{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:35:07Z","timestamp":1785890107404,"version":"3.56.0"},"reference-count":61,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T00:00:00Z","timestamp":1570406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RO 957\/10-1"],"award-info":[{"award-number":["RO 957\/10-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Bone marrow-derived fibrocytes (FC) represent a unique cell type, sharing features of both mesenchymal and hematopoietic cells. FC were shown to specifically infiltrate the injured liver and participate in fibrogenesis. Moreover, FC exert a variety of paracrine functions, thus possibly influencing the disease progression. However, the overall contribution of FC to liver fibrosis remains unclear. We aimed to study the effect of a specific FC depletion, utilizing a herpes simplex virus thymidine kinase (HSV-TK)\/Valganciclovir suicide gene strategy. Fibrosis was induced by oral thioacetamide (TAA) administration in C57BL\/6J mice. Hepatic hydroxyproline content was assessed for the primary readout. The HSV-TK model enabled the specific depletion of fibrocytes. Hepatic hydroxyproline content was significantly reduced as a result of the fibrocyte ablation (\u22127.8%; 95% CI: 0.7\u201314.8%; p = 0.033), denoting a reduced deposition of fibrillar collagens. Lower serum alanine transaminase levels (\u221220.9%; 95% CI: 0.4\u201336.9%; p = 0.049) indicate a mitigation of liver-specific cellular damage. A detailed mode of action, however, remains yet to be identified. The present study demonstrates a relevant functional contribution of fibrocytes to chronic toxic liver fibrosis, contradicting recent reports. Our results emphasize the need to thoroughly study the biology of fibrocytes in order to understand their importance for hepatic fibrogenesis.<\/jats:p>","DOI":"10.3390\/cells8101210","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T10:05:12Z","timestamp":1570442712000},"page":"1210","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Depletion of Bone Marrow-Derived Fibrocytes Attenuates TAA-Induced Liver Fibrosis in Mice"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2733-4313","authenticated-orcid":false,"given":"Felix","family":"Hempel","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Justus Liebig University, D-35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Roderfeld","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Justus Liebig University, D-35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1538-2091","authenticated-orcid":false,"given":"Rajkumar","family":"Savai","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), D-61231 Bad Nauheim, Germany"},{"name":"Department of Internal Medicine, Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus Liebig University, D-35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8122-7033","authenticated-orcid":false,"given":"Akylbek","family":"Sydykov","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus Liebig University, D-35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karuna","family":"Irungbam","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Justus Liebig University, D-35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5167-6970","authenticated-orcid":false,"given":"Ralph","family":"Schermuly","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus Liebig University, D-35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Voswinckel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, B\u00fcrgerhospital, D-61169 Friedberg, Germany"},{"name":"Department of Internal Medicine, Hochwaldkrankenhaus, D-61231 Bad Nauheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kernt","family":"K\u00f6hler","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology, Justus Liebig University, D-35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0065-0252","authenticated-orcid":false,"given":"Yury","family":"Churin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Justus Liebig University, D-35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ladislau","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus Liebig University, D-35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Bier","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus Liebig University, D-35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8211-4399","authenticated-orcid":false,"given":"J\u00f6rn","family":"Pons-K\u00fchnemann","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics, Justus Liebig University, D-35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Roeb","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Justus Liebig University, D-35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1002\/hep.29085","article-title":"Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta-analysis","volume":"65","author":"Dulai","year":"2017","journal-title":"Hepatology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF03403533","article-title":"Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair","volume":"1","author":"Bucala","year":"1994","journal-title":"Mol. Med."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Pilling, D., Fan, T., Huang, D., Kaul, B., and Gomer, R.H. (2009). Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0007475"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/stem.1648","article-title":"Tracking the elusive fibrocyte: Identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing","volume":"32","author":"Suga","year":"2014","journal-title":"Stem Cells"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1067-1927.2005.130407.x","article-title":"Identification of fibrocytes in postburn hypertrophic scar","volume":"13","author":"Yang","year":"2005","journal-title":"Wound Repair Regen."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1172\/JCI200420997","article-title":"Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis","volume":"114","author":"Phillips","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"14098","DOI":"10.1073\/pnas.0511200103","article-title":"Secondary lymphoid tissue chemokine (SLC\/CCL21)\/CCR7 signaling regulates fibrocytes in renal fibrosis","volume":"103","author":"Sakai","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"18284","DOI":"10.1073\/pnas.0608799103","article-title":"Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice","volume":"103","author":"Haudek","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1007\/s10620-013-2813-8","article-title":"Fibrocytes are involved in inflammation as well as fibrosis in the pathogenesis of crohn\u2019s disease","volume":"59","author":"Sazuka","year":"2014","journal-title":"Dig. Dis. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"8568","DOI":"10.1038\/s41598-019-45012-6","article-title":"Infiltrating CCR2(+) monocytes and their progenies, fibrocytes, contribute to colon fibrosis by inhibiting collagen degradation through the production of TIMP-1","volume":"9","author":"Kuroda","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4049\/jimmunol.171.1.380","article-title":"Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma","volume":"171","author":"Schmidt","year":"2003","journal-title":"J. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s10620-009-0730-7","article-title":"Emergence of fibrocytes showing morphological changes in the inflamed colonic mucosa","volume":"55","author":"Uehara","year":"2010","journal-title":"Dig. Dis. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s13287-018-0835-z","article-title":"The emerging role of fibrocytes in ocular disorders","volume":"9","author":"Zhang","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","author":"Mederacke","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"E3297","DOI":"10.1073\/pnas.1400062111","article-title":"Origin of myofibroblasts in the fibrotic liver in mice","volume":"111","author":"Iwaisako","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.jhep.2019.04.012","article-title":"Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice","volume":"71","author":"Nishio","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"10512","DOI":"10.3748\/wjg.v22.i48.10512","article-title":"Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets","volume":"22","author":"Zhang","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","article-title":"Hepatic stellate cells as key target in liver fibrosis","volume":"121","author":"Higashi","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ajpath.2011.03.049","article-title":"Migration of fibrocytes in fibrogenic liver injury","volume":"179","author":"Scholten","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jhep.2006.04.014","article-title":"Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis","volume":"45","author":"Kisseleva","year":"2006","journal-title":"J. Hepatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/hep.23274","article-title":"Bone marrow transplantation demonstrates medullar origin of CD34+ fibrocytes and ameliorates hepatic fibrosis in Abcb4-\/- mice","volume":"51","author":"Roderfeld","year":"2010","journal-title":"Hepatology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7556","DOI":"10.4049\/jimmunol.166.12.7556","article-title":"Peripheral blood fibrocytes: Differentiation pathway and migration to wound sites","volume":"166","author":"Abe","year":"2001","journal-title":"J. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nri2990","article-title":"Fibrocytes: Emerging effector cells in chronic inflammation","volume":"11","author":"Reilkoff","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1586\/17476348.2014.862154","article-title":"Paracrine functions of fibrocytes to promote lung fibrosis","volume":"8","author":"Kleaveland","year":"2014","journal-title":"Expert Rev. Respir. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"419","DOI":"10.4049\/jimmunol.160.1.419","article-title":"Regulated production of type I collagen and inflammatory cytokines by peripheral blood fibrocytes","volume":"160","author":"Chesney","year":"1998","journal-title":"J. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/jhbp.245","article-title":"Recent advancement of molecular mechanisms of liver fibrosis","volume":"22","author":"Seki","year":"2015","journal-title":"J. Hepatobiliary Pancreat. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"7883","DOI":"10.4049\/jimmunol.179.11.7883","article-title":"Cysteinyl leukotrienes are autocrine and paracrine regulators of fibrocyte function","volume":"179","author":"Vannella","year":"2007","journal-title":"J. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"6307","DOI":"10.1073\/pnas.94.12.6307","article-title":"The peripheral blood fibrocyte is a potent antigen-presenting cell capable of priming naive T cells in situ","volume":"94","author":"Chesney","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/hep.21477","article-title":"Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice","volume":"45","author":"Higashiyama","year":"2007","journal-title":"Hepatology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1164\/rccm.201001-0028OC","article-title":"Expression of matrix metalloproteases by fibrocytes: Possible role in migration and homing","volume":"182","author":"Becerril","year":"2010","journal-title":"Am. J. Respir Crit. Care Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1096\/fj.01-0049com","article-title":"Fibrocytes induce an angiogenic phenotype in cultured endothelial cells and promote angiogenesis in vivo","volume":"15","author":"Hartlapp","year":"2001","journal-title":"FASEB J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.ajpath.2013.10.021","article-title":"Circulating fibrocytes stabilize blood vessels during angiogenesis in a paracrine manner","volume":"184","author":"Li","year":"2014","journal-title":"Am. J. Pathol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s00109-011-0756-0","article-title":"Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection","volume":"89","author":"Kisseleva","year":"2011","journal-title":"J. Mol. Med. (Berl)"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"7572","DOI":"10.1073\/pnas.85.20.7572","article-title":"Targeting of an inducible toxic phenotype in animal cells","volume":"85","author":"Borrelli","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/339538a0","article-title":"Transgenic mice with inducible dwarfism","volume":"339","author":"Borrelli","year":"1989","journal-title":"Nature"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1073\/pnas.86.8.2698","article-title":"Thymidine kinase obliteration: Creation of transgenic mice with controlled immune deficiency","volume":"86","author":"Heyman","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0002-9440(10)63706-6","article-title":"An HSV-TK transgenic mouse model to evaluate elimination of fibroblasts for fibrosis therapy","volume":"163","author":"Tian","year":"2003","journal-title":"Am. J. Pathol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.hbpd.2019.02.002","article-title":"Monocyte-derived fibrocytes elimination had little contribution on liver fibrosis","volume":"18","author":"Ozono","year":"2019","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1055\/s-0032-1330422","article-title":"Liver fibrosis - mouse models and relevance in human liver diseases","volume":"51","author":"Mederacke","year":"2013","journal-title":"Z Gastroenterol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/labinvest.2008.91","article-title":"Activation of hepatic stellate cells is associated with cytokine expression in thioacetamide-induced hepatic fibrosis in mice","volume":"88","author":"Roderfeld","year":"2008","journal-title":"Lab. Investig."