{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:57:30Z","timestamp":1792803450975,"version":"4.5.0"},"reference-count":256,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T00:00:00Z","timestamp":1567900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST107-2320-B-264-001-MY2 to HCY, MOST 107-2320-B-182-013 and CMRPD110121 to DTYC, MOST 106-2320-B-255-003-MY3 and MOST107-2320-B-255-003 to TLH"],"award-info":[{"award-number":["MOST107-2320-B-264-001-MY2 to HCY, MOST 107-2320-B-182-013 and CMRPD110121 to DTYC, MOST 106-2320-B-255-003-MY3 and MOST107-2320-B-255-003 to TLH"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chang Gung Medical Research Foundation","award":["MRP450, CMRPF1G0241, CMRPF1G0242, CMRPF1G0243, CMRPF1F0132, CMRPF1H0051, CMRPF1H0052, CMRPF1I0041, and ZRRPF3H0131 to TLH"],"award-info":[{"award-number":["MRP450, CMRPF1G0241, CMRPF1G0242, CMRPF1G0243, CMRPF1F0132, CMRPF1H0051, CMRPF1H0052, CMRPF1I0041, and ZRRPF3H0131 to TLH"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The generation of reducing equivalent NADPH via glucose-6-phosphate dehydrogenase (G6PD) is critical for the maintenance of redox homeostasis and reductive biosynthesis in cells. NADPH also plays key roles in cellular processes mediated by redox signaling. Insufficient G6PD activity predisposes cells to growth retardation and demise. Severely lacking G6PD impairs embryonic development and delays organismal growth. Altered G6PD activity is associated with pathophysiology, such as autophagy, insulin resistance, infection, inflammation, as well as diabetes and hypertension. Aberrant activation of G6PD leads to enhanced cell proliferation and adaptation in many types of cancers. The present review aims to update the existing knowledge concerning G6PD and emphasizes how G6PD modulates redox signaling and affects cell survival and demise, particularly in diseases such as cancer. Exploiting G6PD as a potential drug target against cancer is also discussed.<\/jats:p>","DOI":"10.3390\/cells8091055","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T04:12:40Z","timestamp":1568002360000},"page":"1055","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":219,"title":["The Redox Role of G6PD in Cell Growth, Cell Death, and Cancer"],"prefix":"10.3390","volume":"8","author":[{"given":"Hung-Chi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science and Biotechnology, Yuanpei University of Medical Technology, Hsinchu 30041, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hsuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33043, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chen","family":"Yen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33043, Taiwan"},{"name":"Department of Medical Biotechnology and Laboratory Sciences, College of Medicine, Chang Gung University, Taoyuan 33043, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ya","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology and Laboratory Sciences, College of Medicine, Chang Gung University, Taoyuan 33043, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5780-3977","authenticated-orcid":false,"given":"Tsong-Long","family":"Hwang","sequence":"additional","affiliation":[{"name":"Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33043, Taiwan"},{"name":"Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 33043, Taiwan"},{"name":"Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 33043, Taiwan"},{"name":"Department of Anaesthesiology, Chang Gung Memorial Hospital, Taoyuan 33043, Taiwan"},{"name":"Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan"},{"name":"Research Center for Chinese Herbal Medicine, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33043, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Stern","sequence":"additional","affiliation":[{"name":"School of Medicine, New York University, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Tsun-Yee","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology and Laboratory Sciences, College of Medicine, Chang Gung University, Taoyuan 33043, Taiwan"},{"name":"Research Center for Chinese Herbal Medicine, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33043, Taiwan"},{"name":"Department of Pediatric Hematology\/Oncology, Linkou Chang Gung Memorial Hospital, Taoyuan 33043, Taiwan"},{"name":"Healthy Aging Research Center, Chang Gung University, Taoyuan 33043, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1080\/10715762.2016.1223296","article-title":"What has passed is prolog: New cellular and physiological roles of G6PD","volume":"50","author":"Yang","year":"2016","journal-title":"Free Radic Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1182\/blood.V84.11.3613.bloodjournal84113613","article-title":"G6PD deficiency","volume":"84","author":"Beutler","year":"1994","journal-title":"Blood"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1093\/emboj\/cdf426","article-title":"Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethal","volume":"21","author":"Longo","year":"2002","journal-title":"EMBO J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e616","DOI":"10.1038\/cddis.2013.132","article-title":"Glucose 6-phosphate dehydrogenase deficiency enhances germ cell apoptosis and causes defective embryogenesis in Caenorhabditis elegans","volume":"4","author":"Yang","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e2545","DOI":"10.1038\/cddis.2016.463","article-title":"Impaired embryonic development in glucose-6-phosphate dehydrogenase-deficient Caenorhabditis elegans due to abnormal redox homeostasis induced activation of calcium-independent phospholipase and alteration of glycerophospholipid metabolism","volume":"8","author":"Chen","year":"2017","journal-title":"Cell Death Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00109-018-01740-2","article-title":"IDH-1 deficiency induces growth defects and metabolic alterations in GSPD-1-deficient Caenorhabditis elegans","volume":"97","author":"Yang","year":"2019","journal-title":"J. Mol. Med. (Berl)"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41419-017-0005-8","article-title":"Glucose-6-phosphate dehydrogenase is indispensable in embryonic development by modulation of epithelial-mesenchymal transition via the NOX\/Smad3\/miR-200b axis","volume":"9","author":"Wu","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_8","first-page":"57","article-title":"[Expression of g6pd gene in wild type zebrafish embryos of early development]","volume":"47","author":"Xia","year":"2018","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"10894","DOI":"10.1038\/ncomms10894","article-title":"G6PD protects from oxidative damage and improves healthspan in mice","volume":"7","author":"Brioche","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/iub.1017","article-title":"Glucose-6-phosphate dehydrogenase, NADPH, and cell survival","volume":"64","author":"Stanton","year":"2012","journal-title":"IUBMB Life"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"280","DOI":"10.2174\/18715206113136660337","article-title":"Glucose-6-phosphate dehydrogenase: A biomarker and potential therapeutic target for cancer","volume":"14","author":"Zhang","year":"2014","journal-title":"Anticancer Agents Med. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/iub.1329","article-title":"The regulation of the oxidative phase of the pentose phosphate pathway: New answers to old problems","volume":"66","year":"2014","journal-title":"IUBMB Life"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1111\/febs.13570","article-title":"How does metabolism affect cell death in cancer?","volume":"283","author":"Villa","year":"2016","journal-title":"FEBS J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"R646","DOI":"10.1152\/ajpregu.00247.2017","article-title":"The differential role of reactive oxygen species in early and late stages of cancer","volume":"313","author":"Assi","year":"2017","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bbcan.2018.06.005","article-title":"Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect","volume":"1870","author":"Sun","year":"2018","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"ref_16","first-page":"1610","article-title":"Glucose-6-phosphate dehydrogenase and NADPH oxidase 4 control STAT3 activity in melanoma cells through a pathway involving reactive oxygen species, c-SRC and SHP2","volume":"5","author":"Cai","year":"2015","journal-title":"Am. J. Cancer Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"8159","DOI":"10.1007\/s13277-015-4729-8","article-title":"Altered glycometabolism affects both clinical features and prognosis of triple-negative and neoadjuvant chemotherapy-treated breast cancer","volume":"37","author":"Dong","year":"2016","journal-title":"Tumor Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.3892\/mmr.2016.5449","article-title":"Aspirin inhibits glucose6phosphate dehydrogenase activity in HCT 116 cells through acetylation: Identification of aspirin-acetylated sites","volume":"14","author":"Ai","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_19","first-page":"3533","article-title":"Downregulation of glucose6phosphate dehydrogenase by microRNA1 inhibits the growth of pituitary tumor cells","volume":"40","author":"He","year":"2018","journal-title":"Oncol. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1016\/j.bbamcr.2016.05.016","article-title":"Effects of G6PD activity inhibition on the viability, ROS generation and mechanical properties of cervical cancer cells","volume":"1863","author":"Fang","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1177\/1535370214565971","article-title":"Elevated glucose-6-phosphate dehydrogenase expression in the cervical cancer cases is associated with the cancerigenic event of high-risk human papillomaviruses","volume":"240","author":"Hu","year":"2015","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1159\/000320300","article-title":"Endogenous control genes in prostate cells: Evaluation of gene expression using \u2018real-time\u2019 quantitative polymerase chain reaction","volume":"19","author":"Nna","year":"2010","journal-title":"Med. Princ. Pract."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s11060-018-2911-8","article-title":"G6PD as a predictive marker for glioma risk, prognosis and chemosensitivity","volume":"139","author":"Yang","year":"2018","journal-title":"J. Neurooncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/MNH.0000000000000294","article-title":"Glucose 6-phosphate dehydrogenase and the kidney","volume":"26","author":"Spencer","year":"2017","journal-title":"Curr. Opin. Nephrol. Hypertens"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"106693","DOI":"10.18632\/oncotarget.21601","article-title":"Glucose-6-phosphate dehydrogenase and transketolase modulate breast cancer cell metabolic reprogramming and correlate with poor patient outcome","volume":"8","author":"Benito","year":"2017","journal-title":"Oncotarget"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s13046-019-1164-5","article-title":"Glucose-6-phosphate dehydrogenase blockade potentiates tyrosine kinase inhibitor effect on breast cancer cells through autophagy perturbation","volume":"38","author":"Mele","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e5254","DOI":"10.1097\/MD.0000000000005254","article-title":"Glucose-6-phosphate dehydrogenase deficiency and risk of colorectal cancer in Northern Sardinia: A retrospective observational study","volume":"95","author":"Dore","year":"2016","journal-title":"Medicine (Baltim.)"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"22861","DOI":"10.1074\/jbc.C116.748848","article-title":"Glutathione Depletion, Pentose Phosphate Pathway Activation, and Hemolysis in Erythrocytes Protecting Cancer Cells from Vitamin C-induced Oxidative Stress","volume":"291","author":"Zhang","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1093\/neuonc\/now024","article-title":"Glycolysis and the pentose phosphate pathway are differentially associated with the dichotomous regulation of glioblastoma cell migration versus proliferation","volume":"18","author":"Schulte","year":"2016","journal-title":"Neuro Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e1980","DOI":"10.1038\/cddis.2015.322","article-title":"Hepatitis B virus stimulates G6PD expression through HBx-mediated Nrf2 activation","volume":"6","author":"Liu","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1038\/leu.2017.81","article-title":"High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells","volume":"31","author":"Poulain","year":"2017","journal-title":"Leukemia"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"28329","DOI":"10.18632\/oncotarget.8631","article-title":"Histone deacetylase inhibitor-induced cancer stem cells exhibit high pentose phosphate pathway metabolism","volume":"7","author":"Debeb","year":"2016","journal-title":"Oncotarget"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s13046-017-0637-7","article-title":"ID1 promotes hepatocellular carcinoma proliferation and confers chemoresistance to oxaliplatin by activating pentose phosphate pathway","volume":"36","author":"Yin","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/S0022-5347(05)00919-5","article-title":"Identification and validation of suitable endogenous reference genes for gene expression studies of human bladder cancer","volume":"175","author":"Ohl","year":"2006","journal-title":"J. Urol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1007\/s13277-015-4428-5","article-title":"Inhibition of pentose phosphate pathway suppresses acute myelogenous leukemia","volume":"37","author":"Chen","year":"2016","journal-title":"Tumor Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.biopha.2017.01.047","article-title":"l-arginine alters the effect of 5-fluorouracil on breast cancer cells in favor of apoptosis","volume":"88","author":"Jahani","year":"2017","journal-title":"Biomed. Pharm."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ctrv.2016.03.005","article-title":"Metabolic phenotype of bladder cancer","volume":"45","author":"Massari","year":"2016","journal-title":"Cancer Treat. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"13371","DOI":"10.18632\/oncotarget.3823","article-title":"Metabolomic profile of glycolysis and the pentose phosphate pathway identifies the central role of glucose-6-phosphate dehydrogenase in clear cell-renal cell carcinoma","volume":"6","author":"Lucarelli","year":"2015","journal-title":"Oncotarget"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1002\/ijc.23403","article-title":"Metastasis is promoted by a bioenergetic switch: New targets for progressive renal cell cancer","volume":"122","author":"Langbein","year":"2008","journal-title":"Int. J. Cancer"},{"key":"ref_40","first-page":"5946","article-title":"MicroRNA-206 suppresses proliferation and predicts poor prognosis of HR-HPV-positive cervical cancer cells by targeting G6PD","volume":"16","author":"Cui","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"86103","DOI":"10.18632\/oncotarget.13344","article-title":"miR-1 inhibits progression of high-risk papillomavirus-associated human cervical cancer by targeting G6PD","volume":"7","author":"Hu","year":"2016","journal-title":"Oncotarget"},{"key":"ref_42","first-page":"1703","article-title":"Modulation of G6PD affects bladder cancer via ROS accumulation and the AKT pathway in vitro","volume":"53","author":"Chen","year":"2018","journal-title":"Int. J. Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s42255-019-0043-x","article-title":"NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism","volume":"1","author":"Chen","year":"2019","journal-title":"Nat. Metab."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1111\/jcmm.14241","article-title":"Nrf2 promotes breast cancer cell migration via up-regulation of G6PD\/HIF-1alpha\/Notch1 axis","volume":"23","author":"Zhang","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"8468","DOI":"10.1038\/ncomms9468","article-title":"O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth","volume":"6","author":"Rao","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s13277-011-0251-9","article-title":"Overexpression of G6PD is associated with poor clinical outcome in gastric cancer","volume":"33","author":"Wang","year":"2012","journal-title":"Tumor Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"665","DOI":"10.7150\/jca.16858","article-title":"Overexpression of G6PD Represents a Potential Prognostic Factor in Clear Cell Renal Cell Carcinoma","volume":"8","author":"Zhang","year":"2017","journal-title":"J. Cancer"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/ncb2172","article-title":"p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase","volume":"13","author":"Jiang","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1038\/s41467-017-01647-5","article-title":"Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway","volume":"8","author":"Ma","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/(SICI)1097-0320(19990815)38:4<176::AID-CYTO4>3.0.CO;2-#","article-title":"Prognostic estimation of survival of colorectal cancer patients with the quantitative histochemical assay of G6PDH activity and the multiparameter classification program CLASSIF1","volume":"38","author":"Valet","year":"1999","journal-title":"Cytometry"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2018.04.016","article-title":"Regulation of AMPK-related glycolipid metabolism imbalances redox homeostasis and inhibits anchorage independent growth in human breast cancer cells","volume":"17","author":"Yang","year":"2018","journal-title":"Redox Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.1038\/oncsis.2014.18","article-title":"Regulation of the pentose phosphate pathway by an androgen receptor-mTOR-mediated mechanism and its role in prostate cancer cell growth","volume":"3","author":"Tsouko","year":"2014","journal-title":"Oncogenesis"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.acthis.2009.03.003","article-title":"Renal cell carcinoma and oxidative stress: The lack of peroxisomes","volume":"112","author":"Frederiks","year":"2010","journal-title":"Acta Histochem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.canlet.2016.05.004","article-title":"Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes","volume":"378","author":"Wang","year":"2016","journal-title":"Cancer Lett."