J. Cell Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/boc.201500058","article-title":"Hemin induces mitophagy in a leukemic erythroblast cell line","volume":"108","author":"Fader","year":"2016","journal-title":"Biol. Cell"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1128\/MCB.06166-11","article-title":"Autophagy driven by a master regulator of hematopoiesis","volume":"32","author":"Kang","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1179\/1607845415Y.0000000027","article-title":"Autophagy governs erythroid differentiation both in vitro and in vivo","volume":"21","author":"Cao","year":"2016","journal-title":"Hematology"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1182\/blood-2002-11-3324","article-title":"The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation","volume":"102","author":"Aerbajinai","year":"2003","journal-title":"Blood"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"926","DOI":"10.4161\/auto.6716","article-title":"Selective mitochondrial autophagy during erythroid maturation","volume":"4","author":"Chen","year":"2008","journal-title":"Autophagy"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature07006","article-title":"Essential role for Nix in autophagic maturation of erythroid cells","volume":"454","author":"Sandoval","year":"2008","journal-title":"Nature"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"690","DOI":"10.4161\/auto.5.5.8494","article-title":"Nix directly binds to GABARAP: A possible crosstalk between apoptosis and autophagy","volume":"5","author":"Schwarten","year":"2009","journal-title":"Autophagy"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"881","DOI":"10.4161\/auto.24172","article-title":"Autophagy facilitates organelle clearance during differentiation of human erythroblasts: Evidence for a role for ATG4 paralogs during autophagosome maturation","volume":"9","author":"Betin","year":"2013","journal-title":"Autophagy"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1182\/blood-2014-07-586396","article-title":"Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice","volume":"125","author":"Milasta","year":"2015","journal-title":"Blood"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1182\/blood-2008-02-137398","article-title":"Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation","volume":"112","author":"Kundu","year":"2008","journal-title":"Blood"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.molcel.2011.06.018","article-title":"Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy","volume":"43","author":"Joo","year":"2011","journal-title":"Mol. Cell"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Orsini, M., Chateauvieux, S., Rhim, J., Gaigneaux, A., Cheillan, D., Christov, C., Dicato, M., Morceau, F., and Diederich, M. (2018). Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem\/progenitor cells. Cell Death Differ.","DOI":"10.1038\/s41418-018-0245-x"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Mancias, J.D., Pontano Vaites, L., Nissim, S., Biancur, D.E., Kim, A.J., Wang, X., Liu, Y., Goessling, W., Kimmelman, A.C., and Harper, J.W. (2015). Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis. Elife, 4.","DOI":"10.7554\/eLife.10308"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nri3671","article-title":"Monocytes and macrophages: Developmental pathways and tissue homeostasis","volume":"14","author":"Ginhoux","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1182\/blood-2011-11-392167","article-title":"Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions","volume":"119","author":"Jacquel","year":"2012","journal-title":"Blood"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1182\/blood-2011-08-372383","article-title":"Induction of autophagy is essential for monocyte-macrophage differentiation","volume":"119","author":"Zhang","year":"2012","journal-title":"Blood"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1080\/15548627.2015.1034406","article-title":"The PRKAA1\/AMPK\u03b11 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML","volume":"11","author":"Obba","year":"2015","journal-title":"Autophagy"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1159\/000370112","article-title":"Autophagy Controls Acquisition of Aging Features in Macrophages","volume":"7","author":"Stranks","year":"2015","journal-title":"J. Innate Immun."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.freeradbiomed.2017.05.021","article-title":"Autophagy suppresses isoprenaline-induced M2 macrophage polarization via the ROS\/ERK and mTOR signaling pathway","volume":"110","author":"Shan","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"ref_84","first-page":"81","article-title":"Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview","volume":"8","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.4049\/jimmunol.1201719","article-title":"Neutrophil extracellular traps: Double-edged swords of innate immunity","volume":"189","author":"Kaplan","year":"2012","journal-title":"J. Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.clim.2018.10.003","article-title":"The relationship between autophagy, increased neutrophil extracellular traps formation and endothelial dysfunction in chronic kidney disease","volume":"197","author":"Kim","year":"2018","journal-title":"Clin. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/cr.2010.150","article-title":"Neutrophil extracellular trap cell death requires both autophagy and superoxide generation","volume":"21","author":"Remijsen","year":"2011","journal-title":"Cell Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41420-018-0131-9","article-title":"Human granulocytes undergo cell death via autophagy","volume":"4","author":"Kajiume","year":"2018","journal-title":"Cell Death Discov."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.4049\/jimmunol.1103007","article-title":"C\/EBP\u03b2 is involved in the amplification of early granulocyte precursors during candidemia-induced \u201cemergency\u201d granulopoiesis","volume":"189","author":"Satake","year":"2012","journal-title":"J. Immunol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.immuni.2017.08.005","article-title":"Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation","volume":"47","author":"Riffelmacher","year":"2017","journal-title":"Immunity"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12943-017-0707-7","article-title":"Neutrophils in cancer: Prognostic role and therapeutic strategies","volume":"16","author":"Ocana","year":"2017","journal-title":"Mol. Cancer"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12943-018-0898-6","article-title":"Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration","volume":"17","author":"Zhang","year":"2018","journal-title":"Mol. Cancer"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"eaao3089","DOI":"10.1126\/scitranslmed.aao3089","article-title":"Platelet microparticles sustain autophagy-associated activation of neutrophils in systemic sclerosis","volume":"10","author":"Maugeri","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"ref_94","first-page":"7058","article-title":"Charged molecular silica trigger in vitro NETosis in human granulocytes via both oxidative and autophagic pathways","volume":"22","author":"Rizzi","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1164\/rccm.201603-0596OC","article-title":"Autophagy Primes Neutrophils for Neutrophil Extracellular Trap Formation during Sepsis","volume":"196","author":"Park","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e2283","DOI":"10.1038\/cddis.2016.186","article-title":"Extracellular DNA traps released by acute promyelocytic leukemia cells through autophagy","volume":"7","author":"Ma","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.celrep.2015.08.019","article-title":"Autophagy Is Required for Neutrophil-Mediated Inflammation","volume":"12","author":"Bhattacharya","year":"2015","journal-title":"Cell Rep."