{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:50:32Z","timestamp":1790776232634,"version":"4.1.0"},"reference-count":196,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006280","name":"Ministerio de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["BFU2017-8 2421-P"],"award-info":[{"award-number":["BFU2017-8 2421-P"]}],"id":[{"id":"10.13039\/501100006280","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013117","name":"International Fibrodysplasia Ossificans Progressiva Association","doi-asserted-by":"publisher","award":["ACT for FOP Research"],"award-info":[{"award-number":["ACT for FOP Research"]}],"id":[{"id":"10.13039\/100013117","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Activin A receptor type I (ACVR1) encodes for a bone morphogenetic protein type I receptor of the TGF\u03b2 receptor superfamily. It is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. Moreover, ACVR1 has been extensively studied for its causal role in fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder characterised by progressive heterotopic ossification. ACVR1 is linked to different pathologies, including cardiac malformations and alterations in the reproductive system. More recently, ACVR1 has been experimentally validated as a cancer driver gene in diffuse intrinsic pontine glioma (DIPG), a malignant childhood brainstem glioma, and its function is being studied in other cancer types. Here, we review ACVR1 receptor function and signalling in physiological and pathological processes and its regulation according to cell type and mutational status. Learning from different functions and alterations linked to ACVR1 is a key step in the development of interdisciplinary research towards the identification of novel treatments for these pathologies.<\/jats:p>","DOI":"10.3390\/cells8111366","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T12:38:23Z","timestamp":1572525503000},"page":"1366","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["ACVR1 Function in Health and Disease"],"prefix":"10.3390","volume":"8","author":[{"given":"Jos\u00e9 Antonio","family":"Valer","sequence":"first","affiliation":[{"name":"Departament de Ci\u00e8ncies Fisiol\u00f2giques, Universitat de Barcelona, IDIBELL, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"S\u00e1nchez-de-Diego","sequence":"additional","affiliation":[{"name":"Departament de Ci\u00e8ncies Fisiol\u00f2giques, Universitat de Barcelona, IDIBELL, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Pimenta-Lopes","sequence":"additional","affiliation":[{"name":"Departament de Ci\u00e8ncies Fisiol\u00f2giques, Universitat de Barcelona, IDIBELL, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Luis","family":"Rosa","sequence":"additional","affiliation":[{"name":"Departament de Ci\u00e8ncies Fisiol\u00f2giques, Universitat de Barcelona, IDIBELL, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9673-9405","authenticated-orcid":false,"given":"Francesc","family":"Ventura","sequence":"additional","affiliation":[{"name":"Departament de Ci\u00e8ncies Fisiol\u00f2giques, Universitat de Barcelona, IDIBELL, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s003359900745","article-title":"Chromosomal localization of three human genes encoding members of the TGF-\u03b2 superfamily of type I serine\/threonine kinase receptors","volume":"9","author":"Miyazono","year":"1998","journal-title":"Mamm. 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