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"9105","DOI":"10.1038\/s41598-018-27358-5","article-title":"The role of miR-122 in the dysregulation of glucose-6-phosphate dehydrogenase (G6PD) expression in hepatocellular cancer","volume":"8","author":"Barajas","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_56","first-page":"251","article-title":"RRx-001, a novel clinical-stage chemosensitizer, radiosensitizer, and immunosensitizer, inhibits glucose 6-phosphate dehydrogenase in human tumor cells","volume":"21","author":"Oronsky","year":"2016","journal-title":"Discov. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"32734","DOI":"10.1038\/srep32734","article-title":"SIRT2 activates G6PD to enhance NADPH production and promote leukaemia cell proliferation","volume":"6","author":"Xu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1158\/0008-5472.CAN-17-4047","article-title":"Transcription Factor YY1 Promotes Cell Proliferation by Directly Activating the Pentose Phosphate Pathway","volume":"78","author":"Wu","year":"2018","journal-title":"Cancer Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.micinf.2010.10.008","article-title":"The microbicidal and cytoregulatory roles of NADPH oxidases","volume":"13","author":"Yang","year":"2011","journal-title":"Microbes Infect."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.freeradbiomed.2013.07.003","article-title":"Oxidative stress and vascular inflammation in aging","volume":"65","author":"Angulo","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3934\/molsci.2016.2.196","article-title":"Oxidative stress, innate immunity, and age-related macular degeneration","volume":"3","author":"Shaw","year":"2016","journal-title":"Aims Mol. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.bcp.2017.09.010","article-title":"A timeline of hydrogen sulfide (H2S) research: From environmental toxin to biological mediator","volume":"149","author":"Szabo","year":"2018","journal-title":"Biochem. Pharm."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.tibs.2015.08.007","article-title":"H2S: A Novel Gasotransmitter that Signals by Sulfhydration","volume":"40","author":"Paul","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1089\/ars.2017.7096","article-title":"Beyond a Gasotransmitter: Hydrogen Sulfide and Polysulfide in Cardiovascular Health and Immune Response","volume":"27","author":"Yuan","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1089\/ars.2017.7083","article-title":"The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine","volume":"27","author":"Koning","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"101104","DOI":"10.1016\/j.redox.2019.101104","article-title":"Redoxins as gatekeepers of the transcriptional oxidative stress response","volume":"21","author":"Hopkins","year":"2019","journal-title":"Redox Biol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Balsera, M., and Buchanan, B.B. (2019). Evolution of the thioredoxin system as a step enabling adaptation to oxidative stress. Free Radic Biol. Med.","DOI":"10.1016\/j.freeradbiomed.2019.03.003"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"8267234","DOI":"10.1155\/2019\/8267234","article-title":"Biomarkers of Oxidative Stress in Metabolic Syndrome and Associated Diseases","volume":"2019","author":"Vona","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/978-1-4939-9463-2_3","article-title":"Investigating ROS, RNS, and H2S-Sensitive Signaling Proteins","volume":"1990","author":"Williams","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"20618","DOI":"10.1073\/pnas.0710191104","article-title":"Hydrogen sulfide increases thermotolerance and lifespan in Caenorhabditis elegans","volume":"104","author":"Miller","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1126\/science.1108581","article-title":"H2S induces a suspended animation-like state in mice","volume":"308","author":"Blackstone","year":"2005","journal-title":"Science"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0014-5793(98)01174-0","article-title":"Impaired production of nitric oxide, superoxide, and hydrogen peroxide in glucose 6-phosphate-dehydrogenase-deficient granulocytes","volume":"436","author":"Tsai","year":"1998","journal-title":"FEBS Lett."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1161\/01.ATV.0000205850.49390.3b","article-title":"Glucose-6-phosphate dehydrogenase deficiency decreases vascular superoxide and atherosclerotic lesions in apolipoprotein E(-\/-) mice","volume":"26","author":"Matsui","year":"2006","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.yjmcc.2006.05.003","article-title":"Glucose-6-phosphate dehydrogenase-derived NADPH fuels superoxide production in the failing heart","volume":"41","author":"Gupte","year":"2006","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"8977","DOI":"10.1074\/jbc.M110.193821","article-title":"Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4","volume":"286","author":"Spencer","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1161\/01.ATV.0000056744.26901.BA","article-title":"Glucose-6-phosphate dehydrogenase overexpression decreases endothelial cell oxidant stress and increases bioavailable nitric oxide","volume":"23","author":"Leopold","year":"2003","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.niox.2015.02.002","article-title":"The nitric oxide donor cis-[Ru(bpy)2(SO3)NO](PF6) increases gastric mucosa protection in mice--involvement of the soluble guanylate cyclase\/K(ATP) pathway","volume":"45","author":"Santana","year":"2015","journal-title":"Nitric Oxide"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s00109-016-1398-z","article-title":"TNFalpha-induced M-MDSCs promote transplant immune tolerance via nitric oxide","volume":"94","author":"Yang","year":"2016","journal-title":"J. Mol. Med. (Berl)"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"14726","DOI":"10.1021\/bi026110v","article-title":"Suppression of interleukin-1 beta-induced nitric oxide production in RINm5F cells by inhibition of glucose-6-phosphate dehydrogenase","volume":"41","author":"Guo","year":"2002","journal-title":"Biochemistry"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/smi.2666","article-title":"Increased Salivary Nitric Oxide and G6PD Activity in Refugees with Anxiety and Stress","volume":"32","author":"Gammoh","year":"2016","journal-title":"Stress Health"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0014-5793(00)01687-2","article-title":"Cellular glucose-6-phosphate dehydrogenase (G6PD) status modulates the effects of nitric oxide (NO) on human foreskin fibroblasts","volume":"475","author":"Cheng","year":"2000","journal-title":"FEBS Lett."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1096\/fj.00-0893fje","article-title":"Glucose-6-phosphate dehydrogenase deficiency promotes endothelial oxidant stress and decreases endothelial nitric oxide bioavailability","volume":"15","author":"Leopold","year":"2001","journal-title":"FASEB J."