{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:44:34Z","timestamp":1788410674117,"version":"build-2803163510"},"reference-count":35,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:00:00Z","timestamp":1562716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universit\u00e0 del Piemonte Orientale, Department of Translational Medicine, Novara","award":["2017"],"award-info":[{"award-number":["2017"]}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["ID. 20714 project"],"award-info":[{"award-number":["ID. 20714 project"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Aneurysmal subarachnoid hemorrhage (SAH) is associated with high morbidity and mortality. In SAH patients, plasma osteopontin (OPN) has been shown to independently predict poor outcome. The aim of the study is to investigate, in a selected population with severe SAH, OPN time course in cerebrospinal fluid (CSF) and plasma during the first week after aneurism rupture, and OPN prognostic value. We included 44 patients with the following criteria: (1) age 18 and 80 years, (2) diagnosis of SAH from cerebral aneurysm rupture, (3) insertion of external ventricular drain. Plasma and CSF were sampled at day 1, 4, and 8. OPN levels, in CSF and plasma, displayed a weak correlation on day 1 and were higher, in CSF, in all time points. Only in poor prognosis patients, OPN levels in CSF significantly increased at day 4 and day 8. Plasma OPN at day 1 and 4 was predictor of poor outcome. In conclusion, plasma and CSF OPN displays a weak correlation, on day 1. The higher levels of OPN found in the CSF compared to plasma, suggest OPN production within the CNS after SAH. Furthermore, plasma OPN, at day 1 and 4, seems to be an independent predictor of poor outcome.<\/jats:p>","DOI":"10.3390\/cells8070695","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T11:56:51Z","timestamp":1562759811000},"page":"695","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Osteopontin in the Cerebrospinal Fluid of Patients with Severe Aneurysmal Subarachnoid Hemorrhage"],"prefix":"10.3390","volume":"8","author":[{"given":"Maria Giulia","family":"Abate","sequence":"first","affiliation":[{"name":"School of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy, Neurointensive Care, San Gerardo Hospital, ASST-Monza, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Moretto","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Universit\u00e0 degli Studi del Piemonte Orientale, Via Solaroli 17, 28100 Novara (NO), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Licari","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Universit\u00e0 degli Studi del Piemonte Orientale, Via Solaroli 17, 28100 Novara (NO), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Universit\u00e0 degli Studi del Piemonte Orientale, Via Solaroli 17, 28100 Novara (NO), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Capuano","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Universit\u00e0 degli Studi del Piemonte Orientale, Via Solaroli 17, 28100 Novara (NO), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Olivieri","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care, Sant\u2019Andrea Hospital, Mario Abbiate, 21, 13100 Vercelli (VC), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaldo","family":"Benech","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Universit\u00e0 degli Studi del Piemonte Orientale, Via Solaroli 17, 28100 Novara (NO), Italy"},{"name":"Maxillo facial surgery, \u201cMaggiore della Carit\u00e0\u201d University Hospital, Corso Mazzini 18, 28100 Novara (NO), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Brucoli","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Universit\u00e0 degli Studi del Piemonte Orientale, Via Solaroli 17, 28100 Novara (NO), Italy"},{"name":"Maxillo facial surgery, \u201cMaggiore della Carit\u00e0\u201d University Hospital, Corso Mazzini 18, 28100 Novara (NO), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Carlo","family":"Avanzi","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Universit\u00e0 degli Studi del Piemonte Orientale, Via Solaroli 17, 28100 Novara (NO), Italy"},{"name":"Emergency Department, \u201cMaggiore della Carit\u00e0\u201d University Hospital, Corso Mazzini 18, 28100 Novara (NO), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9112-2705","authenticated-orcid":false,"given":"Gianmaria","family":"Cammarota","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care, \u201cMaggiore della Carit\u00e0\u201d University Hospital, Corso Mazzini 18, 28100 Novara (NO), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Dianzani","sequence":"additional","affiliation":[{"name":"CAAD, IRCAD, Department of Health Sciences, Universit\u00e0 degli Studi del Piemonte Orientale, Corso Trieste 15, 28100 Novara (NO), Italy"},{"name":"Biochemical Chemistry, \u201cMaggiore della Carit\u00e0\u201d University Hospital, Corso Mazzini 18, 28100 Novara (NO), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9860-0148","authenticated-orcid":false,"given":"Nausicaa","family":"Clemente","sequence":"additional","affiliation":[{"name":"CAAD, IRCAD, Department of Health Sciences, Universit\u00e0 degli Studi del Piemonte Orientale, Corso Trieste 15, 28100 Novara (NO), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Panzarasa","sequence":"additional","affiliation":[{"name":"Neurosurgery \u201cMaggiore della Carit\u00e0\u201d University Hospital, Corso Mazzini 18, 28100 Novara (NO), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Citerio","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy, Neurointensive Care, San Gerardo Hospital, ASST-Monza, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1378-1649","authenticated-orcid":false,"given":"Fabio","family":"Carfagna","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Universit\u00e0 degli Studi del Piemonte Orientale, Via Solaroli 17, 28100 Novara (NO), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5193-4688","authenticated-orcid":false,"given":"Giuseppe","family":"Cappellano","sequence":"additional","affiliation":[{"name":"CAAD, IRCAD, Department of Health Sciences, Universit\u00e0 degli Studi del Piemonte Orientale, Corso Trieste 15, 28100 Novara (NO), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Della Corte","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Universit\u00e0 degli Studi del Piemonte Orientale, Via Solaroli 17, 28100 Novara (NO), Italy"},{"name":"Anesthesia and Intensive Care, \u201cMaggiore della Carit\u00e0\u201d University Hospital, Corso Mazzini 18, 28100 Novara (NO), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Vaschetto","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Universit\u00e0 degli Studi del Piemonte Orientale, Via Solaroli 17, 28100 Novara (NO), Italy"},{"name":"Anesthesia and Intensive Care, \u201cMaggiore della Carit\u00e0\u201d University Hospital, Corso Mazzini 18, 28100 Novara (NO), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1056\/NEJMra052732","article-title":"Aneurysmal subarachnoid hemorrhage","volume":"354","author":"Suarez","year":"2006","journal-title":"N. 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