{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:54:43Z","timestamp":1790459683663,"version":"4.1.0"},"reference-count":113,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Autoimmune rheumatic diseases (ARDs), affecting ~1\u20131.5% of all humans, are associated with considerable life long morbidity and early mortality. Early studies in the 1990s showed numerical changes of the recently discovered \u03b3\u03b4 T cells in the peripheral blood and in affected tissues of patients with a variety of ARDs, kindling interest in their role in the immuno-pathogenesis of these chronic inflammatory conditions. Indeed, later studies applied rapid developments in the understanding of \u03b3\u03b4 T cell biology, including antigens recognized by \u03b3\u03b4 T cells, their developmental programs, states of activation, and cytokine production profiles, to analyze their contribution to the pathological immune response in these disorders. Here we review the published studies addressing the role of \u03b3\u03b4 T in the major autoimmune rheumatic diseases, including rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, systemic lupus erythematosus and scleroderma, and animal models thereof. Due to their unique properties spanning adaptive and innate immune functions, the ever deeper understanding of this unique T cell population is shedding new light on the pathogenesis of, while potentially enabling new therapeutic approaches to, these diseases.<\/jats:p>","DOI":"10.3390\/cells9020462","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T04:21:26Z","timestamp":1582604486000},"page":"462","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["The Role of Gamma Delta T Cells in Autoimmune Rheumatic Diseases"],"prefix":"10.3390","volume":"9","author":[{"given":"Ilan","family":"Bank","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Autoimmunity Center, Sheba Medical Center, Tel-Hashomer 52621, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1600-065X.1984.tb01108.x","article-title":"The murine T cell antigen receptor and associated structures","volume":"81","author":"Allison","year":"1984","journal-title":"Immunol. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/0092-8674(83)90528-7","article-title":"The human T cell receptor: Appearance in ontogeny and biochemical relationship of alpha and beta subunits on IL-2 dependent clones and T cell tumors","volume":"34","author":"Acuto","year":"1983","journal-title":"Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/312036a0","article-title":"A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes","volume":"312","author":"Saito","year":"1984","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/322179a0","article-title":"A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes","volume":"322","author":"Bank","year":"1986","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/322145a0","article-title":"Identification of a putative second T-cell receptor","volume":"322","author":"Brenner","year":"1986","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/327677a0","article-title":"A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation","volume":"327","author":"Chien","year":"1987","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.semcdb.2017.10.009","article-title":"gammadelta T cell responses: How many ligands will it take till we know?","volume":"84","author":"Vermijlen","year":"2018","journal-title":"Semin Cell Dev. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1043.e5","DOI":"10.1016\/j.immuni.2019.02.016","article-title":"A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V\u03b39V\u03b42 T Cell Activation","volume":"50","author":"Yang","year":"2019","journal-title":"Immunity"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1038\/s41590-018-0253-5","article-title":"The \u03b3\u03b4TCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness","volume":"19","author":"Melandri","year":"2018","journal-title":"Nat. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cellimm.2015.04.008","article-title":"Human gamma delta T cells: Evolution and ligand recognition","volume":"296","author":"Adams","year":"2015","journal-title":"Cell Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"311","DOI":"10.4049\/jimmunol.1800934","article-title":"gammadelta T Cell Update: Adaptate Orchestrators of Immune Surveillance","volume":"203","author":"Hayday","year":"2019","journal-title":"J. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nri3384","article-title":"Six-of-the-best: Unique contributions of gammadelta T cells to immunology","volume":"13","author":"Vantourout","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jaut.2017.11.006","article-title":"Innately versatile: gammadelta17 T cells in inflammatory and autoimmune diseases","volume":"87","author":"Papotto","year":"2018","journal-title":"J. Autoimmun."