{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:25:37Z","timestamp":1769243137162,"version":"3.49.0"},"reference-count":145,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:00:00Z","timestamp":1568246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Amyotrophic lateral sclerosis (ALS) is one of the most common incurable motor neuron disorders in adults. The majority of all ALS cases occur sporadically (sALS). Symptoms of ALS are caused by a progressive degeneration of motor neurons located in the motor cortex and spinal cord. The question arises why motor neurons selectively degenerate in ALS, while other cells and systems appear to be spared the disease. Members of the intrinsic apoptotic pathway are frequent targets of altered microRNA expression. Therefore, microRNAs and their effects on cell survival are subject of controversial debates. In this study, we investigated the expression of numerous members of the intrinsic apoptotic cascade by qPCR, western blot, and immunostaining in two different regions of the CNS of wobbler mice. Further we addressed the expression of miR-29b-3p targeting BMF, Bax, and, Bak, members of the apoptotic pathway. We show a tissue-specific differential expression of BMF, Bax, and cleaved-Caspase 3 in wobbler mice. An opposing regulation of miR-29b-3p expression in the cerebellum and cervical spinal cord of wobbler mice suggests different mechanisms regulating the intrinsic apoptotic pathway. Based on our findings, it could be speculated that miR-29b-3p might regulate antiapoptotic survival mechanisms in CNS areas that are not affected by neurodegeneration in the wobbler mouse ALS model.<\/jats:p>","DOI":"10.3390\/cells8091077","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T10:56:06Z","timestamp":1568285766000},"page":"1077","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Deregulated miR-29b-3p Correlates with Tissue-Specific Activation of Intrinsic Apoptosis in An Animal Model of Amyotrophic Lateral Sclerosis"],"prefix":"10.3390","volume":"8","author":[{"given":"Christina L.","family":"Klatt","sequence":"first","affiliation":[{"name":"Ruhr University Bochum, Medical Faculty, Institute of Anatomy, Department of Cytology, 44801 Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena","family":"Theis","sequence":"additional","affiliation":[{"name":"Ruhr University Bochum, Medical Faculty, Institute of Anatomy, Department of Cytology, 44801 Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0855-9741","authenticated-orcid":false,"given":"Stephan","family":"Hahn","sequence":"additional","affiliation":[{"name":"Ruhr University Bochum, Clinical Research Center, Department of Molecular Gastrointestinal Oncology, 44801 Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7983-0143","authenticated-orcid":false,"given":"Carsten","family":"Theiss","sequence":"additional","affiliation":[{"name":"Ruhr University Bochum, Medical Faculty, Institute of Anatomy, Department of Cytology, 44801 Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9717-4485","authenticated-orcid":false,"given":"Veronika","family":"Matschke","sequence":"additional","affiliation":[{"name":"Ruhr University Bochum, Medical Faculty, Institute of Anatomy, Department of Cytology, 44801 Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"I17","DOI":"10.1007\/BF03161151","article-title":"Molecular factors underlying selective vulnerability of motor neurons to neurodegeneration in amyotrophic lateral sclerosis","volume":"247","author":"Shaw","year":"2001","journal-title":"J. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.clinthera.2014.12.020","article-title":"Therapeutic development in amyotrophic lateral sclerosis","volume":"37","author":"Bucchia","year":"2015","journal-title":"Clin. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S0140-6736(10)61156-7","article-title":"Amyotrophic lateral sclerosis","volume":"377","author":"Kiernan","year":"2011","journal-title":"Lancet"},{"key":"ref_4","first-page":"CD001447","article-title":"Riluzole for amyotrophic lateral sclerosis (ALS)\/motor neuron disease (MND)","volume":"3","author":"Miller","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S1474-4422(17)30115-1","article-title":"Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: A randomised, double-blind, placebo-controlled trial","volume":"16","author":"Abe","year":"2017","journal-title":"Lancet Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.bbadis.2014.08.010","article-title":"Sporadic and hereditary amyotrophic lateral sclerosis (ALS)","volume":"1852","author":"Siddique","year":"2015","journal-title":"BBA-Mol. Basis Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1056\/NEJMra1603471","article-title":"Amyotrophic lateral sclerosis","volume":"377","author":"Brown","year":"2017","journal-title":"New Engl. J. Med."