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1046\/j.1471-4159.1999.721750.x","article-title":"Induction of glucose-6-phosphate dehydrogenase by lipopolysaccharide contributes to preventing nitric oxide-mediated glutathione depletion in cultured rat astrocytes","volume":"72","author":"Almeida","year":"1999","journal-title":"J. Neurochem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1074\/jbc.M206835200","article-title":"Peroxynitrite protects neurons against nitric oxide-mediated apoptosis. A key role for glucose-6-phosphate dehydrogenase activity in neuroprotection","volume":"278","author":"Almeida","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.abb.2018.12.023","article-title":"Glucose-6-phosphate dehydrogenase deficiency increases cell adhesion molecules and activates human monocyte-endothelial cell adhesion: Protective role of l-cysteine","volume":"663","author":"Parsanathan","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1097\/00019052-199512000-00016","article-title":"Role of nitric oxide in neurodegenerative diseases","volume":"8","author":"Schulz","year":"1995","journal-title":"Curr. Opin. Neurol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/BF03033456","article-title":"Neurotoxins and neurotoxic species implicated in neurodegeneration","volume":"6","author":"Kostrzewa","year":"2004","journal-title":"Neurotox Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","article-title":"The possible role of hydrogen sulfide as an endogenous neuromodulator","volume":"16","author":"Abe","year":"1996","journal-title":"J. Neurosci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1006\/bbrc.1997.6878","article-title":"The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide","volume":"237","author":"Hosoki","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: Hypertension in mice with deletion of cystathionine gamma-lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1096\/fj.04-3583fje","article-title":"Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse","volume":"19","author":"Li","year":"2005","journal-title":"FASEB J."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1096\/fj.06-6270fje","article-title":"Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation","volume":"20","author":"Zanardo","year":"2006","journal-title":"FASEB J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.molcel.2011.10.021","article-title":"Hydrogen sulfide-linked sulfhydration of NF-kappaB mediates its antiapoptotic actions","volume":"45","author":"Sen","year":"2012","journal-title":"Mol. Cell"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cell.2014.11.048","article-title":"Endogenous hydrogen sulfide production is essential for dietary restriction benefits","volume":"160","author":"Hine","year":"2015","journal-title":"Cell"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"12474","DOI":"10.1073\/pnas.1306241110","article-title":"Tumor-derived hydrogen sulfide, produced by cystathionine-beta-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer","volume":"110","author":"Szabo","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41420-017-0010-9","article-title":"Glucose-6-phosphate dehydrogenase is critical for suppression of cardiac hypertrophy by H2S","volume":"4","author":"Chhabra","year":"2018","journal-title":"Cell Death Discov."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.pharmthera.2009.05.005","article-title":"Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation--a tale of three gases!","volume":"123","author":"Li","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1089\/ars.2016.6979","article-title":"Carbon Monoxide Inhibits Islet Apoptosis via Induction of Autophagy","volume":"28","author":"Kim","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jss.2017.09.028","article-title":"Carbon monoxide and hydrogen sulphide reduce reperfusion injury in abdominal compartment syndrome","volume":"222","author":"Murphy","year":"2018","journal-title":"J. Surg. Res."},{"key":"ref_100","first-page":"E2302","article-title":"Carbon monoxide protects the kidney through the central circadian clock and CD39","volume":"115","author":"Gallo","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"e12864","DOI":"10.1111\/acel.12864","article-title":"Carbon monoxide attenuates amyloidogenesis via down-regulation of NF-kappaB-mediated BACE1 gene expression","volume":"18","author":"Kim","year":"2019","journal-title":"Aging Cell"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"C211","DOI":"10.1152\/ajpcell.00022.2017","article-title":"Carbon monoxide in lung cell physiology and disease","volume":"314","author":"Ryter","year":"2018","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000489820","article-title":"Hemolysis and Glucose-6-Phosphate Dehydrogenase Deficiency-Related Neonatal Hyperbilirubinemia","volume":"114","author":"Kaplan","year":"2018","journal-title":"Neonatology"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.redox.2018.05.004","article-title":"Improvement of neuronal differentiation by carbon monoxide: Role of pentose phosphate pathway","volume":"17","author":"Almeida","year":"2018","journal-title":"Redox Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12933-016-0397-2","article-title":"Inflammation, glucose, and vascular cell damage: The role of the pentose phosphate pathway","volume":"15","author":"Peiro","year":"2016","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1515\/intox-2017-0021","article-title":"Antioxidant SMe1EC2 modulates pentose phosphate pathway and glutathione-dependent enzyme activities in tissues of aged diabetic rats","volume":"10","author":"Ulusu","year":"2017","journal-title":"Interdiscip. Toxicol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.2337\/db16-0060","article-title":"Glucose-6-Phosphate Dehydrogenase Deficiency Improves Insulin Resistance With Reduced Adipose Tissue Inflammation in Obesity","volume":"65","author":"Ham","year":"2016","journal-title":"Diabetes"},{"key":"ref_108","first-page":"34","article-title":"Glucose-6-phosphate dehydrogenase deficiency (G6PD) as a risk factor of male neonatal sepsis","volume":"9","author":"Ghadiri","year":"2016","journal-title":"J. Med. Life"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Hsieh, Y.T., Lin, M.H., Ho, H.Y., Chen, L.C., Chen, C.C., and Shu, J.C. (2013). Glucose-6-phosphate dehydrogenase (G6PD)-deficient epithelial cells are less tolerant to infection by Staphylococcus aureus. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0079566"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/cei.13097","article-title":"Glucose-6-phosphate dehydrogenase inhibition attenuates acute lung injury through reduction in NADPH oxidase-derived reactive oxygen species","volume":"191","author":"Nadeem","year":"2018","journal-title":"Clin. Exp. Immunol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1086\/528377","article-title":"Glucose-6-phosphate dehydrogenase deficiency enhances human coronavirus 229E infection","volume":"197","author":"Wu","year":"2008","journal-title":"J. Infect. Dis."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"6689","DOI":"10.3390\/v7122966","article-title":"Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-kappaB Signaling","volume":"7","author":"Wu","year":"2015","journal-title":"Viruses"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Lin, H.R., Wu, Y.H., Yen, W.C., Yang, C.M., and Chiu, D.T. (2016). Diminished COX-2\/PGE2-Mediated Antiviral Response Due to Impaired NOX\/MAPK Signaling in G6PD-Knockdown Lung Epithelial Cells. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0153462"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/tropej\/38.3.139","article-title":"Increased morbidity following acute viral hepatitis in children with glucose-6-phosphate dehydrogenase deficiency","volume":"38","author":"Choudhry","year":"1992","journal-title":"J. Trop. Pediatr."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Al-Alimi, A.A., Ali, S.A., Al-Hassan, F.M., Idris, F.M., Teow, S.Y., and Mohd Yusoff, N. (2014). Dengue virus type 2 (DENV2)-induced oxidative responses in monocytes from glucose-6-phosphate dehydrogenase (G6PD)-deficient and G6PD normal subjects. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0002711"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Chao, Y.C., Huang, C.S., Lee, C.N., Chang, S.Y., King, C.C., and Kao, C.L. (2008). Higher infection of dengue virus serotype 2 in human monocytes of patients with G6PD deficiency. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0001557"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12950-015-0078-z","article-title":"Glucose 6-phosphate dehydrogenase knockdown enhances IL-8 expression in HepG2 cells via oxidative stress and NF-kappaB signaling pathway","volume":"12","author":"Yang","year":"2015","journal-title":"J. Inflamm. (Lond.)"