{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:46:27Z","timestamp":1779896787021,"version":"3.53.1"},"reference-count":56,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T00:00:00Z","timestamp":1574294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["project number 406036362 to JY and project number 390921723 to NNK"],"award-info":[{"award-number":["project number 406036362 to JY and project number 390921723 to NNK"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Preeclampsia (PE) remains a leading cause of maternal and perinatal mortality and morbidity worldwide. Its pathogenesis has not been fully elucidated and no causal therapy is currently available. It is of clinical relevance to decipher novel molecular biomarkers. RITA (RBP-J (recombination signal binding protein J)-interacting and tubulin-associated protein) has been identified as a negative modulator of the Notch pathway and as a microtubule-associated protein important for cell migration and invasion. In the present work, we have systematically studied RITA\u2019s expression in primary placental tissues from patients with early- and late-onset PE as well as in various trophoblastic cell lines. RITA is expressed in primary placental tissues throughout gestation, especially in proliferative villous cytotrophoblasts, in the terminally differentiated syncytiotrophoblast, and in migrating extravillous trophoblasts. RITA\u2019s messenger RNA (mRNA) level is decreased in primary tissue samples from early-onset PE patients. The deficiency of RITA impairs the motility and invasion capacity of trophoblastic cell lines, and compromises the fusion ability of trophoblast-derived choriocarcinoma cells. These data suggest that RITA may play important roles in the development of the placenta and possibly in the pathogenesis of PE.<\/jats:p>","DOI":"10.3390\/cells8121484","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T02:49:27Z","timestamp":1574390967000},"page":"1484","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["RITA Is Expressed in Trophoblastic Cells and Is Involved in Differentiation Processes of the Placenta"],"prefix":"10.3390","volume":"8","author":[{"given":"Julia Maria","family":"Wildner","sequence":"first","affiliation":[{"name":"Division of Obstetrics and Prenatal Medicine, Department of Gynecology and Obstetrics, University Hospital, Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Friemel","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Prenatal Medicine, Department of Gynecology and Obstetrics, University Hospital, Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Jennewein","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Prenatal Medicine, Department of Gynecology and Obstetrics, University Hospital, Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Roth","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Prenatal Medicine, Department of Gynecology and Obstetrics, University Hospital, Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Ritter","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Prenatal Medicine, Department of Gynecology and Obstetrics, University Hospital, Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Sch\u00fcttler","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Prenatal Medicine, Department of Gynecology and Obstetrics, University Hospital, Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Auckland, Auckland 1010, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Louwen","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Prenatal Medicine, Department of Gynecology and Obstetrics, University Hospital, Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0694-0565","authenticated-orcid":false,"given":"Juping","family":"Yuan","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Prenatal Medicine, Department of Gynecology and Obstetrics, University Hospital, Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4304-0160","authenticated-orcid":false,"given":"Nina-Naomi","family":"Kreis","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Prenatal Medicine, Department of Gynecology and Obstetrics, University Hospital, Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/j.placenta.2008.11.009","article-title":"The two stage model of preeclampsia: Variations on the theme","volume":"30","author":"Roberts","year":"2009","journal-title":"Placenta"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"Lancet"},{"key":"ref_3","first-page":"372","article-title":"Endothelial dysfunction and preeclampsia: Role of oxidative stress","volume":"5","author":"Prada","year":"2014","journal-title":"Front. 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