{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T23:21:22Z","timestamp":1792279282811,"version":"4.4.0"},"reference-count":127,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The insufficient and unspecific target of traditional therapeutic approaches in cancer treatment often leads to therapy resistance and cancer recurrence. Over the past decades, accumulating discoveries about stem cell biology have provided new potential approaches to cure cancer patients. Stem cells possess unique biological actions, including self-renewal, directional migration, differentiation, and modulatory effects on other cells, which can be utilized as regenerative medicine, therapeutic carriers, drug targeting, and generation of immune cells. In this review, we emphasize the mechanisms underlying the use of various types of stem cells in cancer treatment. In addition, we summarize recent progress in the clinical applications of stem cells, as well as common risks of this therapy. We finally give general directions for future studies, aiming to improve overall outcomes in the fight against cancer.<\/jats:p>","DOI":"10.3390\/cells9030563","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T07:35:30Z","timestamp":1583134530000},"page":"563","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":205,"title":["Recent Progress of Stem Cell Therapy in Cancer Treatment: Molecular Mechanisms and Potential Applications"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4596-2022","authenticated-orcid":false,"given":"Dinh-Toi","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Human and Animal Physiology, Faculty of Biology, Hanoi National University of Education, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiep Tien","family":"Nguyen","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yeungnam University, 280 Daehak-ro, Gyeongsan-si, Gyeongbuk-do 38541, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Le Bao","family":"Tien","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics and Trauma Surgery, Viet Duc Hospital, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8363-0918","authenticated-orcid":false,"given":"Dang-Khoa","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of Medicine Pham Ngoc Thach, Ho Chi Minh City 700000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7120-169X","authenticated-orcid":false,"given":"Jee-Heon","family":"Jeong","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yeungnam University, 280 Daehak-ro, Gyeongsan-si, Gyeongbuk-do 38541, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pham Gia","family":"Anh","sequence":"additional","affiliation":[{"name":"Oncology Department, Viet Duc Hospital, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vo Van","family":"Thanh","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics and Trauma Surgery, Viet Duc Hospital, Hanoi 100000, Vietnam"},{"name":"Department of Surgery, Hanoi Medical University, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8587-0440","authenticated-orcid":false,"given":"Dang Tien","family":"Truong","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Vietnam Military Medical University, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thien Chu","family":"Dinh","sequence":"additional","affiliation":[{"name":"Institute for Research and Development, Duy Tan University, Danang 550000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21332","article-title":"Cancer statistics, 2016","volume":"66","author":"Siegel","year":"2016","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1021\/mp1004228","article-title":"The Suppressive Tumor Microenvironment: A Challenge in Cancer Immunotherapy","volume":"8","author":"Vasievich","year":"2011","journal-title":"Mol. Pharm."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nrc3237","article-title":"Combining immunotherapy and targeted therapies in cancer treatment","volume":"12","author":"Vanneman","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1158\/2326-6066.CIR-18-0487","article-title":"The Balancing Act between Cancer Immunity and Autoimmunity in Response to Immunotherapy","volume":"6","author":"Young","year":"2018","journal-title":"Cancer Immunol. Res."},{"key":"ref_5","first-page":"4747","article-title":"Deepening a Simple Question: Can MSCs Be Used to Treat Cancer?","volume":"37","author":"Gomes","year":"2017","journal-title":"Anticancer Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"274","DOI":"10.5966\/sctm.2012-0084","article-title":"Clinical-Scale Derivation of Natural Killer Cells From Human Pluripotent Stem Cells for Cancer Therapy","volume":"2","author":"Knorr","year":"2013","journal-title":"Stem Cells Transl. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.stem.2018.06.002","article-title":"Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity","volume":"23","author":"Li","year":"2018","journal-title":"Cell Stem Cell"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s40259-017-0247-0","article-title":"Next-Generation Chimeric Antigen Receptor T-Cell Therapy: Going off the Shelf","volume":"31","author":"Ruella","year":"2017","journal-title":"BioDrugs"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6879","DOI":"10.4049\/jimmunol.0803670","article-title":"Generation of T Cells from Human Embryonic Stem Cell-Derived Hematopoietic Zones","volume":"182","author":"Timmermans","year":"2009","journal-title":"J. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.stem.2018.01.016","article-title":"Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo","volume":"22","author":"Kooreman","year":"2018","journal-title":"Cell Stem Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.3389\/fimmu.2019.01510","article-title":"Induced Pluripotent Stem Cell-Based Cancer Vaccines","volume":"10","author":"Ouyang","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1056\/NEJMra052638","article-title":"Hematopoietic Stem-Cell Transplantation","volume":"354","author":"Copelan","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1186\/s13287-018-1078-8","article-title":"Mesenchymal stem cells in preclinical cancer cytotherapy: A systematic review","volume":"9","author":"Christodoulou","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2820853-12","DOI":"10.1155\/2019\/2820853","article-title":"Mesenchymal Stem Cells and Cancer: Clinical Challenges and Opportunities","volume":"2019","author":"Lin","year":"2019","journal-title":"BioMed Res. Int."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1002\/stem.2109","article-title":"Neural Stem Cells Secreting Anti-HER2 Antibody Improve Survival in a Preclinical Model of HER2 Overexpressing Breast Cancer Brain Metastases","volume":"33","author":"Kanojia","year":"2015","journal-title":"Stem Cells"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.canlet.2013.01.048","article-title":"Cytosine deaminase-expressing human neural stem cells inhibit tumor growth in prostate cancer-bearing mice","volume":"335","author":"Lee","year":"2013","journal-title":"Cancer Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"12835","DOI":"10.18632\/oncotarget.2547","article-title":"Co-treatment with therapeutic neural stem cells expressing carboxyl esterase and CPT-11 inhibit growth of primary and metastatic lung cancers in mice","volume":"5","author":"Yi","year":"2014","journal-title":"Oncotarget"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Chang, J.C. (2016). Cancer stem cells: Role in tumor growth, recurrence, metastasis, and treatment resistance. Medicine, 95.","DOI":"10.1097\/MD.0000000000004766"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1196\/annals.1349.011","article-title":"The Role of Sphingosine 1-Phosphate Receptors in the Trafficking of Hematopoietic Progenitor Cells","volume":"1044","author":"Seitz","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1749-6632.2009.04609.x","article-title":"Novel trafficking routes for hematopoietic stem and progenitor cells","volume":"1176","author":"Massberg","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1182\/blood-2011-04-348904","article-title":"Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice","volume":"119","author":"Juarez","year":"2012","journal-title":"Blood"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1182\/blood-2006-01-035634","article-title":"The extracellular nucleotide UTP is a potent inducer of hematopoietic stem cell migration","volume":"109","author":"Rossi","year":"2006","journal-title":"Blood"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nature04247","article-title":"Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor","volume":"439","author":"Adams","year":"2005","journal-title":"Nature"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1016\/j.cellsig.2013.07.022","article-title":"Regulation of inflammation by extracellular acidification and proton-sensing GPCRs","volume":"25","author":"Okajima","year":"2013","journal-title":"Cell. Signal."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1182\/blood-2005-04-1417","article-title":"How do stem cells find their way home?","volume":"106","author":"Lapidot","year":"2005","journal-title":"Blood"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1002\/stem.81","article-title":"Trafficking mesenchymal stem cell engraftment and differentiation in tumor-bearing mice by bioluminescence imaging","volume":"27","author":"Wang","year":"2009","journal-title":"Stem Cells"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nrd4253","article-title":"Tackling the cancer stem cells\u2014What challenges do they pose?","volume":"13","author":"Pattabiraman","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1056\/NEJM198612253152606","article-title":"Tumors: Wounds That Do Not Heal","volume":"315","author":"Flier","year":"1986","journal-title":"N. Engl. J. Med."