{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:09:12Z","timestamp":1793923752957,"version":"4.8.0"},"reference-count":142,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chinese Postdoctoral Science Foundation","award":["2019M651553"],"award-info":[{"award-number":["2019M651553"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Physical exercise promotes cardiorespiratory fitness, and is considered the mainstream of non-pharmacological therapies along with lifestyle modification for various chronic diseases, in particular cardiovascular diseases. Physical exercise may positively affect various cardiovascular risk factors including body weight, blood pressure, insulin sensitivity, lipid and glucose metabolism, heart function, endothelial function, and body fat composition. With the ever-rising prevalence of obesity and other types of metabolic diseases, as well as sedentary lifestyle, regular exercise of moderate intensity has been indicated to benefit cardiovascular health and reduce overall disease mortality. Exercise offers a wide cadre of favorable responses in the cardiovascular system such as improved dynamics of the cardiovascular system, reduced prevalence of coronary heart diseases and cardiomyopathies, enhanced cardiac reserve capacity, and autonomic regulation. Ample clinical and experimental evidence has indicated an emerging role for autophagy, a conservative catabolism process to degrade and recycle cellular organelles and nutrients, in exercise training-offered cardiovascular benefits. Regular physical exercise as a unique form of physiological stress is capable of triggering adaptation while autophagy in particular selective autophagy seems to be permissive to such cardiovascular adaptation. Here in this mini-review, we will summarize the role for autophagy in particular mitochondrial selective autophagy namely mitophagy in the benefit versus risk of physical exercise on cardiovascular function.<\/jats:p>","DOI":"10.3390\/cells8111436","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T10:56:34Z","timestamp":1573728994000},"page":"1436","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Physical Exercise and Selective Autophagy: Benefit and Risk on Cardiovascular Health"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7238-6825","authenticated-orcid":false,"given":"Ne N.","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China"},{"name":"Shanghai Institute of Cardiovascular Diseases, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haili","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijie","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sport Training, Shanghai University of Sport, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China"},{"name":"Shanghai Institute of Cardiovascular Diseases, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China"},{"name":"Shanghai Institute of Cardiovascular Diseases, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1152\/physrev.00043.2016","article-title":"Understanding key mechanisms of exercise-induced cardiac protection to mitigate disease: Current knowledge and emerging concepts","volume":"98","author":"Bernardo","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jshs.2018.12.002","article-title":"Children\u2019s motor skill competence, physical activity, fitness, andhealthpromotion","volume":"8","author":"Gao","year":"2019","journal-title":"J. Sport Health Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e13651","DOI":"10.14814\/phy2.13651","article-title":"Exercise and exercise training-induced increase in autophagy markers in human skeletal muscle","volume":"6","author":"Brandt","year":"2018","journal-title":"Physiol. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1152\/physrev.00014.2016","article-title":"Vascular adaptation to exercise in humans: Role of hemodynamic stimuli","volume":"97","author":"Green","year":"2017","journal-title":"Physiol. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.pcad.2018.07.011","article-title":"Obesity paradox in aging: From prevalence to pathophysiology","volume":"61","author":"Wang","year":"2018","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Mee-Inta, O., Zhao, Z.W., and Kuo, Y.M. (2019). Physical exercise inhibits inflammation and microglial activation. Cells, 8.","DOI":"10.3390\/cells8070691"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fcvm.2019.00069","article-title":"Effects of exercise to improve cardiovascular health","volume":"6","author":"Pinckard","year":"2019","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1152\/physrev.00029.2014","article-title":"Are there deleterious cardiac effects of acute and chronic endurance exercise?","volume":"96","author":"Eijsvogels","year":"2016","journal-title":"Physiol. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jshs.2017.05.002","article-title":"Sociodemographic, biological, and psychosocial correlates of light- and moderate-to-vigorous-intensity physical activity during school time, recesses, and physical education classes","volume":"8","author":"Minatto","year":"2019","journal-title":"J. Sport Health Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jshs.2017.09.012","article-title":"Effects of a 3-month vigorous physical activity intervention on eating behaviors and body composition in overweight and obese boys and girls","volume":"8","author":"Alegre","year":"2019","journal-title":"J. Sport Health Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e000143","DOI":"10.1136\/bmjsem-2016-000143","article-title":"Update on the effects of physical activity on insulin sensitivity in humans","volume":"2","author":"Bird","year":"2016","journal-title":"BMJ Open Sport Exerc. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jshs.2019.04.002","article-title":"Exercise as a prescription for patients with various diseases","volume":"8","author":"Luan","year":"2019","journal-title":"J. Sport Health Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.numecd.2017.12.008","article-title":"Effects of aerobic or resistance exercise training on cardiovascular autonomic function of subjects with type 2 diabetes: A pilot study","volume":"28","author":"Bellavere","year":"2018","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Demine, S., Renard, P., and Arnould, T. (2019). Mitochondrial uncoupling: A key controller of biological processes in physiology and diseases. Cells, 8.","DOI":"10.3390\/cells8080795"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Sanchez, A.M., Candau, R., and Bernardi, H. (2019). Recent data on cellular component turnover: Focus on adaptations to physical exercise. Cells, 8.","DOI":"10.3390\/cells8060542"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1016\/j.bbadis.2018.03.016","article-title":"Role of autophagy and regulatory mechanisms in alcoholic cardiomyopathy","volume":"1864","author":"Wang","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/s41556-018-0037-z","article-title":"Cargo recognition and degradation by selective autophagy","volume":"20","author":"Gatica","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.tem.2018.08.001","article-title":"Metabolic stress, autophagy, and cardiovascular aging: From pathophysiology to therapeutics","volume":"29","author":"Ren","year":"2018","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1152\/physrev.00005.2018","article-title":"Evolving and expanding the roles of mitophagy as a homeostatic and pathogenic process","volume":"99","author":"Gustafsson","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"9825061","DOI":"10.1155\/2019\/9825061","article-title":"Mitophagy, mitochondrial dynamics and homeostasis in cardiovascular aging","volume":"2019","author":"Wu","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.yjmcc.2015.11.023","article-title":"Parkin-dependent mitophagy in the heart","volume":"95","author":"Dorn","year":"2016","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1111\/bph.12477","article-title":"Autophagy and mitophagy in the myocardium: Therapeutic potential and concerns","volume":"171","author":"Jimenez","year":"2014","journal-title":"Br. J. Pharm."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1161\/CIRCRESAHA.116.309765","article-title":"Does autophagy mediate cardiac myocyte death during stress?","volume":"119","author":"Nah","year":"2016","journal-title":"Circ. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.4161\/auto.24135","article-title":"After the banquet: Mitochondrial biogenesis, mitophagy, and cell survival","volume":"9","author":"Zhu","year":"2013","journal-title":"Autophagy"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1161\/CIRCULATIONAHA.113.008115","article-title":"Targeting autophagy for the therapeutic application of histone deacetylase inhibitors in ischemia\/reperfusion heart injury","volume":"129","author":"Zhang","year":"2014","journal-title":"Circulation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.4161\/auto.6.8.13652","article-title":"Autophagy in aldh2-elicited cardioprotection against ischemic heart disease: Slayer or savior?","volume":"6","author":"Zhang","year":"2010","journal-title":"Autophagy"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.3389\/fphys.2019.01088","article-title":"Regular endurance exercise promotes fission, mitophagy, and oxidative phosphorylation in human skeletal muscle independently of age","volume":"10","author":"Balan","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1136\/bjsports-2013-092576","article-title":"High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: A systematic review and meta-analysis","volume":"48","author":"Weston","year":"2014","journal-title":"Br. J. Sports Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.cmet.2017.04.025","article-title":"Molecular mechanisms underlying cardiac adaptation to exercise","volume":"25","author":"Vega","year":"2017","journal-title":"Cell Metab."