},{"key":"ref_8","first-page":"23","article-title":"Wobbler (wr)","volume":"15","author":"Falconer","year":"1956","journal-title":"Mouse News Lett."},{"key":"ref_9","first-page":"ng1661","article-title":"Mutation of Vps54 causes motor neuron disease and defective spermiogenesis in the wobbler mouse","volume":"37","author":"Drepper","year":"2005","journal-title":"Nat. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"12860","DOI":"10.1073\/pnas.1004756107","article-title":"Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex","volume":"107","author":"Kajava","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Fuchs, S., Resch, K., Thiel, C., Ulbrich, M., Platzer, M., Jockusch, H., and Schmitt-John, T. (2002). Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14. BMC Genet., 3.","DOI":"10.1186\/1471-2156-3-40"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1136\/jnnp.31.6.535","article-title":"An hereditary motor neurone disease with progressive denervation of muscle in the mouse: The mutant \u201cwobbler\u201d","volume":"31","author":"Duchen","year":"1968","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1146\/annurev.neuro.27.070203.144244","article-title":"Unraveling the mechanisms involved in motor neuron degeneration in ALS","volume":"27","author":"Bruijn","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"806306","DOI":"10.1155\/2012\/806306","article-title":"ALS and frontotemporal dysfunction: A review","volume":"2012","author":"Achi","year":"2012","journal-title":"Neurol. Res. Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1432-0436.1991.tb00225.x","article-title":"Defect of sperm assembly in a neurological mutant of the mouse, wobbler (WR)","volume":"47","author":"Heimann","year":"1991","journal-title":"Differentiation"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrneurol.2011.152","article-title":"Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis","volume":"7","author":"Ferraiuolo","year":"2001","journal-title":"Nat. Rev. Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.neuroscience.2008.10.030","article-title":"Citron Wobbler mice modeling motor neuron disease display elevated transactive response DNA binding protein","volume":"158","author":"Dennis","year":"2009","journal-title":"Neuroscience"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/mus.880130206","article-title":"Impairment of retrograde axonal transport in wobbler mouse motor neuron disease","volume":"13","author":"Mitsumoto","year":"1990","journal-title":"Muscle Nerve"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Palmisano, R., Golfi, P., Heimann, P., Shaw, C., Troakes, C., Schmitt-John, T., and Bartsch, J.W. (2011). Endosomal accumulation of APP in wobbler motor neurons reflects impaired vesicle trafficking: Implications for human motor neuron disease. BMC Neurosci., 12.","DOI":"10.1186\/1471-2202-12-24"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00438-013-0741-0","article-title":"The wobbler mouse, an ALS animal model","volume":"288","author":"Moser","year":"2013","journal-title":"Mol. Genet. Genomics"},{"key":"ref_21","first-page":"255","article-title":"Whole-brain and regional brain atrophy in amyotrophic lateral sclerosis","volume":"28","author":"Mezzapesa","year":"2001","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.3174\/ajnr.A2469","article-title":"The topography of brain microstructural damage in amyotrophic lateral sclerosis assessed using diffusion tensor MR imaging","volume":"32","author":"Canu","year":"2011","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1001\/archneur.65.5.636","article-title":"Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis","volume":"65","author":"Geser","year":"2008","journal-title":"Arch. Neurol. (Chicago)"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1440-1789.2011.01286.x","article-title":"An MND\/ALS phenotype associated with C9orf72 repeat expansion: Abundant p62-positive, TDP-43-negative inclusions in cerebral cortex, hippocampus and cerebellum but without associated cognitive decline","volume":"32","author":"Troakes","year":"2012","journal-title":"Neuropathology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/jnen\/nlw005","article-title":"The spatiotemporal pattern of degeneration in the cerebellum of the wobbler mouse","volume":"75","author":"Saberi","year":"2016","journal-title":"J. Neuropath. Exp. Neur."