{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:23:56Z","timestamp":1790760236425,"version":"4.1.0"},"reference-count":148,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01ES023569"],"award-info":[{"award-number":["R01ES023569"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01 ES 024050"],"award-info":[{"award-number":["R01 ES 024050"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01 ES 027059"],"award-info":[{"award-number":["R01 ES 027059"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["ETN-2014-642023"],"award-info":[{"award-number":["ETN-2014-642023"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"GGET\/SIEMENS Program","award":["Establishing a Multidisciplinary and Effective Innovation and Entrepreneurship Hub"],"award-info":[{"award-number":["Establishing a Multidisciplinary and Effective Innovation and Entrepreneurship Hub"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Purine 5\u2032,8-cyclo-2\u2032-deoxynucleosides (cPu) are tandem-type lesions observed among the DNA purine modifications and identified in mammalian cellular DNA in vivo. These lesions can be present in two diasteroisomeric forms, 5\u2032R and 5\u2032S, for each 2\u2032-deoxyadenosine and 2\u2032-deoxyguanosine moiety. They are generated exclusively by hydroxyl radical attack to 2\u2032-deoxyribose units generating C5\u2032 radicals, followed by cyclization with the C8 position of the purine base. This review describes the main recent achievements in the preparation of the cPu molecular library for analytical and DNA synthesis applications for the studies of the enzymatic recognition and repair mechanisms, their impact on transcription and genetic instability, quantitative determination of the levels of lesions in various types of cells and animal model systems, and relationships between the levels of lesions and human health, disease, and aging, as well as the defining of the detection limits and quantification protocols.<\/jats:p>","DOI":"10.3390\/cells8060513","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T11:18:09Z","timestamp":1559042289000},"page":"513","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["5\u2032,8-Cyclopurine Lesions in DNA Damage: Chemical, Analytical, Biological, and Diagnostic Significance"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2626-2925","authenticated-orcid":false,"given":"Chryssostomos","family":"Chatgilialoglu","sequence":"first","affiliation":[{"name":"Istituto per la Sintesi Organica e la Fotoreattivit\u00e0, Consiglio Nazionale delle Ricerche, Via P. Gobetti 101, 40129 Bologna, Italy"},{"name":"Center for Advanced Technologies, Adam Mickiewicz University, 61-614 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1359-0869","authenticated-orcid":false,"given":"Carla","family":"Ferreri","sequence":"additional","affiliation":[{"name":"Istituto per la Sintesi Organica e la Fotoreattivit\u00e0, Consiglio Nazionale delle Ricerche, Via P. Gobetti 101, 40129 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas E.","family":"Geacintov","sequence":"additional","affiliation":[{"name":"Department of Chemistry, New York University, 31 Washington Place, New York, NY 10003-5180, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marios G.","family":"Krokidis","sequence":"additional","affiliation":[{"name":"Institute of Nanoscience and Nanotechnology, N.C.S.R. \u201cDemokritos\u201d, 15310 Agia Paraskevi Attikis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA"},{"name":"Biochemistry Ph.D. Program, Florida International University, Miami, FL 33199, USA"},{"name":"Biomolecular Sciences Institute, Florida International University, Miami, FL 33199, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7163-3978","authenticated-orcid":false,"given":"Annalisa","family":"Masi","sequence":"additional","affiliation":[{"name":"Istituto per la Sintesi Organica e la Fotoreattivit\u00e0, Consiglio Nazionale delle Ricerche, Via P. Gobetti 101, 40129 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Shafirovich","sequence":"additional","affiliation":[{"name":"Department of Chemistry, New York University, 31 Washington Place, New York, NY 10003-5180, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Terzidis","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical and Environmental Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawlos S.","family":"Tsegay","sequence":"additional","affiliation":[{"name":"Biochemistry Ph.D. Program, Florida International University, Miami, FL 33199, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5753","DOI":"10.1016\/S0021-9258(18)91929-0","article-title":"The reduction of cytochrome c by milk xanthine oxidase","volume":"243","author":"McCord","year":"1968","journal-title":"J. Biol. Chem."},{"key":"ref_2","first-page":"1260","article-title":"Biological chemistry of reactive oxygen species","volume":"Volume 3","author":"Chatgilialoglu","year":"2012","journal-title":"Encyclopedia of Radicals in Chemistry, Biology and Materials"},{"key":"ref_3","first-page":"1284","article-title":"Reactions of small reactive species with DNA","volume":"Volume 3","author":"Chatgilialoglu","year":"2012","journal-title":"Encyclopedia of Radicals in Chemistry, Biology and Materials"},{"key":"ref_4","unstructured":"Friedberg, E.C., Walker, G.C., and Siede, W. (1995). DNA Repair Mutagenesis, ASM Press."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a025130","article-title":"DNA Damage, DNA Repair, Aging, and Neurodegeneration","volume":"5","author":"Maynard","year":"2015","journal-title":"Cold Spring Harb Perspect. Med."