{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T10:22:17Z","timestamp":1793960537966,"version":"4.8.0"},"reference-count":33,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"B.J.L. was supported by the Priority Research Centers Program (2014R1A6A1030318) through the National Research Foundation of Korea","award":["2014R1A6A1030318"],"award-info":[{"award-number":["2014R1A6A1030318"]}]},{"name":"Thai Hien Tu was supported by an Incheon National University (Foreign post-doctor program-2016) Research Grant","award":["Foreign post-doctor program-2016"],"award-info":[{"award-number":["Foreign post-doctor program-2016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Beta-aminoisobutyric acid (BAIBA), a natural thymine catabolite, is involved in the beneficial effects of exercise on metabolic disorders. In particular, it has been reported to reverse the inflammatory processes observed in the peripheral organs of animal models of obesity. Therefore, this study aimed to investigate whether BAIBA improves hypothalamic inflammation, which is also tightly coupled with the development of obesity. We observed that treatment with BAIBA effectively reversed palmitic acid-induced hypothalamic inflammation and microglial activation in vivo. Consistent with these findings, we confirmed that BAIBA reversed body weight gain and increased adiposity observed in mice fed with a high-fat diet. Collectively, the current findings evidence the beneficial impacts of BAIBA on the imbalance of energy metabolism linked to hypothalamic inflammation.<\/jats:p>","DOI":"10.3390\/cells8121609","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T03:20:16Z","timestamp":1576120816000},"page":"1609","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Beta-Aminoisobutyric Acid Inhibits Hypothalamic Inflammation by Reversing Microglia Activation"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6463-9645","authenticated-orcid":false,"given":"Byong Seo","family":"Park","sequence":"first","affiliation":[{"name":"Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 406-772, Korea"},{"name":"Department of Biological Sciences, University of Ulsan, Ulsan 680-749, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thai Hien","family":"Tu","sequence":"additional","affiliation":[{"name":"Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 406-772, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 406-772, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da Yeon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 406-772, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunggu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nano-Bioengineering, Incheon National University, Incheon 406-772, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Ulsan, Ulsan 680-749, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Geun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 406-772, Korea"},{"name":"Institute for New Drug Development, Division of Life Sciences, Incheon National University, Incheon 406-772, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/nature05026","article-title":"Central nervous system control of food intake and body weight","volume":"443","author":"Morton","year":"2006","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nature11705","article-title":"Central nervous system control of metabolism","volume":"491","author":"Myers","year":"2012","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1172\/JCI59660","article-title":"Obesity is associated with hypothalamic injury in rodents and humans","volume":"122","author":"Thaler","year":"2012","journal-title":"J. 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