{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:11:38Z","timestamp":1790475098275,"version":"4.1.0"},"reference-count":62,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006827","name":"Florida Department of Health","doi-asserted-by":"publisher","award":["7ZK29"],"award-info":[{"award-number":["7ZK29"]}],"id":[{"id":"10.13039\/100006827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The Zika virus (ZIKV) is a mosquito-borne Flavivirus and can be transmitted through an infected mosquito bite or through human-to-human interaction by sexual activity, blood transfusion, breastfeeding, or perinatal exposure. After the 2015\u20132016 outbreak in Brazil, a strong link between ZIKV infection and microcephaly emerged. ZIKV specifically targets human neural progenitor cells, suggesting that proteins encoded by ZIKV bind and inactivate host cell proteins, leading to microcephaly. Here, we present a systematic annotation of interactions between human proteins and the seven non-structural ZIKV proteins corresponding to a Brazilian isolate. The interaction network was generated by combining tandem-affinity purification followed by mass spectrometry with yeast two-hybrid screens. We identified 150 human proteins, involved in distinct biological processes, as interactors to ZIKV non-structural proteins. Our interacting network is composed of proteins that have been previously associated with microcephaly in human genetic disorders and\/or animal models. Further, we show that the protein inhibitor of activated STAT1 (PIAS1) interacts with NS5 and modulates its stability. This study builds on previously published interacting networks of ZIKV and genes related to autosomal recessive primary microcephaly to generate a catalog of human cellular targets of ZIKV proteins implicated in processes related to microcephaly in humans. Collectively, these data can be used as a resource for future characterization of ZIKV infection biology and help create a basis for the discovery of drugs that may disrupt the interaction and reduce the health damage to the fetus.<\/jats:p>","DOI":"10.3390\/cells9010153","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T03:07:11Z","timestamp":1578539231000},"page":"153","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Network of Interactions between ZIKA Virus Non-Structural Proteins and Human Host Proteins"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5430-3507","authenticated-orcid":false,"given":"Volha A.","family":"Golubeva","sequence":"first","affiliation":[{"name":"Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1171-1030","authenticated-orcid":false,"given":"Thales C.","family":"Nepomuceno","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA"},{"name":"Divis\u00e3o de Pesquisa Cl\u00ednica, Instituto Nacional de C\u00e2ncer, Rio de Janeiro 20230-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"de Gregoriis","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Pesquisa Cl\u00ednica, Instituto Nacional de C\u00e2ncer, Rio de Janeiro 20230-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2882-3362","authenticated-orcid":false,"given":"Rafael D.","family":"Mesquita","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Qu\u00edmica, Federal University of Rio de Janeiro, Rio de Janeiro 21941-909, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueli","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sweta","family":"Dash","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA"},{"name":"Cancer Biology PhD Program, University of South Florida, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9107-1335","authenticated-orcid":false,"given":"Patr\u00edcia P.","family":"Garcez","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Science, Federal University of Rio de Janeiro, Rio de Janeiro 20230-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1115-8319","authenticated-orcid":false,"given":"Guilherme","family":"Suarez-Kurtz","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Pesquisa Cl\u00ednica, Instituto Nacional de C\u00e2ncer, Rio de Janeiro 20230-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Izumi","sequence":"additional","affiliation":[{"name":"Proteomics and Metabolomics Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Koomen","sequence":"additional","affiliation":[{"name":"Chemical Biology and Molecular Medicine Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7053-0053","authenticated-orcid":false,"given":"Marcelo A.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Pesquisa Cl\u00ednica, Instituto Nacional de C\u00e2ncer, Rio de Janeiro 20230-130, Brazil"},{"name":"Instituto Federal do Rio de Janeiro-IFRJ, Rio de Janeiro 20270-021, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8448-4801","authenticated-orcid":false,"given":"Alvaro N. A.","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"aaf8160","DOI":"10.1126\/science.aaf8160","article-title":"Assessing the global threat from zika virus","volume":"353","author":"Lessler","year":"2016","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"675","DOI":"10.2471\/BLT.16.171082","article-title":"Zika: The origin and spread of a mosquito-borne virus","volume":"94","author":"Kindhauser","year":"2016","journal-title":"Bull. 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