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3389\/fimmu.2018.00269","article-title":"Autophagy Mediates Interleukin-1\u03b2 Secretion in Human Neutrophils","volume":"9","author":"Iula","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1083\/jcb.201304054","article-title":"The incredible journey: From megakaryocyte development to platelet formation","volume":"201","author":"Machlus","year":"2013","journal-title":"J. Cell Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.exphem.2015.01.001","article-title":"Loss of autophagy leads to failure in megakaryopoiesis, megakaryocyte differentiation, and thrombopoiesis in mice","volume":"43","author":"Cao","year":"2015","journal-title":"Exp. Hematol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"642","DOI":"10.4161\/auto.27832","article-title":"Dissection of autophagy in human platelets","volume":"10","author":"Feng","year":"2014","journal-title":"Autophagy"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/35000501","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling","volume":"403","author":"Alizadeh","year":"2000","journal-title":"Nature"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1182\/blood-2017-04-737320","article-title":"How I treat double-hit lymphoma","volume":"130","author":"Friedberg","year":"2017","journal-title":"Blood"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/modpathol.2010.80","article-title":"Autophagy-active beclin-1 correlates with favourable clinical outcome in non-Hodgkin lymphomas","volume":"23","author":"Nicotra","year":"2010","journal-title":"Mod. Pathol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.humpath.2010.12.014","article-title":"Beclin 1 expression predicts favorable clinical outcome in patients with diffuse large B-cell lymphoma treated with R-CHOP","volume":"42","author":"Huang","year":"2011","journal-title":"Hum. Pathol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"15077","DOI":"10.1073\/pnas.2436255100","article-title":"Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor","volume":"100","author":"Yue","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1172\/JCI20039","article-title":"Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene","volume":"112","author":"Qu","year":"2003","journal-title":"J. Clin. Invest."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/bjh.12440","article-title":"LITAF, a BCL6 target gene, regulates autophagy in mature B-cell lymphomas","volume":"162","author":"Bertolo","year":"2013","journal-title":"Br. J. Haematol."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Li, Y., Zhou, X., Zhang, Y., Yang, J., Xu, Y., Zhao, Y., and Wang, X. (2019). CUL4B regulates autophagy via JNK signaling in diffuse large B-cell lymphoma. Cell Cycle.","DOI":"10.1080\/15384101.2018.1560718"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1038\/leu.2014.19","article-title":"Disruption of autophagy by the histone deacetylase inhibitor MGCD0103 and its therapeutic implication in B-cell chronic lymphocytic leukemia","volume":"28","author":"Pierson","year":"2014","journal-title":"Leukemia"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"30925","DOI":"10.1074\/jbc.M114.553230","article-title":"Control of Toll-like receptor-mediated T cell-independent type 1 antibody responses by the inducible nuclear protein I\u03baB-\u03b6","volume":"289","author":"Miura","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.3324\/haematol.2017.165878","article-title":"Toll-like receptor 9 stimulation can induce I\u03baB\u03b6 expression and IgM secretion in chronic lymphocytic leukemia cells","volume":"102","author":"Fonte","year":"2017","journal-title":"Haematologica"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.leukres.2015.02.008","article-title":"High expression of PI3K core complex genes is associated with poor prognosis in chronic lymphocytic leukemia","volume":"39","author":"Kristensen","year":"2015","journal-title":"Leuk. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1476-4598-2-24","article-title":"Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: Its relationship to clinical outcome","volume":"2","author":"Narayan","year":"2003","journal-title":"Mol. Cancer"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.cell.2007.03.043","article-title":"Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia","volume":"129","author":"Raval","year":"2007","journal-title":"Cell"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"22030","DOI":"10.1074\/jbc.M116.725796","article-title":"Death-associated Protein Kinase-1 Expression and Autophagy in Chronic Lymphocytic Leukemia Are Dependent on Activating Transcription Factor-6 and CCAAT\/Enhancer-binding Protein-\u03b2","volume":"291","author":"Gade","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1172\/JCI83013","article-title":"SLAMF1 regulation of chemotaxis and autophagy determines CLL patient response","volume":"126","author":"Bologna","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"4867","DOI":"10.1200\/JCO.2006.07.9665","article-title":"Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphoma","volume":"24","author":"Fisher","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.3109\/10428190903207548","article-title":"Exploring mammalian target of rapamycin (mTOR) inhibition for treatment of mantle cell lymphoma and other hematologic malignancies","volume":"50","author":"Coiffier","year":"2009","journal-title":"Leuk. Lymphoma"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"6410","DOI":"10.1158\/0008-5472.CAN-16-0595","article-title":"TG2 and NF-\u03baB Signaling Coordinates the Survival of Mantle Cell Lymphoma Cells via IL6-Mediated Autophagy","volume":"76","author":"Zhang","year":"2016","journal-title":"Cancer Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1182\/blood.V95.8.2593","article-title":"Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha","volume":"95","author":"Zhou","year":"2000","journal-title":"Blood"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1182\/blood-2004-04-1630","article-title":"Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: Its role in leukemic cell differentiation","volume":"104","author":"Zhao","year":"2004","journal-title":"Blood"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"41913","DOI":"10.18632\/oncotarget.9630","article-title":"Phospholipid scramblase 1 as a critical node at the crossroad between autophagy and apoptosis in mantle cell lymphoma","volume":"7","author":"Mastorci","year":"2016","journal-title":"Oncotarget"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"14350","DOI":"10.18632\/oncotarget.7320","article-title":"Hedgehog inhibitors selectively target cell migration and adhesion of mantle cell lymphoma in bone marrow microenvironment","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1172\/JCI33700","article-title":"Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis","volume":"118","author":"Maclean","year":"2008","journal-title":"J. Clin. Investig."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1172\/JCI61188","article-title":"Molecular pathogenesis of multiple myeloma and its premalignant precursor","volume":"122","author":"Kuehl","year":"2012","journal-title":"J. Clin. Invest."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/1097-0142(197208)30:2<382::AID-CNCR2820300213>3.0.CO;2-C","article-title":"Combination chemotherapy for multiple myeloma","volume":"30","author":"Alexanian","year":"1972","journal-title":"Cancer"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S0140-6736(83)90739-0","article-title":"High-Dose Intravenous Melphalan For Plasma-Cell Leukaemia And Myeloma","volume":"322","author":"Mcelwain","year":"1983","journal-title":"Lancet"},{"key":"ref_129","first-page":"1136","article-title":"The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents","volume":"9","author":"Ma","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e1254856","DOI":"10.1080\/2162402X.2016.1254856","article-title":"PD-1\/PD-L1 inhibitors in multiple myeloma: The present and the future","volume":"5","author":"Jelinek","year":"2016","journal-title":"OncoImmunology"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1600-0609.2010.01558.x","article-title":"Novel therapeutic strategies in multiple myeloma: Role of the heat shock protein inhibitors","volume":"86","author":"Allegra","year":"2011","journal-title":"Eur. J. Haematol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"12050","DOI":"10.1038\/ncomms12050","article-title":"Genome-wide association study identifies multiple susceptibility loci for multiple myeloma","volume":"7","author":"Mitchell","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1038\/s41467-018-04989-w","article-title":"Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma","volume":"9","author":"Went","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000368848","article-title":"Autophagic Markers BECLIN 1 and LC3 are Associated with Prognosis of Multiple Myeloma","volume":"134","author":"Jung","year":"2015","journal-title":"Acta Haematol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.canlet.2018.11.002","article-title":"Myeloid-derived suppressor cells induce multiple myeloma cell survival by activating the AMPK pathway","volume":"442","author":"Menu","year":"2019","journal-title":"Cancer Lett."