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Von Sonntag, C. (2006). Free-Radical-Induced DNA Damage and Its Repair: A Chemical Persective, Springer.","DOI":"10.1007\/3-540-30592-0"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"9738","DOI":"10.1073\/pnas.95.17.9738","article-title":"DNA strand breaking by the hydroxyl radical is governed by the accessible surface areas of the hydrogen atoms of the DNA backbone","volume":"95","author":"Balasubramanian","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6145","DOI":"10.1021\/ja910928n","article-title":"Quantification of the 2-deoxyribonolactone and nucleoside 5\u2032-aldehyde products of 2-deoxyribose oxidation in DNA and cells by isotope-dilution gas chromatography mass mpectrometry: Differential effects of \u03b3-radiation and Fe2+ \u2212EDTA","volume":"132","author":"Chan","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1667\/0033-7587(2002)157[0038:SSOATT]2.0.CO;2","article-title":"Site-specific OH attack to the sugar moiety of DNA: A comparison of experimental data and computational simulation","volume":"157","author":"Aydogan","year":"2002","journal-title":"Radiat. Res."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Greenberg, M.M. (2009). Reactivity of nucleic acid sugar radicals. Radical and Radical Ion Reactivity in Nucleic Acid Chemistry, Wiley. Chapter 4.","DOI":"10.1002\/9780470526279.ch5"},{"key":"ref_11","first-page":"1345","article-title":"Oxidatively formed sugar radicals in nucleic acids","volume":"Volume 3","author":"Chatgilialoglu","year":"2012","journal-title":"Encyclopedia of Radicals in Chemistry, Biology and Materials"},{"key":"ref_12","first-page":"119","article-title":"Reactivity of Nucleic Acid Radicals","volume":"50","author":"Greenberg","year":"2016","journal-title":"Adv. Phys. Org. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1039\/c0cs00061b","article-title":"Purine 5\u2032,8-cyclonucleoside lesions: Chemistry and biology","volume":"40","author":"Chatgilialoglu","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"ref_14","unstructured":"Von Sonntag, C. (1987). The Chemical Basis of Radiation Biology, Taylor & Francis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1515\/znb-1968-0804","article-title":"Bildung von cyclonudleotiden bei bestrahlung wassiriger losungen von purinenucleotiden","volume":"23b","author":"Keck","year":"1968","journal-title":"Z. Naturforsch."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1042\/bj2380247","article-title":"Free-radical-induced formation of an 8,5\u2032-cyclo-2\u2032-deoxyguanosine moiety in deoxyribonucleic acid","volume":"238","author":"Dizdaroglu","year":"1986","journal-title":"Biochem. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/09553008814551631","article-title":"Effect of DNA conformation on the hydroxyl radical-induced formation of 8,5\u2032-cyclopurine 2\u2032-deoxyribonucleoside residues in DNA","volume":"54","author":"Dirksen","year":"1988","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1042\/bj2410929","article-title":"Ionizing-radiation-induced damage in the DNA of cultured human cells. Identification of 8,5\u2032-cyclo-2-deoxyguanosine","volume":"241","author":"Dizdaroglu","year":"1987","journal-title":"Biochem. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.dnarep.2008.06.005","article-title":"8,5\u2032-Cyclopurine-2\u2032-deoxynucleosides in DNA: Mechanisms of formation, measurement, repair and biological effects","volume":"7","author":"Jaruga","year":"2008","journal-title":"DNA Repair"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3109\/10715762.2011.653969","article-title":"Mechanisms of free radical-induced damage to DNA","volume":"46","author":"Dizdaroglu","year":"2012","journal-title":"Free Radic. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1021\/tx700282x","article-title":"(5\u2032S)- and (5\u2032R)-5\u2032,8-Cyclo-2\u2032-deoxyguanosine: Mechanistic insights on the 2\u2032-deoxyguanosin-5\u2032-yl radical cyclization","volume":"20","author":"Chatgilialoglu","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1021\/ja9941577","article-title":"Fate of the 2\u2032-deoxyadenosin-5\u2032-yl radical under anaerobic conditions","volume":"122","author":"Flyunt","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1021\/ja029374d","article-title":"Model studies of DNA C5\u2032 radicals. Selective generation and reactivity of 2\u2032-deoxyadenosin-5\u2032-yl radical","volume":"125","author":"Chatgilialoglu","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"8377","DOI":"10.1021\/ja800763j","article-title":"The fate of C5\u2032 radicals of purine nucleosides under oxidative conditions","volume":"130","author":"Boussicault","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1021\/tx2003245","article-title":"New insights into the reaction paths of hydroxyl radicals with 2\u2032-deoxyguanosine","volume":"24","author":"Chatgilialoglu","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1039\/b410939b","article-title":"The photochemistry of 8-bromo-2\u2032-deoxyadenosine. A direct entry to cyclopurine lesions","volume":"3","author":"Jimenez","year":"2004","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4445","DOI":"10.1021\/jo060197z","article-title":"C5\u2032-adenosinyl radical cyclization. A stereochemical investigation","volume":"71","author":"Navacchia","year":"2006","journal-title":"J. Org. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1071\/CH12494","article-title":"Radical cascade protocol for the synthesis of (5\u2032S)- and (5\u2032R)-5\u2032,8-cyclo-2\u2032-deoxyguanosine derivatives","volume":"66","author":"Terzidis","year":"2013","journal-title":"Aust. J. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1021\/ac103099s","article-title":"Quantification of oxidative DNA lesions in tissues of Long-Evans Cinnamon rats by capillary high-performance liquid chromatography-tandem mass spectrometry coupled with stable isotope-dilution method","volume":"83","author":"Wang","year":"2011","journal-title":"Anal. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fchem.2015.00047","article-title":"An ameliorative protocol for the quantification of purine 5\u2032,8-cyclo-2\u2032-deoxynucleosides in oxidized DNA","volume":"3","author":"Terzidis","year":"2015","journal-title":"Front. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1021\/bi016004d","article-title":"Mass spectrometric assays for the tandem lesion 8,5\u2032-cyclo-2\u2032-deoxyguanosine in mammalian DNA","volume":"41","author":"Jaruga","year":"2002","journal-title":"Biochemistry"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1039\/c4qo00133h","article-title":"A problem solving approach for the diastereoselective synthesis of (5\u2032S)- and (5\u2032R)-5\u2032,8-cyclopurine lesions","volume":"1","author":"Chatgilialoglu","year":"2014","journal-title":"Org. Chem. Front."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1016\/0040-4020(78)88398-7","article-title":"Synthesis of carbon-bridged 8,5\u2032-cyclopurine Nucleosides: Nucleosides and Nucleotides","volume":"34","author":"Matsuda","year":"1978","journal-title":"Tetrahedron"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1021\/jo980083q","article-title":"Site-Specific Introduction of (5\u2032S)-5\u2032,8-Cyclo-2\u2032-deoxyadenosine into oligodeoxyribonucleotides","volume":"63","author":"Romieu","year":"1998","journal-title":"J. Org. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1021\/tx9802668","article-title":"Synthesis and characterization of oligonucleotides containing 5\u2032,8-cyclopurine 2\u2032-deoxyribonucleosides: (5\u2032R)-5\u2032,8-cyclo-2\u2032-deoxyadenosine, (5\u2032S)-5\u2032,8-cyclo-2\u2032-deoxyguanosine, and (5\u2032R)-5\u2032,8-cyclo-2\u2032-deoxyguanosine","volume":"12","author":"Romieu","year":"1999","journal-title":"Chem. Res. Toxicol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"22355","DOI":"10.1074\/jbc.M002259200","article-title":"The oxidative DNA lesion 8,5\u2032-(S)-cyclo-2\u2032-deoxyadenosine is repaired by the nucleotide excision repair pathway and blocks gene expression in mammalian cells","volume":"275","author":"Brooks","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1021\/tx300193k","article-title":"Structure and stability of duplex DNA containing (5\u2032S)-5\u2032,8-cyclo-2\u2032-deoxyadenosine: An oxidatively generated lesion repaired by NER","volume":"25","author":"Zaliznyak","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"20357","DOI":"10.1021\/ja207407n","article-title":"Structure of (5\u2032S)-8,5\u2032-cyclo-2\u2032-deoxyguanosine in DNA","volume":"133","author":"Huang","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.1093\/nar\/gku162","article-title":"Structural basis for the recognition of diastereomeric 5\u2032,8-cyclo-2\u2032-deoxypurine lesions by the human nucleotide excision repair system","volume":"42","author":"Kropachev","year":"2014","journal-title":"Nucl. Acids Res."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Masi, A., Sabbia, A., Ferreri, C., Manoli, F., Lai, Y., Laverde, E., Liu, Y., Krokidis, M.G., Chatgilialoglu, C., and Faraone Mennella, M.R. (2019). Diastereomeric recognition of 5\u2032,8-cyclo-2\u2032-deoxyadenosine lesions by human Poly(ADP-ribose) polymerase 1 in a biomimetic model. Cells, 8.","DOI":"10.3390\/cells8020116"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1021\/bi00549a031","article-title":"Enzyme-bound conformations of nucleotide substrates. X-ray structure and absolute configuration of 8,5\u2032-cycloadenosine monohydrate","volume":"19","author":"Haromy","year":"1980","journal-title":"Biochemistry"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1021\/tx2005053","article-title":"Structures of (5\u2032S)-8,5\u2032-cyclo-2\u2032-deoxyguanosine mismatched with dA or dT","volume":"25","author":"Huang","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.comptc.2013.01.014","article-title":"The role of (5\u2032R) and (5\u2032S) 5\u2032,8-cyclo-2\u2032-deoxyadenosine in ds-DNA structure: A comparative QM\/MM theoretical study","volume":"1010","author":"Karwowski","year":"2013","journal-title":"Comput. Theor. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3832","DOI":"10.1073\/pnas.070471597","article-title":"Removal of oxygen free-radical-induced 5\u2032,8-purine cyclodeoxynucleosides from DNA by the nucleotide excision-repair pathway in human cells","volume":"97","author":"Kuraoka","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3109\/10409238.2013.875514","article-title":"Interplay between DNA repair and inflammation, and the link to cancer","volume":"49","author":"Kidane","year":"2014","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.canlet.2011.12.038","article-title":"Base excision repair and cancer","volume":"327","author":"Wallace","year":"2012","journal-title":"Cancer Lett."