{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:02:27Z","timestamp":1767826947892,"version":"3.49.0"},"reference-count":50,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T00:00:00Z","timestamp":1559865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["CTQ2017-87974-R"],"award-info":[{"award-number":["CTQ2017-87974-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Turkish Higher Education Council (Y\u00d6K) under Mevlana-Project Based Academic Exchange Programme","award":["MEV-2017-230"],"award-info":[{"award-number":["MEV-2017-230"]}]},{"DOI":"10.13039\/100007801","name":"Fundaci\u00f3n S\u00e9neca","doi-asserted-by":"publisher","award":["20988\/PI\/18"],"award-info":[{"award-number":["20988\/PI\/18"]}],"id":[{"id":"10.13039\/100007801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007801","name":"Fundaci\u00f3n S\u00e9neca","doi-asserted-by":"publisher","award":["20524\/PDC\/18"],"award-info":[{"award-number":["20524\/PDC\/18"]}],"id":[{"id":"10.13039\/100007801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Halophila stipulacea is a well-known invasive marine sea grass in the Mediterranean Sea. Having been introduced into the Mediterranean Sea via the Suez Channel, it is considered a Lessepsian migrant. Although, unlike other invasive marine seaweeds, it has not demonstrated serious negative impacts on indigenous species, it does have remarkable invasive properties. The present in-silico study reveals the biotechnological features of H. stipulacea by showing bioactive peptides from its rubisc\/o protein. These are features such as antioxidant and hypolipideamic activities, dipeptidyl peptidase-IV and angiotensin converting enzyme inhibitions. The reported data open up new applications for such bioactive peptides in the field of pharmacy, medicine and also the food industry.<\/jats:p>","DOI":"10.3390\/cells8060557","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T11:35:05Z","timestamp":1559907305000},"page":"557","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["In Silico Analysis of Bioactive Peptides in Invasive Sea Grass Halophila stipulacea"],"prefix":"10.3390","volume":"8","author":[{"given":"Cagin","family":"Kandemir-Cavas","sequence":"first","affiliation":[{"name":"Department of Computer Science, Faculty of Science, Dokuz Eyl\u00fcl University, \u0130zmir 35390, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4468-7898","authenticated-orcid":false,"given":"Horacio","family":"P\u00e9rez-Sanchez","sequence":"additional","affiliation":[{"name":"Bioinformatics and High Performance Computing Research Group (BIO-HPC), Computer Engineering Department, Universidad Cat\u00f3lica de Murcia (UCAM), 30107 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazli","family":"Mert-Ozupek","sequence":"additional","affiliation":[{"name":"Institute of Oncology, Dokuz Eyl\u00fcl University, \u0130zmir 35320, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2136-6928","authenticated-orcid":false,"given":"Levent","family":"Cavas","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Dokuz Eyl\u00fcl University, \u0130zmir 35390, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0304-3770(75)90023-6","article-title":"Halophila stipulacea, a review of a successful immigration","volume":"1","author":"Lipkin","year":"1975","journal-title":"Aquat. 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