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-immunol-032713-120216","article-title":"gammadelta T cells: First line of defense and beyond","volume":"32","author":"Chien","year":"2014","journal-title":"Annu Rev. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s12016-013-8391-x","article-title":"Quantitative peripheral blood perturbations of \u03b3\u03b4 T cells in human disease and their clinical implications","volume":"47","author":"Bank","year":"2014","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/s41568-019-0153-5","article-title":"gammadelta T cells: Pleiotropic immune effectors with therapeutic potential in cancer","volume":"19","author":"Mensurado","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"ref_17","first-page":"010409","article-title":"Prevalence of rheumatoid arthritis in low- and middle-income countries: A systematic review and analysis","volume":"5","author":"Rudan","year":"2015","journal-title":"J. Glob. Health"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s100670050089","article-title":"Distribution of double-negative (CD4- CD8-, DN) T subsets in blood and synovial fluid from patients with rheumatoid arthritis","volume":"18","author":"Liu","year":"1999","journal-title":"Clin. Rheumatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.clim.2015.07.012","article-title":"Natural killer cell and gamma delta T cell alterations in enthesitis related arthritis category of juvenile idiopathic arthritis","volume":"161","author":"Gaur","year":"2015","journal-title":"Clin. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF00332557","article-title":"Effect of gold therapy on CD5+ B-cells and TCR gamma delta+ T-cells in patients with rheumatoid arthritis","volume":"11","author":"Hassan","year":"1991","journal-title":"Rheumatol. Int."},{"key":"ref_21","first-page":"1869","article-title":"Increased HLA-DR and CD44 antigen expression in the gut: Evidence of extraarticular immunological activity in rheumatoid arthritis","volume":"26","author":"Abuzakouk","year":"1999","journal-title":"J. Rheumatol."},{"key":"ref_22","first-page":"371","article-title":"Frequency of gamma delta T cells in peripheral blood, synovial fluid, synovial membrane and lungs from patients with rheumatoid arthritis","volume":"46","author":"Mitogawa","year":"1992","journal-title":"Acta. Med. Okayama"},{"key":"ref_23","first-page":"175","article-title":"Coordinate expansion of \u2018fetal type\u2019 lymphocytes (TCR gamma delta+T and CD5+B) in rheumatoid arthritis and primary Sjogren\u2019s syndrome","volume":"77","author":"Brennan","year":"1989","journal-title":"Clin. Exp. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/cmi.2011.50","article-title":"Antigen-presenting effects of effector memory Vgamma9Vdelta2 T cells in rheumatoid arthritis","volume":"9","author":"Hu","year":"2012","journal-title":"Cell Mol. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s13075-018-1740-7","article-title":"Downregulation of miRNA17-92 cluster marks Vgamma9Vdelta2 T cells from patients with rheumatoid arthritis","volume":"20","author":"Guggino","year":"2018","journal-title":"Arthritis. Res. Ther."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/1756-185X.12292","article-title":"(99) Tc-methylene diphosphonate improves rheumatoid arthritis disease activity by increasing the frequency of peripheral gammadelta T cells and CD4(+) CD25(+) Foxp3(+) Tregs","volume":"19","author":"Su","year":"2016","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1136\/annrheumdis-2016-211069","article-title":"Chemotaxis of Vdelta2 T cells to the joints contributes to the pathogenesis of rheumatoid arthritis","volume":"76","author":"Mo","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1365-2249.1992.tb06935.x","article-title":"Analysis of T cell receptors in rheumatoid arthritis: The increased expression of HLA-DR antigen on circulating gamma delta+ T cells is correlated with disease activity","volume":"89","author":"Lamour","year":"1992","journal-title":"Clin. Exp. Immunol."},{"key":"ref_29","first-page":"1914","article-title":"Prevalence and Characteristics of Persistent Clonal T Cell Large Granular Lymphocyte Expansions in Rheumatoid Arthritis: A Comprehensive Analysis of 529 Patients","volume":"70","author":"Schwaneck","year":"2018","journal-title":"Okayama Rheumatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1309\/AJCPJSA1E1YWSZEY","article-title":"Clinicopathologic, Immunophenotypic, Cytogenetic, and Molecular Features of gammadelta T-Cell Large Granular Lymphocytic Leukemia: An Analysis of 14 Patients Suggests Biologic Differences With alphabeta T-Cell Large Granular Lymphocytic Leukemia. [corrected]","volume":"144","author":"Yabe","year":"2015","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.leukres.2007.04.011","article-title":"Clinical spectrum of gammadelta+ T cell LGL leukemia: Analysis of 20 cases","volume":"32","author":"Loughran","year":"2008","journal-title":"Leuk. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/BF00918143","article-title":"Increase in TCR gamma delta T lymphocytes in synovia from rheumatoid arthritis patients with active synovitis","volume":"12","author":"Jacobs","year":"1992","journal-title":"J. Clin. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0049-0172(92)90054-H","article-title":"Immunohistologic study of T-cell receptor delta-chain expression in rheumatoid synovial membranes","volume":"21","author":"Keillor","year":"1992","journal-title":"Semin. Arthritis Rheumatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1046\/j.1365-2567.2000.00017.x","article-title":"Decreased expression of FcgammaRIII (CD16) by gammadelta T cells in patients with rheumatoid arthritis","volume":"99","author":"Anand","year":"2000","journal-title":"Immunology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1002\/art.1780340705","article-title":"Selective expansion of T cells bearing the gamma\/delta receptor and expressing an unusual repertoire in the synovial membrane of patients with rheumatoid arthritis","volume":"34","author":"Andreu","year":"1991","journal-title":"Arthritis Rheumatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"6017","DOI":"10.4049\/jimmunol.152.12.6017","article-title":"High expression of V gamma 8 is a shared feature of human gamma delta T cells in the epithelium of the gut and in the inflamed synovial tissue","volume":"152","author":"Soderstrom","year":"1994","journal-title":"J. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1002\/eji.1830240517","article-title":"The biased V gamma gene usage in the synovial fluid of patients with rheumatoid arthritis","volume":"24","author":"Kageyama","year":"1994","journal-title":"Eur. J. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1365-2249.1992.tb02970.x","article-title":"Variable gene usage of T cell receptor gamma- and delta-chain transcripts expressed in synovia and peripheral blood of patients with rheumatoid arthritis","volume":"87","author":"Olive","year":"1992","journal-title":"Clin. Exp. Immunol."},{"key":"ref_39","first-page":"1143","article-title":"Analysis of T cell receptor gamma transcripts in right and left knee synovial fluids of patients with rheumatoid arthritis","volume":"23","author":"Doherty","year":"1996","journal-title":"J. Rheumatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1002\/eji.1830221018","article-title":"Evidence for oligoclonality of T cell receptor delta chain transcripts expressed in rheumatoid arthritis patients","volume":"22","author":"Olive","year":"1992","journal-title":"Eur. J. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1126\/science.aav3900","article-title":"A class of gammadelta T cell receptors recognize the underside of the antigen-presenting molecule MR1","volume":"366","author":"Gherardin","year":"2019","journal-title":"Science"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1002\/eji.1830240923","article-title":"Different cytokine production profiles of gamma delta T cell clones: Relation to inflammatory arthritis","volume":"24","author":"Chomarat","year":"1994","journal-title":"Eur. J. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/clin.1995.1024","article-title":"V gamma 9-V delta 2+ gamma delta T cells from a patient with Felty syndrome that exhibit aberrant response to triggering of the CD3 molecule can regulate immunoglobulin secretion by B cells","volume":"74","author":"Bank","year":"1995","journal-title":"Clin. Immunol. Immunopathol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.4049\/jimmunol.1003370","article-title":"Th17 cells, not IL-17+ gammadelta T cells, drive arthritic bone destruction in mice and humans","volume":"186","author":"Pollinger","year":"2011","journal-title":"J. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"8175","DOI":"10.1073\/pnas.91.17.8175","article-title":"Nonpeptide ligands for human gamma delta T cells","volume":"91","author":"Tanaka","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Laurent, A.J., Bindslev, N., Johansson, B., and Berg, L. (2014). Synergistic effects of ethanol and isopentenyl pyrophosphate on expansion of gammadelta T cells in synovial fluid from patients with arthritis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0103683"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/sj.cr.7290034","article-title":"Isolation and characteristics of autoreactive T cells specific to aggrecan G1 domain from rheumatoid arthritis patients","volume":"10","author":"Li","year":"2000","journal-title":"Cell Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1365-2249.1994.tb06067.x","article-title":"The cytotoxic analysis of T cell receptor V delta 1+ T cell lines derived from the synovial fluid of rheumatoid arthritis patients","volume":"97","author":"Ohta","year":"1994","journal-title":"Clin. Exp. Immunol."