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1126\/science.286.5446.1897","article-title":"Quality control by DNA repair","volume":"286","author":"Lindahl","year":"1999","journal-title":"Science"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"a012583","DOI":"10.1101\/cshperspect.a012583","article-title":"Base excision repair","volume":"5","author":"Krokan","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0921-8777(90)90004-O","article-title":"The enzymology of apurinic\/apyrimidinic endonucleases","volume":"236","author":"Doetsch","year":"1990","journal-title":"Mutat. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1042\/bj2420565","article-title":"Escherichia coli endonuclease III is not an endonuclease but a beta-elimination catalyst","volume":"242","author":"Bailly","year":"1987","journal-title":"Biochem. J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1042\/bj2610707","article-title":"Delta-elimination in the repair of AP (apurinic\/apyrimidinic) sites in DNA","volume":"261","author":"Bailly","year":"1989","journal-title":"Biochem. J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"14756","DOI":"10.1021\/bi981594+","article-title":"Single-turnover and pre-steady-state kinetics of the reaction of the adenine glycosylase MutY with mismatch-containing DNA substrates","volume":"37","author":"Porello","year":"1998","journal-title":"Biochemistry"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1523\/JNEUROSCI.16-03-00939.1996","article-title":"DNA mismatch repair and DNA methylation in adult brain neurons","volume":"16","author":"Brooks","year":"1996","journal-title":"J. Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev.biochem.68.1.255","article-title":"Initiation of base excision repair: Glycosylase mechanisms and structures","volume":"68","author":"McCullough","year":"1999","journal-title":"Annu. Rev. Biochem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.dnarep.2012.09.002","article-title":"Repair efficiency of (5\u2032S)-8,5-cyclo-2\u2032-deoxyguanosine and (5\u2032S)-8,5\u2032-cyclo-2\u2032-deoxyadenosine depends on the complementary base","volume":"11","author":"Pande","year":"2012","journal-title":"DNA Repair"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1021\/acs.chemrestox.7b00128","article-title":"Repair-resistant DNA lesions","volume":"30","author":"Geacintov","year":"2017","journal-title":"Chem. Res. Toxicol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.dnarep.2011.04.019","article-title":"The xeroderma pigmentosum pathway: Decision tree analysis of DNA quality","volume":"10","author":"Naegeli","year":"2011","journal-title":"DNA Repair"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1021\/cr040483f","article-title":"Molecular mechanisms of mammalian global genome nucleotide excision repair","volume":"106","author":"Gillet","year":"2006","journal-title":"Chem. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5309","DOI":"10.1074\/jbc.M115.693218","article-title":"Base and nucleotide excision repair of oxidatively generated guanine lesions in DNA","volume":"291","author":"Shafirovich","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1021\/acs.chemrestox.8b00411","article-title":"Excision of oxidatively generated guanine lesions by competing base and nucleotide excision repair mechanisms in human cells","volume":"32","author":"Shafirovich","year":"2019","journal-title":"Chem. Res. Toxicol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.dnarep.2008.03.016","article-title":"The 8,5\u2032-cyclopurine-2\u2032-deoxynucleosides: Candidate neurodegenerative DNA lesions in xeroderma pigmentosum, and unique probes of transcription and nucleotide excision repair","volume":"7","author":"Brooks","year":"2008","journal-title":"DNA Repair"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"7069","DOI":"10.1128\/MCB.17.12.7069","article-title":"Base pair conformation-dependent excision of benzo[a]pyrene diol epoxide-guanine adducts by human nucleotide excision repair enzymes","volume":"17","author":"Hess","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"9173","DOI":"10.1128\/MCB.20.24.9173-9181.2000","article-title":"DNA damage in the nucleosome core is refractory to repair by human excision nuclease","volume":"20","author":"Hara","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"6779","DOI":"10.1128\/MCB.22.19.6779-6787.2002","article-title":"The SWI\/SNF chromatin-remodeling factor stimulates repair by human excision nuclease in the mononucleosome core particle","volume":"22","author":"Hara","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1128\/MCB.23.12.4121-4125.2003","article-title":"Effect of damage type on stimulation of human excision nuclease by SWI\/SNF chromatin remodeling factor","volume":"23","author":"Hara","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1021\/acs.biochem.8b01066","article-title":"Nucleotide excision repair and impact of site-specific 5\u2032,8-cyclopurine and bulky DNA lesions on the physical properties of nucleosomes","volume":"58","author":"Shafirovich","year":"2019","journal-title":"Biochemistry"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmb.2010.08.039","article-title":"Crystal structures of nucleosome core particles containing the \u2018601\u2019 strong positioning sequence","volume":"403","author":"Vasudevan","year":"2010","journal-title":"J. Mol. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1021\/acs.biochem.5b00564","article-title":"Differences in the access of lesions to the nucleotide excision repair machinery in nucleosomes","volume":"54","author":"Cai","year":"2015","journal-title":"Biochemistry"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"13749","DOI":"10.1093\/nar\/gku1239","article-title":"A 5\u2032, 8-cyclo-2\u2032-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase \u03b2","volume":"42","author":"Xu","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"28548","DOI":"10.1074\/jbc.M113.480459","article-title":"Translesion synthesis of 8,5\u2032-cyclopurine-2\u2032-deoxynucleosides by DNA polymerases \u03b7, \u03b9, and \u03b6","volume":"288","author":"You","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"49283","DOI":"10.1074\/jbc.M107779200","article-title":"Oxygen free radical damage to DNA. Translesion synthesis by human DNA polymerase \u03b7 and resistance to exonuclease action at cyclopurine deoxynucleoside residues","volume":"276","author":"Kuraoka","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"E410","DOI":"10.1073\/pnas.1415186112","article-title":"Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions","volume":"112","author":"Walmacq","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1021\/tx300351p","article-title":"Effects of 5\u2032,8-cyclodeoxyadenosine triphosphates on DNA synthesis","volume":"25","author":"Kamakura","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1073\/pnas.65.1.168","article-title":"Selective elimination of the exonuclease activity of the deoxyribonucleic acid polymerase from Escherichia coli B by limited proteolysis","volume":"65","author":"Klenow","year":"1970","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S1568-7864(02)00148-9","article-title":"A single 8,5\u2032-cyclo-2\u2032-deoxyadenosine lesion in a TATA box prevents binding of the TATA binding protein and strongly reduces transcription in vivo","volume":"1","author":"Marietta","year":"2002","journal-title":"DNA Repair"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"8671","DOI":"10.1039\/C4OB01089B","article-title":"Effects of (5\u2032S)-5\u2032,8-cyclo-2\u2032-deoxyadenosine on the base excision repair of oxidatively generated clustered DNA damage. A biochemical and theoretical study","volume":"12","author":"Karwowski","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1021\/bi2004944","article-title":"(5\u2032S)-8,5\u2032-cyclo-2\u2032-deoxyguanosine is a strong block to replication, a potent pol V-dependent mutagenic lesion, and is inefficiently repaired in Escherichia coli","volume":"50","author":"Jasti","year":"2011","journal-title":"Biochemistry"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1021\/tx4002786","article-title":"Mutagenicity and genotoxicity of (5\u2032S)-8,5\u2032-cyclo-2\u2032-deoxyadenosine in Escherichia coli and replication of (5\u2032S)-8,5\u2032-cyclopurine-2\u2032-deoxynucleosides in vitro by DNA polymerase IV, exo-free Klenow fragment, and Dpo4","volume":"27","author":"Pednekar","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1021\/bi5014936","article-title":"Kinetic and structural mechanisms of (5\u2032S)-8,5\u2032-cyclo-2\u2032-deoxyguanosine-induced DNA replication stalling","volume":"54","author":"Xu","year":"2015","journal-title":"Biochemistry"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1021\/tx3001576","article-title":"Accurate and efficient bypass of 8,5\u2032-cyclopurine-2\u2032-deoxynucleosides by human and yeast DNA polymerase \u03b7","volume":"25","author":"Swanson","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"10660","DOI":"10.1073\/pnas.1812856115","article-title":"Bypassing a 8,5\u2032-cyclo-2\u2032-deoxyadenosine lesion by human DNA polymerase \u03b7 at atomic resolution","volume":"115","author":"Weng","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1021\/cr0404904","article-title":"Structure and mechanism of DNA polymerase \u03b2","volume":"106","author":"Beard","year":"2006","journal-title":"Chem. Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1021\/bi500139h","article-title":"Structure and mechanism of DNA polymerase \u03b2","volume":"53","author":"Beard","year":"2014","journal-title":"Biochemistry"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.dnarep.2015.06.004","article-title":"Bypass of a 5\u2032,8-cyclopurine-2\u2032-deoxynucleoside by DNA polymerase beta during DNA replication and base excision repair leads to nucleotide misinsertions and DNA strand breaks","volume":"33","author":"Jiang","year":"2015","journal-title":"DNA Repair"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1093\/nar\/gks1306","article-title":"Trinucleotide repeat deletion via a unique hairpin bypass by DNA polymerase beta and alternate flap cleavage by flap endonuclease 1","volume":"41","author":"Xu","year":"2013","journal-title":"Nucl. Acids Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"12465","DOI":"10.1038\/ncomms12465","article-title":"Crosstalk between MSH2-MSH3 and pol\u03b2 promotes trinucleotide repeat expansion during base excision repair","volume":"7","author":"Lai","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cotox.2017.11.001","article-title":"DNA damage by oxidative stress: Measurement strategies for two genomes","volume":"7","author":"Wadhwa","year":"2018","journal-title":"Curr. Opin. Toxicol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1096\/fj.02-0752rev","article-title":"Oxidative DNA damage: Mechanisms, mutation, and disease","volume":"17","author":"Cooke","year":"2003","journal-title":"FASEB J."