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1002\/jcb.25987","article-title":"LncRNA MALAT-1 Elevates HMGB1 to Promote Autophagy Resulting in Inhibition of Tumor Cell Apoptosis in Multiple Myeloma","volume":"118","author":"Gao","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.15252\/embj.201489920","article-title":"Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy","volume":"34","author":"Desantis","year":"2015","journal-title":"EMBO J."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1158\/1535-7163.MCT-08-1177","article-title":"Effect of autophagy on multiple myeloma cell viability","volume":"8","author":"Hoang","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1080\/15384047.2017.1345386","article-title":"The novel autophagy inhibitor elaiophylin exerts antitumor activity against multiple myeloma with mutant TP53 in part through endoplasmic reticulum stress-induced apoptosis","volume":"18","author":"Wang","year":"2017","journal-title":"Cancer Biol. Ther."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ccr.2013.02.017","article-title":"Control of autophagic cell death by caspase-10 in multiple myeloma","volume":"23","author":"Lamy","year":"2013","journal-title":"Cancer Cell"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"80770","DOI":"10.18632\/oncotarget.20415","article-title":"PP2A mediates apoptosis or autophagic cell death in multiple myeloma cell lines","volume":"8","author":"Zhou","year":"2017","journal-title":"Oncotarget"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1146\/annurev-pathol-012513-104656","article-title":"Gammaherpesviruses and lymphoproliferative disorders","volume":"9","author":"Cesarman","year":"2014","journal-title":"Annu. Rev. Pathol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1200\/JCO.2003.06.013","article-title":"Clinical features and outcome of primary effusion lymphoma in HIV-infected patients: A single-institution study","volume":"21","author":"Simonelli","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s10495-016-1277-7","article-title":"Inhibition of autophagy by chloroquine induces apoptosis in primary effusion lymphoma in vitro and in vivo through induction of endoplasmic reticulum stress","volume":"21","author":"Kariya","year":"2016","journal-title":"Apoptosis"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Tsai, C.-Y., Chen, C.-Y., Chiou, Y.-H., Shyu, H.-W., Lin, K.-H., Chou, M.-C., Huang, M.-H., and Wang, Y.-F. (2018). Epigallocatechin-3-Gallate Suppresses Human Herpesvirus 8 Replication and Induces ROS Leading to Apoptosis and Autophagy in Primary Effusion Lymphoma Cells. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19010016"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/bjh.13958","article-title":"Anaplastic large cell lymphoma in paediatric and young adult patients","volume":"173","author":"Turner","year":"2016","journal-title":"Br. J. Haematol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3109\/08880018.2013.805347","article-title":"Anaplastic large cell lymphoma in children and adolescents","volume":"30","author":"Lowe","year":"2013","journal-title":"Pediatr. Hematol. Oncol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1126\/science.8122112","article-title":"Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non- Hodgkin\u2019s lymphoma","volume":"263","author":"Morris","year":"1994","journal-title":"Science"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrc2291","article-title":"The anaplastic lymphoma kinase in the pathogenesis of cancer","volume":"8","author":"Chiarle","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.phrs.2012.11.007","article-title":"Anaplastic lymphoma kinase (ALK): Structure, oncogenic activation, and pharmacological inhibition","volume":"68","author":"Roskoski","year":"2013","journal-title":"Pharmacol. Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1158\/1535-7163.MCT-07-0365","article-title":"Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma","volume":"6","author":"Christensen","year":"2007","journal-title":"Mol. Cancer Ther"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"104","DOI":"10.5306\/wjco.v6.i5.104","article-title":"Current and future treatment of anaplastic lymphoma kinase-rearranged cancer","volume":"6","author":"Mologni","year":"2015","journal-title":"World J. Clin. Oncol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.coph.2015.05.010","article-title":"Anaplastic lymphoma kinase inhibitors","volume":"23","author":"Crescenzo","year":"2015","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_154","first-page":"djt378","article-title":"Crizotinib in advanced, chemoresistant anaplastic lymphoma kinase-positive lymphoma patients","volume":"106","author":"Farina","year":"2014","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S1470-2045(13)70095-0","article-title":"Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: A Children\u2019s Oncology Group phase 1 consortium study","volume":"14","author":"Mosse","year":"2013","journal-title":"Lancet Oncol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/2040620712471553","article-title":"The pathobiology of the oncogenic tyrosine kinase NPM-ALK: A brief update","volume":"4","author":"Lai","year":"2013","journal-title":"Ther. Adv. Hematol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00109-009-0460-5","article-title":"Anaplastic lymphoma kinase: An oncogene for tumor vaccination","volume":"87","author":"Mastini","year":"2009","journal-title":"J. Mol. Med."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"30149","DOI":"10.18632\/oncotarget.4999","article-title":"Targeting autophagy enhances the anti-tumoral action of crizotinib in ALK-positive anaplastic large cell lymphoma","volume":"6","author":"Mitou","year":"2015","journal-title":"Oncotarget"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"8447","DOI":"10.1200\/JCO.2005.03.1674","article-title":"New Treatment Options Have Changed the Survival of Patients with Follicular Lymphoma","volume":"23","author":"Fisher","year":"2005","journal-title":"JCO"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1182\/blood-2005-01-0016","article-title":"Frontline therapy with rituximab added to the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) significantly improves the outcome for patients with advanced-stage follicular lymphoma compared with therapy with CHOP alone: Results of a prospective randomized study of the German Low-Grade Lymphoma Study Group","volume":"106","author":"Hiddemann","year":"2005","journal-title":"Blood"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1200\/JCO.2010.28.4786","article-title":"Long-term follow-up of patients with follicular lymphoma receiving single-agent rituximab at two different schedules in trial SAKK 35\/98","volume":"28","author":"Martinelli","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1172\/JCI63186","article-title":"Pathogenesis of follicular lymphoma","volume":"122","author":"Kridel","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"e1224044","DOI":"10.1080\/2162402X.2016.1224044","article-title":"Impaired functional responses in follicular lymphoma CD8+TIM-3+ T lymphocytes following TCR engagement","volume":"5","author":"Gravelle","year":"2016","journal-title":"Oncoimmunology"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"11653","DOI":"10.18632\/oncotarget.2605","article-title":"Dysregulation of autophagy in human follicular lymphoma is independent of overexpression of BCL-2","volume":"5","author":"McCarthy","year":"2014","journal-title":"Oncotarget"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.hemonc.2013.02.001","article-title":"Overexpression of LC3A autophagy protein in follicular and diffuse large B-cell lymphomas","volume":"6","author":"Giatromanolaki","year":"2013","journal-title":"Hematol. Oncol. Stem Cell Ther."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/nature05690","article-title":"Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia","volume":"446","author":"Mullighan","year":"2007","journal-title":"Nature"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1056\/NEJMoa033513","article-title":"Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment","volume":"351","author":"Holleman","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ng.3230","article-title":"The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias","volume":"47","author":"Andersson","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1002\/cncr.22631","article-title":"Imatinib compared with chemotherapy as front-line treatment of elderly patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL)","volume":"109","author":"Ottmann","year":"2007","journal-title":"Cancer"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1200\/JCO.2012.41.6768","article-title":"Monoclonal antibody-based therapies: A new dawn in the treatment of acute lymphoblastic leukemia","volume":"30","author":"Kantarjian","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa1215134","article-title":"Chimeric antigen receptor-modified T cells for acute lymphoid leukemia","volume":"368","author":"Grupp","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.7314\/APJCP.2014.15.5.2153","article-title":"Alternative messenger RNA splicing of autophagic gene Beclin 1 in human B-cell acute lymphoblastic leukemia cells","volume":"15","author":"Niu","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.leukres.2014.05.009","article-title":"Rapamycin inhibits pre-B acute lymphoblastic leukemia cells by downregulating DNA and RNA polymerases","volume":"38","author":"Wang","year":"2014","journal-title":"Leuk. Res."