},{"key":"ref_26","first-page":"507","article-title":"The involvement of the cerebellum in amyotrophic lateral sclerosis","volume":"14","author":"Prell","year":"2013","journal-title":"Amyotroph. Lat. Scl. Fr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00221-001-0981-9","article-title":"Pattern of cortical reorganization in amyotrophic lateral sclerosis: A functional magnetic resonance imaging study","volume":"143","author":"Konrad","year":"2002","journal-title":"Exp. Brain Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00221-006-0352-7","article-title":"Subcortical reorganization in amyotrophic lateral sclerosis","volume":"172","author":"Konrad","year":"2006","journal-title":"Exp. Brain Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1007\/s00415-005-0787-y","article-title":"Functional motor compensation in amyotrophic lateral sclerosis","volume":"252","author":"Schoenfeld","year":"2005","journal-title":"J. Neurol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1093\/cercor\/bhr002","article-title":"Sensorimotor functional connectivity changes in amyotrophic lateral sclerosis","volume":"21","author":"Agosta","year":"2011","journal-title":"Cereb. Cortex"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.brainresbull.2006.01.013","article-title":"Subcortical motor plasticity in patients with sporadic ALS: An fMRI study","volume":"69","author":"Tessitore","year":"2006","journal-title":"Brain Res. Bull."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00259-011-1979-6","article-title":"Brain hypermetabolism in amyotrophic lateral sclerosis: A FDG PET study in ALS of spinal and bulbar onset","volume":"39","author":"Cistaro","year":"2012","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1385\/MN:28:1:65","article-title":"The wobbler mouse","volume":"28","author":"Peschanski","year":"2003","journal-title":"Mol. Neurobiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.aanat.2015.03.007","article-title":"Implementation of a manual for working with wobbler mice and criteria for discontinuation of the experiment","volume":"200","author":"Ott","year":"2015","journal-title":"Ann. Anat."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1006\/nbdi.2000.0314","article-title":"p53 is abnormally elevated and active in the CNS of patients with amyotrophic lateral sclerosis","volume":"7","author":"Martin","year":"2000","journal-title":"Neurobiol. Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.33594\/000000099","article-title":"The microRNA miR-375-3p and the tumor suppressor NDRG2 are involved in sporadic amyotrophic lateral sclerosis","volume":"52","author":"Rohm","year":"2019","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s12974-015-0435-0","article-title":"Inflammation and neuronal death in the motor cortex of the wobbler mouse, an ALS animal model","volume":"12","author":"Dahlke","year":"2015","journal-title":"J. Neuroinflamm."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","article-title":"Metazoan microRNAs","volume":"173","author":"Bartel","year":"2018","journal-title":"Cell"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fnins.2012.00048","article-title":"Cause or effect: Misregulation of microRNA pathways in neurodegeneration","volume":"6","author":"Gascon","year":"2012","journal-title":"Front. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.pneurobio.2016.06.005","article-title":"MicroRNA: Small RNA mediators of the brains genomic response to environmental stress","volume":"143","author":"Hollins","year":"2016","journal-title":"Prog. Neurobiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1007\/s12035-017-0537-z","article-title":"MicroRNA metabolism and dysregulation in amyotrophic lateral sclerosis","volume":"55","author":"Rinchetti","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3233\/JAD-2008-14103","article-title":"Identification of miRNA changes in Alzheimer\u2019s disease brain and CSF yields putative biomarkers and insights into disease pathways","volume":"14","author":"Cogswell","year":"2008","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tcb.2012.08.013","article-title":"MicroRNAs and neurodegeneration: Role and impact","volume":"23","author":"Abe","year":"2013","journal-title":"Trends Cell Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"154","DOI":"10.2174\/138920209788185252","article-title":"MicroRNA: Implications for Alzheimer disease and other human CNS disorders","volume":"10","author":"Maes","year":"2009","journal-title":"Curr. Genomics"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.1073\/pnas.0710263105","article-title":"Loss of microRNA cluster miR-29a\/b-1 in sporadic Alzheimer\u2019s disease correlates with increased BACE1\/\u03b2-secretase expression","volume":"105","author":"Papadopoulou","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.nbd.2008.11.009","article-title":"MicroRNA regulation of Alzheimer\u2019s Amyloid precursor protein expression","volume":"33","author":"Bergmans","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/bs.ircmb.2017.04.002","article-title":"Chapter seven microRNAs in neurodegenerative diseases","volume":"334","author":"Quinlan","year":"2017","journal-title":"Int. Rev. Cel. Mol. Bio."