},{"key":"ref_49","first-page":"1403","article-title":"Proliferative response of synovial fluid mononuclear cells of patients with rheumatoid arthritis to mycobacterial 65 kDa heat shock protein and its association with HLA-DR+.gamma delta+ T cells","volume":"21","author":"Kogure","year":"1994","journal-title":"J. Rheumatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1172\/JCI115577","article-title":"Dual antigenic recognition by cloned human gamma delta T cells","volume":"89","author":"Holoshitz","year":"1992","journal-title":"J. Clin. Invest."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1136\/ard.61.5.438","article-title":"gammadelta T cell subsets in patients with arthritis and chronic neutropenia","volume":"61","author":"Bank","year":"2002","journal-title":"Ann. Rheum. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/art.1780390206","article-title":"Depletion of gamma\/delta T cells does not prevent or ameliorate, but rather aggravates, rat adjuvant arthritis","volume":"39","author":"Pelegri","year":"1996","journal-title":"Arthritis Rheumatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1002\/eji.1830201241","article-title":"Suppression and prevention of adjuvant arthritis in rats by a monoclonal antibody to the alpha\/beta T cell receptor","volume":"20","author":"Yoshino","year":"1990","journal-title":"Eur. J. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1046\/j.1365-2249.2000.01241.x","article-title":"CD8+ cells suppress oil-induced arthritis","volume":"120","author":"Jansson","year":"2000","journal-title":"Clin. Exp. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1016\/S0002-9440(10)65077-8","article-title":"The endogenous adjuvant squalene can induce a chronic T-cell-mediated arthritis in rats","volume":"156","author":"Carlson","year":"2000","journal-title":"Am. J. Pathol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1093\/intimm\/11.7.1065","article-title":"Collagen-induced arthritis development requires alpha beta T cells but not gamma delta T cells: Studies with T cell-deficient (TCR mutant) mice","volume":"11","author":"Corthay","year":"1999","journal-title":"Int. Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.4049\/jimmunol.157.11.5170","article-title":"Extrathymic differentiation of resident T cells in the joints of mice with collagen-induced arthritis","volume":"157","author":"Arai","year":"1996","journal-title":"J. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"5576","DOI":"10.4049\/jimmunol.179.8.5576","article-title":"Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells","volume":"179","author":"Roark","year":"2007","journal-title":"J. Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"R194","DOI":"10.1186\/ar2893","article-title":"Interleukin-23 is critical for full-blown expression of a non-autoimmune destructive arthritis and regulates interleukin-17A and RORgammat in gammadelta T cells","volume":"11","author":"Cornelissen","year":"2009","journal-title":"Arthritis. Res. Ther."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"37977","DOI":"10.1038\/srep37977","article-title":"Pharmacologic modulation of RORgammat translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis","volume":"6","author":"Xue","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1084\/jem.20140995","article-title":"IFN-lambda resolves inflammation via suppression of neutrophil infiltration and IL-1beta production","volume":"212","author":"Blazek","year":"2015","journal-title":"J. Exp. Med."},{"key":"ref_62","unstructured":"Harnett, M.M., Harnett, W., and Pineda, M.A. (2014). The parasitic worm product ES-62 up-regulates IL-22 production by gammadelta T cells in the murine model of Collagen-Induced Arthritis. Inflamm. Cell Signal., 1."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1002\/art.34581","article-title":"The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17-producing cellular network at multiple sites","volume":"64","author":"Pineda","year":"2012","journal-title":"Arthritis Rheumatol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"R212","DOI":"10.1186\/ar3545","article-title":"IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis","volume":"13","author":"Tao","year":"2011","journal-title":"Arthritis. Res. Ther."