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/21623945.2017.1288321","article-title":"The role of glucose-6-phosphate dehydrogenase in adipose tissue inflammation in obesity","volume":"6","author":"Park","year":"2017","journal-title":"Adipocyte"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1128\/MCB.01260-12","article-title":"Macrophage glucose-6-phosphate dehydrogenase stimulates proinflammatory responses with oxidative stress","volume":"33","author":"Ham","year":"2013","journal-title":"Mol. Cell Biol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1210\/en.2010-0606","article-title":"G6PD up-regulation promotes pancreatic beta-cell dysfunction","volume":"152","author":"Lee","year":"2011","journal-title":"Endocrinology"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"L383","DOI":"10.1152\/ajplung.00301.2013","article-title":"Dehydroepiandrosterone promotes pulmonary artery relaxation by NADPH oxidation-elicited subunit dimerization of protein kinase G 1alpha","volume":"306","author":"Patel","year":"2014","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"H330","DOI":"10.1152\/ajpheart.01010.2011","article-title":"Roles for cytosolic NADPH redox in regulating pulmonary artery relaxation by thiol oxidation-elicited subunit dimerization of protein kinase G1alpha","volume":"305","author":"Neo","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s12311-010-0172-y","article-title":"Activation of neuronal nitric oxide synthase in cerebellum of chronic hepatic encephalopathy rats is associated with up-regulation of NADPH-producing pathway","volume":"9","author":"Singh","year":"2010","journal-title":"Cerebellum"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neuroscience.2015.07.028","article-title":"Reactive nitrogen species mediate oxidative stress and astrogliosis provoked by in vivo administration of phytanic acid in cerebellum of adolescent rats: A potential contributing pathomechanism of cerebellar injury in peroxisomal disorders","volume":"304","author":"Borges","year":"2015","journal-title":"Neuroscience"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1385\/ENDO:19:2:191","article-title":"Decreased blood activity of glucose-6-phosphate dehydrogenase associates with increased risk for diabetes mellitus","volume":"19","author":"Wan","year":"2002","journal-title":"Endocrine"},{"key":"ref_126","first-page":"749","article-title":"G6PD deficiency: Its role in the high prevalence of hypertension and diabetes mellitus","volume":"11","author":"Gaskin","year":"2001","journal-title":"Ethn. Dis."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1096\/fj.09-136572","article-title":"High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis","volume":"24","author":"Zhang","year":"2010","journal-title":"FASEB J."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"6296","DOI":"10.1096\/fj.201801921R","article-title":"High glucose-induced ubiquitination of G6PD leads to the injury of podocytes","volume":"33","author":"Wang","year":"2019","journal-title":"FASEB J."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Zhang, W., Ni, C., Sheng, J., Hua, Y., Ma, J., Wang, L., Zhao, Y., and Xing, Y. (2013). TLQP-21 protects human umbilical vein endothelial cells against high-glucose-induced apoptosis by increasing G6PD expression. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0079760"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1515\/cclm.2011.250","article-title":"Oxidative stress and diabetes mellitus","volume":"49","author":"Yang","year":"2011","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1463-1326.2010.01280.x","article-title":"Glucose regulation of beta-cell stress in type 2 diabetes","volume":"12","author":"Leibowitz","year":"2010","journal-title":"Diabetes Obes. Metab."},{"key":"ref_132","first-page":"245","article-title":"Acute viral hepatitis E presenting with haemolytic anaemia and acute renal failure in a patient with glucose-6-phosphate dehydrogenase deficiency","volume":"45","author":"Tomar","year":"2015","journal-title":"Trop. Dr."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1007\/s00431-008-0694-1","article-title":"Etiology of hemolysis in two patients with hepatitis A infection: Glucose-6-phosphate dehydrogenase deficiency or autoimmune hemolytic anemia","volume":"167","author":"Ozcay","year":"2008","journal-title":"Eur. J. Pediatr."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Araujo, T., Katiyar, V., and Gonzales Zamora, J.A. (2018). Acute Retroviral Syndrome Presenting with Hemolytic Anemia Induced by G6PD Deficiency. Trop. Med. Infect. Dis., 4.","DOI":"10.3390\/tropicalmed4010006"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"45963","DOI":"10.1038\/srep45963","article-title":"Association of glucose-6-phosphate dehydrogenase deficiency and malaria: A systematic review and meta-analysis","volume":"7","author":"Mbanefo","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.intimp.2017.04.010","article-title":"Acute lung injury leads to depression-like symptoms through upregulation of neutrophilic and neuronal NADPH oxidase signaling in a murine model","volume":"47","author":"Nadeem","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"H2295","DOI":"10.1152\/ajpheart.00624.2011","article-title":"Roles for redox mechanisms controlling protein kinase G in pulmonary and coronary artery responses to hypoxia","volume":"301","author":"Neo","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"L287","DOI":"10.1152\/ajplung.00229.2014","article-title":"Hypoxia-induced glucose-6-phosphate dehydrogenase overexpression and -activation in pulmonary artery smooth muscle cells: Implication in pulmonary hypertension","volume":"308","author":"Chettimada","year":"2015","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"10609","DOI":"10.1074\/jbc.273.17.10609","article-title":"Importance of glucose-6-phosphate dehydrogenase activity for cell growth","volume":"273","author":"Tian","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_140","first-page":"81","article-title":"A new G6PD knockdown tumor-cell line with reduced proliferation and increased susceptibility to oxidative stress","volume":"24","author":"Li","year":"2009","journal-title":"Cancer Biother. Radiopharm."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/ncb3255","article-title":"6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling","volume":"17","author":"Lin","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1182\/blood-2004-03-0835","article-title":"G6PD is indispensable for erythropoiesis after the embryonic-adult hemoglobin switch","volume":"104","author":"Paglialunga","year":"2004","journal-title":"Blood"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/s12957-015-0733-0","article-title":"Overexpression of G6PD is associated with high risks of recurrent metastasis and poor progression-free survival in primary breast carcinoma","volume":"13","author":"Pu","year":"2015","journal-title":"World J. Surg. Oncol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/onc.2016.196","article-title":"Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin","volume":"36","author":"Elf","year":"2017","journal-title":"Oncogene"},{"key":"ref_145","first-page":"15719","article-title":"Exosomes mediated pentose phosphate pathway in ovarian cancer metastasis: A proteomics analysis","volume":"8","author":"Yi","year":"2015","journal-title":"Int J. Clin. Exp. Pathol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"109043","DOI":"10.18632\/oncotarget.22566","article-title":"G6PD promotes renal cell carcinoma proliferation through positive feedback regulation of p-STAT3","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/bjc.1992.240","article-title":"Increased activity of 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase in purified cell suspensions and single cells from the uterine cervix in cervical intraepithelial neoplasia","volume":"66","author":"Jonas","year":"1992","journal-title":"Br. J. Cancer"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/S0140-6736(72)91416-X","article-title":"G.-6-P.D. deficiency and cancer","volume":"1","author":"Sulis","year":"1972","journal-title":"Lancet"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.tibs.2014.06.005","article-title":"The pentose phosphate pathway and cancer","volume":"39","author":"Patra","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1161\/ATVBAHA.109.184812","article-title":"Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells","volume":"29","author":"Pan","year":"2009","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"4945","DOI":"10.1038\/s41467-018-07472-8","article-title":"Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis","volume":"9","author":"Roeth","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Ye, H., Huang, H., Cao, F., Chen, M., Zheng, X., and Zhan, R. (2016). HSPB1 Enhances SIRT2-Mediated G6PD Activation and Promotes Glioma Cell Proliferation. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0164285"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"811","DOI":"10.15252\/embr.201541643","article-title":"SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense","volume":"17","author":"Zhou","year":"2016","journal-title":"EMBO Rep."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"700","DOI":"10.18632\/oncotarget.6396","article-title":"BAG3 elevation inhibits cell proliferation via direct interaction with G6PD in hepatocellular carcinomas","volume":"7","author":"Kong","year":"2016","journal-title":"Oncotarget"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.biopha.2017.05.066","article-title":"Phytol induces ROS mediated apoptosis by induction of caspase 9 and 3 through activation of TRAIL, FAS and TNF receptors and inhibits tumor progression factor Glucose 6 phosphate dehydrogenase in lung carcinoma cell line (A549)","volume":"92","author":"Thakor","year":"2017","journal-title":"Biomed. Pharm."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.trecan.2017.10.004","article-title":"Targeting Oncogenic Transcription Factors: Therapeutic Implications of Endogenous STAT Inhibitors","volume":"3","author":"Heppler","year":"2017","journal-title":"Trends Cancer"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1172\/JCI0215617","article-title":"Stat proteins and oncogenesis","volume":"109","author":"Bromberg","year":"2002","journal-title":"J. Clin. Investig."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Hu, T., Zhang, C., Tang, Q., Su, Y., Li, B., Chen, L., Zhang, Z., Cai, T., and Zhu, Y. (2013). Variant G6PD levels promote tumor cell proliferation or apoptosis via the STAT3\/5 pathway in the human melanoma xenograft mouse model. BMC Cancer, 13.","DOI":"10.1186\/1471-2407-13-251"},{"key":"ref_159","first-page":"2415","article-title":"S100A4 (MTS1) calcium binding protein in cancer growth, invasion and metastasis","volume":"18","author":"Sherbet","year":"1998","journal-title":"Anticancer Res."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/imr.12720","article-title":"FAS and RAS related Apoptosis defects: From autoimmunity to leukemia","volume":"287","author":"Meynier","year":"2019","journal-title":"Immunol. Rev."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"17276","DOI":"10.18632\/oncotarget.3640","article-title":"Overexpression of Id1 in transgenic mice promotes mammary basal stem cell activity and breast tumorigenesis","volume":"6","author":"Shin","year":"2015","journal-title":"Oncotarget"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.ejso.2014.01.004","article-title":"VEGF and Id-1 in pancreatic adenocarcinoma: Prognostic significance and impact on angiogenesis","volume":"40","author":"Georgiadou","year":"2014","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.humpath.2007.02.011","article-title":"Increased Id-1 expression is significantly associated with poor survival of patients with prostate cancer","volume":"38","author":"Forootan","year":"2007","journal-title":"Hum. Pathol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrc1673","article-title":"Id family of helix-loop-helix proteins in cancer","volume":"5","author":"Perk","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1158\/1078-0432.CCR-10-3381","article-title":"Inhibitor of differentiation-1 as a novel prognostic factor in NSCLC patients with adenocarcinoma histology and its potential contribution to therapy resistance","volume":"17","author":"Nguewa","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"6831","DOI":"10.1074\/jbc.M115.704361","article-title":"Inhibitor of Differentiation\/DNA Binding 1 (ID1) Inhibits Etoposide-induced Apoptosis in a c-Jun\/c-Fos-dependent Manner","volume":"291","author":"Zhao","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1479-5876-11-13","article-title":"Id1 and Id3 co-expression correlates with clinical outcome in stage III-N2 non-small cell lung cancer patients treated with definitive chemoradiotherapy","volume":"11","author":"Castanon","year":"2013","journal-title":"J. Transl. Med."},{"key":"ref_168","first-page":"5703","article-title":"Overexpression of Id-1 protein is a marker for unfavorable prognosis in early-stage cervical cancer","volume":"61","author":"Schindl","year":"2001","journal-title":"Cancer Res."},{"key":"ref_169","first-page":"2179","article-title":"The mRNA expression of inhibitors of DNA binding-1 and -2 is associated with advanced tumour stage and adverse clinical outcome in human breast cancer","volume":"33","author":"Wazir","year":"2013","journal-title":"Anticancer Res."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/s41467-017-00902-z","article-title":"Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development","volume":"8","author":"Xiao","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"65514","DOI":"10.18632\/oncotarget.11804","article-title":"c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma","volume":"7","author":"Ciribilli","year":"2016","journal-title":"Oncotarget"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1158\/0008-5472.CAN-14-2345","article-title":"Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer","volume":"75","author":"Jain","year":"2015","journal-title":"Cancer Res."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.tcb.2015.10.013","article-title":"AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs","volume":"26","author":"Hardie","year":"2016","journal-title":"Trends Cell Biol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ncb2329","article-title":"The AMPK signalling pathway coordinates cell growth, autophagy and metabolism","volume":"13","author":"Mihaylova","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Gandhi, N., and Das, G.M. (2019). Metabolic Reprogramming in Breast Cancer and Its Therapeutic Implications. Cells, 8.","DOI":"10.3390\/cells8020089"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.2174\/1871520614666140804224637","article-title":"Follow the ATP: Tumor energy production: A perspective","volume":"14","author":"Oronsky","year":"2014","journal-title":"Anticancer Agents Med. Chem."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s10549-007-9732-3","article-title":"Central carbon metabolism in the progression of mammary carcinoma","volume":"110","author":"Richardson","year":"2008","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/nrc3789","article-title":"Cancer cell survival during detachment from the ECM: Multiple barriers to tumour progression","volume":"14","author":"Buchheit","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.1038\/s41467-018-05850-w","article-title":"Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin","volume":"9","author":"Haun","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s10555-008-9168-1","article-title":"Pak protein kinases and their role in cancer","volume":"28","author":"Dummler","year":"2009","journal-title":"Cancer Metastasis Rev."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrc3645","article-title":"PAK signalling during the development and progression of cancer","volume":"14","author":"Radu","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"14173","DOI":"10.18632\/oncotarget.13309","article-title":"Deciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer?","volume":"8","author":"Thillai","year":"2017","journal-title":"Oncotarget"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4161\/cl.21882","article-title":"PAK signaling in cancer","volume":"2","author":"Ye","year":"2012","journal-title":"Cell Logist."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"41359","DOI":"10.1074\/jbc.M111.291500","article-title":"Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo","volume":"286","author":"Wang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"e2820","DOI":"10.1038\/cddis.2017.85","article-title":"PAK4 regulates G6PD activity by p53 degradation involving colon cancer cell growth","volume":"8","author":"Zhang","year":"2017","journal-title":"Cell Death Dis."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"9446","DOI":"10.1073\/pnas.0911863107","article-title":"Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth","volume":"107","author":"Murray","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1101\/gad.247452.114","article-title":"Limiting the power of p53 through the ubiquitin proteasome pathway","volume":"28","author":"Pant","year":"2014","journal-title":"Genes Dev."