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1177\/0023677215573040","article-title":"Standard operating procedures in experimental liver research: Thioacetamide model in mice and rats","volume":"49","author":"Wallace","year":"2015","journal-title":"Lab. Anim."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jmoldx.2011.08.002","article-title":"RNAscope: A novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues","volume":"14","author":"Wang","year":"2012","journal-title":"J. Mol. Diagn."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","author":"Ishak","year":"1995","journal-title":"J. Hepatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Roderfeld, M., Padem, S., Lichtenberger, J., Quack, T., Weiskirchen, R., Longerich, T., Schramm, G., Churin, Y., Irungbam, K., and Tschuschner, A. (2019). Schistosoma mansoni egg-secreted antigens activate hepatocellular carcinoma-associated transcription factors c-Jun and STAT3 in hamster and human hepatocytes. Hepatology.","DOI":"10.1002\/hep.30192"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00216-007-1718-9","article-title":"Direct eicosanoid profiling of the hypoxic lung by comprehensive analysis via capillary liquid chromatography with dual online photodiode-array and tandem mass-spectrometric detection","volume":"390","author":"Kiss","year":"2008","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1136\/gutjnl-2011-300608","article-title":"Bone marrow transplantation improves hepatic fibrosis in Abcb4-\/- mice via Th1 response and matrix metalloproteinase activity","volume":"61","author":"Roderfeld","year":"2012","journal-title":"Gut"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Lefebvre, E., Moyle, G., Reshef, R., Richman, L.P., Thompson, M., Hong, F., Chou, H.L., Hashiguchi, T., Plato, C., and Poulin, D. (2016). Antifibrotic effects of the dual CCR2\/CCR5 antagonist cenicriviroc in animal models of liver and kidney fibrosis. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0158156"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"S159","DOI":"10.1016\/S0168-8278(16)01667-6","article-title":"The dual CCR2\/CCR5 antagonist cenicriviroc ameliorates steatohepatitis and fibrosis in vivo by inhibiting the infiltration of inflammatory monocytes into injured liver","volume":"64","author":"Puengel","year":"2016","journal-title":"J. Hepatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0002-9440(10)62289-4","article-title":"CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury","volume":"166","author":"Moore","year":"2005","journal-title":"Am. J. Pathol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1165\/rcmb.2005-0239OC","article-title":"The role of CCL12 in the recruitment of fibrocytes and lung fibrosis","volume":"35","author":"Moore","year":"2006","journal-title":"Am. J. Respir Cell Mol. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1002\/hep.29477","article-title":"A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis","volume":"67","author":"Friedman","year":"2018","journal-title":"Hepatology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/hep.26053","article-title":"A novel murine model to deplete hepatic stellate cells uncovers their role in amplifying liver damage in mice","volume":"57","author":"Puche","year":"2013","journal-title":"Hepatology"},{"key":"ref_55","first-page":"34","article-title":"Contribution of bone marrow-derived fibrocytes to liver fibrosis","volume":"4","author":"Xu","year":"2015","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"5229","DOI":"10.4049\/jimmunol.1400753","article-title":"Fibrocytes are not an essential source of type I collagen during lung fibrosis","volume":"193","author":"Kleaveland","year":"2014","journal-title":"J. Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.jhep.2007.02.003","article-title":"Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies","volume":"46","author":"Hemmann","year":"2007","journal-title":"J. Hepatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1002\/art.30386","article-title":"Role of semaphorin 7a signaling in transforming growth factor beta1-induced lung fibrosis and scleroderma-related interstitial lung disease","volume":"63","author":"Gan","year":"2011","journal-title":"Arthritis Rheum"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.4049\/jimmunol.171.10.5537","article-title":"Inhibition of fibrocyte differentiation by serum amyloid P","volume":"171","author":"Pilling","year":"2003","journal-title":"J. Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3892\/ijmm.2017.3028","article-title":"Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice","volume":"40","author":"Cong","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1053\/j.gastro.2014.07.018","article-title":"Cell death and cell death responses in liver disease: Mechanisms and clinical relevance","volume":"147","author":"Luedde","year":"2014","journal-title":"Gastroenterology"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/8\/10\/1210\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:28:02Z","timestamp":1760189282000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/8\/10\/1210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,7]]},"references-count":61,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10]]}},"alternative-id":["cells8101210"],"URL":"https:\/\/doi.org\/10.3390\/cells8101210","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,7]]}}}