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"10034","DOI":"10.18632\/oncotarget.2490","article-title":"Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation","volume":"5","author":"Simioni","year":"2014","journal-title":"Oncotarget"},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Jia, L., Gopinathan, G., Sukumar, J.T., and Gribben, J.G. (2012). Blocking autophagy prevents bortezomib-induced NF-\u03baB activation by reducing I-\u03baB\u03b1 degradation in lymphoma cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0032584"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3109\/10428194.2013.806800","article-title":"Inhibition of pan-class I phosphatidyl-inositol-3-kinase by NVP-BKM120 effectively blocks proliferation and induces cell death in diffuse large B-cell lymphoma","volume":"55","author":"Zang","year":"2014","journal-title":"Leuk. Lymphoma"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"14912","DOI":"10.18632\/oncotarget.14741","article-title":"Tenovin-6 inhibits proliferation and survival of diffuse large B-cell lymphoma cells by blocking autophagy","volume":"8","author":"Yuan","year":"2017","journal-title":"Oncotarget"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/cam4.1276","article-title":"Induction of autophagy and autophagy-dependent apoptosis in diffuse large B-cell lymphoma by a new antimalarial artemisinin derivative, SM1044","volume":"7","author":"Cheng","year":"2018","journal-title":"Cancer Med."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.biopha.2017.02.011","article-title":"The effects of the long non-coding RNA MALAT-1 regulated autophagy-related signaling pathway on chemotherapy resistance in diffuse large B-cell lymphoma","volume":"89","author":"Li","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"19665","DOI":"10.1074\/jbc.M710169200","article-title":"Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells","volume":"283","author":"Han","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.leukres.2010.05.029","article-title":"P53 and autophagy contribute to dasatinib resistance in primary CLL lymphocytes","volume":"35","author":"Amrein","year":"2011","journal-title":"Leuk. Res."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1158\/0008-5472.CAN-11-3671","article-title":"miRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells","volume":"72","author":"Kovaleva","year":"2012","journal-title":"Cancer Res."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/bjh.14859","article-title":"Chlorinated adenosine analogue induces AMPK and autophagy in chronic lymphocytic leukaemia cells during therapy","volume":"179","author":"Stellrecht","year":"2017","journal-title":"Br. J. Haematol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1158\/1535-7163.MCT-09-1000","article-title":"The histone deacetylase inhibitor MGCD0103 induces apoptosis in B-cell chronic lymphocytic leukemia cells through a mitochondria-mediated caspase activation cascade","volume":"9","author":"Moussay","year":"2010","journal-title":"Mol. Cancer Ther."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/srep01275","article-title":"Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6","volume":"3","author":"MacCallum","year":"2013","journal-title":"Sci. Rep."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"e2608","DOI":"10.1038\/cddis.2017.25","article-title":"Tenovin-6 impairs autophagy by inhibiting autophagic flux","volume":"8","author":"Yuan","year":"2017","journal-title":"Cell Death Dis."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.2147\/OTT.S170392","article-title":"Targeting the autophagy in bone marrow stromal cells overcomes resistance to vorinostat in chronic lymphocytic leukemia","volume":"11","author":"Ding","year":"2018","journal-title":"Onco Targets Ther."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1158\/1078-0432.CCR-15-0987","article-title":"ROS-induced CXCR4 signaling regulates mantle cell lymphoma (MCL) cell survival and drug resistance in the bone marrow microenvironment via autophagy","volume":"22","author":"Chen","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"391","DOI":"10.4149\/neo_2015_047","article-title":"17-AAG enhances the cytotoxicity of flavopiridol in mantle cell lymphoma via autophagy suppression","volume":"62","author":"Xiao","year":"2015","journal-title":"Neoplasma"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"416","DOI":"10.4161\/auto.19050","article-title":"FTY720-induced blockage of autophagy enhances anticancer efficacy of milatuzumab in mantle cell lymphoma: Is FTY720 the next autophagy-blocking agent in lymphoma treatment?","volume":"8","author":"Alinari","year":"2012","journal-title":"Autophagy"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.1182\/blood-2010-08-303354","article-title":"Combination anti-CD74 (milatuzumab) and anti-CD20 (rituximab) monoclonal antibody therapy has in vitro and in vivo activity in mantle cell lymphoma","volume":"117","author":"Alinari","year":"2011","journal-title":"Blood"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s13045-018-0657-6","article-title":"Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA","volume":"11","author":"Heine","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"5278","DOI":"10.1158\/1078-0432.CCR-12-0351","article-title":"Counteracting autophagy overcomes resistance to everolimus in mantle cell lymphoma","volume":"18","author":"Rosich","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1182\/blood-2008-08-173369","article-title":"The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies","volume":"113","author":"Nahimana","year":"2009","journal-title":"Blood"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"603","DOI":"10.4161\/auto.27722","article-title":"A critical role of autophagy in antileukemia\/lymphoma effects of APO866, an inhibitor of NAD biosynthesis","volume":"10","author":"Ginet","year":"2014","journal-title":"Autophagy"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1172\/JCI28833","article-title":"Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma","volume":"117","author":"Amaravadi","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.1172\/JCI62973","article-title":"ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth","volume":"122","author":"Hart","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.3109\/10428194.2013.775437","article-title":"Natural Bcl-2 inhibitor (\u2212)-gossypol induces protective autophagy via reactive oxygen species-high mobility group box 1 pathway in Burkitt lymphoma","volume":"54","author":"Ni","year":"2013","journal-title":"Leuk. Lymphoma"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"e840","DOI":"10.1038\/cddis.2013.359","article-title":"Recombinant human arginase induced caspase-dependent apoptosis and autophagy in non-Hodgkin\u2019s lymphoma cells","volume":"4","author":"Zeng","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"M\u00e9tayer, L.E., Brown, R.D., Carlebur, S., Burke, G.A.A., and Brown, G.C. (2018). Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts. Apoptosis.","DOI":"10.1007\/s10495-018-1506-3"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"7305","DOI":"10.1007\/s13277-015-4614-5","article-title":"A novel therapeutic approach against B-cell non-Hodgkin\u2019s lymphoma through co-inhibition of Hedgehog signaling pathway and autophagy","volume":"37","author":"Fan","year":"2016","journal-title":"Tumour Biol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1080\/15548627.2015.1115939","article-title":"Constitutive autophagy contributes to resistance to TP53-mediated apoptosis in Epstein-Barr virus-positive latency III B-cell lymphoproliferations","volume":"11","author":"Pujals","year":"2015","journal-title":"Autophagy"},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Fan, J., Zeng, X., Li, Y., Wang, S., Wang, Z., Sun, Y., Gao, H., Zhang, G., Feng, M., and Ju, D. (2013). Autophagy Plays a Critical Role in ChLym-1-Induced Cytotoxicity of Non-Hodgkin\u2019s Lymphoma Cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0072478"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.biocel.2016.09.006","article-title":"Concomitant reduction of c-Myc expression and PI3K\/AKT\/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt\u2019s lymphoma","volume":"79","author":"Granato","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.3892\/or.2014.3369","article-title":"Arsenic trioxide induces autophagy and antitumor effects in Burkitt\u2019s lymphoma Raji cells","volume":"32","author":"Li","year":"2014","journal-title":"Oncol. Rep."