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Changes in the composition and physical properties of the ECM lead to the development of many diseases, including osteoarthritis (OA). OA is a chronic degenerative rheumatic disease characterized by a progressive loss of synovial joint function as a consequence of the degradation of articular cartilage, also associated with alterations in the synovial membrane and subchondral bone. During OA, ECM-degrading enzymes, including urokinase-type plasminogen activator (uPA), matrix metalloproteinases (MMPs), and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs), cleave ECM components, such as fibronectin (Fn), generating fibronectin fragments (Fn-fs) with catabolic properties. In turn, Fn-fs promote activation of these proteinases, establishing a degradative and inflammatory feedback loop. Thus, the aim of this review is to update the contribution of ECM-degrading proteinases to the physiopathology of OA as well as their modulation by Fn-fs.<\/jats:p>","DOI":"10.3390\/cells9010040","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T03:23:12Z","timestamp":1577071392000},"page":"40","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4500-8132","authenticated-orcid":false,"given":"Selene","family":"P\u00e9rez-Garc\u00eda","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Celular, Facultad de Biolog\u00eda y Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Carri\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular, Facultad de Biolog\u00eda y Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0678-3619","authenticated-orcid":false,"given":"Irene","family":"Guti\u00e9rrez-Ca\u00f1as","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular, Facultad de Biolog\u00eda y Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Villanueva-Romero","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular, Facultad de Biolog\u00eda y Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2446-5075","authenticated-orcid":false,"given":"David","family":"Castro","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular, Facultad de Biolog\u00eda y Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular, Facultad de Biolog\u00eda y Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9614-5199","authenticated-orcid":false,"given":"Isidoro","family":"Gonz\u00e1lez-\u00c1lvaro","sequence":"additional","affiliation":[{"name":"Servicio de Reumatolog\u00eda, Instituto de Investigaci\u00f3n M\u00e9dica, Hospital Universitario La Princesa, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Blanco","sequence":"additional","affiliation":[{"name":"Servicio de Reumatolog\u00eda, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), Complexo Hospitalario Universitario de A Coru\u00f1a, Sergas, Universidade da Coru\u00f1a (UDC), 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5886-8273","authenticated-orcid":false,"given":"Yasmina","family":"Juarranz","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular, Facultad de Biolog\u00eda y Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2839-1923","authenticated-orcid":false,"given":"Rosa P.","family":"Gomariz","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular, Facultad de Biolog\u00eda y Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/S0140-6736(11)60243-2","article-title":"Osteoarthritis: An update with relevance for clinical practice","volume":"377","author":"Bijlsma","year":"2011","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.joca.2015.03.036","article-title":"Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use","volume":"23","author":"Kraus","year":"2015","journal-title":"Osteoarthr. 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