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In AD mouse models, relevant information can be derived from brain electrical activity. With a multi-site linear probe, we recorded local field potentials simultaneously at the posterior-parietal cortex and hippocampus of wild-type and double transgenic AD mice, under anesthesia. We focused on PS2APP (B6.152H) mice carrying both presenilin-2 (PS2) and amyloid precursor protein (APP) mutations, at three and six months of age, before and after plaque deposition respectively. To highlight defects linked to either the PS2 or APP mutation, we included in the analysis age-matched PS2.30H and APP-Swedish mice, carrying each of the mutations individually. Our study also included PSEN2\u2212\/\u2212 mice. At three months, only predeposition B6.152H mice show a reduction in the functional connectivity of slow oscillations (SO) and in the power ratio between SO and delta waves. At six months, plaque-seeding B6.152H mice undergo a worsening of the low\/high frequency power imbalance and show a massive loss of cortico-hippocampal phase-amplitude coupling (PAC) between SO and higher frequencies, a feature shared with amyloid-free PS2.30H mice. We conclude that the PS2 mutation is sufficient to impair SO PAC and accelerate network dysfunctions in amyloid-accumulating mice.<\/jats:p>","DOI":"10.3390\/cells9010054","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T10:28:43Z","timestamp":1577183323000},"page":"54","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Dampened Slow Oscillation Connectivity Anticipates Amyloid Deposition in the PS2APP Mouse Model of Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9110-1055","authenticated-orcid":false,"given":"Alessandro","family":"Leparulo","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University of Padua, Via U. Bassi 58\/B, 35131 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mufti","family":"Mahmud","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padua, Via U. Bassi 58\/B, 35131 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Scremin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padua, Via U. Bassi 58\/B, 35131 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tullio","family":"Pozzan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padua, Via U. Bassi 58\/B, 35131 Padua, Italy"},{"name":"Neuroscience Institute-Italian National Research Council (CNR), Via U. Bassi 58\/B, 35131 Padua, Italy"},{"name":"Venetian Institute of Molecular Medicine (VIMM), Via G. Orus 2B, 35129 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0389-8023","authenticated-orcid":false,"given":"Stefano","family":"Vassanelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padua, Via U. Bassi 58\/B, 35131 Padua, Italy"},{"name":"Padua Neuroscience Center (PNC), University of Padua, Via G. Orus 2B, 35129 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-7751","authenticated-orcid":false,"given":"Cristina","family":"Fasolato","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padua, Via U. 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Drug Discov."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1038\/s41467-019-10217-w","article-title":"Abeta-induced vulnerability propagates via the brain\u2019s default mode network","volume":"10","author":"Pascoal","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.neuron.2010.10.020","article-title":"Transsynaptic Progression of Amyloid-\u03b2-Induced Neuronal Dysfunction within the Entorhinal-Hippocampal Network","volume":"68","author":"Harris","year":"2010","journal-title":"Neuron"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41593-018-0070-z","article-title":"Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals","volume":"21","author":"Jacobs","year":"2018","journal-title":"Nat. Neurosci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/nn.3606","article-title":"Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer\u2019s disease","volume":"17","author":"Khan","year":"2014","journal-title":"Nat. Neurosci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s41586-018-0718-6","article-title":"Somatic APP gene recombination in Alzheimer\u2019s disease and normal neurons","volume":"563","author":"Lee","year":"2018","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1523\/JNEUROSCI.5215-08.2009","article-title":"Amyloid -Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy","volume":"29","author":"Minkeviciene","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"8740","DOI":"10.1073\/pnas.1206171109","article-title":"Critical role of soluble amyloid-\u03b2 for early hippocampal hyperactivity in a mouse model of Alzheimer\u2019s disease","volume":"109","author":"Busche","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neurobiolaging.2016.10.027","article-title":"Early hippocampal hyperexcitability in PS2APP mice: Role of mutant PS2 and APP","volume":"50","author":"Fontana","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s40478-014-0149-z","article-title":"p38 MAP kinase-mediated NMDA receptor-dependent suppression of hippocampal hypersynchronicity in a mouse model of Alzheimer\u2019s disease","volume":"2","author":"Ittner","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"E2895","DOI":"10.1073\/pnas.1121081109","article-title":"Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer\u2019s disease model","volume":"109","author":"Sanchez","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.cell.2012.02.046","article-title":"Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model","volume":"149","author":"Verret","year":"2012","journal-title":"Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1001\/archneurol.2009.15","article-title":"Epilepsy and cognitive impairments in Alzheimer disease","volume":"66","author":"Palop","year":"2009","journal-title":"Arch. Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrn.2016.141","article-title":"Network abnormalities and interneuron dysfunction in Alzheimer disease","volume":"17","author":"Palop","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.nicl.2015.02.009","article-title":"Response of the medial temporal lobe network in amnestic mild cognitive impairment to therapeutic intervention assessed by fMRI and memory task performance","volume":"7","author":"Bakker","year":"2015","journal-title":"NeuroImage Clin."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nm.4330","article-title":"Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer\u2019s disease","volume":"23","author":"Lam","year":"2017","journal-title":"Nat. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/nature08860","article-title":"Human memory strength is predicted by theta-frequency phase-locking of single neurons","volume":"464","author":"Rutishauser","year":"2010","journal-title":"Nature"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1111\/ejn.12233","article-title":"Alterations in hippocampal network oscillations and theta-gamma coupling arise before A\u03b2 overproduction in a mouse model of Alzheimer\u2019s disease","volume":"37","author":"Goutagny","year":"2013","journal-title":"Eur. J. Neurosci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"E6868","DOI":"10.1073\/pnas.1607289113","article-title":"Human cortical\u2013hippocampal dialogue in wake and slow-wave sleep","volume":"113","author":"Mitra","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1038\/nn.4137","article-title":"Rescue of long-range circuit dysfunction in Alzheimer\u2019s disease models","volume":"18","author":"Busche","year":"2015","journal-title":"Nat. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Kastanenka, K.V., Hou, S.S., Shakerdge, N., Logan, R., Feng, D., Wegmann, S., Chopra, V., Hawkes, J.M., Chen, X., and Bacskai, B.J. (2017). Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer\u2019s Disease. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0170275"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7111","DOI":"10.1523\/JNEUROSCI.0260-17.2017","article-title":"Promoting Sleep Oscillations and Their Functional Coupling by Transcranial Stimulation Enhances Memory Consolidation in Mild Cognitive Impairment","volume":"37","author":"Ladenbauer","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000170884","article-title":"Expression of Transgenic APP mRNA Is the Key Determinant for Beta-Amyloid Deposition in PS2APP Transgenic Mice","volume":"6","author":"Ozmen","year":"2009","journal-title":"Neurodegener. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"8989","DOI":"10.1523\/JNEUROSCI.23-26-08989.2003","article-title":"PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation","volume":"23","author":"Richards","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"954","DOI":"10.2967\/jnumed.115.167858","article-title":"Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple-Tracer PET Study","volume":"57","author":"Brendel","year":"2016","journal-title":"J. Nucl. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fnagi.2017.00008","article-title":"Increase of TREM2 during aging of an Alzheimer\u2019s disease mouse model is paralleled by microglial activation and amyloidosis","volume":"9","author":"Brendel","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/mrm.21985","article-title":"Cortical hypoperfusion in the B6.PS2APP mouse model for Alzheimer\u2019s disease: Comprehensive phenotyping of vascular and tissular parameters by MRI","volume":"62","author":"Weidensteiner","year":"2009","journal-title":"Magn. Reson. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.nbd.2014.11.017","article-title":"Altered GluN2B NMDA receptor function and synaptic plasticity during early pathology in the PS2APP mouse model of Alzheimer\u2019s disease","volume":"74","author":"Hanson","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/j.1474-9726.2012.00858.x","article-title":"Ca2+ dysregulation in neurons from transgenic mice expressing mutant presenilin 2","volume":"11","author":"Kipanyula","year":"2012","journal-title":"Aging Cell"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"11872","DOI":"10.1073\/pnas.96.21.11872","article-title":"Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency","volume":"96","author":"Herreman","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.molmed.2011.06.002","article-title":"Presenilins in synaptic function and disease","volume":"17","author":"Ho","year":"2011","journal-title":"Trends Mol. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jneumeth.2010.11.024","article-title":"An automated method for detection of layer activation order in information processing pathway of rat barrel cortex under mechanical whisker stimulation","volume":"196","author":"Mahmud","year":"2011","journal-title":"J. Neurosci. Methods"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"468","DOI":"10.55782\/ane-2012-1917","article-title":"A new approach to location of the dentate gyrus and perforant path in rats\/mice by landmarks on the skull","volume":"72","author":"Huang","year":"2012","journal-title":"Acta Neurobiol. Exp."