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-8722-6-53","article-title":"Histone deacetylase inhibitor potentiated the ability of MTOR inhibitor to induce autophagic cell death in Burkitt leukemia\/lymphoma","volume":"6","author":"Dong","year":"2013","journal-title":"J. Hematol. Oncol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"e180","DOI":"10.1038\/bcj.2014.2","article-title":"A novel strategy inducing autophagic cell death in Burkitt\u2019s lymphoma cells with anti-CD19-targeted liposomal rapamycin","volume":"4","author":"Ono","year":"2014","journal-title":"Blood Cancer J."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1365-2141.2008.07555.x","article-title":"Involvement of macroautophagy in the caspase-independent killing of Burkitt lymphoma cell lines by rituximab","volume":"145","author":"Turzanski","year":"2009","journal-title":"Br. J. Haematol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fimmu.2014.00103","article-title":"Autophagy in plasma cell pathophysiology","volume":"5","author":"Oliva","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1158\/1078-0432.CCR-10-0890","article-title":"Targeting autophagy augments in vitro and in vivo antimyeloma activity of DNA-damaging chemotherapy","volume":"17","author":"Pan","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s13046-018-0883-3","article-title":"HMGB1 knockdown increases MM cell vulnerability by regulating autophagy and DNA damage repair","volume":"37","author":"Guo","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1182\/blood-2014-03-564534","article-title":"A Bim-targeting strategy overcomes adaptive bortezomib resistance in myeloma through a novel link between autophagy and apoptosis","volume":"124","author":"Chen","year":"2014","journal-title":"Blood"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/s41416-018-0232-5","article-title":"The HDAC6 inhibitor C1A modulates autophagy substrates in diverse cancer cells and induces cell death","volume":"119","author":"Kaliszczak","year":"2018","journal-title":"Br. J. Cancer"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"5955","DOI":"10.1111\/jcmm.13865","article-title":"Inhibition of autophagy enhances the antitumour activity of tigecycline in multiple myeloma","volume":"22","author":"Ma","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1080\/15548627.2015.1017185","article-title":"Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells","volume":"11","author":"Zhao","year":"2015","journal-title":"Autophagy"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1038\/leu.2015.157","article-title":"Pharmacologic screens reveal metformin that suppresses GRP78-dependent autophagy to enhance the anti-myeloma effect of bortezomib","volume":"29","author":"Jagannathan","year":"2015","journal-title":"Leukemia"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2016.08.019","article-title":"Inhibition of autophagy with chloroquine potentiates carfilzomib-induced apoptosis in myeloma cells in vitro and in vivo","volume":"382","author":"Jarauta","year":"2016","journal-title":"Cancer Lett."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"70845","DOI":"10.18632\/oncotarget.12226","article-title":"Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells","volume":"7","author":"Baranowska","year":"2016","journal-title":"Oncotarget"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1111\/cas.13711","article-title":"Profilin 1 induces drug resistance through Beclin1 complex-mediated autophagy in multiple myeloma","volume":"109","author":"Lu","year":"2018","journal-title":"Cancer Sci."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3727\/096504017X15049221237147","article-title":"ClC5 Decreases the Sensitivity of Multiple Myeloma Cells to Bortezomib via Promoting Prosurvival Autophagy","volume":"26","author":"Zhang","year":"2018","journal-title":"Oncol. Res."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1159\/000492690","article-title":"Knockdown of Linc00515 Inhibits Multiple Myeloma Autophagy and Chemoresistance by Upregulating miR-140-5p and Downregulating ATG14","volume":"48","author":"Lu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1080\/15548627.2015.1052928","article-title":"A plastic SQSTM1\/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells","volume":"11","author":"Milan","year":"2015","journal-title":"Autophagy"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"4690","DOI":"10.1182\/blood-2007-09-112904","article-title":"Targeting the p27 E3 ligase SCF(Skp2) results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy","volume":"111","author":"Chen","year":"2008","journal-title":"Blood"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"61093","DOI":"10.18632\/oncotarget.17862","article-title":"Endoplasmic reticulum stress induces autophagy and apoptosis while inhibiting proliferation and drug resistance in multiple myeloma through the PI3K\/Akt\/mTOR signaling pathway","volume":"8","author":"Fu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.tranon.2018.08.014","article-title":"Autophagy: A New Mechanism of Prosurvival and Drug Resistance in Multiple Myeloma","volume":"11","author":"Desantis","year":"2018","journal-title":"Transl. Oncol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.leukres.2017.06.002","article-title":"Targeting autophagy in multiple myeloma","volume":"59","author":"Yun","year":"2017","journal-title":"Leuk. Res."},{"key":"ref_227","doi-asserted-by":"crossref","unstructured":"Sommermann, T., O\u2019Neill, K., Plas, D.R., and Cahir-McFarland, E. (2011). IKK\u03b2 and NF-\u03baB transcription govern lymphoma cell survival through AKT-induced plasma membrane trafficking of GLUT1. Cancer Res., 7291\u20137300.","DOI":"10.1158\/0008-5472.CAN-11-1715"},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Granato, M., Santarelli, R., Lotti, L.V., Di Renzo, L., Gonnella, R., Garufi, A., Trivedi, P., Frati, L., D\u2019Orazi, G., and Faggioni, A. (2013). JNK and macroautophagy activation by bortezomib has a pro-survival effect in primary effusion lymphoma cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0075965"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jnutbio.2016.12.011","article-title":"Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K\/AKT\/mTOR and STAT3 signaling pathways","volume":"41","author":"Granato","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Torossian, A., Broin, N., Frentzel, J., Daugrois, C., Gandarillas, S., AlSaati, T., Lamant, L., Brousset, P., Giuriato, S., and Espinos, E. (2019). Blockade of crizotinib-induced BCL-2 elevation in ALK-positive ALCL triggers autophagy associated with cell death. Haematologica.","DOI":"10.3324\/haematol.2017.181966"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1365-2141.2011.08669.x","article-title":"Distinct cellular and therapeutic effects of obatoclax in rituximab-sensitive and -resistant lymphomas","volume":"153","author":"Brem","year":"2011","journal-title":"Br. J. Haematol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1182\/blood-2007-04-085092","article-title":"PKC zeta mTOR pathway: A new target for rituximab therapy in follicular lymphoma","volume":"111","author":"Leseux","year":"2008","journal-title":"Blood"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/cdd.2009.46","article-title":"Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy","volume":"16","author":"Laane","year":"2009","journal-title":"Cell Death Differ."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.4161\/auto.5.8.10122","article-title":"Autophagy as the main means of cytotoxicity by glucocorticoids in hematological malignancies","volume":"5","author":"Grander","year":"2009","journal-title":"Autophagy"},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Polak, A., Kiliszek, P., Sewastianik, T., Szyd\u0142owski, M., Jab\u0142o\u0144ska, E., Bia\u0142opiotrowicz, E., G\u00f3rniak, P., Markowicz, S., Nowak, E., and Grygorowicz, M.A. (2016). MEK Inhibition Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells to Dexamethasone through Modulation of mTOR Activity and Stimulation of Autophagy. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0155893"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.yexcr.2014.05.021","article-title":"Idarubicin induces mTOR-dependent cytotoxic autophagy in leukemic cells","volume":"326","author":"Ristic","year":"2014","journal-title":"Exp. Cell Res."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/leu.2013.226","article-title":"Targeting the PI3K\/Akt\/mTOR signaling pathway in B-precursor acute lymphoblastic leukemia and its therapeutic potential","volume":"28","author":"Neri","year":"2014","journal-title":"Leukemia"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"727","DOI":"10.4161\/auto.5.5.8507","article-title":"RAD001 (Everolimus) induces autophagy in acute lymphoblastic leukemia","volume":"5","author":"Crazzolara","year":"2009","journal-title":"Autophagy"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1046\/j.1365-2141.1997.2623081.x","article-title":"Inhibition of autophagy abrogates tumour necrosis factor alpha induced apoptosis in human T-lymphoblastic leukaemic cells","volume":"98","author":"Jia","year":"1997","journal-title":"Br. J. Haematol."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1016\/j.febslet.2013.06.011","article-title":"ATF4 activation by the p38MAPK-eIF4E axis mediates apoptosis and autophagy induced by selenite in Jurkat cells","volume":"587","author":"Jiang","year":"2013","journal-title":"FEBS Lett."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/j.1440-1754.2011.02212.x","article-title":"Glucocorticoid resistance in paediatric acute lymphoblastic leukaemia","volume":"48","author":"Bhadri","year":"2012","journal-title":"J. Paediatr. Child Health"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.1038\/cddis.2010.53","article-title":"GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy","volume":"1","author":"Heidari","year":"2010","journal-title":"Cell Death Dis."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1182\/blood-2012-04-425033","article-title":"Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia","volume":"121","author":"Urtishak","year":"2013","journal-title":"Blood"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1172\/JCI39987","article-title":"Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance","volume":"120","author":"Bonapace","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/ejh.12753","article-title":"Altered expression of autophagy-related genes might contribute to glucocorticoid resistance in precursor B-cell-type acute lymphoblastic leukemia","volume":"97","author":"Sarang","year":"2016","journal-title":"Eur. J. Haematol."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"707","DOI":"10.4161\/auto.7.7.15154","article-title":"FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells","volume":"7","author":"Hewson","year":"2011","journal-title":"Autophagy"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/jcp.22407","article-title":"Preclinical testing of the Akt inhibitor triciribine in T-cell acute lymphoblastic leukemia","volume":"226","author":"Evangelisti","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/nm.3955","article-title":"Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia","volume":"21","author":"Herranz","year":"2015","journal-title":"Nat. Med."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1182\/blood.V89.8.2959","article-title":"In vitro drug sensitivity testing can predict induction failure and early relapse of childhood acute lymphoblastic leukemia","volume":"89","author":"Hongo","year":"1997","journal-title":"Blood"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1182\/blood.V90.7.2723","article-title":"In vitro cellular drug resistance and prognosis in newly diagnosed childhood acute lymphoblastic leukemia","volume":"90","author":"Kaspers","year":"1997","journal-title":"Blood"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1038\/onc.2017.59","article-title":"Autophagy is required for cell survival under L-asparaginase-induced metabolic stress in acute lymphoblastic leukemia cells","volume":"36","author":"Takahashi","year":"2017","journal-title":"Oncogene"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2141.1982.tb08475.x","article-title":"Proposals for the classification of the myelodysplastic syndromes","volume":"51","author":"Bennett","year":"1982","journal-title":"Br. J. Haematol."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/ijc.27896","article-title":"Myelodysplastic syndrome hematopoietic stem cell","volume":"133","author":"Li","year":"2013","journal-title":"Int. J. Cancer"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.ccr.2014.03.036","article-title":"Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo","volume":"25","author":"Woll","year":"2014","journal-title":"Cancer Cell"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1182\/blood-2013-08-518886","article-title":"Clinical and biological implications of driver mutations in myelodysplastic syndromes","volume":"122","author":"Papaemmanuil","year":"2013","journal-title":"Blood"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1053\/j.seminoncol.2011.04.012","article-title":"Hematopoietic stem cell transplantation for myelodysplastic syndrome: A review","volume":"38","author":"Parmar","year":"2011","journal-title":"Semin. Oncol."},{"key":"ref_257","doi-asserted-by":"crossref","unstructured":"Odenike, O., Onida, F., and Padron, E. (2015). Myelodysplastic syndromes and myelodysplastic\/myeloproliferative neoplasms: An update on risk stratification, molecular genetics, and therapeutic approaches including allogeneic hematopoietic stem cell transplantation. Am. Soc. Clin. Oncol. Educ. Book, e398\u2013e412.","DOI":"10.14694\/EdBook_AM.2015.35.e398"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/ng.3380","article-title":"Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies","volume":"47","author":"Saliba","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.molcel.2016.04.011","article-title":"U2AF35(S34F) Promotes Transformation by Directing Aberrant ATG7 Pre-mRNA 3\u2032 End Formation","volume":"62","author":"Park","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"6328051","DOI":"10.1155\/2018\/6328051","article-title":"Impaired Mitophagy of Nucleated Erythroid Cells Leads to Anemia in Patients with Myelodysplastic Syndromes","volume":"2018","author":"Jiang","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_261","doi-asserted-by":"crossref","unstructured":"Zhuang, L., Ma, Y., Wang, Q., Zhang, J., Zhu, C., Zhang, L., and Xu, X. (2016). Atg3 Overexpression Enhances Bortezomib-Induced Cell Death in SKM-1 Cell. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0158761"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1182\/blood-2014-08-551499","article-title":"How I treat the older patient with acute myeloid leukemia","volume":"125","author":"Ossenkoppele","year":"2015","journal-title":"Blood"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","article-title":"The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia","volume":"127","author":"Arber","year":"2016","journal-title":"Blood"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.canep.2017.11.008","article-title":"Improvement of relative survival in elderly patients with acute myeloid leukaemia emerging from population-based cancer registries in Switzerland between 2001 and 2013","volume":"52","author":"Feller","year":"2018","journal-title":"Cancer Epidemiol."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1182\/blood-2011-12-379008","article-title":"Acute myeloid leukemia in the real world: Why population-based registries are needed","volume":"119","author":"Juliusson","year":"2012","journal-title":"Blood"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"1482795","DOI":"10.1155\/2018\/1482795","article-title":"Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy","volume":"2018","author":"Jin","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"15008","DOI":"10.1038\/cddiscovery.2015.8","article-title":"Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia","volume":"1","author":"Watson","year":"2015","journal-title":"Cell Death Discov."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1182\/blood-2011-02-336487","article-title":"MiR-17\/20\/93\/106 promote hematopoietic cell expansion by targeting sequestosome 1-regulated pathways in mice","volume":"118","author":"Meenhuis","year":"2011","journal-title":"Blood"},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1038\/cdd.2014.102","article-title":"p62\/SQSTM1 upregulation constitutes a survival mechanism that occurs during granulocytic differentiation of acute myeloid leukemia cells","volume":"21","author":"Trocoli","year":"2014","journal-title":"Cell Death Differ."