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"174","DOI":"10.2174\/1871520615666150907093358","article-title":"Escape, or Vanish: Control the Fate of p53 through MDM2-Mediated Ubiquitination","volume":"16","author":"Wei","year":"2015","journal-title":"Anticancer Agents Med. Chem."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/cdd.2008.150","article-title":"Classification of cell death: Recommendations of the Nomenclature Committee on Cell Death 2009","volume":"16","author":"Kroemer","year":"2009","journal-title":"Cell Death Differ."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Green, D.R., and Llambi, F. (2015). Cell Death Signaling. Cold Spring Harb. Perspect. Biol., 7.","DOI":"10.1101\/cshperspect.a006080"},{"key":"ref_193","first-page":"527","article-title":"Genetic heterogeneity of glucose-6-phosphate dehydrogenase deficiency revealed by single-strand conformation and sequence analysis","volume":"52","author":"Calabro","year":"1993","journal-title":"Am. J. Hum. Genet."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1179\/135100007X200209","article-title":"Glucose-6-phosphate dehydrogenase--from oxidative stress to cellular functions and degenerative diseases","volume":"12","author":"Ho","year":"2007","journal-title":"Redox Rep."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1159\/000447848","article-title":"Vitamin C Inhibits Aggravated Eryptosis by Hydrogen Peroxide in Glucose-6-Phosphated Dehydrogenase Deficiency","volume":"39","author":"Shan","year":"2016","journal-title":"Cell Physiol. Biochem."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Qasim, N., and Mahmood, R. (2015). Diminution of Oxidative Damage to Human Erythrocytes and Lymphocytes by Creatine: Possible Role of Creatine in Blood. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0141975"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1089\/ars.2013.5747","article-title":"Oxidative stress and suicidal erythrocyte death","volume":"21","author":"Lang","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1096\/fj.09-135731","article-title":"Glucose-6-phosphate dehydrogenase-deficient mice have increased renal oxidative stress and increased albuminuria","volume":"24","author":"Xu","year":"2010","journal-title":"FASEB J."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.freeradbiomed.2010.04.019","article-title":"Impaired dephosphorylation renders G6PD-knockdown HepG2 cells more susceptible to H(2)O(2)-induced apoptosis","volume":"49","author":"Lin","year":"2010","journal-title":"Free Radic Biol. Med."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/nrm2529","article-title":"Autophagic cell death: The story of a misnomer","volume":"9","author":"Kroemer","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.freeradbiomed.2013.05.014","article-title":"Cellular metabolic and autophagic pathways: Traffic control by redox signaling","volume":"63","author":"Dodson","year":"2013","journal-title":"Free Radic Biol. Med."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"16848","DOI":"10.3390\/ijms150916848","article-title":"Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways","volume":"15","author":"Jenwitheesuk","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1016\/j.bbamcr.2013.06.001","article-title":"Crosstalk between apoptosis, necrosis and autophagy","volume":"1833","author":"Nikoletopoulou","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1099\/vir.0.2008\/001404-0","article-title":"Glucose-6-phosphate dehydrogenase deficiency enhances enterovirus 71 infection","volume":"89","author":"Ho","year":"2008","journal-title":"J. Gen. Virol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"41749","DOI":"10.1038\/srep41749","article-title":"Transcriptional firing helps to drive NETosis","volume":"7","author":"Khan","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/cr.2010.150","article-title":"Neutrophil extracellular trap cell death requires both autophagy and superoxide generation","volume":"21","author":"Remijsen","year":"2011","journal-title":"Cell Res."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3109\/10715762.2013.816420","article-title":"Effective NET formation in neutrophils from individuals with G6PD Taiwan-Hakka is associated with enhanced NADP(+) biosynthesis","volume":"47","author":"Cheng","year":"2013","journal-title":"Free Radic Res."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jaci.2016.04.041","article-title":"Severe glucose-6-phosphate dehydrogenase deficiency leads to susceptibility to infection and absent NETosis","volume":"139","author":"Siler","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1006\/abbi.1995.1199","article-title":"On the mechanism of interaction of steroids with human glucose 6-phosphate dehydrogenase","volume":"318","author":"Gordon","year":"1995","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/s41419-018-0635-5","article-title":"A new inhibitor of glucose-6-phosphate dehydrogenase blocks pentose phosphate pathway and suppresses malignant proliferation and metastasis in vivo","volume":"9","author":"Mele","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.3892\/mmr.2015.3995","article-title":"Zoledronic acid inhibits the pentose phosphate pathway through attenuating the Ras-TAp73-G6PD axis in bladder cancer cells","volume":"12","author":"Wang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10571-018-0638-x","article-title":"APC-Cdh1 Regulates Neuronal Apoptosis Through Modulating Glycolysis and Pentose-Phosphate Pathway After Oxygen-Glucose Deprivation and Reperfusion","volume":"39","author":"Li","year":"2019","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00432-018-2820-4","article-title":"LncRNA GAS5 regulates redox balance and dysregulates the cell cycle and apoptosis in malignant melanoma cells","volume":"145","author":"Chen","year":"2019","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1016\/j.febslet.2010.07.027","article-title":"miR-1\/miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes","volume":"584","author":"Shan","year":"2010","journal-title":"FEBS Lett."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"e2213","DOI":"10.1038\/cddis.2016.117","article-title":"Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma","volume":"7","author":"Ahmad","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/9780470122938.ch3","article-title":"Glucose-6-phosphate dehydrogenases","volume":"48","author":"Levy","year":"1979","journal-title":"Adv. Enzym. Relat. Areas Mol. Biol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1021\/jm300317k","article-title":"Novel steroid inhibitors of glucose 6-phosphate dehydrogenase","volume":"55","author":"Hamilton","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0014-5793(70)80063-1","article-title":"Inhibition of NADP dependent oxidoreductases by the 6-aminonicotinamide analogue of NADP","volume":"6","author":"Kohler","year":"1970","journal-title":"FEBS Lett."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.canlet.2010.02.021","article-title":"Metabolic oxidative stress induced by a combination of 2-DG and 6-AN enhances radiation damage selectively in malignant cells via non-coordinated expression of antioxidant enzymes","volume":"295","author":"Sharma","year":"2010","journal-title":"Cancer Lett."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.3109\/13880209.2013.792849","article-title":"Polydatin: A review of pharmacology and pharmacokinetics","volume":"51","author":"Du","year":"2013","journal-title":"Pharm. Biol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"713","DOI":"10.2165\/11536520-000000000-00000","article-title":"Medications and glucose-6-phosphate dehydrogenase deficiency: An evidence-based review","volume":"33","author":"Youngster","year":"2010","journal-title":"Drug Saf."},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Romanuik, T.L., Wang, G., Morozova, O., Delaney, A., Marra, M.A., and Sadar, M.D. (2010). LNCaP Atlas: Gene expression associated with in vivo progression to castration-recurrent prostate cancer. BMC Med. Genom., 3.","DOI":"10.1186\/1755-8794-3-43"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1038\/cdd.2013.110","article-title":"Negative regulation of lncRNA GAS5 by miR-21","volume":"20","author":"Zhang","year":"2013","journal-title":"Cell Death Differ."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1002\/mc.22120","article-title":"A critical role for the long non-coding RNA GAS5 in proliferation and apoptosis in non-small-cell lung cancer","volume":"54","author":"Shi","year":"2015","journal-title":"Mol. Carcinog."