{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:16:57Z","timestamp":1770833817577,"version":"3.50.1"},"reference-count":68,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T00:00:00Z","timestamp":1561766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Portal hypertension is a common complication of liver disease, either acute or chronic. Consequently, in chronic liver disease, such as the hypertensive mesenteric venous pathology, the coexisting inflammatory response is classically characterized by the splanchnic blood circulation. However, a vascular lymphatic pathology is produced simultaneously with the splanchnic arterio-venous impairments. The pathological increase of the mesenteric venous pressure, by mechanotransduction of the venous endothelium hyperpressure, causes an inflammatory response involving the subendothelial mast cells and the lymphatic endothelium of the intestinal villi lacteal. In portal hypertension, the intestinal lymphatic inflammatory response through the development of mesenteric-systemic lymphatic collateral vessels favors the systemic diffusion of substances with a molecular pattern associated with damage and pathogens of intestinal origin. When the chronic hepatic insufficiency worsens the portal hypertensive inflammatory response, the splanchnic lymphatic system transports the hyperplasied intestinal mast cells to the mesenteric lymphatic complex. Then, an acquired immune response regulating a new hepato-intestinal metabolic scenario is activated. Therefore, reduction of the hepatic metabolism would reduce its key centralized functions, such as the metabolic, detoxifying and antioxidant functions which would try to be substituted by their peroxisome activity, among other functions of the mast cells.<\/jats:p>","DOI":"10.3390\/cells8070658","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T03:23:59Z","timestamp":1561951439000},"page":"658","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Lymphatic Headmaster of the Mast Cell-Related Splanchnic Inflammation in Portal Hypertension"],"prefix":"10.3390","volume":"8","author":[{"given":"Maria-Angeles","family":"Aller","sequence":"first","affiliation":[{"name":"Department of Surgery, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Blanco-Rivero","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Autonomous University of Madrid, 28049 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica La Paz (IdIPAZ), 28046 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (Ciber) de Enfermedades Cardiovasculares, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Arias","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London WC2R 2LS, UK"},{"name":"INEUROPA (Instituto de Neurociencias del Principado de Asturias), 33003 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Santamaria","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology and Neuroscience, School of Medicine, Autonoma University of Madrid, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Arias","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/imj.12590","article-title":"Portal hypertension: Pathophysiology, diagnosis and management","volume":"45","author":"Bloom","year":"2015","journal-title":"Intern. Med. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.2174\/1389450117666160613101413","article-title":"Recent Advancements in Diagnosis and Therapy of Liver Cirrhosis","volume":"17","author":"Romanelli","year":"2016","journal-title":"Curr. Drug Targets"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3748\/wjg.v25.i2.163","article-title":"Current status, problems, and perspectives of non-alcoholic fatty liver disease research","volume":"25","author":"Tanaka","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_4","first-page":"944","article-title":"Portal hypertensive intestinal vasculopathy: A review of the clinical, endoscopic, and histopathologic features","volume":"87","author":"Viggiano","year":"1992","journal-title":"Am. J. Gastroenterol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/j.1440-1746.2007.04876.x","article-title":"Evolutive phases of experimental prehepatic portal hypertension","volume":"22","author":"Aller","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1742-4682-4-44","article-title":"Inflammation: A way to understanding the evolution of portal hypertension","volume":"4","author":"Aller","year":"2007","journal-title":"Theor. Biol. Med. Model."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/jgh.14514","article-title":"Hepatic encephalopathy: Sometimes more portal than hepatic","volume":"34","author":"Aller","year":"2019","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.it.2017.10.005","article-title":"Mast Cells as Drivers of Disease and Therapeutic Targets","volume":"39","author":"Siebenhaar","year":"2018","journal-title":"Trends Immunol."