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1186\/gb-2004-5-3-r13","article-title":"Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation","volume":"5","author":"Sempere","year":"2004","journal-title":"Genome Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"10105","DOI":"10.1038\/s41598-018-28366-1","article-title":"MicroRNA expression analysis identifies a subset of downregulated miRNAs in ALS motor neuron progenitors","volume":"8","author":"Rizzuti","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40035-016-0050-8","article-title":"Genotype-phenotype correlations of amyotrophic lateral sclerosis","volume":"5","author":"Li","year":"2016","journal-title":"Transl. Neurodegener."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.15252\/embj.201490493","article-title":"Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: A new mechanism for ALS","volume":"34","author":"Emde","year":"2015","journal-title":"Embo. J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1756-6606-6-26","article-title":"Altered microRNA expression profile in amyotrophic lateral sclerosis: A role in the regulation of NFL mRNA levels","volume":"6","author":"Droppelmann","year":"2013","journal-title":"Mol. Brain"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1073\/pnas.1112427109","article-title":"TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes","volume":"109","author":"Kawahara","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4502","DOI":"10.1038\/emboj.2012.319","article-title":"FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitment","volume":"31","author":"Morlando","year":"2012","journal-title":"Embo. J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mcn.2015.12.008","article-title":"Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms","volume":"71","author":"Hur","year":"2016","journal-title":"Mol. Cell Neurosci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3389\/fncel.2015.00423","article-title":"Alterations in stress granule dynamics driven by TDP-43 and FUS: A link to pathological inclusions in ALS?","volume":"9","author":"Aulas","year":"2015","journal-title":"Front. Cell Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Liu-Yesucevitz, L., Bilgutay, A., Zhang, Y.-J., Vanderweyde, T., Citro, A., Mehta, T., Zaarur, N., McKee, A., Bowser, R., and Sherman, M. (2011). Correction: Tar DNA binding protein-43 (TDP-43) associates with stress granules: Analysis of cultured cells and pathological brain tissue. PLoS ONE, 6.","DOI":"10.1371\/annotation\/7d880410-06e3-4fe3-a8f1-e84c89bcf8d0"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Liu-Yesucevitz, L., Bilgutay, A., Zhang, Y.-J., Vanderweyde, T., Vanderwyde, T., Citro, A., Mehta, T., Zaarur, N., McKee, A., and Bowser, R. (2010). Tar DNA binding protein-43 (TDP-43) associates with stress granules: Analysis of cultured cells and pathological brain tissue. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013250"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1111\/jcmm.13976","article-title":"MicroRNAs as regulators of cell death mechanisms in amyotrophic lateral sclerosis","volume":"23","author":"Gagliardi","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1128\/MCB.00589-15","article-title":"Regulation of neuronal cell cycle and apoptosis by microRNA 34a","volume":"36","author":"Modi","year":"2016","journal-title":"Mol. Cell Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/stem.2233","article-title":"MiR-375 is essential for human spinal motor neuron development and may be involved in motor neuron degeneration","volume":"34","author":"Bhinge","year":"2016","journal-title":"Stem Cells"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/j.stemcr.2017.09.004","article-title":"FUS mutant human motoneurons display altered transcriptome and microRNA pathways with implications for ALS pathogenesis","volume":"9","author":"Santis","year":"2017","journal-title":"Stem Cell Rep."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1074\/jbc.M111.285718","article-title":"miR-125b and miR-155 Contribute to BCL2 Repression and proliferation in response to CD40 ligand (CD154) in human leukemic B-cells","volume":"287","author":"Willimott","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13041-015-0095-0","article-title":"Upregulation of neural and cell cycle-related microRNAs in brain of amyotrophic lateral sclerosis mice at late disease stage","volume":"8","author":"Marcuzzo","year":"2015","journal-title":"Mol. Brain"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1093\/hmg\/ddx250","article-title":"Amyotrophic lateral sclerosis-related mutant superoxide dismutase 1 aggregates inhibit 14-3-3-mediated cell survival by sequestration into the JUNQ compartment","volume":"26","author":"Park","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/cdd.2015.153","article-title":"MicroRNA-125b regulates microglia activation and motor neuron death in ALS","volume":"23","author":"Parisi","year":"2016","journal-title":"Cell Death Differ."