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1002\/art.24687","article-title":"Gamma\/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis","volume":"60","author":"Ito","year":"2009","journal-title":"Arthritis Rheumatol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1002\/art.40657","article-title":"Microbiota-Dependent Involvement of Th17 Cells in Murine Models of Inflammatory Arthritis","volume":"70","author":"Rogier","year":"2018","journal-title":"Arthritis. Rheumatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"7590","DOI":"10.1038\/s41598-018-25988-3","article-title":"gammadeltaTCR regulates production of interleukin-27 by neutrophils and attenuates inflammatory arthritis","volume":"8","author":"Bouchareychas","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"7464","DOI":"10.1038\/ncomms8464","article-title":"IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)Vgamma6(+)gammadelta T cells","volume":"6","author":"Akitsu","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3389\/fcimb.2017.00398","article-title":"Activation of iNKT Cells Prevents Salmonella-Enterocolitis and Salmonella-Induced Reactive Arthritis by Downregulating IL-17-Producing gammadeltaT Cells","volume":"7","author":"Sarnacki","year":"2017","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"E3669","DOI":"10.1073\/pnas.1405798111","article-title":"Mannan induces ROS-regulated, IL-17A-dependent psoriasis arthritis-like disease in mice","volume":"111","author":"Khmaladze","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_71","first-page":"1944","article-title":"Association of methotrexate treatment with a decrease of double negative (CD4-CD8-) and gamma\/delta T cell levels in patients with juvenile rheumatoid arthritis","volume":"20","author":"Massa","year":"1993","journal-title":"J. Rheumatol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/art.40731","article-title":"Innate Lymphoid Cells and T Cells Contribute to the Interleukin-17A Signature Detected in the Synovial Fluid of Patients With Juvenile Idiopathic Arthritis","volume":"71","author":"Rosser","year":"2019","journal-title":"Arthritis. Rheumatol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.clim.2009.09.010","article-title":"Distribution of circulating cells in systemic juvenile idiopathic arthritis across disease activity states","volume":"134","author":"Macaubas","year":"2010","journal-title":"Clin. Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/cyto.b.21597","article-title":"Low synovial double negative T and gammadelta T cells predict longer free-disease survival in oligoarticular JIA","volume":"94","author":"Licciardi","year":"2018","journal-title":"Cytometry B Clin. Cytom."},{"key":"ref_75","first-page":"202","article-title":"A high proportion of the V delta 1+ synovial fluid gamma delta T cells in juvenile rheumatoid arthritis patients express the very early activation marker CD69, but carry the high molecular weight isoform of the leucocyte common antigen (CD45RA)","volume":"91","author":"Quayle","year":"1993","journal-title":"Clin. Exp. Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.3899\/jrheum.100938","article-title":"GammadeltaT cells in juvenile idiopathic arthritis: Higher percentages of synovial Vdelta1+ and Vgamma9+ T cell subsets are associated with milder disease","volume":"38","author":"Berkun","year":"2011","journal-title":"J. Rheumatol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1002\/art.40099","article-title":"Proinflammatory Cytokine Environments Can Drive Interleukin-17 Overexpression by gamma\/delta T Cells in Systemic Juvenile Idiopathic Arthritis","volume":"69","author":"Kessel","year":"2017","journal-title":"Arthritis. Rheumatol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.4049\/jimmunol.1102403","article-title":"Cellular interactions of synovial fluid gammadelta T cells in juvenile idiopathic arthritis","volume":"188","author":"Bendersky","year":"2012","journal-title":"J. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1002\/art.38359","article-title":"Systemic juvenile idiopathic arthritis-like syndrome in mice following stimulation of the immune system with Freund\u2019s complete adjuvant: Regulation by interferon-gamma","volume":"66","author":"Avau","year":"2014","journal-title":"Arthritis. Rheumatol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/art.33507","article-title":"Enrichment of circulating interleukin-17-secreting interleukin-23 receptor-positive gamma\/delta T cells in patients with active ankylosing spondylitis","volume":"64","author":"Kenna","year":"2012","journal-title":"Arthritis Rheum."