{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:10:33Z","timestamp":1790269833174,"version":"4.1.0"},"reference-count":100,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH103848"],"award-info":[{"award-number":["R01MH103848"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS073899"],"award-info":[{"award-number":["R01NS073899"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Tau dysfunction is common in several neurodegenerative diseases including Alzheimer\u2019s disease (AD) and frontotemporal dementia (FTD). Affective symptoms have often been associated with aberrant tau pathology and are commonly comorbid in patients with tauopathies, indicating a connection between tau functioning and mechanisms of depression. The current study investigated depression-like behavior in Mapt\u2212\/\u2212 mice, which contain a targeted deletion of the gene coding for tau. We show that 6-month Mapt\u2212\/\u2212 mice are resistant to depressive behaviors, as evidenced by decreased immobility time in the forced swim and tail suspension tests, as well as increased escape behavior in a learned helplessness task. Since depression has also been linked to deficient adult neurogenesis, we measured neurogenesis in the hippocampal dentate gyrus and subventricular zone using 5-bromo-2-deoxyuridine (BrdU) labeling. We found that neurogenesis is increased in the dentate gyrus of 14-month-old Mapt\u2212\/\u2212 brains compared to wild type, providing a potential mechanism for their behavioral phenotypes. In addition to the hippocampus, an upregulation of proteins involved in neurogenesis was observed in the frontal cortex and amygdala of the Mapt\u2212\/\u2212 mice using proteomic mass spectrometry. All together, these findings suggest that tau may have a role in the depressive symptoms observed in many neurodegenerative diseases and identify tau as a potential molecular target for treating depression.<\/jats:p>","DOI":"10.3390\/cells9010210","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T11:50:28Z","timestamp":1579089028000},"page":"210","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Hippocampal Neurogenesis Is Enhanced in Adult Tau Deficient Mice"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8307-0183","authenticated-orcid":false,"given":"Marangelie","family":"Criado-Marrero","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, USF Health Byrd Institute, University of South Florida, Tampa, FL 33613, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan J.","family":"Sabbagh","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, USF Health Byrd Institute, University of South Florida, Tampa, FL 33613, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0540-6312","authenticated-orcid":false,"given":"Margaret R.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, USF Health Byrd Institute, University of South Florida, Tampa, FL 33613, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale","family":"Chaput","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad A.","family":"Dickey","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, USF Health Byrd Institute, University of South Florida, Tampa, FL 33613, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4981-5564","authenticated-orcid":false,"given":"Laura J.","family":"Blair","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, USF Health Byrd Institute, University of South Florida, Tampa, FL 33613, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0197-4580(95)00021-6","article-title":"Staging of Alzheimer\u2019s Disease-Related Neurofibrillary Changes","volume":"16","author":"Braak","year":"1995","journal-title":"Neurobiol. 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