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1016\/S0092-8674(02)00704-3","article-title":"Pathways of apoptosis in lymphocyte development, homeostasis, and disease","volume":"109","author":"Rathmell","year":"2002","journal-title":"Cell"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/cdd.2013.139","article-title":"Building blocks of the apoptotic pore: How Bax and Bak are activated and oligomerize during apoptosis","volume":"21","author":"Westphal","year":"2014","journal-title":"Cell Death Differ."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s10495-014-0967-2","article-title":"Autophagy and apoptosis: Where do they meet?","volume":"19","author":"Mukhopadhyay","year":"2014","journal-title":"Apoptosis"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0092-8674(93)90509-O","article-title":"Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death","volume":"74","author":"Oltval","year":"1993","journal-title":"Cell"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/cdd.2016.20","article-title":"Endothelial cell survival during angiogenesis requires the pro-survival protein MCL1","volume":"23","author":"Watson","year":"2016","journal-title":"Cell Death Differ."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"8512","DOI":"10.1073\/pnas.1406425111","article-title":"Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak","volume":"111","author":"Lindqvist","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/cdd.2013.25","article-title":"Mcl-1 antagonizes Bax\/Bak to promote effector CD4+ and CD8+ T-cell responses","volume":"20","author":"Tripathi","year":"2013","journal-title":"Cell Death Differ."},{"key":"ref_76","first-page":"3811","article-title":"Combinatorial effects of miR-20a and miR-29b on neuronal apoptosis induced by spinal cord injury","volume":"8","author":"Liu","year":"2015","journal-title":"Int. J. Clin. Exp. Patho."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1038\/jcbfm.2015.156","article-title":"MicroRNA-29b is a therapeutic target in cerebral ischemia associated with aquaporin 4","volume":"35","author":"Wang","year":"2015","journal-title":"J. Cereb. Blood F. Met."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.mcn.2018.02.011","article-title":"The proapoptotic protein Bmf co-operates with Bim and Puma in neuron death induced by \u03b2-amyloid or NGF deprivation","volume":"88","author":"Akhter","year":"2018","journal-title":"Mol. Cell Neurosci."},{"key":"ref_79","first-page":"a008722","article-title":"Multiple functions of BCL-2 family proteins","volume":"5","author":"Hardwick","year":"2013","journal-title":"Csh. Perspect. Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.molcel.2005.02.003","article-title":"BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly","volume":"17","author":"Kuwana","year":"2005","journal-title":"Mol. Cell"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1073\/pnas.94.8.3668","article-title":"Cytosol-to-membrane redistribution of Bax and Bcl-XL during\u2009apoptosis","volume":"94","author":"Hsu","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"eaao6047","DOI":"10.1126\/science.aao6047","article-title":"BAK\/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis","volume":"359","author":"McArthur","year":"2018","journal-title":"Science"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"238","DOI":"10.4161\/auto.2730","article-title":"Deficiency in apoptotic effectors BAX and BAK reveals an autophagic cell death pathway initiated by photodamage to the endoplasmic reticulum","volume":"2","author":"Buytaert","year":"2006","journal-title":"Autophagy"},{"key":"ref_84","first-page":"3399","article-title":"miR-29b affects neurocyte apoptosis by targeting MCL-1 during cerebral ischemia\/reperfusion injury","volume":"16","author":"Huang","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2004.12.030","article-title":"Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function","volume":"17","author":"Chen","year":"2005","journal-title":"Mol. Cell"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1101\/gad.1156903","article-title":"DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells","volume":"17","author":"Cuconati","year":"2003","journal-title":"Gene Dev."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1101\/gad.1975411","article-title":"miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis","volume":"25","author":"Kole","year":"2011","journal-title":"Gene Dev."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394C T method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1600-0404.1999.tb00403.x","article-title":"Upregulation of Bax protein and increased DNA degradation in ALS spinal cord motor neurons","volume":"100","author":"Ekegren","year":"1999","journal-title":"Acta Neurol. Scand."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1750-1172-4-3","article-title":"Amyotrophic lateral sclerosis","volume":"4","author":"Wijesekera","year":"2009","journal-title":"Orphanet. J. Rare Dis."