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"6213","DOI":"10.1523\/JNEUROSCI.5594-05.2006","article-title":"Hippocampal Slow Oscillation: A Novel EEG State and Its Coordination with Ongoing Neocortical Activity","volume":"26","author":"Wolansky","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1523\/JNEUROSCI.3175-15.2016","article-title":"Phase of Spontaneous Slow Oscillations during Sleep Influences Memory-Related Processing of Auditory Cues","volume":"36","author":"Batterink","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/15622971003637637","article-title":"Slow-wave sleep and the consolidation of long-term memory","volume":"11","author":"Born","year":"2010","journal-title":"World J. Biol. Psychiatry"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5665","DOI":"10.1523\/JNEUROSCI.0279-06.2006","article-title":"Precise Long-Range Synchronization of Activity and Silence in Neocortical Neurons during Slow-Wave Sleep","volume":"26","author":"Volgushev","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Pagliardini, S., Gosgnach, S., and Dickson, C.T. (2013). Spontaneous Sleep-Like Brain State Alternations and Breathing Characteristics in Urethane Anesthetized Mice. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0070411"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0006-8993(02)02617-3","article-title":"Alteration of cortical EEG in mice carrying mutated human APP transgene","volume":"943","author":"Wang","year":"2002","journal-title":"Brain Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jneumeth.2010.06.019","article-title":"Cross-correlation of instantaneous amplitudes of field potential oscillations: A straightforward method to estimate the directionality and lag between brain areas","volume":"191","author":"Adhikari","year":"2010","journal-title":"J. Neurosci. Methods"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.conb.2014.08.002","article-title":"Untangling cross-frequency coupling in neuroscience","volume":"31","author":"Aru","year":"2015","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.tins.2015.09.001","article-title":"Neural Cross-Frequency Coupling: Connecting Architectures, Mechanisms, and Functions","volume":"38","author":"Hyafil","year":"2015","journal-title":"Trends Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/cercor\/bhu232","article-title":"Slow-Theta-to-Gamma Phase-Amplitude Coupling in Human Hippocampus Supports the Formation of New Episodic Memories","volume":"26","author":"Lega","year":"2016","journal-title":"Cereb. Cortex"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1523\/JNEUROSCI.5171-13.2014","article-title":"Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer\u2019s Disease","volume":"34","author":"Born","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e1601068","DOI":"10.1126\/sciadv.1601068","article-title":"Differential contribution of APP metabolites to early cognitive deficits in a TgCRND8 mouse model of Alzheimer\u2019s disease","volume":"3","author":"Hamm","year":"2017","journal-title":"Sci. Adv."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3389\/fncel.2018.00121","article-title":"Alzheimer\u2019s Transgenic Model Is Characterized by Very Early Brain Network Alterations and \u03b2-CTF Fragment Accumulation: Reversal by \u03b2-Secretase Inhibition","volume":"12","author":"Gu","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.expneurol.2014.12.008","article-title":"Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of A\u03b2PP metabolites in the Tg2576 mouse model of Alzheimer\u2019s disease","volume":"264","author":"Xu","year":"2015","journal-title":"Exp. Neurol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Brendel, M., Jaworska, A., Grie\u00dfinger, E., R\u00f6tzer, C., Burgold, S., Gildehaus, F.-J., Carlsen, J., Cumming, P., Baumann, K., and Haass, C. (2015). Cross-Sectional Comparison of Small Animal [18F]-Florbetaben Amyloid-PET between Transgenic AD Mouse Models. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0116678"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.nbd.2009.09.004","article-title":"Phosphorylation of Tau at S422 is enhanced by A\u03b2 in TauPS2APP triple transgenic mice","volume":"37","author":"Grueninger","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/nn.4035","article-title":"\u03b2-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation","volume":"18","author":"Mander","year":"2015","journal-title":"Nat. Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.cell.2019.08.040","article-title":"Competing Roles of Slow Oscillations and Delta Waves in Memory Consolidation versus Forgetting","volume":"179","author":"Kim","year":"2019","journal-title":"Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.neuron.2017.11.020","article-title":"Old Brains Come Uncoupled in Sleep: Slow Wave-Spindle Synchrony, Brain Atrophy, and Forgetting","volume":"97","author":"Helfrich","year":"2018","journal-title":"Neuron"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"18453","DOI":"10.1073\/pnas.1112378108","article-title":"Astrocytic regulation of cortical UP states","volume":"108","author":"Poskanzer","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.neuron.2004.08.011","article-title":"Neuronal Synchrony Mediated by Astrocytic Glutamate through Activation of Extrasynaptic NMDA Receptors","volume":"43","author":"Fellin","year":"2004","journal-title":"Neuron"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"15037","DOI":"10.1073\/pnas.0906419106","article-title":"Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo","volume":"106","author":"Fellin","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.neuron.2008.11.024","article-title":"Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss","volume":"61","author":"Halassa","year":"2009","journal-title":"Neuron"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"E3343","DOI":"10.1073\/pnas.1410893111","article-title":"Astrocytes