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000343990","article-title":"Exercise limitations by the oxygen delivery and utilization systems in aging and disease: Coordinated adaptation and deadaptation of the lung-heart muscle axis - A mini-review","volume":"59","author":"Burtscher","year":"2013","journal-title":"Gerontology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/bs.pmbts.2015.07.017","article-title":"Molecular mechanisms for exercise training-induced changes in vascular structure and function: Skeletal muscle, cardiac muscle, and the brain","volume":"135","author":"Olver","year":"2015","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_32","first-page":"1","article-title":"Cardiovascular adaptations to exercise training","volume":"6","author":"Hellsten","year":"2015","journal-title":"Compr. Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jacc.2009.03.061","article-title":"Sympathetic nervous system activation in human heart failure: Clinical implications of an updated model","volume":"54","author":"Floras","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1043-6618(03)00099-9","article-title":"Benefit and risk of exercise on myocardial function in diabetes","volume":"48","author":"Li","year":"2003","journal-title":"Pharm. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1210\/er.2017-00211","article-title":"Metabolic flexibility as an adaptation to energy resources and requirements in health and disease","volume":"39","author":"Smith","year":"2018","journal-title":"Endocr. Rev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1152\/physrev.00012.2011","article-title":"Physical activity and exercise in the regulation of human adipose tissue physiology","volume":"92","author":"Thompson","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00125-016-4106-1","article-title":"High-intensity interval training: A review of its impact on glucose control and cardiometabolic health","volume":"60","author":"Cassidy","year":"2017","journal-title":"Diabetologia"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1089\/ars.2015.6304","article-title":"How exercise may amend metabolic disturbances in diabetic cardiomyopathy","volume":"22","author":"Hafstad","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1161\/CIRCRESAHA.118.312017","article-title":"Metabolic coordination of physiological and pathological cardiac remodeling","volume":"123","author":"Gibb","year":"2018","journal-title":"Circ. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.cmet.2017.04.015","article-title":"Metabolic flexibility in health and disease","volume":"25","author":"Goodpaster","year":"2017","journal-title":"Cell Metab."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1152\/physrev.00038.2012","article-title":"Exercise, glut4, and skeletal muscle glucose uptake","volume":"93","author":"Richter","year":"2013","journal-title":"Physiol. Rev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrendo.2016.162","article-title":"Exercise-stimulated glucose uptake - Regulation and implications for glycaemic control","volume":"13","author":"Sylow","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fphys.2019.00026","article-title":"Effect of exercise on fatty acid metabolism and adipokine secretion in adipose tissue","volume":"10","author":"Mika","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s11306-017-1303-y","article-title":"Untargeted metabolomics analysis of ischemia-reperfusion-injured hearts ex vivo from sedentary and exercise-trained rats","volume":"14","author":"Parry","year":"2018","journal-title":"Metabolomics"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1016\/j.bbadis.2018.07.020","article-title":"Cardiomyocyte-specific knockout of endothelin receptor a attenuates obesity cardiomyopathy","volume":"1864","author":"Ceylan","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/s41366-018-0030-4","article-title":"Aldh2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: Role of cam kinase ii, histone h3k9 methyltransferase suv39h, sirt1, and pgc-1alpha deacetylation","volume":"42","author":"Wang","year":"2018","journal-title":"Int. J. Obes."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3389\/fcvm.2018.00135","article-title":"Cardiovascular effects and benefits of exercise","volume":"5","author":"Nystoriak","year":"2018","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.cmet.2015.01.014","article-title":"Using exercise to measure and modify cardiac function","volume":"21","author":"Platt","year":"2015","journal-title":"Cell Metab."