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"e970066","DOI":"10.4161\/23723548.2014.970066","article-title":"Pro-survival role of p62 during granulocytic differentiation of acute myeloid leukemia cells","volume":"1","author":"Tschan","year":"2014","journal-title":"Mol. Cell. Oncol."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1182\/blood-2018-02-833475","article-title":"Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy","volume":"133","author":"Nguyen","year":"2019","journal-title":"Blood"},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1038\/s41375-018-0102-4","article-title":"RET-mediated autophagy suppression as targetable co-dependence in acute myeloid leukemia","volume":"32","author":"Rudat","year":"2018","journal-title":"Leukemia"},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1182\/blood-2015-05-646497","article-title":"Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells","volume":"127","author":"Larrue","year":"2016","journal-title":"Blood"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/onc.2017.376","article-title":"Oncogenic FLT3-ITD supports autophagy via ATF4 in acute myeloid leukemia","volume":"37","author":"Heydt","year":"2018","journal-title":"Oncogene"},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.7150\/thno.19439","article-title":"NPM1 Mutant Mediated PML Delocalization and Stabilization Enhances Autophagy and Cell Survival in Leukemic Cells","volume":"7","author":"Zou","year":"2017","journal-title":"Theranostics"},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1182\/blood-2015-12-684696","article-title":"Cytoprotective autophagy maintains leukemia-initiating cells in murine myeloid leukemia","volume":"128","author":"Sumitomo","year":"2016","journal-title":"Blood"},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1182\/blood-2016-10-745034","article-title":"Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner","volume":"129","author":"Man","year":"2017","journal-title":"Blood"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1080\/15548627.2017.1287652","article-title":"Autophagy is dispensable for Kmt2a\/Mll-Mllt3\/Af9 AML maintenance and anti-leukemic effect of chloroquine","volume":"13","author":"Chen","year":"2017","journal-title":"Autophagy"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"e2361","DOI":"10.1038\/cddis.2016.264","article-title":"Atg5-dependent autophagy contributes to the development of acute myeloid leukemia in an MLL-AF9-driven mouse model","volume":"7","author":"Liu","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1038\/s41467-018-05311-4","article-title":"A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways","volume":"9","author":"Piragyte","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"724","DOI":"10.2174\/15680096113139990088","article-title":"Autophagy in chronic myeloid leukaemia: Stem cell survival and implication in therapy","volume":"13","author":"Helgason","year":"2013","journal-title":"Curr. Cancer Drug Targets"},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1182\/blood-2012-01-402578","article-title":"Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide","volume":"120","author":"Goussetis","year":"2012","journal-title":"Blood"},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1080\/15548627.2015.1084454","article-title":"MAPK15 mediates BCR-ABL1-induced autophagy and regulates oncogene-dependent cell proliferation and tumor formation","volume":"11","author":"Colecchia","year":"2015","journal-title":"Autophagy"},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1182\/blood-2010-12-322537","article-title":"BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription","volume":"118","author":"Sheng","year":"2011","journal-title":"Blood"},{"key":"ref_285","doi-asserted-by":"crossref","unstructured":"Baquero, P., Dawson, A., Mukhopadhyay, A., Kuntz, E.M., Mitchell, R., Olivares, O., Ianniciello, A., Scott, M.T., Dunn, K., and Nicastri, M.C. (2018). Targeting quiescent leukemic stem cells using second generation autophagy inhibitors. Leukemia.","DOI":"10.1038\/s41375-018-0252-4"},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"96984","DOI":"10.18632\/oncotarget.18904","article-title":"Chronic myeloid leukemia progenitor cells require autophagy when leaving hypoxia-induced quiescence","volume":"8","author":"Ianniciello","year":"2017","journal-title":"Oncotarget"},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1038\/leu.2015.112","article-title":"The BMI1 polycomb protein represses cyclin G2-induced autophagy to support proliferation in chronic myeloid leukemia cells","volume":"29","author":"Mourgues","year":"2015","journal-title":"Leukemia"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"5362","DOI":"10.2174\/13816128113199990334","article-title":"How recent advances in high-risk myelodysplastic syndrome physiopathology may impact future treatments","volume":"19","author":"Cluzeau","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"4302320","DOI":"10.1155\/2017\/4302320","article-title":"Decitabine-Induced Changes in Human Myelodysplastic Syndrome Cell Line SKM-1 Are Mediated by FOXO3A Activation","volume":"2017","author":"Zeng","year":"2017","journal-title":"J. Immunol. Res."},{"key":"ref_290","doi-asserted-by":"crossref","unstructured":"Dubois, A., Furstoss, N., Calleja, A., Zerhouni, M., Cluzeau, T., Savy, C., Marchetti, S., Hamouda, M.A., Boulakirba, S., and Orange, F. (2019). LAMP2 expression dictates azacytidine response and prognosis in MDS\/AML. Leukemia.","DOI":"10.1038\/s41375-018-0336-1"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1038\/sj.onc.1210187","article-title":"NF-\u03baB inhibition sensitizes to starvation-induced cell death in high-risk myelodysplastic syndrome and acute myeloid leukemia","volume":"26","author":"Fabre","year":"2007","journal-title":"Oncogene"},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1182\/blood-2012-02-407999","article-title":"Cytotoxic effects of bortezomib in myelodysplastic syndrome\/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1","volume":"120","author":"Fang","year":"2012","journal-title":"Blood"},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bbamcr.2014.09.023","article-title":"Autophagy in acute leukemias: A double-edged sword with important therapeutic implications","volume":"1853","author":"Evangelisti","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1038\/leu.2011.339","article-title":"The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia","volume":"26","author":"Willems","year":"2012","journal-title":"Leukemia"},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/leu.2010.225","article-title":"HMGB1-induced autophagy promotes chemotherapy resistance in leukemia cells","volume":"25","author":"Liu","year":"2011","journal-title":"Leukemia"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.3892\/mmr.2016.4949","article-title":"Enhanced autophagy in cytarabine arabinoside-resistant U937 leukemia cells and its potential as a target for overcoming resistance","volume":"13","author":"Cheong","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1182\/blood-2016-01-692244","article-title":"Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia","volume":"128","author":"Piya","year":"2016","journal-title":"Blood"},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.1182\/blood.V124.21.5209.5209","article-title":"Autophagy Is an Important Event for Low Dose Cytarabine Treatment in Acute Myeloid Leukemia U937 Cell Line","volume":"124","author":"Chen","year":"2014","journal-title":"Blood"},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1158\/1078-0432.CCR-13-3218","article-title":"Autophagy is a survival mechanism of acute myelogenous leukemia precursors during dual mTORC2\/mTORC1 targeting","volume":"20","author":"Altman","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1182\/blood-2013-03-493163","article-title":"Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia","volume":"122","author":"Willems","year":"2013","journal-title":"Blood"},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1182\/blood-2013-05-500629","article-title":"Targeting autophagy potentiates the apoptotic effect of histone deacetylase inhibitors in t(8;21) AML cells","volume":"122","author":"Torgersen","year":"2013","journal-title":"Blood"},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/leu.2013.264","article-title":"Histone deacetylase inhibitors induce apoptosis in myeloid leukemia by suppressing autophagy","volume":"28","author":"Stankov","year":"2014","journal-title":"Leukemia"},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"6089","DOI":"10.1182\/blood-2011-09-378141","article-title":"Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process","volume":"119","author":"Rahmani","year":"2012","journal-title":"Blood"},{"key":"ref_304","first-page":"3343","article-title":"Induction of non-apoptotic cell death by morphinone in human promyelocytic leukemia HL-60 cells","volume":"26","author":"Takeuchi","year":"2006","journal-title":"Anti-Cancer Res."