contribute to gamma oscillations and recognition memory","volume":"111","author":"Lee","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.neuron.2016.09.031","article-title":"Peri-Synaptic Glia Recycles Brain-Derived Neurotrophic Factor for LTP Stabilization and Memory Retention","volume":"92","author":"Vignoli","year":"2016","journal-title":"Neuron"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.biopsych.2009.08.024","article-title":"Amyloid Plaques Disrupt Resting State Default Mode Network Connectivity in Cognitively Normal Elderly","volume":"67","author":"Sheline","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/s41467-017-01150-x","article-title":"Earliest accumulation of \u03b2-amyloid occurs within the default-mode network and concurrently affects brain connectivity","volume":"8","author":"Palmqvist","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"6315","DOI":"10.1523\/JNEUROSCI.0503-19.2019","article-title":"Sleep as a Potential Biomarker of Tau and \u03b2-Amyloid Burden in the Human Brain","volume":"39","author":"Winer","year":"2019","journal-title":"J. Neurosci."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Pendin, D., Fasolato, C., Basso, E., Filadi, R., Greotti, E., Galla, L., Gomiero, C., Leparulo, A., Redolfi, N., and Scremin, E. (2019). Familial Alzheimer\u2019s disease presenilin-2 mutants affect Ca2+ homeostasis and brain network excitability. Aging Clin. Exp. Res., 1\u20134.","DOI":"10.1007\/s40520-019-01341-0"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1016\/j.celrep.2016.05.013","article-title":"Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2","volume":"15","author":"Filadi","year":"2016","journal-title":"Cell Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ceca.2019.02.005","article-title":"Familial Alzheimer\u2019s disease-linked presenilin mutants and intracellular Ca2+ handling: A single-organelle, FRET-based analysis","volume":"74","author":"Greotti","year":"2019","journal-title":"Cell Calcium"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e12924","DOI":"10.1111\/acel.12924","article-title":"Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer\u2019s disease neurons","volume":"18","author":"Theurey","year":"2019","journal-title":"Aging Cell"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1073\/pnas.1100735108","article-title":"Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk","volume":"108","author":"Zampese","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"7916","DOI":"10.1073\/pnas.1300677110","article-title":"Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer\u2019s disease and related models","volume":"110","author":"Hedskog","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1096\/fj.201700359","article-title":"Amyloid precursor protein & endosomal-lysosomal dysfunction in Alzheimer\u2019s disease: Inseparable partners in a multifactorial disease","volume":"31","author":"Nixon","year":"2017","journal-title":"FASEB J."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nn.3306","article-title":"Layer-specific excitatory circuits differentially control recurrent network dynamics in the neocortex","volume":"16","author":"Beltramo","year":"2013","journal-title":"Nat. Neurosci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1093\/cercor\/bhq009","article-title":"Origin of Active States in Local Neocortical Networks during Slow Sleep Oscillation","volume":"20","author":"Chauvette","year":"2010","journal-title":"Cereb. Cortex"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/79848","article-title":"Cellular and network mechanisms of rhytmic recurrent activity in neocortex","volume":"3","author":"McCormick","year":"2000","journal-title":"Nat. Neurosci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"5442","DOI":"10.1523\/JNEUROSCI.3603-14.2015","article-title":"A distinct class of slow (~0.2\u20132 Hz) intrinsically bursting layer 5 pyramidal neurons determines UP\/DOWN state dynamics in the neocortex","volume":"35","author":"Lorincz","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.nbd.2013.11.014","article-title":"Disrupted cross-laminar cortical processing in \u03b2 amyloid pathology precedes cell death","volume":"63","author":"Lison","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.pneurobio.2009.06.004","article-title":"Assessing neuronal networks: Understanding Alzheimer\u2019s disease","volume":"89","author":"Bokde","year":"2009","journal-title":"Prog. Neurobiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/nn1788","article-title":"Phase-locking of hippocampal interneurons\u2019 membrane potential to neocortical up-down states","volume":"9","author":"Hahn","year":"2006","journal-title":"Nat. Neurosci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"14998","DOI":"10.1523\/JNEUROSCI.2339-11.2011","article-title":"Properties of slow oscillation during slow-wave sleep and anesthesia in cats","volume":"31","author":"Chauvette","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1162\/jocn.2009.21305","article-title":"Ketamine Modulates Theta and Gamma Oscillations","volume":"22","author":"Lazarewicz","year":"2009","journal-title":"J. Cogn. Neurosci."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/1\/54\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:45:25Z","timestamp":1760190325000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/1\/54"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,24]]},"references-count":80,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1]]}},"alternative-id":["cells9010054"],"URL":"https:\/\/doi.org\/10.3390\/cells9010054","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,24]]}}}