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Wang, C., Redgrave, J., Shafizadeh, M., Majid, A., Kilner, K., and Ali, A.N. (2018). Aerobic exercise interventions reduce blood pressure in patients after stroke or transient ischaemic attack: A systematic review and meta-analysis. Br. J. Sports Med., bjsports-2017.","DOI":"10.1136\/bjsports-2017-098903"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/ejhf.735","article-title":"The future of pleiotropic therapy in heart failure. Lessons from the benefits of exercise training on endothelial function","volume":"19","author":"Segers","year":"2017","journal-title":"Eur. J. Heart Fail."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1093\/cvr\/cvw056","article-title":"Cardiac salvage by tweaking with beta-3-adrenergic receptors","volume":"111","author":"Balligand","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s11883-016-0580-7","article-title":"Cardiorespiratory fitness and atherosclerosis: Recent data and future directions","volume":"18","author":"Mehanna","year":"2016","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.vph.2012.02.004","article-title":"Nitric oxide synthase uncoupling: A therapeutic target in cardiovascular diseases","volume":"57","author":"Roe","year":"2012","journal-title":"Vasc. Pharm."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1254\/jjp.89.327","article-title":"Nitric oxide synthase gene therapy for cardiovascular disease","volume":"89","author":"Chen","year":"2002","journal-title":"Jpn. J. Pharm."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"H106","DOI":"10.1152\/ajpheart.00561.2018","article-title":"Elevated arterial shear rate increases indexes of endothelial cell autophagy and nitric oxide synthase activation in humans","volume":"316","author":"Park","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/eurheartj\/ehy585","article-title":"Differential effects of endurance, interval, and resistance training on telomerase activity and telomere length in a randomized, controlled study","volume":"40","author":"Werner","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.18632\/aging.102129","article-title":"Physical exercise, autophagy and cardiometabolic stress in aging","volume":"11","author":"Tian","year":"2019","journal-title":"Aging"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.cmet.2016.11.003","article-title":"Transcription factor eb controls metabolic flexibility during exercise","volume":"25","author":"Mansueto","year":"2017","journal-title":"Cell Metab."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s12576-017-0555-7","article-title":"Potential signaling pathways of acute endurance exercise-induced cardiac autophagy and mitophagy and its possible role in cardioprotection","volume":"67","author":"Lee","year":"2017","journal-title":"J. Physiol. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1249\/JES.0000000000000192","article-title":"Exercise-induced mitophagy in skeletal muscle and heart","volume":"47","author":"Guan","year":"2019","journal-title":"Exerc. Sport Sci. Rev."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Zhao, D., Sun, Y., Tan, Y., Zhang, Z., Hou, Z., Gao, C., Feng, P., Zhang, X., Yi, W., and Gao, F. (2018). Short-duration swimming exercise after myocardial infarction attenuates cardiac dysfunction and regulates mitochondrial quality control in aged mice. Oxid. Med. Cell. Longev., 2018.","DOI":"10.1155\/2018\/4079041"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"8402","DOI":"10.1073\/pnas.1703338114","article-title":"Metabolic profiles of exercise in patients with mcardle disease or mitochondrial myopathy","volume":"114","author":"Delaney","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41467-017-00520-9","article-title":"Ampk phosphorylation of ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy","volume":"8","author":"Laker","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/s41422-018-0078-7","article-title":"Skeletal muscle mitochondrial remodeling in exercise and diseases","volume":"28","author":"Gan","year":"2018","journal-title":"Cell Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.cmet.2017.04.029","article-title":"Pparbeta is essential for maintaining normal levels of pgc-1alpha and mitochondria and for the increase in muscle mitochondria induced by exercise","volume":"25","author":"Koh","year":"2017","journal-title":"Cell Metab."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e13731","DOI":"10.14814\/phy2.13731","article-title":"Impact of liver pgc-1alpha on exercise and exercise training-induced regulation of hepatic autophagy and mitophagy in mice on hff","volume":"6","author":"Dethlefsen","year":"2018","journal-title":"Physiol. Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"C710","DOI":"10.1152\/ajpcell.00380.2014","article-title":"Role of pgc-1alpha during acute exercise-induced autophagy and mitophagy in skeletal muscle","volume":"308","author":"Vainshtein","year":"2015","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.freeradbiomed.2015.12.032","article-title":"Pgc-1alpha overexpression via local transfection attenuates mitophagy pathway in muscle disuse atrophy","volume":"93","author":"Kang","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jshs.2018.12.003","article-title":"The effect of the champ intervention on fundamental motor skills and outdoor physical activity in preschoolers","volume":"8","author":"Palmer","year":"2019","journal-title":"J. Sport Health Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1136\/bjsports-2014-306596rep","article-title":"Basic science behind the cardiovascular benefits of exercise","volume":"50","author":"Wilson","year":"2016","journal-title":"Br. J. Sports Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1001\/jama.2015.10858","article-title":"Exercise is medicine: At any dose?","volume":"314","author":"Eijsvogels","year":"2015","journal-title":"JAMA"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.jacc.2014.04.058","article-title":"Leisure-time running reduces all-cause and cardiovascular mortality risk","volume":"64","author":"Lee","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e225","DOI":"10.1161\/CIRCULATIONAHA.115.017263","article-title":"Response to letter regarding article \u201cFrequent physical activity may not reduce vascular disease risk as much as moderate activity: Large prospective study of women in the united kingdom\u201d","volume":"132","author":"Armstrong","year":"2015","journal-title":"Circulation"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jacc.2014.11.023","article-title":"Dose of jogging and long-term mortality: The copenhagen city heart study","volume":"65","author":"Schnohr","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/ajh\/hpu191","article-title":"Exercise and cardiovascular risk in patients with hypertension","volume":"28","author":"Sharman","year":"2015","journal-title":"Am. J. Hypertens"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3390\/ijerph9020391","article-title":"Physical activity and risk of cardiovascular disease--A meta-analysis of prospective cohort studies","volume":"9","author":"Li","year":"2012","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1249\/MSS.0000000000001373","article-title":"Fifty men, 3510 marathons, cardiac risk factors, and coronary artery calcium scores","volume":"49","author":"Roberts","year":"2017","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/j.mayocp.2017.07.016","article-title":"25-year physical activity trajectories and development of subclinical coronary artery disease as measured by coronary artery calcium: The coronary artery risk development in young adults (cardia) study","volume":"92","author":"Laddu","year":"2017","journal-title":"Mayo Clin. Proc."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1152\/physrev.00031.2007","article-title":"Exercise-induced oxidative stress: Cellular mechanisms and impact on muscle force production","volume":"88","author":"Powers","year":"2008","journal-title":"Physiol. Rev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1093\/eurheartj\/ehv090","article-title":"Exercise and the heart: The good, the bad, and the ugly","volume":"36","author":"Sharma","year":"2015","journal-title":"Eur. Heart J."},{"key":"ref_82","first-page":"E86","article-title":"Mechanisms of the beneficial effects of beta-adrenoceptor antagonists in congestive heart failure","volume":"15","author":"Rehsia","year":"2010","journal-title":"Exp. Clin. Cardiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.jcmg.2015.07.004","article-title":"Cardiac imaging to evaluate left ventricular diastolic function","volume":"8","author":"Flachskampf","year":"2015","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_84","first-page":"131","article-title":"Stress signaling in paraquat-induced target organ toxicity","volume":"1","author":"Wang","year":"2016","journal-title":"ROS"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41586-018-0211-2","article-title":"Structural basis of mitochondrial receptor binding and constriction by drp1","volume":"558","author":"Kalia","year":"2018","journal-title":"Nature"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1161\/CIRCRESAHA.116.303790","article-title":"Molecular mechanisms of mitochondrial autophagy\/mitophagy in the heart","volume":"116","author":"Saito","year":"2015","journal-title":"Circ. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature14893","article-title":"The ubiquitin kinase pink1 recruits autophagy receptors to induce mitophagy","volume":"524","author":"Lazarou","year":"2015","journal-title":"Nature"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1080\/15548627.2016.1240856","article-title":"Human atg8-cardiolipin interactions in mitophagy: Specific properties of lc3b, gabarapl2 and gabarap","volume":"12","author":"Anton","year":"2016","journal-title":"Autophagy"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/cr.2014.75","article-title":"Receptor-mediated mitophagy in yeast and mammalian systems","volume":"24","author":"Liu","year":"2014","journal-title":"Cell Res."