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41467-018-07911-6","article-title":"RORgammat inhibition selectively targets IL-17 producing iNKT and gammadelta-T cells enriched in Spondyloarthritis patients","volume":"10","author":"Venken","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1038\/s41467-017-01771-2","article-title":"Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis","volume":"8","author":"Chen","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.3389\/fimmu.2018.01610","article-title":"Increased IL-22- and IL-17A-Producing Mucosal-Associated Invariant T Cells in the Peripheral Blood of Patients With Ankylosing Spondylitis","volume":"9","author":"Toussirot","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.3899\/jrheum.160425","article-title":"Gamma Delta T Cell Subset V Gamma 2+ Expansion Associated with Longterm Infliximab Treatment in a Patient with Ankylosing Spondylitis","volume":"43","author":"Gracey","year":"2016","journal-title":"J. Rheumatol."},{"key":"ref_85","first-page":"187","article-title":"Synovial fluid MHC-unrestricted gamma delta-T lymphocytes contribute to antibacterial and anti-self cytotoxicity in the spondylarthropathies","volume":"13","author":"Hermann","year":"1995","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1002\/art.39732","article-title":"Interleukin-23-Dependent gamma\/delta T Cells Produce Interleukin-17 and Accumulate in the Enthesis, Aortic Valve, and Ciliary Body in Mice","volume":"68","author":"Reinhardt","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1365-3083.2012.02705.x","article-title":"Downregulation of CD94\/NKG2A inhibitory receptor on decreased gammadelta T cells in patients with systemic lupus erythematosus","volume":"76","author":"Wang","year":"2012","journal-title":"Scand. J. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Ma, H., Yuan, Y., Zhao, L., Ye, Z., Xu, J., Li, M., Jiang, Z., and Jiang, Y. (2016). Association of gammadelta T Cell Compartment Size to Disease Activity and Response to Therapy in SLE. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0157772"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"6693","DOI":"10.4049\/jimmunol.1002776","article-title":"Generation of human regulatory gammadelta T cells by TCRgammadelta stimulation in the presence of TGF-beta and their involvement in the pathogenesis of systemic lupus erythematosus","volume":"186","author":"Li","year":"2011","journal-title":"J. Immunol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/09629350124724","article-title":"Lymphocyctes Tgammadelta in clinically normal skin and peripheral blood of patients with systemic lupus erythematosus and their correlation with disease activity","volume":"10","author":"Robak","year":"2001","journal-title":"Mediators. Inflamm."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1136\/ard.54.1.69","article-title":"Natural killer cells and gamma delta T cells in scleroderma: Relationship to disease duration and anti-Scl-70 antibodies","volume":"54","author":"Holcombe","year":"1995","journal-title":"Ann. Rheum. Dis."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"7020","DOI":"10.1073\/pnas.87.18.7020","article-title":"Pathogenic anti-DNA autoantibody-inducing T helper cell lines from patients with active lupus nephritis: Isolation of CD4-8- T helper cell lines that express the gamma delta T-cell antigen receptor","volume":"87","author":"Rajagopalan","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Samuelson, E.M., Laird, R.M., Papillion, A.M., Tatum, A.H., Princiotta, M.F., and Hayes, S.M. (2014). Reduced B lymphoid kinase (Blk) expression enhances proinflammatory cytokine production and induces nephrosis in C57BL\/6-lpr\/lpr mice. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0092054"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Page, N., Schall, N., Strub, J.M., Quinternet, M., Chaloin, O., Decossas, M., Cung, M.T., Van Dorsselaer, A., Briand, J.P., and Muller, S. (2009). The spliceosomal phosphopeptide P140 controls the lupus disease by interacting with the HSC70 protein and via a mechanism mediated by gammadelta T cells. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0005273"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/1529-0131(199802)41:2<327::AID-ART17>3.0.CO;2-S","article-title":"Circulating Vdelta1+ T cells are activated and accumulate in the skin of systemic sclerosis patients","volume":"41","author":"Giacomelli","year":"1998","journal-title":"Arthritis Rheumatol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1002\/art.1780371021","article-title":"Characteristics of HPRT-mutant T cell lines in a lupus patient treated with cyclophosphamide","volume":"37","author":"Wood","year":"1994","journal-title":"Arthritis Rheumatol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"5689","DOI":"10.4049\/jimmunol.157.12.5689","article-title":"Propagation and regulation of systemic autoimmunity by