},{"key":"ref_91","first-page":"a024117","article-title":"Clinical spectrum of amyotrophic lateral sclerosis (ALS)","volume":"7","author":"Grad","year":"2017","journal-title":"Csh. Perspect. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.4161\/cc.26696","article-title":"BH3-only proteins, Bmf and Bim, in autophagy","volume":"12","author":"Delgado","year":"2013","journal-title":"Cell Cycle"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e1735","DOI":"10.1038\/cddis.2015.105","article-title":"Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax","volume":"6","author":"Hockings","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1126\/science.1062257","article-title":"Bmf: A proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis","volume":"293","author":"Puthalakath","year":"2001","journal-title":"Science"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1073\/pnas.0700115104","article-title":"Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis","volume":"104","author":"Schmelzle","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"26533","DOI":"10.1074\/jbc.M111.265322","article-title":"BCL-2 modifying factor (BMF) is a central regulator of anoikis in human intestinal epithelial cells","volume":"286","author":"Hausmann","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1209852","DOI":"10.1038\/sj.onc.1209852","article-title":"Upregulation of two BH3-only proteins, Bmf and Bim, during TGF\u03b2-induced apoptosis","volume":"26","author":"Ramjaun","year":"2007","journal-title":"Oncogene"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"474","DOI":"10.2337\/db11-0141","article-title":"Bcl-2\u2013modifying factor induces renal proximal tubular cell apoptosis in diabetic mice","volume":"61","author":"Lau","year":"2012","journal-title":"Diabetes"},{"key":"ref_99","first-page":"129","article-title":"Bmf is a possible mediator in histone deacetylase inhibitors FK228 and CBHA-induced apoptosis","volume":"13","author":"Imai","year":"2005","journal-title":"Cell Death Differ."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s10495-006-8266-1","article-title":"Bmf contributes to histone deacetylase inhibitor-mediated enhancing effects on apoptosis after ionizing radiation","volume":"11","author":"Zhang","year":"2006","journal-title":"Apoptosis"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Lossi, L., Castagna, C., and Merighi, A. (2018). Caspase-3 mediated cell death in the normal development of the mammalian cerebellum. Int. J. Mol. Sci., 19.","DOI":"10.20944\/preprints201811.0592.v1"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0753-3322(99)80002-X","article-title":"Neuronal death in the central nervous system during development","volume":"52","author":"Clarke","year":"1998","journal-title":"Biomed. Pharmacother."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"4752","DOI":"10.1523\/JNEUROSCI.21-13-04752.2001","article-title":"Programmed cell death of developing mammalian neurons after genetic deletion of caspases","volume":"21","author":"Oppenheim","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/(SICI)1097-4695(199705)32:5<502::AID-NEU5>3.0.CO;2-9","article-title":"Increased inferior olivary neuron and cerebellar granule cell numbers in transgenic mice overexpressing the human Bcl-2 gene","volume":"32","author":"Zanjani","year":"1997","journal-title":"J. Neurobiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/(SICI)1097-4547(19990815)57:4<557::AID-JNR16>3.0.CO;2-I","article-title":"AMPA receptor protein expression and function in astrocytes cultured from hippocampus","volume":"57","author":"Fan","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1523\/JNEUROSCI.18-05-01763.1998","article-title":"Ectopic overexpression of Engrailed-2 in cerebellar purkinje cells causes restricted cell loss and retarded external germinal layer development at lobule junctions","volume":"18","author":"Baader","year":"1998","journal-title":"J. Neurosci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.mcn.2005.02.010","article-title":"Enhanced Purkinje cell survival but compromised cerebellar function in targeted antiapoptotic protein transgenic mice","volume":"29","author":"Goswami","year":"2005","journal-title":"Mol. Cell Neurosci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s12311-010-0222-5","article-title":"Cell death as a regulator of cerebellar histogenesis and compartmentation","volume":"10","author":"Jankowski","year":"2011","journal-title":"Cerebellum"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s12311-009-0093-9","article-title":"Physiological Purkinje cell death is spatiotemporally organized in the developing mouse cerebellum","volume":"8","author":"Jankowski","year":"2009","journal-title":"Cerebellum"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1523\/JNEUROSCI.3897-07.2008","article-title":"Misplacement