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.celrep.2015.04.063","article-title":"Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia","volume":"11","author":"Sujobert","year":"2015","journal-title":"Cell Rep."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"29989","DOI":"10.1074\/jbc.M109.090530","article-title":"Autophagy is a critical mechanism for the induction of the antileukemic effects of arsenic trioxide","volume":"285","author":"Goussetis","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1182\/blood-2010-01-261040","article-title":"Autophagy contributes to therapy-induced degradation of the PML\/RARA oncoprotein","volume":"116","author":"Isakson","year":"2010","journal-title":"Blood"},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1182\/blood-2008-04-150250","article-title":"Management of acute promyelocytic leukemia: Recommendations from an expert panel on behalf of the European LeukemiaNet","volume":"113","author":"Sanz","year":"2009","journal-title":"Blood"},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"401","DOI":"10.4161\/auto.7.4.14397","article-title":"Autophagy regulates myeloid cell differentiation by p62\/SQSTM1-mediated degradation of PML-RARalpha oncoprotein","volume":"7","author":"Wang","year":"2011","journal-title":"Autophagy"},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.4161\/auto.7.10.16623","article-title":"ATRA-induced upregulation of Beclin 1 prolongs the life span of differentiated acute promyelocytic leukemia cells","volume":"7","author":"Trocoli","year":"2011","journal-title":"Autophagy"},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.4161\/auto.7.10.16636","article-title":"PML-RARalpha enhances constitutive autophagic activity through inhibiting the Akt\/mTOR pathway","volume":"7","author":"Huang","year":"2011","journal-title":"Autophagy"},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"e1315","DOI":"10.1038\/cddis.2014.261","article-title":"WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells","volume":"5","author":"Brigger","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.bbrc.2013.07.056","article-title":"Inhibition of GATE-16 attenuates ATRA-induced neutrophil differentiation of APL cells and interferes with autophagosome formation","volume":"438","author":"Brigger","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.leukres.2012.08.024","article-title":"Inhibition of damage-regulated autophagy modulator-1 (DRAM-1) impairs neutrophil differentiation of NB4 APL cells","volume":"36","author":"Humbert","year":"2012","journal-title":"Leuk. Res."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.leukres.2014.06.010","article-title":"Induction of the autophagy-associated gene MAP1S via PU.1 supports APL differentiation","volume":"38","author":"Haimovici","year":"2014","journal-title":"Leuk. Res."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1159\/000475277","article-title":"MiR-34a Promotes Apoptosis and Inhibits Autophagy by Targeting HMGB1 in Acute Myeloid Leukemia Cells","volume":"41","author":"Liu","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.4161\/auto.29592","article-title":"MIR125B1 represses the degradation of the PML-RARA oncoprotein by an autophagylysosomal pathway in acute promyelocytic leukemia","volume":"10","author":"Zeng","year":"2014","journal-title":"Autophagy"},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/cdd.2016.111","article-title":"The lncRNA HOTAIRM1 regulates the degradation of PML-RARA oncoprotein and myeloid cell differentiation by enhancing the autophagy pathway","volume":"24","author":"Chen","year":"2017","journal-title":"Cell Death Differ."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1038\/leu.2016.227","article-title":"Rationale and efficacy of proteasome inhibitor combined with arsenic trioxide in the treatment of acute promyelocytic leukemia","volume":"30","author":"Ganesan","year":"2016","journal-title":"Leukemia"},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.bcp.2014.02.019","article-title":"Autophagy contributes to dasatinib-induced myeloid differentiation of human acute myeloid leukemia cells","volume":"89","author":"Xie","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1128\/MCB.01748-12","article-title":"Arsenic inhibits autophagic flux, activating the Nrf2-Keap1 pathway in a p62-dependent manner","volume":"33","author":"Lau","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/ajh.23428","article-title":"Induction of autophagy by Imatinib sequesters Bcr-Abl in autophagosomes and down-regulates Bcr-Abl protein","volume":"88","author":"Elzinga","year":"2013","journal-title":"Am. J. Hematol."},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1182\/blood-2006-10-050260","article-title":"Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance","volume":"110","author":"Carew","year":"2007","journal-title":"Blood"},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1172\/JCI35660","article-title":"Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells","volume":"119","author":"Bellodi","year":"2009","journal-title":"J. Clin. Investig."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1182\/blood-2011-01-330621","article-title":"Kill one bird with two stones: Potential efficacy of BCR-ABL and autophagy inhibition in CML","volume":"118","author":"Helgason","year":"2011","journal-title":"Blood"},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3109\/10428194.2010.546913","article-title":"Inhibition of autophagy: A new strategy to enhance sensitivity of chronic myeloid leukemia stem cells to tyrosine kinase inhibitors","volume":"52","author":"Calabretta","year":"2011","journal-title":"Leuk. Lymphoma"},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.3892\/or.2013.2377","article-title":"Pharmacological agents with inherent anti-autophagic activity improve the cytotoxicity of imatinib","volume":"29","author":"Crowley","year":"2013","journal-title":"Oncol. Rep."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"355","DOI":"10.4161\/15548627.2014.994368","article-title":"Targeting Hedgehog signaling pathway and autophagy overcomes drug resistance of BCR-ABLpositive chronic myeloid leukemia","volume":"11","author":"Zeng","year":"2015","journal-title":"Autophagy"},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"655","DOI":"10.4161\/auto.6.5.12126","article-title":"AMPK- and p62\/SQSTM1-dependent autophagy mediate resveratrol-induced cell death in chronic myelogenous leukemia","volume":"6","author":"Puissant","year":"2010","journal-title":"Autophagy"},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1158\/0008-5472.CAN-09-3537","article-title":"Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62\/SQSTM1 expression and AMPK activation","volume":"70","author":"Puissant","year":"2010","journal-title":"Cancer Res."},{"key":"ref_331","doi-asserted-by":"crossref","unstructured":"Robert, G., Ben Sahra, I., Puissant, A., Colosetti, P., Belhacene, N., Gounon, P., Hofman, P., Bost, F., Cassuto, J.P., and Auberger, P. (2009). Acadesine kills Chronic Myelogenous Leukemia (CML) cells through PKC-dependent induction of autophagic cell death. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0007889"},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"860","DOI":"10.18632\/oncotarget.1018","article-title":"Potent antitumor activity of oncolytic adenovirus expressing Beclin-1 via induction of autophagic cell death in leukemia","volume":"4","author":"Tong","year":"2013","journal-title":"Oncotarget"},{"key":"ref_333","unstructured":"Thorburn, A. (2017). Autophagy and Disease. J. Biol. Chem."},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15548627.2018.1474314","article-title":"Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion","volume":"14","author":"Mauthe","year":"2018","journal-title":"Autophagy"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/8\/2\/103\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:29:50Z","timestamp":1760185790000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/8\/2\/103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,30]]},"references-count":334,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2]]}},"alternative-id":["cells8020103"],"URL":"https:\/\/doi.org\/10.3390\/cells8020103","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,30]]}}}