},{"key":"ref_9","first-page":"620","article-title":"Mast Cell: A Multi-Functional Master Cell","volume":"6","author":"Dileepan","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_10","first-page":"383","article-title":"Prophylaxis with ketotifen in rats with portal hypertension: Involvement of mast cell and eicosanoids","volume":"7","author":"Anchuelo","year":"2008","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.etp.2008.03.008","article-title":"Mast cell inhibition by ketotifen reduces splanchnic inflammatory response in a portal hypertension model in rats","volume":"60","author":"Aller","year":"2008","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/j.1440-1827.2009.02451.x","article-title":"Mast cell leukemia with rapidly progressing portal hypertension","volume":"59","author":"Yoshida","year":"2009","journal-title":"Pathol. Int."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000050094","article-title":"Increased duodenal mucosa infiltration by mast cells in rats with portal hypertension","volume":"18","author":"Aller","year":"2001","journal-title":"Dig. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/09629350310001599684","article-title":"Differential regulation of the release of tumor necrosis factor-alpha and of eicosanoids by mast cells in rat airways after antigen challenge","volume":"12","author":"Trezena","year":"2003","journal-title":"Mediat. Inflamm."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4168\/aair.2018.10.3.268","article-title":"Immune Characterization of Bone Marrow-Derived Models of Mucosal and Connective Tissue Mast Cells","volume":"10","author":"Cody","year":"2018","journal-title":"Allergy Asthma Immunol. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"220","DOI":"10.4103\/2045-8932.97609","article-title":"Mast cell number, phenotype, and function in human pulmonary arterial hypertension","volume":"2","author":"Farha","year":"2012","journal-title":"Pulm. Circ."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/jlb.61.3.233","article-title":"Development, significance, and heterogeneity of mast cells with particular regard to the mast cell-specific proteases chymase and tryptase","volume":"61","author":"Welle","year":"1997","journal-title":"J. Leukoc. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/ni.2109","article-title":"Phenotypic and functional plasticity of cells of innate immunity: Macrophages, mast cells and neutrophils","volume":"12","author":"Galli","year":"2011","journal-title":"Nat. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1146\/annurev.immunol.21.120601.141025","article-title":"Mast cells as \u201ctunable\u201d effector and immunoregulatory cells: Recent advances","volume":"23","author":"Galli","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6577","DOI":"10.3748\/wjg.v12.i41.6577","article-title":"Animal models of portal hypertension","volume":"12","author":"Abraldes","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1111\/j.1572-0241.1999.01232.x","article-title":"Stromal mast cells and nerve fibers in various chronic liver diseases: Relevance to hepatic fibrosis","volume":"94","author":"Matsunaga","year":"1999","journal-title":"Am. J. Gastroenterol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1479-5876-5-44","article-title":"The mast cell integrates the splanchnic and systemic inflammatory response in portal hypertension","volume":"5","author":"Aller","year":"2007","journal-title":"J. Transl. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12931-017-0534-9","article-title":"Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF","volume":"18","author":"Roos","year":"2017","journal-title":"Respir. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.coi.2018.05.002","article-title":"Innate effector cells in angiogenesis and lymphangiogenesis","volume":"53","author":"Varricchi","year":"2018","journal-title":"Curr. Opin. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1007\/s10753-015-0118-0","article-title":"Role of Mast Cells and C-Sensory Fibers in Concanavalin A-Induced Paw Edema in Two Rat Strains","volume":"38","year":"2015","journal-title":"Inflammation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.jcmgh.2018.12.002","article-title":"The Intestinal Lymphatic System: Functions and Metabolic Implications","volume":"7","author":"Cifarelli","year":"2018","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1152\/physrev.00001.2017","article-title":"Endothelial Cell Metabolism","volume":"98","author":"Eelen","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.biomaterials.2017.05.026","article-title":"A heparin conjugate, LHbisD4, inhibits lymphangiogenesis and attenuates lymph node metastasis by blocking VEGF-C signaling pathway","volume":"139","author":"Choi","year":"2017","journal-title":"Biomaterials"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.devcel.2018.03.021","article-title":"Emerging