of Purkinje cells during postnatal development in Bax knock-out mice: A novel role for programmed cell death in the nervous system?","volume":"28","author":"Jung","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/cne.902790404","article-title":"Purkinje cell reduction in the reeler mutant mouse: A quantitative immunohistochemical study","volume":"279","author":"Heckroth","year":"1989","journal-title":"J. Comp. Neurol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1242\/dev.02437","article-title":"A key role for the HLH transcription factor EBF2COE2,O\/E-3 in Purkinje neuron migration and cerebellar cortical topography","volume":"133","author":"Croci","year":"2006","journal-title":"Development"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.neures.2005.07.007","article-title":"Postnatal development and synapse elimination of climbing fiber to Purkinje cell projection in the cerebellum","volume":"53","author":"Hashimoto","year":"2005","journal-title":"Neurosci. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0166-2236(92)90014-Y","article-title":"Dependence of postnatal motoneurones on their targets: Review and hypothesis","volume":"15","author":"Lowrie","year":"1992","journal-title":"Trends Neurosci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"12138","DOI":"10.1073\/pnas.0604911103","article-title":"Cellular scaling rules for rodent brains","volume":"103","author":"Mota","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e1456","DOI":"10.1038\/cddis.2014.426","article-title":"Analysis of BH3-only proteins upregulated in response to oxygen\/glucose deprivation in cortical neurons identifies Bmf but not Noxa as potential mediator of neuronal injury","volume":"5","author":"Pfeiffer","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1159\/000491896","article-title":"MicroRNA-29b regulates the mitochondria-dependent apoptotic pathway by targeting Bax in doxorubicin cardiotoxicity","volume":"48","author":"Jing","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm3722","article-title":"Control of apoptosis by the BCL-2 protein family: Implications for physiology and therapy","volume":"15","author":"Czabotar","year":"2013","journal-title":"Nat. Rev. Mol. Cell Bio."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1002\/glia.22556","article-title":"Astrocyte-enriched miR-29a targets PUMA and reduces neuronal vulnerability to forebrain ischemia","volume":"61","author":"Ouyang","year":"2013","journal-title":"Glia"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.1136235","article-title":"A Hexanucleotide element directs microRNA nuclear import","volume":"315","author":"Hwang","year":"2007","journal-title":"Science"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1111\/j.1460-9568.2005.03978.x","article-title":"Regulation of miRNA expression during neural cell specification","volume":"21","author":"Smirnova","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"ref_122","first-page":"nsmb1533","article-title":"miR-29 miRNAs activate p53 by targeting p85\u03b1 and CDC42","volume":"16","author":"Park","year":"2008","journal-title":"Nat. Struct. Mol. Bio."},{"key":"ref_123","first-page":"173","article-title":"Systematic review of miR-29 in cancer","volume":"12","author":"Kwon","year":"2018","journal-title":"Mol Ther."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1165\/rcmb.2010-0323OC","article-title":"miR-29 is a major regulator of genes associated with pulmonary fibrosis","volume":"45","author":"Cushing","year":"2011","journal-title":"Am. J. Resp. Cell Mol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1016\/j.febslet.2014.05.011","article-title":"Induction of miR-29a by saturated fatty acids impairs insulin signaling and glucose uptake through translational repression of IRS-1 in myocytes","volume":"588","author":"Yang","year":"2014","journal-title":"Febs. Lett."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s12013-014-0029-y","article-title":"MiR-29b protects dorsal root ganglia neurons from diabetic rat","volume":"70","author":"Zhang","year":"2014","journal-title":"Cell Biochem. Biophys."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"8978","DOI":"10.1007\/s12035-018-1009-9","article-title":"Expression of miR-145 and its target proteins are regulated by miR-29b in differentiated neurons","volume":"55","author":"Jauhari","year":"2001","journal-title":"Mol. Neurobiol."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Lugli, G., Cohen, A.M., Bennett, D.A., Shah, R.C., Fields, C.J., Hernandez, A.G., and Smalheiser, N.R. (2015). Plasma exosomal miRNAs in persons with and without Alzheimer disease: Altered expression and prospects for biomarkers. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0139233"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Jiao, J., Herl, L.D., Farese, R.V., and Gao, F.