{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:51:08Z","timestamp":1787500268168,"version":"build-2736575974"},"reference-count":39,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,5,5]],"date-time":"2019-05-05T00:00:00Z","timestamp":1557014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Direct-acting antiviral drugs to cure infections with Hepatitis C virus (HCV) achieve a sustained virological response (SVR) in more than 90% of adult patients. At present, clinical trials are ongoing and real-life data are still limited in children. Herein, we report two cases of pediatric patients treated with fixed-dose combination of sofosbuvir\/ledipasvir, already approved to treat HCV4 genotype. Both young girls achieved SVR even though HCV4 isolates carried L28M and M31L NS5A resistance-associated substitutions (RASs). Therefore, possible effects of these RASs merit further study, especially in children.<\/jats:p>","DOI":"10.3390\/cells8050416","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T05:35:39Z","timestamp":1557725739000},"page":"416","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical, Virological Characteristics, and Outcomes of Treatment with Sofosbuvir\/Ledipasvir in Two Pediatric Patients Infected by HCV Genotype 4"],"prefix":"10.3390","volume":"8","author":[{"given":"Nadia","family":"Marascio","sequence":"first","affiliation":[{"name":"Department of Health Sciences, Unit of Clinical Microbiology, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0263-0703","authenticated-orcid":false,"given":"Maria","family":"Mazzitelli","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Unit of Infectious and Tropical Diseases, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia","family":"Pavia","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Unit of Clinical Microbiology, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Giancotti","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Unit of Clinical Microbiology, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio Settimo","family":"Barreca","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Unit of Clinical Microbiology, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Unit of Infectious and Tropical Diseases, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Pisani","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Unit of Infectious and Tropical Diseases, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Greco","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Unit of Infectious and Tropical Diseases, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Serapide","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Unit of Infectious and Tropical Diseases, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico Maria","family":"Trecarichi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Unit of Infectious and Tropical Diseases, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Casalinuovo","sequence":"additional","affiliation":[{"name":"Institute for Experimental Veterinary Medicine of Southern Italy, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carla","family":"Liberto","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Unit of Clinical Microbiology, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Matera","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Unit of Clinical Microbiology, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Torti","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Unit of Infectious and Tropical Diseases, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.4254\/wjh.v6.i9.643","article-title":"Vertical transmission of Hepatitis C virus: Current knowledge and perspectives","volume":"6","author":"Yeung","year":"2014","journal-title":"World J. 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