{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T05:46:04Z","timestamp":1786945564957,"version":"build-2736575974"},"reference-count":58,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T00:00:00Z","timestamp":1567036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science","award":["16K20453, 17H06848, 19K19025"],"award-info":[{"award-number":["16K20453, 17H06848, 19K19025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Dentin consists of inorganic hard tissue and organic dentin matrix components (DMCs). Various kinds of bioactive molecules are included in DMCs and some of them can be released after digestion by endogenous matrix metalloproteinases (MMPs) in the caries region. Digested DMCs induced by MMP20 have been reported to promote pulpal wound healing processes, but the released critical molecules responsible for this phenomenon are unclear. Here, we identified protein S100-A7 as a critical molecule for pulpal healing in digested DMCs by comprehensive proteomic approaches and following pulp capping experiments in rat molars. In addition, immunohistochemical results indicated the specific distribution of S100-A7 and receptor for advanced glycation end-products (RAGE) as receptor for S100-A7 in the early stage of the pulpal healing process, and following accumulation of CD146-positive stem cells in wounded pulp. Our findings indicate that protein S100-A7 released from dentin by MMP20 might play a key role in dentin pulp regeneration.<\/jats:p>","DOI":"10.3390\/cells8091002","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T11:26:22Z","timestamp":1567077982000},"page":"1002","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Protein S100-A7 Derived from Digested Dentin Is a Critical Molecule for Dentin Pulp Regeneration"],"prefix":"10.3390","volume":"8","author":[{"given":"Shungo","family":"Komichi","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita-shi, Osaka 565 0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7974-1252","authenticated-orcid":false,"given":"Yusuke","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita-shi, Osaka 565 0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3759-5031","authenticated-orcid":false,"given":"Motoki","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita-shi, Osaka 565 0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manahil","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita-shi, Osaka 565 0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakatsu","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita-shi, Osaka 565 0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailing","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita-shi, Osaka 565 0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Nakai","sequence":"additional","affiliation":[{"name":"Osaka Research Institute of Industrial Science and Technology, 1-6-50 Morinomiya, Jyoutou-ku, Oosaka-shi, Osaka 536 8853, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Cooper","sequence":"additional","affiliation":[{"name":"Oral Biology, School of Dentistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikako","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita-shi, Osaka 565 0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.archoralbio.2011.07.008","article-title":"Dentine as a Bioactive Extracellular Matrix","volume":"57","author":"Smith","year":"2012","journal-title":"Arch. Oral Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"13625","DOI":"10.1073\/pnas.240309797","article-title":"Postnatal Human Dental Pulp Stem Cells (DPSCs) in Vitro and In vivo","volume":"97","author":"Gronthos","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.bone.2009.06.018","article-title":"Molecular Characterization of Young and Mature Odontoblasts","volume":"45","author":"Simon","year":"2009","journal-title":"Bone"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2341\/09-038CR1","article-title":"Pulp Capping with Mineral Trioxide Aggregate (MTA): A Retrospective Analysis of Carious Pulp Exposures Treated by Undergraduate Dental Students","volume":"35","author":"Miles","year":"2010","journal-title":"Oper. Dent."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/00004770-200009000-00010","article-title":"Pulp Capping of Carious Exposures: Treatment Outcome after 5 and 10 Years: A Retrospective Study","volume":"26","author":"Barthel","year":"2000","journal-title":"J. Endod."