Concepts in Organ-Specific Lymphatic Vessels and Metabolic Regulation of Lymphatic Development","volume":"45","author":"Wong","year":"2018","journal-title":"Dev. Cell"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"871","DOI":"10.3389\/fphys.2018.00871","article-title":"Fluid Osmolarity Acutely and Differentially Modulates Lymphatic Vessels Intrinsic Contractions and Lymph Flow","volume":"9","author":"Solari","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1161\/CIRCRESAHA.116.302855","article-title":"Endothelial cell metabolism in normal and diseased vasculature","volume":"116","author":"Eelen","year":"2015","journal-title":"Circ. Res."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Ding, N., Jiang, J., Qin, P., Wang, Q., Hu, J., and Li, Z. (2018). Mast cells are important regulator of acupoint sensitization via the secretion of tryptase, 5-hydroxytryptamine, and histamine. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0194022"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4161\/epi.24042","article-title":"Bridging epigenetics and metabolism: Role of non-essential amino acids","volume":"8","author":"Phang","year":"2013","journal-title":"Epigenetics"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Stoll, S., Wang, C., and Qiu, H. (2018). DNA Methylation and Histone Modification in Hypertension. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19041174"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.diabres.2018.06.018","article-title":"Endothelial cell regulation through epigenetic mechanisms: Depicting parallels and its clinical application within an intra-islet microenvironment","volume":"143","author":"Narayanan","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/MOT.0000000000000175","article-title":"Organ preservation review: History of organ preservation","volume":"20","author":"Cameron","year":"2015","journal-title":"Curr. Opin. Organ. Transpl."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"43570","DOI":"10.1038\/srep43570","article-title":"Contribution of engineered nanomaterials physicochemical properties to mast cell degranulation","volume":"7","author":"Johnson","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1055\/s-0038-1676805","article-title":"Child-Pugh Classification: Time to Abandon?","volume":"39","author":"Kok","year":"2019","journal-title":"Semin. Liver Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.diii.2017.10.008","article-title":"Albumin-bilirubin grade versus MELD score for predicting survival after transjugular intrahepatic portosystemic shunt (TIPS) creation","volume":"99","author":"Ronald","year":"2018","journal-title":"Diagn. Interv. Imaging"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Aller, M.\u00c1., Mart\u00ednez, V., Arias, A., Nava, M.P., Cuervas-Mons, V., Vergara, P., and Arias, J. (2019). Mast cell-mediated splanchnic cholestatic inflammation. Clin. Res. Hepatol. Gastroenterol.","DOI":"10.1016\/j.clinre.2019.02.001"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.immuni.2013.04.001","article-title":"The immune system as a sensor of the metabolic state","volume":"38","author":"Odegaard","year":"2013","journal-title":"Immunity"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/hep.510310226","article-title":"Endotoxin induces structure-function alterations of rat liver peroxisomes: Kupffer cells released factors as possible modulators","volume":"31","author":"Contreras","year":"2000","journal-title":"Hepatology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/imm.12699","article-title":"Peroxisome proliferator-activated receptor-\u03b2\/\u03b4 modulates mast cell phenotype","volume":"150","author":"Yao","year":"2017","journal-title":"Immunology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI88881","article-title":"Liver inflammation and fibrosis","volume":"127","author":"Koyama","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.3748\/wjg.v20.i15.4300","article-title":"Invasive and non-invasive diagnosis of cirrhosis and portal hypertension","volume":"20","author":"Kim","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s12072-017-9815-0","article-title":"Management of ascites and hepatorenal syndrome","volume":"12","author":"Piano","year":"2018","journal-title":"Hepatol. Int."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00424-017-1954-6","article-title":"Liver macrophages in healthy and diseased liver","volume":"469","author":"Abdullah","year":"2017","journal-title":"Pflugers Arch."