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Gyongyosi, A., Terraneo, L., Bianciardi, P., Tosaki, A., Lekli, I., and Samaja, M. (2018). The impact of moderate chronic hypoxia and hyperoxia on the level of apoptotic and autophagic proteins in myocardial tissue. Oxid. Med. Cell. Longev., 2018.","DOI":"10.1155\/2018\/5786742"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13395-018-0157-y","article-title":"Role of parkin and endurance training on mitochondrial turnover in skeletal muscle","volume":"8","author":"Chen","year":"2018","journal-title":"Skelet. Muscle"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15384101.2018.1559556","article-title":"Exercise-induced mitophagy in skeletal muscle occurs in the absence of stabilization of pink1 on mitochondria","volume":"18","author":"Drake","year":"2019","journal-title":"Cell Cycle"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Li, H., Miao, W., Ma, J., Xv, Z., Bo, H., Li, J., Zhang, Y., and Ji, L.L. (2016). Acute exercise-induced mitochondrial stress triggers an inflammatory response in the myocardium via nlrp3 inflammasome activation with mitophagy. Oxid. Med. Cell. Longev., 2016.","DOI":"10.1155\/2016\/1987149"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1249\/MSS.0000000000001906","article-title":"Downhill running acutely elicits mitophagy in rat soleus muscle","volume":"51","author":"Shang","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1139\/cjpp-2014-0017","article-title":"Impairment of autophagy in endothelial cells prevents shear-stress-induced increases in nitric oxide bioavailability","volume":"92","author":"Bharath","year":"2014","journal-title":"Can. J. Physiol Pharm."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s12576-016-0440-9","article-title":"Autophagy plays a role in skeletal muscle mitochondrial biogenesis in an endurance exercise-trained condition","volume":"66","author":"Ju","year":"2016","journal-title":"J. Physiol. Sci."},{"key":"ref_97","first-page":"243","article-title":"Effects of regular exercise plus food restriction on left ventricular pathological remodeling in heart failureinduced rats","volume":"120","author":"Moradi","year":"2019","journal-title":"Bratisl. Lek. Listy."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1159\/000494723","article-title":"Resistance exercise improves mitochondrial quality control in a rat model of sporadic inclusion body myositis","volume":"65","author":"Koo","year":"2019","journal-title":"Gerontology"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00018-015-2087-8","article-title":"Mitophagy programs: Mechanisms and physiological implications of mitochondrial targeting by autophagy","volume":"73","author":"Brady","year":"2016","journal-title":"Cell Mol. Life Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrendo.2016.87","article-title":"The role of diet and exercise in the transgenerational epigenetic landscape of t2dm","volume":"12","author":"Barres","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"E457","DOI":"10.1016\/S1470-2045(17)30411-4","article-title":"Physical activity, sedentary behaviour, diet, and cancer: An update and emerging new evidence","volume":"18","author":"Kerr","year":"2017","journal-title":"Lancet Oncol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1161\/CIRCRESAHA.116.303550","article-title":"Lifestyle effects on hematopoiesis and atherosclerosis","volume":"116","author":"Nahrendorf","year":"2015","journal-title":"Circ. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1161\/CIR.0000000000000510","article-title":"Dietary fats and cardiovascular disease: A presidential advisory from the american heart association","volume":"136","author":"Sacks","year":"2017","journal-title":"Circulation"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"K2139","DOI":"10.1136\/bmj.k2139","article-title":"Dietary fat and cardiometabolic health: Evidence, controversies, and consensus for guidance","volume":"361","author":"Forouhi","year":"2018","journal-title":"BMJ"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41574-019-0170-1","article-title":"Combating osteoporosis and obesity with exercise: Leveraging cell mechanosensitivity","volume":"15","author":"Pagnotti","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1136\/bjsports-2016-097132","article-title":"Exercise therapy for functional capacity in chronic diseases: An overview of meta-analyses of randomised controlled trials","volume":"51","author":"Pasanen","year":"2017","journal-title":"Br. J. Sports Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1139\/apnm-2015-0470","article-title":"Exercise mitigates mitochondrial permeability transition pore and quality control mechanisms alterations in nonalcoholic steatohepatitis","volume":"41","author":"Goncalves","year":"2016","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1139\/apnm-2016-0280","article-title":"Moderate physical activity promotes basal hepatic autophagy in diet-induced obese mice","volume":"42","author":"Lee","year":"2017","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.molmet.2017.10.006","article-title":"Skeletal muscle autophagy and mitophagy in endurance-trained runners before and after a high-fat meal","volume":"6","author":"Tarpey","year":"2017","journal-title":"Mol. Metab."