{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:20:33Z","timestamp":1794000033148,"version":"4.8.0"},"reference-count":350,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:00:00Z","timestamp":1579046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH 2 T32 HL120822"],"award-info":[{"award-number":["NIH 2 T32 HL120822"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH R01 NS091242"],"award-info":[{"award-number":["NIH R01 NS091242"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH R42 NS105238"],"award-info":[{"award-number":["NIH R42 NS105238"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["AHA 19SFRN34830008"],"award-info":[{"award-number":["AHA 19SFRN34830008"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["AHA 19POST34380705"],"award-info":[{"award-number":["AHA 19POST34380705"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The current standard of care for acute myocardial infarction or \u2018heart attack\u2019 is timely restoration of blood flow to the ischemic region of the heart. While reperfusion is essential for the salvage of ischemic myocardium, re-introduction of blood flow paradoxically kills (rather than rescues) a population of previously ischemic cardiomyocytes\u2014a phenomenon referred to as \u2018lethal myocardial ischemia-reperfusion (IR) injury\u2019. There is long-standing and exhaustive evidence that mitochondria are at the nexus of lethal IR injury. However, during the past decade, the paradigm of mitochondria as mediators of IR-induced cardiomyocyte death has been expanded to include the highly orchestrated process of mitochondrial quality control. Our aims in this review are to: (1) briefly summarize the current understanding of the pathogenesis of IR injury, and (2) incorporating landmark data from a broad spectrum of models (including immortalized cells, primary cardiomyocytes and intact hearts), provide a critical discussion of the emerging concept that mitochondrial dynamics and mitophagy (the components of mitochondrial quality control) may contribute to the pathogenesis of cardiomyocyte death in the setting of ischemia-reperfusion.<\/jats:p>","DOI":"10.3390\/cells9010214","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T04:14:41Z","timestamp":1579234481000},"page":"214","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Mitochondrial Quality Control: Role in Cardiac Models of Lethal Ischemia-Reperfusion Injury"],"prefix":"10.3390","volume":"9","author":[{"given":"Andrew R.","family":"Kulek","sequence":"first","affiliation":[{"name":"Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA"},{"name":"Department of Biochemistry, Microbiology and Immunology, Wayne State University School of Medicine, Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Anzell","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA"},{"name":"Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA"},{"name":"Departments of Emergency Medicine and Molecular &amp; Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2859-4846","authenticated-orcid":false,"given":"Joseph M.","family":"Wider","sequence":"additional","affiliation":[{"name":"Departments of Emergency Medicine and Molecular &amp; Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Sanderson","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA"},{"name":"Departments of Emergency Medicine and Molecular &amp; Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9602-6349","authenticated-orcid":false,"given":"Karin","family":"Przyklenk","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA"},{"name":"Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA"},{"name":"Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1056\/NEJMra1606915","article-title":"Acute Myocardial Infarction","volume":"376","author":"Anderson","year":"2017","journal-title":"N. 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