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1177\/154405910408300802","article-title":"Dentin Regeneration by Dental Pulp Stem Cell Therapy with Recombinant Human Bone Morphogenetic Protein 2","volume":"83","author":"Iohara","year":"2004","journal-title":"J. Dent. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1016\/j.joen.2010.08.052","article-title":"Tertiary Dentin Formation after Direct Pulp Capping with Odontogenic Ameloblast-Associated Protein in Rat Teeth","volume":"36","author":"Yang","year":"2010","journal-title":"J. Endod."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"976","DOI":"10.4012\/dmj.2013-091","article-title":"The Possibility of Genistein as a New Direct Pulp Capping Agent","volume":"32","author":"Hayashi","year":"2013","journal-title":"Dent. Mater. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1046\/j.1523-1747.2002.01790.x","article-title":"Epilysin (MMP-28) Expression Is Associated with Cell Proliferation During Epithelial Repair","volume":"119","author":"Suomela","year":"2002","journal-title":"J. Investig. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1080\/00365520410003470","article-title":"Collagenase-1 (MMP-1), Matrilysin-1 (MMP-7), and Stromelysin-2 (MMP-10) Are Expressed by Migrating Enterocytes during Intestinal Wound Healing","volume":"39","author":"Salmela","year":"2004","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.matbio.2015.03.002","article-title":"Matrix Remodeling by MMPs during Wound Repair","volume":"44\u201346","author":"Rohani","year":"2015","journal-title":"Matrix Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2353\/ajpath.2009.081080","article-title":"MMP-13 Plays a Role in Keratinocyte Migration, Angiogenesis, and Contraction in Mouse Skin Wound Healing","volume":"175","author":"Hattori","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"398","DOI":"10.4049\/jimmunol.171.1.398","article-title":"A Site on Laminin A5, AQARSAASKVKVSMKF, Induces Inflammatory Cell Production of Matrix Metalloproteinase-9 and Chemotaxis","volume":"171","author":"Atkinson","year":"2003","journal-title":"J. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/term.123","article-title":"Chemoattractant Activity of Degradation Products of Fetal and Adult Skin Extracellular Matrix for Keratinocyte Progenitor Cells","volume":"2","author":"Brennan","year":"2008","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/jb\/mvs117","article-title":"Activation of the Wnt\/-Catenin Pathway and Tissue Inhibitor of Metalloprotease 1 during Tertiary Dentinogenesis","volume":"153","author":"Yoshioka","year":"2013","journal-title":"J. Biochem. (Tokyo)"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/154405910608500104","article-title":"The Role of Matrix Metalloproteinases (MMPs) in Human Caries","volume":"85","author":"Fioretti","year":"2006","journal-title":"J. Dent. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1159\/000330525","article-title":"Activity of Matrix Metalloproteinases in Bovine versus Human Dentine","volume":"45","author":"Kato","year":"2011","journal-title":"Caries Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nm.1979","article-title":"TGF-\u03921\u2013Induced Migration of Bone Mesenchymal Stem Cells Couples Bone Resorption with Formation","volume":"15","author":"Tang","year":"2009","journal-title":"Nat. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1749-6632.1990.tb16102.x","article-title":"Role of TGF? In Bone Remodeling","volume":"593","author":"Mundy","year":"1990","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"21352","DOI":"10.1074\/jbc.M111663200","article-title":"Proteolysis of Latent Transforming Growth Factor-\u03b2 (TGF-\u03b2)-Binding Protein-1 by Osteoclasts: A CELLULAR MECHANISM FOR RELEASE OF TGF-\u03b2 FROM BONE MATRIX","volume":"277","author":"Dallas","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1016\/j.yexcr.2008.05.018","article-title":"MT1-MMP Releases Latent TGF-\u03921 from Endothelial Cell Extracellular Matrix via Proteolytic Processing of LTBP-1","volume":"314","author":"Tatti","year":"2008","journal-title":"Exp. Cell Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1074\/jbc.M604732200","article-title":"Matrix Macromolecules in Hard Tissues Control the Nucleation and Hierarchical Assembly of Hydroxyapatite","volume":"282","author":"Gajjeraman","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1177\/0022034510363250","article-title":"Different Forms of DMP1 Play Distinct Roles in Mineralization","volume":"89","author":"Gericke","year":"2010","journal-title":"J. Dent. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.matbio.2009.03.006","article-title":"Dentin Sialoprotein and Dentin Phosphoprotein Have Distinct Roles in Dentin Mineralization","volume":"28","author":"Suzuki","year":"2009","journal-title":"Matrix Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/eos.12020","article-title":"Role of the NH2-Terminal Fragment of Dentin Sialophosphoprotein in Dentinogenesis","volume":"121","author":"Gibson","year":"2013","journal-title":"Eur. J. Oral Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"30426","DOI":"10.1074\/jbc.M112.388587","article-title":"Proteolytic Processing of Dentin Sialophosphoprotein (DSPP) Is Essential to Dentinogenesis","volume":"287","author":"Zhu","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/j.yexcr.2012.07.008","article-title":"Recruitment of Dental Pulp Cells by Dentine and Pulp Extracellular Matrix Components","volume":"318","author":"Smith","year":"2012","journal-title":"Exp. Cell Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"10690","DOI":"10.1038\/s41598-018-29112-3","article-title":"Dentinogenic Effects of Extracted Dentin Matrix Components Digested with Matrix Metalloproteinases","volume":"8","author":"Okamoto","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.jdent.2007.04.008","article-title":"Dissolution of Bio-Active Dentine Matrix Components by Mineral Trioxide Aggregate","volume":"35","author":"Tomson","year":"2007","journal-title":"J. Dent."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1038\/s41598-017-03628-6","article-title":"Development of a Root Canal Treatment Model in the Rat","volume":"7","author":"Yoneda","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.1128\/AEM.00421-14","article-title":"Promotion of Endodontic Lesions in Rats by a Novel Extraradicular Biofilm Model Using Obturation Materials","volume":"80","author":"Kuremoto","year":"2014","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 Years of Image Analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant Enables High Peptide Identification Rates, Individualized p.p.b.-Range Mass Accuracies and Proteome-Wide Protein Quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/sj.onc.1207254","article-title":"Plakoglobin (\u03b3-Catenin) Has TCF\/LEF Family-Dependent Transcriptional Activity in \u03b2-Catenin-Deficient Cell Line","volume":"23","author":"Maeda","year":"2004","journal-title":"Oncogene"},{"key":"ref_35","first-page":"1499","article-title":"Chemotactic Activity of S100A7 (Psoriasin) Is Mediated by the Receptor for Advanced Glycation End Products and Potentiates Inflammation with Highly Homologous but Functionally Distinct S100A15","volume":"181","author":"Wolf","year":"2008","journal-title":"J. Immunol. Baltim. Md 1950"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"18991","DOI":"10.1074\/jbc.R115.645085","article-title":"Nutritional Immunity: S100 Proteins at the Host-Pathogen Interface","volume":"290","author":"Zackular","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/ijc.2910600215","article-title":"Mitogenic Effect of the 15-KDa Gross Cystic Disease Fluid Protein (GCDFP-15) on Breast-Cancer Cell Lines and on Immortal Mammary Cells","volume":"60","author":"Cassoni","year":"2006","journal-title":"Int. J. Cancer"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/j.joen.2014.07.001","article-title":"Proteomic Analysis of Human Tooth Pulp: Proteomics of Human Tooth","volume":"40","author":"Eckhardt","year":"2014","journal-title":"J. Endod."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1600-0722.2012.00977.x","article-title":"Comprehensive Proteomic Analysis of Human Dentin","volume":"120","author":"Eckhardt","year":"2012","journal-title":"Eur. J. Oral Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/0003-9969(84)90153-5","article-title":"Proteolytic Activity of Rabbit Incisor Dentine","volume":"29","author":"Smith","year":"1984","journal-title":"Arch. Oral Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1177\/0022034514534690","article-title":"DPP and DSP Are Necessary for Maintaining TGF-\u03921 Activity in Dentin","volume":"93","author":"Yamakoshi","year":"2014","journal-title":"J. Dent. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"38235","DOI":"10.1074\/jbc.M607767200","article-title":"Dentin Sialophosphoprotein Is Processed by MMP-2 and MMP-20 in Vitro and in Vivo","volume":"281","author":"Yamakoshi","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Ishimoto, K., Hayano, S., Yanagita, T., Kurosaka, H., Kawanabe, N., Itoh, S., Ono, M., Kuboki, T., Kamioka, H., and Yamashiro, T. (2015). Topical Application of Lithium Chloride on the Pulp Induces Dentin Regeneration. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0121938"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Yang, Z., Chen, W., Xia, Z., Liu, Y., Peggrem, S., Geng, T., Yang, Z., Li, H., Xu, B., and Zhang, C. (2015). Local Application of Ibandronate\/Gelatin Sponge Improves Osteotomy Healing in Rabbits. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0125807"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00441-013-1790-8","article-title":"Dentin Matrix Proteins (DMPs) Enhance Differentiation of BMMSCs via ERK and P38 MAPK Pathways","volume":"356","author":"Yu","year":"2014","journal-title":"Cell Tissue Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2174\/156652413804486214","article-title":"Functions of S100 Proteins","volume":"13","author":"Donato","year":"2013","journal-title":"Curr. Mol. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1189\/jlb.0306170","article-title":"S100 Proteins Expressed in Phagocytes: A Novel Group of Damage-Associated Molecular Pattern Molecules","volume":"81","author":"Foell","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1128\/IAI.72.7.4102-4108.2004","article-title":"S100 and Cytokine Expression in Caries","volume":"72","author":"McLachlan","year":"2004","journal-title":"Infect. Immun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/S0169-409X(02)00160-6","article-title":"Receptor for Advanced Glycation Endproducts: A Multiligand Receptor Magnifying Cell Stress in Diverse Pathologic Settings","volume":"54","author":"Stern","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00441-006-0293-2","article-title":"Expression of HMGB1 during Tooth Development","volume":"327","author":"Sugars","year":"2007","journal-title":"Cell Tissue Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1111\/iej.12112","article-title":"Effects of High-Mobility Group Box 1 on the Proliferation and Odontoblastic Differentiation of Human Dental Pulp Cells","volume":"46","author":"Qi","year":"2013","journal-title":"Int. Endod. J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/jid.2008.268","article-title":"The Antimicrobial Protein Psoriasin (S100A7) Is Upregulated in Atopic Dermatitis and after Experimental Skin Barrier Disruption","volume":"129","author":"Harder","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/mi.2008.3","article-title":"Psoriasin (S100A7) Is a Principal Antimicrobial Peptide of the Human Tongue","volume":"1","author":"Meyer","year":"2008","journal-title":"Mucosal Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1177\/0022034516645333","article-title":"Osteopontin Is Essential for Type I Collagen Secretion in Reparative Dentin","volume":"95","author":"Saito","year":"2016","journal-title":"J. Dent. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1007\/s00784-018-2353-x","article-title":"Expression and Localization of CRAMP in Rat Tooth Germ and during Reparative Dentin Formation","volume":"22","author":"Horibe","year":"2018","journal-title":"Clin. Oral Investig."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.bbrc.2014.07.027","article-title":"Expression of High Mobility Group Box 1 in Inflamed Dental Pulp and Its Chemotactic Effect on Dental Pulp Cells","volume":"450","author":"Zhang","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Rombouts, C., Jeanneau, C., Bakopoulou, A., and About, I. (2016). Dental Pulp Stem Cell Recruitment Signals within Injured Dental Pulp Tissue. Dent. J., 4.","DOI":"10.3390\/dj4020008"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1177\/0022034516657817","article-title":"DPSCs from Inflamed Pulp Modulate Macrophage Function via the TNF-\u03b1\/IDO Axis","volume":"95","author":"Lee","year":"2016","journal-title":"J. Dent. Res."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/8\/9\/1002\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:15:04Z","timestamp":1760188504000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/8\/9\/1002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,29]]},"references-count":58,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9]]}},"alternative-id":["cells8091002"],"URL":"https:\/\/doi.org\/10.3390\/cells8091002","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,29]]}}}