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1113\/JP275998","article-title":"Autophagy and mitophagy flux in young and aged skeletal muscle following chronic contractile activity","volume":"596","author":"Carter","year":"2018","journal-title":"J. Physiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00424-018-2225-x","article-title":"Regulation of autophagic and mitophagic flux during chronic contractile activity-induced muscle adaptations","volume":"471","author":"Kim","year":"2019","journal-title":"Pflug. Arch."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1536\/ihj.18-310","article-title":"Changes in autophagy levels in rat myocardium during exercise preconditioning-initiated cardioprotective effects","volume":"60","author":"Li","year":"2019","journal-title":"Int. Heart J."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1080\/17461391.2018.1561950","article-title":"Effects of a resistance-training programme on endoplasmic reticulum unfolded protein response and mitochondrial functions in pbmcs from elderly subjects","volume":"19","author":"Estebanez","year":"2019","journal-title":"Eur. J. Sport Sci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/FJC.0000000000000572","article-title":"Parkin mediates mitophagy to participate in cardioprotection induced by late exercise preconditioning but bnip3 does not","volume":"71","author":"Yuan","year":"2018","journal-title":"J. Cardiovasc. Pharm."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Yuan, Y., Pan, S.S., Wan, D.F., Lu, J., and Huang, Y. (2018). H2o2 signaling-triggered pi3k mediates mitochondrial protection to participate in early cardioprotection by exercise preconditioning. Oxid. Med. Cell. Longev., 2018.","DOI":"10.1155\/2018\/1916841"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Dun, Y., Liu, S., Zhang, W., Xie, M., and Qiu, L. (2017). Exercise combined with rhodiola sacra supplementation improves exercise capacity and ameliorates exhaustive exercise-induced muscle damage through enhancement of mitochondrial quality control. Oxid. Med. Cell. Longev., 2017.","DOI":"10.1155\/2017\/8024857"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1249\/MSS.0000000000001887","article-title":"Exercise training prevents doxorubicin-induced mitochondrial dysfunction of the liver","volume":"51","author":"Hinkley","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s12012-017-9412-4","article-title":"Exercise and doxorubicin treatment modulate cardiac mitochondrial quality control signaling","volume":"18","author":"Torrella","year":"2018","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Lee, Y., Kwon, I., Jang, Y., Cosio-Lima, L., and Barrington, P. (2019). Endurance exercise attenuates doxorubicin-induced cardiotoxicity. Med. Sci. Sports Exerc.","DOI":"10.1249\/MSS.0000000000002094"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.bbadis.2019.05.007","article-title":"Mitophagy and mitochondrial integrity in cardiac ischemia-reperfusion injury","volume":"1865","author":"Yang","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1111\/jcmm.13053","article-title":"Autophagy: An adaptive physiological countermeasure to cellular senescence and ischaemia\/reperfusion-associated cardiac arrhythmias","volume":"21","author":"Lekli","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Czegledi, A., Tosaki, A., Gyongyosi, A., Zilinyi, R., Tosaki, A., and Lekli, I. (2019). Electrically-induced ventricular fibrillation alters cardiovascular function and expression of apoptotic and autophagic proteins in rat hearts. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20071628"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.2174\/1381612825666190619145025","article-title":"The role of autophagy and death pathways in dose-dependent isoproterenolinduced cardiotoxicity","volume":"25","author":"Gyongyosi","year":"2019","journal-title":"Curr. Pharm. Des."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.tips.2018.10.005","article-title":"Targeting autophagy in aging and aging-related cardiovascular diseases","volume":"39","author":"Ren","year":"2018","journal-title":"Trends Pharm. Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"e13069","DOI":"10.1111\/apha.13069","article-title":"Autophagy is induced by resistance exercise in young men, but unfolded protein response is induced regardless of age","volume":"224","author":"Hentila","year":"2018","journal-title":"Acta Physiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"7587","DOI":"10.18632\/aging.102273","article-title":"Attenuated activation of the unfolded protein response following exercise in skeletal muscle of older adults","volume":"11","author":"Hart","year":"2019","journal-title":"Aging"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"R127","DOI":"10.1152\/ajpregu.00337.2011","article-title":"Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training","volume":"303","author":"Koltai","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/07435800.2017.1323914","article-title":"Influence of endurance training on skeletal muscle mitophagy regulatory proteins in type 2 diabetic men","volume":"42","author":"Brinkmann","year":"2017","journal-title":"Endocr. Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.exger.2018.07.011","article-title":"Regulation of apoptosis and autophagy in mouse and human skeletal muscle with aging and lifelong exercise training","volume":"111","author":"Dethlefsen","year":"2018","journal-title":"Exp. Gerontol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"R734","DOI":"10.1152\/ajpregu.00005.2014","article-title":"Effects of age and unaccustomed resistance exercise on mitochondrial transcript and protein abundance in skeletal muscle of men","volume":"308","author":"Ogborn","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1440-1681.2007.04591.x","article-title":"Influence of gender on oxidative stress, lipid peroxidation, protein damage and apoptosis in hearts and brains from spontaneously hypertensive rats","volume":"34","author":"Ren","year":"2007","journal-title":"Clin. Exp. Pharm. Physiol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1081\/ERC-120022318","article-title":"Influence of gender on intrinsic contractile properties of isolated ventricular myocytes from calmodulin-induced diabetic transgenic mice","volume":"29","author":"Zhang","year":"2003","journal-title":"Endocr. Res."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Lau, E.S., Cunningham, T., Hardin, K.M., Liu, E., Malhotra, R., Nayor, M., Lewis, G.D., and Ho, J.E. (2019). Sex differences in cardiometabolic traits and determinants of exercise capacity in heart failure with preserved ejection fraction. JAMA Cardiol.","DOI":"10.1001\/jamacardio.2019.4150"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev-nutr-071715-050901","article-title":"Understanding age-related changes in skeletal muscle metabolism: Differences between females and males","volume":"36","author":"Gheller","year":"2016","journal-title":"Annu. Rev. Nutr."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1249\/MSS.0000000000001256","article-title":"Lack of activation of mitophagy during endurance exercise in human","volume":"49","author":"Schwalm","year":"2017","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cryobiol.2019.08.007","article-title":"Effects of exercise in a cold environment on gene expression for mitochondrial biogenesis and mitophagy","volume":"90","author":"Opichka","year":"2019","journal-title":"Cryobiology"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41574-018-0009-1","article-title":"Targeting autophagy in obesity: From pathophysiology to management","volume":"14","author":"Zhang","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2018.06.004","article-title":"Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management","volume":"191","author":"Zhang","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fcvm.2018.00038","article-title":"Autophagic regulation of lipid homeostasis in cardiometabolic syndrome","volume":"5","author":"Yang","year":"2018","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.2174\/138945011815171019092703","article-title":"Editorial: New therapetic approaches in the management of ischemia reperfusion injury and cardiometabolic diseases: Opportunities and challenges","volume":"18","author":"Ren","year":"2017","journal-title":"Curr. Drug Targets"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1177\/2047487316675823","article-title":"Longer-term effects of home-based exercise interventions on exercise capacity and physical activity in coronary artery disease patients: A systematic review and meta-analysis","volume":"24","author":"Claes","year":"2017","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev-publhealth-032315-021859","article-title":"Preventing obesity across generations: Evidence for early life intervention","volume":"37","author":"Tabak","year":"2016","journal-title":"Annu. Rev. Public Health"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/8\/11\/1436\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:34:24Z","timestamp":1760189664000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/8\/11\/1436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,14]]},"references-count":142,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,11]]}},"alternative-id":["cells8111436"],"URL":"https:\/\/doi.org\/10.3390\/cells8111436","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,14]]}}}