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1083\/jcb.200911036","article-title":"microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7","volume":"190","author":"Chen","year":"2010","journal-title":"J. Cell Biol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.biocel.2009.03.002","article-title":"MicroRNAs 1, 133, and 206: Critical factors of skeletal and cardiac muscle development, function, and disease","volume":"42","author":"Callis","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s12192-014-0565-9","article-title":"MicroRNA-1 aggravates cardiac oxidative stress by post-transcriptional modification of the antioxidant network","volume":"20","author":"Wang","year":"2015","journal-title":"Cell Stress Chaperones"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cmet.2010.07.008","article-title":"MicroRNAs involved in molecular circuitries relevant for the Duchenne muscular dystrophy pathogenesis are controlled by the dystrophin\/nNOS pathway","volume":"12","author":"Cacchiarelli","year":"2010","journal-title":"Cell Metab."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1126\/science.279.5349.349","article-title":"Extension of life-span by introduction of telomerase into normal human cells","volume":"279","author":"Bodnar","year":"1998","journal-title":"Science"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.7605428","article-title":"Specific association of human telomerase activity with immortal cells and cancer","volume":"266","author":"Kim","year":"1994","journal-title":"Science"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"795","DOI":"10.4161\/auto.7.7.15844","article-title":"BAG3 and friends: Co-chaperones in selective autophagy during aging and disease","volume":"7","author":"Behl","year":"2011","journal-title":"Autophagy"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"e141","DOI":"10.1038\/cddis.2011.24","article-title":"BAG3: A multifaceted protein that regulates major cell pathways","volume":"2","author":"Rosati","year":"2011","journal-title":"Cell Death Dis."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.chembiol.2011.12.008","article-title":"RNA-based therapeutics: Current progress and future prospects","volume":"19","author":"Burnett","year":"2012","journal-title":"Chem. Biol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"6518","DOI":"10.1093\/nar\/gkw236","article-title":"The delivery of therapeutic oligonucleotides","volume":"44","author":"Juliano","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_235","first-page":"993","article-title":"Glucose-6-phosphate dehydrogenase: A novel therapeutic target in cardiovascular diseases","volume":"9","author":"Gupte","year":"2008","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jmgm.2014.05.009","article-title":"Computational determination of binding structures and free energies of glucose 6-phosphate dehydrogenase with novel steroid inhibitors","volume":"51","author":"Zhao","year":"2014","journal-title":"J. Mol. Graph. Model."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"317","DOI":"10.18632\/oncoscience.158","article-title":"Erratum: Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question","volume":"2","author":"Alfarouk","year":"2015","journal-title":"Oncoscience"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fonc.2018.00284","article-title":"Metabolic Switch in the Tumor Microenvironment Determines Immune Responses to Anti-cancer Therapy","volume":"8","author":"Wegiel","year":"2018","journal-title":"Front. Oncol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.molcel.2015.06.017","article-title":"Acute Activation of Oxidative Pentose Phosphate Pathway as First-Line Response to Oxidative Stress in Human Skin Cells","volume":"59","author":"Kuehne","year":"2015","journal-title":"Mol. Cell"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"S1461","DOI":"10.1245\/s10434-015-4522-3","article-title":"Pyruvate Kinase M2 Modulates Esophageal Squamous Cell Carcinoma Chemotherapy Response by Regulating the Pentose Phosphate Pathway","volume":"22","author":"Fukuda","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/ncb2789","article-title":"TAp73 enhances the pentose phosphate pathway and supports cell proliferation","volume":"15","author":"Du","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S1357-2725(01)00011-5","article-title":"Kinetic properties of human placental glucose-6-phosphate dehydrogenase","volume":"33","author":"Ozer","year":"2001","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/0306-4522(90)90074-E","article-title":"Characterization of glucose-6-phosphate dehydrogenase isozymes from human and pig brain","volume":"38","author":"Cho","year":"1990","journal-title":"Neuroscience"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1021\/acschemneuro.8b00644","article-title":"Cdh1-Mediated Metabolic Switch from Pentose Phosphate Pathway to Glycolysis Contributes to Sevoflurane-Induced Neuronal Apoptosis in Developing Brain","volume":"10","author":"Liu","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"E6669","DOI":"10.1073\/pnas.1603876113","article-title":"ATM\/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia","volume":"113","author":"Gregory","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_246","first-page":"5994","article-title":"Adriamycin resistance in human tumor cells associated with marked alteration in the regulation of the hexose monophosphate shunt and its response to oxidant stress","volume":"47","author":"Yeh","year":"1987","journal-title":"Cancer Res."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1667\/0033-7587(2003)159[0484:RROCDA]2.0.CO;2","article-title":"Radiation response of cells during altered protein thiol redox","volume":"159","author":"Biaglow","year":"2003","journal-title":"Radiat. Res."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1667\/0033-7587(2000)153[0781:GPDATO]2.0.CO;2","article-title":"Glucose-6-phosphate dehydrogenase and the oxidative pentose phosphate cycle protect cells against apoptosis induced by low doses of ionizing radiation","volume":"153","author":"Tuttle","year":"2000","journal-title":"Radiat. Res."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/s41467-019-08921-8","article-title":"Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance","volume":"10","author":"Liu","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_250","doi-asserted-by":"crossref","unstructured":"Heller, S., Maurer, G.D., Wanka, C., Hofmann, U., Luger, A.L., Bruns, I., Steinbach, J.P., and Rieger, J. (2018). Gene Suppression of Transketolase-Like Protein 1 (TKTL1) Sensitizes Glioma Cells to Hypoxia and Ionizing Radiation. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19082168"},{"key":"ref_251","doi-asserted-by":"crossref","unstructured":"Chen, C., Mei, Q., Wang, L., Feng, X., Tao, X., Qiu, C., and Zhu, J. (2019). TIGAR suppresses seizures induced by kainic acid through inhibiting oxidative stress and neuronal apoptosis. Biochem. Biophys. Res. Commun.","DOI":"10.1016\/j.bbrc.2019.05.156"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1002\/elps.200800806","article-title":"Upregulation of glycolytic enzymes in proteins secreted from human colon cancer cells with 5-fluorouracil resistance","volume":"30","author":"Shin","year":"2009","journal-title":"Electrophoresis"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1073\/pnas.76.2.954","article-title":"NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals","volume":"76","author":"Bachur","year":"1979","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3389\/fphar.2019.00203","article-title":"Metabolism-Based Therapeutic Strategies Targeting Cancer Stem Cells","volume":"10","author":"Jagust","year":"2019","journal-title":"Front. Pharm."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"E725","DOI":"10.1073\/pnas.1508779113","article-title":"Transketolase counteracts oxidative stress to drive cancer development","volume":"113","author":"Xu","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fphar.2018.00043","article-title":"Inhibition of Glucose-6-Phosphate Dehydrogenase Reverses Cisplatin Resistance in Lung Cancer Cells via the Redox System","volume":"9","author":"Hong","year":"2018","journal-title":"Front. Pharm."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/8\/9\/1055\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:17:47Z","timestamp":1760188667000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/8\/9\/1055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,8]]},"references-count":256,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9]]}},"alternative-id":["cells8091055"],"URL":"https:\/\/doi.org\/10.3390\/cells8091055","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,8]]}}}