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Maurer, M., K\u00f6berle, M., Metz, M., and Biedermann, T. (2019). Mast cells\u2014Promotors of health and modulators of disease. J. Allergy Clin. Immunol.","DOI":"10.1016\/j.jaci.2019.01.048"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Dudeck, A., K\u00f6berle, M., Goldmann, O., Meyer, N., Dudeck, J., Lemmens, S., Rohde, M., Rold\u00e1n, N.G., Dietze-Schwonberg, K., and Orinska, Z. (2018). Mast cells as protectors of health. J. Allergy Clin. Immunol.","DOI":"10.1016\/j.jaci.2018.10.054"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/hep4.1290","article-title":"Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis","volume":"3","author":"Chen","year":"2018","journal-title":"Hepatol. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Sung, S., Kim, J., and Jung, Y. (2018). Liver-Derived Exosomes and Their Implications in Liver Pathobiology. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19123715"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00418-018-1722-5","article-title":"The peroxisome: An update on mysteries 2.0","volume":"150","author":"Islinger","year":"2018","journal-title":"Histochem. Cell Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10522-018-9761-9","article-title":"Peroxisomes: Role in cellular ageing and age related disorders","volume":"19","author":"Deori","year":"2018","journal-title":"Biogerontology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1007\/s00424-018-2195-z","article-title":"Catalase and nonalcoholic fatty liver disease","volume":"470","author":"Shin","year":"2018","journal-title":"Pflugers Arch."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1007\/s00018-018-2838-4","article-title":"Role of peroxisome proliferator-activated receptors in non-alcoholic fatty liver disease inflammation","volume":"75","author":"Silva","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.bbamcr.2015.09.035","article-title":"Hepatic dysfunction in peroxisomal disorders","volume":"1863","author":"Baes","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejphar.2015.07.020","article-title":"Lipid droplets in activated mast cells\u2014A significant source of triglyceride-derived arachidonic acid for eicosanoid production","volume":"785","author":"Dichlberger","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Botta, M., Audano, M., Sahebkar, A., Sirtori, C.R., Mitro, N., and Ruscica, M. (2018). PPAR Agonists and Metabolic Syndrome: An Established Role?. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19041197"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ceb.2015.05.002","article-title":"Signaling dynamics and peroxisomes","volume":"35","author":"Mast","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4331\/wjbc.v6.i4.301","article-title":"Crosstalk between mitochondria and peroxisomes","volume":"6","author":"Demarquoy","year":"2015","journal-title":"World J. Biol. Chem."},{"key":"ref_62","first-page":"9860841","article-title":"Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease","volume":"2017","author":"Proft","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.3748\/wjg.v11.i8.1141","article-title":"Alterations of mast cells and TGF-beta1 on the silymarin treatment for CCl(4)-induced hepatic fibrosis","volume":"11","author":"Jeong","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1152\/japplphysiol.00113.2017","article-title":"Oxygen metabolism and innate immune responses in the gut","volume":"123","author":"Colgan","year":"2017","journal-title":"J. Appl. Physiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/mi.2017.73","article-title":"Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity","volume":"11","author":"Worthington","year":"2018","journal-title":"Mucosal. Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0009-739X(06)70945-9","article-title":"Chronic inflammatory portal hypertensive enteropathy in the rat","volume":"80","author":"Aller","year":"2006","journal-title":"Cirug\u00eda Espa\u00f1ola"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"G360","DOI":"10.1152\/ajpgi.00181.2017","article-title":"Frontline defenders: goblet cell mediators dictate host-microbe interactions in the intestinal tract during health and disease","volume":"314","author":"Allaire","year":"2018","journal-title":"Am. J. Physiol. Gastrointest Liver Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bpg.2006.07.006","article-title":"The future treatment of portal hypertension","volume":"21","author":"Reichen","year":"2007","journal-title":"Best Pract. Res. Clin. Gastroenterol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/8\/7\/658\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:02:32Z","timestamp":1760187752000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/8\/7\/658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,29]]},"references-count":68,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,7]]}},"alternative-id":["cells8070658"],"URL":"https:\/\/doi.org\/10.3390\/cells8070658","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,29]]}}}