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1021\/acs.chemrestox.6b00265","article-title":"Occurrence, biological consequences, and human health relevance of oxidative stress-induced DNA damage","volume":"29","author":"Yu","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"36051","DOI":"10.1074\/jbc.M105472200","article-title":"A 32P-postlabeling assay for the oxidative DNA lesion 8,5\u2032-cyclo-2\u2032-deoxyadenosine in mammalian tissues: Evidence that four type II I-compounds are dinucleotides containing the lesion in the 3\u2032 nucleotide","volume":"276","author":"Randerath","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"17.17.1","DOI":"10.1002\/0471140856.tx1717s64","article-title":"Detection of bulky endogenous oxidative DNA lesions derived from 8,5\u2032-cyclo-2\u2032-deoxyadenosine by 32P-postlabeling assay","volume":"64","author":"Zhou","year":"2015","journal-title":"Curr. Protoc. Toxicol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1093\/carcin\/7.9.1543","article-title":"Nuclease P1-mediated enhancement of sensitivity of 32P-postlabeling test for structurally diverse DNA adducts","volume":"7","author":"Reddy","year":"1986","journal-title":"Carcinogenesis"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1021\/tx000131d","article-title":"An improved (32)P-postlabeling assay for the sensitive detection of 8-oxodeoxyguanosine in tissue DNA","volume":"14","author":"Gupta","year":"2001","journal-title":"Chem. Res. Toxicol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/ijc.20375","article-title":"Effects of NQO1 deficiency on levels of cyclopurines and other oxidative DNA lesions in liver and kidney of young mice","volume":"112","author":"Zhou","year":"2004","journal-title":"Int. J. Cancer"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2307\/3579440","article-title":"An assay for quantifying DNA double-strand break repair that is suitable for small numbers of unlabeled cells","volume":"147","author":"Longo","year":"1997","journal-title":"Radiat. Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e133","DOI":"10.1093\/nar\/gkq233","article-title":"Quantitative detection of 4-hydroxyequilenin-DNA adducts in mammalian cells using an immunoassay with a novel monoclonal antibody","volume":"38","author":"Okahashi","year":"2010","journal-title":"Nucl. Acids Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1158\/1055-9965.EPI-07-0751","article-title":"European standards committee on urinary (DNA) lesion analysis","volume":"17","author":"Cooke","year":"2008","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/php.12239","article-title":"Quantitative and in situ detection of oxidatively generated DNA damage 8,5\u2032-cyclo-2\u2032-deoxyadenosine using an immunoassay with a novel monoclonal antibody","volume":"90","author":"Iwamoto","year":"2014","journal-title":"Photochem. Photobiol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Mori, T., Nakane, H., Iwamoto, T., Krokidis, M.G., Chatgilialoglu, C., Tanaka, K., Kaidoh, T., Hasegawa, M., and Sugiura, S. (2019). High levels of oxidatively generated DNA damage 8,5\u2032-cyclo-2\u2032-deoxyadenosine accumulate in the brain tissues of xeroderma pigmentosum group A gene knockout mice. DNA Repair, in press.","DOI":"10.1016\/j.dnarep.2019.04.004"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"32581","DOI":"10.1038\/srep32581","article-title":"Association between oxidative DNA damage and risk of colorectal cancer: Sensitive determination of urinary 8-hydroxy-2\u2032-deoxyguanosine by UPLC\u2013MS\/MS analysis","volume":"6","author":"Guo","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"7829","DOI":"10.1039\/C5CS00316D","article-title":"Mass spectrometry for the assessment of the occurrence and biological consequences of DNA adducts","volume":"44","author":"Liu","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1093\/nar\/gnh087","article-title":"Complete release of (5\u2032S)-8,5\u2032-cyclo-2\u2032-deoxyadenosine from dinucleotides, oligodeoxynucleotides and DNA, and direct comparison of its levels in cellular DNA with other oxidatively induced DNA lesions","volume":"32","author":"Jaruga","year":"2004","journal-title":"Nucl. Acids Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3109\/10715762.2015.1014814","article-title":"Measurement of oxidatively induced DNA damage and its repair, by mass spectrometric techniques","volume":"49","author":"Dizdaroglu","year":"2015","journal-title":"Free Radic. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fchem.2015.00018","article-title":"Radiation-induced formation of purine lesions in single and double stranded DNA: Revised quantification","volume":"3","author":"Terzidis","year":"2015","journal-title":"Front. Chem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1039\/c004531d","article-title":"Radiation-induced formation of purine 5\u2032,8-cyclonucleosides in isolated and cellular DNA: High stereospecificity and modulating effect of oxygen","volume":"8","author":"Belmadoui","year":"2010","journal-title":"Org. Biomol. Chem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.bbrc.2009.06.107","article-title":"Measurement of (5\u2032R)- and (5\u2032S)-8,5\u2032-cyclo-2\u2032-deoxyadenosines in DNA in vivo by liquid chromatography\/isotope-dilution tandem mass spectrometry","volume":"386","author":"Jaruga","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.radphyschem.2016.05.026","article-title":"Purine 5\u2032,8-cyclo-2\u2032-deoxynucleoside lesions in irradiated DNA","volume":"128","author":"Chatgilialoglu","year":"2016","journal-title":"Radiat. Phys. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nrg2663","article-title":"Disorders of nucleotide excision repair: The genetic and molecular basis of heterogeneity","volume":"10","author":"Cleaver","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/jid.2011.426","article-title":"Shining a light on xeroderma pigmentosum","volume":"132","author":"Kraemer","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.neuroscience.2006.10.025","article-title":"The Case for 8,5\u2032-Cyclopurine-2\u2032-Deoxynucleosides as Endogenous DNA Lesions That Cause Neurodegeneration in Xeroderma Pigmentosum","volume":"145","author":"Brooks","year":"2007","journal-title":"Neuroscience"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.mrfmmm.2006.06.010","article-title":"Heterozygous individuals bearing a founder mutation in the XPA DNA repair gene comprise nearly 1% of the Japanese population","volume":"601","author":"Hirai","year":"2006","journal-title":"Mutat. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"9908","DOI":"10.1073\/pnas.87.24.9908","article-title":"Characterization of a splicing mutation in group A xeroderma pigmentosum","volume":"87","author":"Satokata","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1093\/brain\/114.3.1335","article-title":"Neurological disease in xeroderma pigmentosum. Documentation of a late onset type of the juvenile onset form","volume":"114","author":"Robbins","year":"1991","journal-title":"Brain"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1073\/pnas.75.4.1984","article-title":"Xeroderma pigmentosum neurological abnormalities correlate with colony-forming ability after ultraviolet radiation","volume":"75","author":"Andrews","year":"1978","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1177\/088307388900400215","article-title":"A childhood neurodegeneration due to defective DNA repair: A novel concept of disease based on studies xeroderma pigmentosum","volume":"4","author":"Robbins","year":"1989","journal-title":"J. Child Neurol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.mad.2007.06.006","article-title":"The oxidatively induced DNA lesions 8,5\u2032-cyclo-2\u2032-deoxyadenosine and 8-hydroxy-2\u2032-deoxyadenosine are strongly resistant to acid-induced hydrolysis of the glycosidic bond","volume":"128","author":"Theruvathu","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1021\/tx300302a","article-title":"Stability of N-glycosidic bond of (5\u2032S)-8,5\u2032-cyclo-2\u2032-deoxyguanosine","volume":"25","author":"Das","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/j.1474-9726.2012.00828.x","article-title":"The oxidative DNA lesions 8,5\u2032-cyclopurines accumulate with aging in a tissue-specific manner","volume":"11","author":"Wang","year":"2012","journal-title":"Aging Cell"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.freeradbiomed.2016.12.028","article-title":"The cyclopurine deoxynucleosides: DNA repair, biological effects, mechanistic insights, and unanswered questions","volume":"107","author":"Brooks","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/nchembio.1046","article-title":"A quantitative assay for assessing the effects of DNA lesions on transcription","volume":"8","author":"You","year":"2012","journal-title":"Nat. Chem. Biol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/sj.embor.7400932","article-title":"Transcriptional bypass of bulky DNA lesions causes new mutant RNA transcripts in human cells","volume":"8","author":"Marietta","year":"2007","journal-title":"EMBO Rep."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/em.20619","article-title":"Divergent effects of oxidatively induced modification to the C8 of 2\u2032-deoxyadenosine on transcription factor binding: 8,5\u2032(s)-cyclo-2\u2032-deoxyadenosine inhibits the binding of multiple sequence specific transcription factors, while 8-oxo-2\u2032-deoxyadenosine increases binding of CREB and NF-kappa B to DNA","volume":"52","author":"Abraham","year":"2011","journal-title":"Environ. Mol. Mutagen."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"5368","DOI":"10.1093\/nar\/gkt225","article-title":"Active transcriptomic and proteomic reprogramming in the C. elegans nucleotide excision repair mutant xpa-1","volume":"41","author":"Arczewska","year":"2013","journal-title":"Nucl. Acids Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.mad.2013.03.006","article-title":"The role of CSA and CSB protein in the oxidative stress response","volume":"134","author":"Pascucci","year":"2013","journal-title":"Mech. Ageing Dev."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/exd.12484","article-title":"Mitochondrial dysfunction: A neglected component of skin diseases","volume":"23","author":"Feichtinger","year":"2014","journal-title":"Exp. Dermatol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.cell.2014.03.026","article-title":"Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)\/SIRT1 reduction","volume":"157","author":"Fang","year":"2014","journal-title":"Cell"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0387-7604(99)00033-9","article-title":"Neurodegeneration in hereditary nucleotide repair disorders","volume":"21","author":"Itoh","year":"1999","journal-title":"Brain Dev."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1038\/sj.onc.1210232","article-title":"The role of CSA in the response to oxidative DNA damage in human cells","volume":"26","author":"Parlanti","year":"2007","journal-title":"Oncogene"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.dnarep.2013.04.018","article-title":"Blinded by the UV light: How the focus on transcription-coupled NER has distracted from understanding the mechanisms of Cockayne syndrome neurologic disease","volume":"12","author":"Brooks","year":"2013","journal-title":"DNA Repair"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.mrrev.2014.11.002","article-title":"Oxidatively induced DNA damage and its repair in cancer","volume":"763","author":"Dizdaroglu","year":"2015","journal-title":"Mutat. Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.abb.2003.12.017","article-title":"Reactive nitrogen species in the chemical biology of inflammation","volume":"423","author":"Dedon","year":"2004","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nrg3729","article-title":"Mechanisms underlying mutational signatures in human cancers","volume":"15","author":"Helleday","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1080\/10715762.2017.1325485","article-title":"Purine 5\u2032,8-cyclo-2\u2032-deoxynucleoside lesions: Formation by radical stress and repair in human breast epithelial cancer cells","volume":"51","author":"Krokidis","year":"2017","journal-title":"Free Radic. Res."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Matta, J., Morales, L., Ortiz, C., Adams, D., Vargas, W., Casbas, P., Dutil, J., Echenique, M., and Su\u00e1rez, E. (2016). Estrogen receptor expression is associated with DNA repair capacity in breast cancer. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0152422"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1158\/0008-5472.CAN-09-3800","article-title":"Coordination of centrosome homeostasis and DNA repair is intact in MCF-7 and disrupted in MDA-MB 231 breast cancer cells","volume":"70","author":"Acu","year":"2010","journal-title":"Cancer Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.4161\/cc.6.12.4301","article-title":"Accumulation of oxidatively induced DNA damage in human breast cancer cell lines following treatment with hydrogen peroxide","volume":"6","author":"Nyaga","year":"2007","journal-title":"Cell Cycle"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1021\/bi062022p","article-title":"Lymphoblasts of women with BRCA1 mutations are deficient in cellular repair of 8,5\u2032- Cyclopurine-2\u2032-deoxynucleosides and 8-hydroxy-2\u2032-deoxyguanosine","volume":"46","author":"Rodriguez","year":"2007","journal-title":"Biochemistry"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"8038","DOI":"10.1038\/sj.onc.1208821","article-title":"Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin 1","volume":"24","author":"Egler","year":"2005","journal-title":"Oncogene"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nature11624","article-title":"An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair\/fair skin background","volume":"491","author":"Mitra","year":"2012","journal-title":"Nature"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Krokidis, M., Louka, M., Efthimiadou, E., Zervou, S.-K., Papadopoulos, K., Hiskia, A., Ferreri, C., and Chatgilialoglu, C. (2019). Membrane lipidome reorganization and accumulation of tissue DNA lesions in tumor-bearing mice: An exploratory study. Cancers, 11.","DOI":"10.3390\/cancers11040480"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nrc3497","article-title":"How ageing processes influence cancer","volume":"13","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.redox.2018.04.007","article-title":"Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging","volume":"17","author":"Robinson","year":"2018","journal-title":"Redox Biol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1074\/mcp.M115.052696","article-title":"Comprehensive assessment of oxidatively induced modifications of DNA in a rat model of human Wilson\u2019s disease","volume":"15","author":"Yu","year":"2016","journal-title":"Mol. Cell. Proteomics"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1021\/bi902161f","article-title":"Evidence for the involvement of DNA repair enzyme NEIL1 in nucleotide excision repair of (5\u2032R)- and (5\u2032S)-8, 5\u2032-cyclo-2\u2032-deoxyadenosines","volume":"49","author":"Jaruga","year":"2010","journal-title":"Biochemistry"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.dnarep.2008.09.009","article-title":"Accumulation of (5\u2032S)-8,5\u2032-cyclo-2\u2032-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice","volume":"8","author":"Kirkali","year":"2009","journal-title":"DNA Repair"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.freeradbiomed.2007.09.020","article-title":"Oxidative DNA damage in polymorphonuclear leukocytes of patients with familial Mediterranean fever","volume":"44","author":"Kirkali","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.dnarep.2016.09.004","article-title":"Elevated urinary levels of 8-oxo-2\u2032-deoxyguanosine, (5\u2032R)- and (5\u2032S)-8,5\u2032-cyclo-2\u2032-deoxyadenosines, and 8-iso-prostaglandin F2\u03b1 as potential biomarkers of oxidative stress in patients with prediabetes","volume":"48","author":"Kant","year":"2016","journal-title":"DNA Repair"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Cadet, J., Di Mascio, P., and Wagner, J.R. (2019). Radiation-induced (5\u2032R)- and (5\u2032S)-purine 5\u2032,8-cyclo-2\u2032-deoxyribonucleosides in human cells: A revisited analysis of HPLC\u2013MS\/MS measurements. Free Radic. Res.","DOI":"10.1080\/10715762.2019.1605169"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/8\/6\/513\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:53:58Z","timestamp":1760187238000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/8\/6\/513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,28]]},"references-count":148,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6]]}},"alternative-id":["cells8060513"],"URL":"https:\/\/doi.org\/10.3390\/cells8060513","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,28]]}}}