gammadelta T cells","volume":"157","author":"Peng","year":"1996","journal-title":"J. Immunol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.intimp.2016.05.004","article-title":"CD4(+)B220(+)TCRgammadelta(+) T cells produce IL-17 in lupus-prone MRL\/lpr mice","volume":"38","author":"Qiu","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1177\/0961203311428459","article-title":"Disparate effects of depletion of CD1d-reactive T cells during early versus late stages of disease in a genetically susceptible model of lupus","volume":"21","author":"Jacinto","year":"2012","journal-title":"Lupus"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1038\/s41467-018-05487-9","article-title":"gammadelta T cells control humoral immune response by inducing T follicular helper cell differentiation","volume":"9","author":"Rezende","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1681\/ASN.2015101077","article-title":"IL-17F Promotes Tissue Injury in Autoimmune Kidney Diseases","volume":"27","author":"Riedel","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_102","first-page":"283","article-title":"Reduced circulating natural killer T cells and gamma\/delta T cells in patients with systemic sclerosis","volume":"32","author":"Riccieri","year":"2005","journal-title":"J. Rheumatol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.imbio.2009.05.012","article-title":"Vgamma9+ gammadelta T cells in systemic sclerosis patients are numerically and functionally preserved and induce fibroblast apoptosis","volume":"215","author":"Bendersky","year":"2010","journal-title":"Immunobiology"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1093\/rheumatology\/keu246","article-title":"Involvement of CD161+ Vdelta1+ gammadelta T cells in systemic sclerosis: Association with interstitial pneumonia","volume":"53","author":"Segawa","year":"2014","journal-title":"Rheumatology"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jdermsci.2012.10.003","article-title":"Circulating gamma\/delta T cells in systemic sclerosis exhibit activated phenotype and enhance gene expression of proalpha2(I) collagen of fibroblasts","volume":"69","author":"Hasegawa","year":"2013","journal-title":"J. Dermatol. Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s00011-016-0982-6","article-title":"Subset-specific alterations in frequencies and functional signatures of gammadelta T cells in systemic sclerosis patients","volume":"65","author":"Henriques","year":"2016","journal-title":"Inflamm. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1006\/clim.1999.4694","article-title":"Gammadelta receptor bearing T cells in scleroderma: Enhanced interaction with vascular endothelial cells in vitro","volume":"91","author":"Kahaleh","year":"1999","journal-title":"Clin. Immunol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"881","DOI":"10.4049\/jimmunol.153.2.881","article-title":"Expansion of selected V delta 1+ gamma delta T cells in systemic sclerosis patients","volume":"153","author":"Yurovsky","year":"1994","journal-title":"J. Immunol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3389\/fimmu.2018.00753","article-title":"Dysregulated CD25 and Cytokine Expression by gammadelta T Cells of Systemic Sclerosis Patients Stimulated With Cardiolipin and Zoledronate","volume":"9","author":"Fisch","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_110","first-page":"414","article-title":"A Novel Prothrombotic Pathway in Systemic Sclerosis Patients: Possible Role of Bisphosphonate-Activated gammadelta T Cells","volume":"5","author":"Dardik","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_111","first-page":"23","article-title":"Anti-fibrotic characteristics of Vgamma9+ gammadelta T cells in systemic sclerosis","volume":"34","author":"Markovits","year":"2016","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1365-2249.2006.03216.x","article-title":"Pamidronate infusion in patients with systemic sclerosis results in changes in blood mononuclear cell cytokine profiles","volume":"146","author":"Carbone","year":"2006","journal-title":"Clin. Exp. Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Bank, I. (2016). The Role of gammadelta T Cells in Fibrotic Diseases. Rambam Maimonides Med. J., 7.","DOI":"10.5041\/RMMJ.10256"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/2\/462\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:58:45Z","timestamp":1760173125000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/2\/462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,18]]},"references-count":113,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2]]}},"alternative-id":["cells9020462"],"URL":"https:\/\/doi.org\/10.3390\/cells9020462","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,18]]}}}