-B. (2010). MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0010551"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1261\/rna.044008.113","article-title":"Brain-specific knockdown of miR-29 results in neuronal cell death and ataxia in mice","volume":"20","author":"Roshan","year":"2014","journal-title":"RNA"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.nbd.2014.10.006","article-title":"Deficiency of the miR-29a\/b-1 cluster leads to ataxic features and cerebellar alterations in mice","volume":"73","author":"Papadopoulou","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"ref_132","first-page":"67","article-title":"MicroRNA-29b alleviates oxygen and glucose deprivation\/reperfusion-induced injury via inhibition of the p53-dependent apoptosis pathway in N2a neuroblastoma cells","volume":"15","author":"Cao","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2174\/1567202615666180403170902","article-title":"MiR-29 targets PUMA to suppress oxygen and glucose deprivation\/reperfusion (OGD\/R)-induced cell death in hippocampal neurons","volume":"15","author":"Wei","year":"2018","journal-title":"Curr. Neurovasc. Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/jcbfm.2013.68","article-title":"Loss of miR-29b following acute ischemic stroke contributes to neural cell death and infarct size","volume":"33","author":"Khanna","year":"2013","journal-title":"J. Cereb. Blood F. Met."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Fuller-Carter, P.I., Carter, K.W., Anderson, D., Harvey, A.R., Giles, K.M., and Rodger, J. (2015). Integrated analyses of zebrafish miRNA and mRNA expression profiles identify miR-29b and miR-223 as potential regulators of optic nerve regeneration. BMC Genomics, 16.","DOI":"10.1186\/s12864-015-1772-1"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"781","DOI":"10.4161\/rna.20146","article-title":"MicroRNAs, wild-type and mutant p53: More questions than answers","volume":"9","author":"Jones","year":"2014","journal-title":"RNA Biol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.brainres.2007.02.088","article-title":"Transcription factor p53 in degenerating spinal cords","volume":"1150","author":"Eve","year":"2007","journal-title":"Brain Res."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2174\/1874375701004010011","article-title":"p53 and cell cycle proteins participate in spinal motor neuron cell death in ALS","volume":"4","author":"Ranganathan","year":"2010","journal-title":"Open Pathol. J."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/ejn.13160","article-title":"Endoplasmic reticulum stress-mediated upregulation of miR-29a enhances sensitivity to neuronal apoptosis","volume":"43","author":"Nolan","year":"2016","journal-title":"Eur. J. Neurosci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.nbd.2009.12.021","article-title":"miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia","volume":"38","author":"Yin","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1038\/jcbfm.2013.157","article-title":"Inhibition of microRNA-181 reduces forebrain ischemia-induced neuronal loss","volume":"33","author":"Moon","year":"2013","journal-title":"J. Cereb. Blood F. Met."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Ripa, R., Dolfi, L., Terrigno, M., Pandolfini, L., Savino, A., Arcucci, V., Groth, M., Tozzini, E., Baumgart, M., and Cellerino, A. (2017). MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging. BMC Biol., 15.","DOI":"10.1186\/s12915-017-0354-x"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Pandi, G., Nakka, V.P., Dharap, A., Roopra, A., and Vemuganti, R. (2013). MicroRNA miR-29c downregulation leading to de-repression of its target DNA methyltransferase 3a promotes ischemic brain damage. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0058039"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.nbd.2012.08.015","article-title":"Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis","volume":"49","author":"Russell","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Catapano, F., Domingos, J., Perry, M., Ricotti, V., Phillips, L., Servais, L., Seferian, A., de Groot, I., Krom, Y.D., and Niks, E.H. (2018). Downregulation of miRNA-29, -23 and -21 in urine of Duchenne muscular dystrophy patients. Epigenomics, 10.","DOI":"10.2217\/epi-2018-0022"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/8\/9\/1077\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:19:39Z","timestamp":1760188779000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/8\/9\/1077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,12]]},"references-count":145,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9]]}},"alternative-id":["cells8091077"],"URL":"https:\/\/doi.org\/10.3390\/cells8091077","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,12]]}}}