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Jiang, Y., Wells, A., Sylakowski, K., Clark, A., and Ma, B. (2019). Adult Stem Cell Functioning in the Tumor Micro-Environment. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20102566"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1756-8722-7-14","article-title":"The roles of mesenchymal stem cells in tumor inflammatory microenvironment","volume":"7","author":"Sun","year":"2014","journal-title":"J. Hematol. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1038\/ncomms2766","article-title":"Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis","volume":"4","author":"Jung","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1016\/j.yexcr.2010.07.002","article-title":"Interleukin 6 mediated recruitment of mesenchymal stem cells to the hypoxic tumor milieu","volume":"316","author":"Rattigan","year":"2010","journal-title":"Exp. Cell Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.canlet.2009.02.022","article-title":"Human mesenchymal stem cells (hMSCs) target osteosarcoma and promote its growth and pulmonary metastasis","volume":"281","author":"Xu","year":"2009","journal-title":"Cancer Lett."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/stem.787","article-title":"Bone Marrow-Derived Mesenchymal Stromal Cells are Attracted by Multiple Myeloma Cell-Produced Chemokine CCL25 and Favor Myeloma Cell Growth in Vitro and In Vivo","volume":"30","author":"Xu","year":"2012","journal-title":"Stem Cells"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/scrt492","article-title":"TNF\u03b1 and IL-1\u03b2 influence the differentiation and migration of murine MSCs independently of the NF-\u03baB pathway","volume":"5","author":"Sullivan","year":"2014","journal-title":"Stem Cell Res. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1158\/0008-5472.CAN-12-0088","article-title":"NF-\u03baB Activity Regulates Mesenchymal Stem Cell Accumulation at Tumor Sites","volume":"73","author":"Uchibori","year":"2012","journal-title":"Cancer Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.2147\/IJN.S200036","article-title":"Mesenchymal stem cell exosomes: A two-edged sword in cancer therapy","volume":"14","author":"Vakhshiteh","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1002\/jcb.23250","article-title":"Therapeutic factors secreted by mesenchymal stromal cells and tissue repair","volume":"112","author":"Lee","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.transci.2004.10.007","article-title":"Mobilization and collection of peripheral blood progenitor cells for transplantation","volume":"32","author":"Reddy","year":"2005","journal-title":"Transfus. Apher. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1097\/MD.0000000000004765","article-title":"Cancer stem cell signaling pathways","volume":"95","author":"Matsui","year":"2016","journal-title":"Medicine"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1056\/NEJMra061808","article-title":"Cancer stem cells","volume":"355","author":"Jordan","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1158\/1078-0432.CCR-09-2824","article-title":"Cancer Stem Cells and Self-renewal","volume":"16","author":"Kreso","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.semcancer.2014.06.004","article-title":"A role for cancer stem cells in therapy resistance: Cellular and molecular mechanisms","volume":"31","author":"Cojoc","year":"2015","journal-title":"Semin. Cancer Boil."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/nm.4409","article-title":"Cancer stem cells revisited","volume":"23","author":"Batlle","year":"2017","journal-title":"Nat. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/imm.12866","article-title":"Cancer stem cells as targets for immunotherapy","volume":"153","author":"Codd","year":"2017","journal-title":"Immunology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4252\/wjsc.v10.i12.183","article-title":"Cancer stem cell impact on clinical oncology","volume":"10","year":"2018","journal-title":"World J. Stem Cells"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1073\/pnas.0530291100","article-title":"Prospective identification of tumorigenic breast cancer cells","volume":"100","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1111\/j.1582-4934.2008.00455.x","article-title":"High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability","volume":"13","author":"Croker","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1200\/JCO.2009.23.3429","article-title":"Allogeneic Hematopoietic Stem-Cell Transplantation in Patients With Hematologic Malignancies After Dose-Escalated Treosulfan\/Fludarabine Conditioning","volume":"28","author":"Casper","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1365-2796.2007.01844.x","article-title":"Immunomodulation by mesenchymal stem cells and clinical experience","volume":"262","year":"2007","journal-title":"J. Intern. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cell.2007.08.025","article-title":"Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment","volume":"131","author":"Sacchetti","year":"2007","journal-title":"Cell"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nature09262","article-title":"Mesenchymal and haematopoietic stem cells form a unique bone marrow niche","volume":"466","author":"Michurina","year":"2010","journal-title":"Nature"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jcyt.2017.05.002","article-title":"Adipose tissue-derived mesenchymal stromal cells as part of therapy for chronic graft-versus-host disease: A phase I\/II study","volume":"19","author":"Jurado","year":"2017","journal-title":"Cytotherapy"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12185-015-1915-9","article-title":"Bone marrow-derived mesenchymal stem cells (JR-031) for steroid-refractory grade III or IV acute graft-versus-host disease: A phase II\/III study","volume":"103","author":"Muroi","year":"2015","journal-title":"Int. J. Hematol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1002\/stem.1638","article-title":"Bone marrow mesenchymal stromal cells to treat tissue damage in allogeneic stem cell transplant recipients: Correlation of biological markers with clinical responses","volume":"32","author":"Yin","year":"2014","journal-title":"Stem Cells"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.bbmt.2010.01.011","article-title":"Cotransplantation of Mesenchymal Stem Cells Might Prevent Death from Graft-versus-Host Disease (GVHD) without Abrogating Graft-versus-Tumor Effects after HLA-Mismatched Allogeneic Transplantation following Nonmyeloablative Conditioning","volume":"16","author":"Baron","year":"2010","journal-title":"Boil. Blood Marrow Transplant."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.bbmt.2009.11.006","article-title":"Efficacy of Bone Marrow-Derived Mesenchymal Stem Cells in the Treatment of Sclerodermatous Chronic Graft-versus-Host Disease: Clinical Report","volume":"16","author":"Zhou","year":"2010","journal-title":"Boil. Blood Marrow Transplant."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.jcyt.2016.09.003","article-title":"Genetically modified mesenchymal stromal cells in cancer therapy","volume":"18","author":"Sage","year":"2016","journal-title":"Cytotherapy"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s40495-016-0073-y","article-title":"Enzyme\/Prodrug Systems for Cancer Gene Therapy","volume":"2","author":"Malekshah","year":"2016","journal-title":"Curr. Pharmacol. Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/jgm.1239","article-title":"Cytosine deaminase expressing human mesenchymal stem cells mediated tumour regression in melanoma bearing mice","volume":"10","author":"Kucerova","year":"2008","journal-title":"J. Gene Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1002\/ijc.25383","article-title":"The growth of brain tumors can be suppressed by multiple transplantation of mesenchymal stem cells expressing cytosine deaminase","volume":"127","author":"Chang","year":"2010","journal-title":"Int. J. Cancer"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.omto.2016.11.004","article-title":"Optimization of a Neural Stem-Cell-Mediated Carboxylesterase\/Irinotecan Gene Therapy for Metastatic Neuroblastoma","volume":"4","author":"Gutova","year":"2016","journal-title":"Mol. Ther. Oncolytics"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"75319","DOI":"10.18632\/oncotarget.12173","article-title":"Tumor-specific gene therapy for pancreatic cancer using human neural stem cells encoding carboxylesterase","volume":"7","author":"Choi","year":"2016","journal-title":"Oncotarget"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Von Einem, J.C. (2019). Treatment of advanced gastrointestinal cancer with genetically modified autologous mesenchymal stem cells: Results from the Phase 1\/2 TREAT-ME-1 Trial. Int. J. Cancer.","DOI":"10.1002\/ijc.32230"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"80156","DOI":"10.18632\/oncotarget.20964","article-title":"Treatment of advanced gastrointestinal cancer with genetically modified autologous mesenchymal stem cells-TREAT-ME-1-a phase I, first in human, first in class trial","volume":"8","author":"Jobst","year":"2017","journal-title":"Oncotarget"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nn.3019","article-title":"Encapsulated therapeutic stem cells implanted in the tumor resection cavity induce cell death in gliomas","volume":"15","author":"Kauer","year":"2011","journal-title":"Nat. Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.scr.2013.09.010","article-title":"Selective antitumor effect of neural stem cells expressing cytosine deaminase and interferon-beta against ductal breast cancer cells in cellular and xenograft models","volume":"12","author":"Yi","year":"2014","journal-title":"Stem Cell Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5985","DOI":"10.18632\/oncotarget.6719","article-title":"Synergistic effect of therapeutic stem cells expressing cytosine deaminase and interferon-beta via apoptotic pathway in the metastatic mouse model of breast cancer","volume":"7","author":"Yi","year":"2015","journal-title":"Oncotarget"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/s41467-018-03705-y","article-title":"Progress and challenges towards targeted delivery of cancer therapeutics","volume":"9","author":"Rosenblum","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1039\/C6CS00636A","article-title":"Cellular uptake of nanoparticles: Journey inside the cell","volume":"46","author":"Behzadi","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"8393","DOI":"10.1016\/j.biomaterials.2010.07.048","article-title":"Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors","volume":"31","author":"Roger","year":"2010","journal-title":"Biomaterials"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1158\/1535-7163.MCT-17-0682","article-title":"Nano-Engineered Mesenchymal Stem Cells Increase Therapeutic Efficacy of Anticancer Drug Through True Active Tumor Targeting","volume":"17","author":"Layek","year":"2018","journal-title":"Mol. Cancer Ther."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.stem.2009.05.003","article-title":"Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6","volume":"5","author":"Lee","year":"2009","journal-title":"Cell Stem Cell"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.apsb.2018.08.006","article-title":"Efficient lung cancer-targeted drug delivery via a nanoparticle\/MSC system","volume":"9","author":"Wang","year":"2018","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Moku, G., Layek, B., Trautman, L., Putnam, S., Panyam, J., and Prabha, S. (2019). Improving Payload Capacity and Anti-Tumor Efficacy of Mesenchymal Stem Cells Using TAT Peptide Functionalized Polymeric Nanoparticles. Cancers, 11.","DOI":"10.3390\/cancers11040491"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1021\/nn901319y","article-title":"Nanoparticulate Cellular Patches for Cell-Mediated Tumoritropic Delivery","volume":"4","author":"Cheng","year":"2010","journal-title":"ACS Nano"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1021\/bc800345q","article-title":"Chemical Engineering of Mesenchymal Stem Cells to Induce a Cell Rolling Response","volume":"19","author":"Sarkar","year":"2008","journal-title":"Bioconjugate Chem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/nm.2198","article-title":"Therapeutic cell engineering with surface-conjugated synthetic nanoparticles","volume":"16","author":"Stephan","year":"2010","journal-title":"Nat. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.nantod.2011.04.001","article-title":"Enhancing cell therapies from the outside in: Cell surface engineering using synthetic nanomaterials","volume":"6","author":"Stephan","year":"2011","journal-title":"Nano Today"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1900043","DOI":"10.1002\/adtp.201900043","article-title":"Nanoengineering of Mesenchymal Stem Cells via Surface Modification for Efficient Cancer Therapy","volume":"2","author":"Layek","year":"2019","journal-title":"Adv. Ther."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1021\/acs.nanolett.8b04697","article-title":"Engineered Mesenchymal Stem Cell\/Nanomedicine Spheroid as an Active Drug Delivery Platform for Combinational Glioblastoma Therapy","volume":"19","author":"Suryaprakash","year":"2019","journal-title":"Nano Lett."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"866","DOI":"10.3389\/fimmu.2018.00866","article-title":"Oncolytic Viral Therapy and the Immune System: A Double-Edged Sword against Cancer","volume":"9","author":"Marelli","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"655","DOI":"10.5966\/sctm.2013-0039","article-title":"The timing of neural stem cell-based virotherapy is critical for optimal therapeutic efficacy when applied with radiation and chemotherapy for the treatment of glioblastoma","volume":"2","author":"Tobias","year":"2013","journal-title":"Stem Cells Transl. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.jhep.2013.07.010","article-title":"Systemically delivered measles virus-infected mesenchymal stem cells can evade host immunity to inhibit liver cancer growth","volume":"59","author":"Ong","year":"2013","journal-title":"J. Hepatol."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Duebgen, M., Martinez-Quintanilla, J., Tamura, K., Hingtgen, S., Redjal, N., Shah, K., and Wakimoto, H. (2014). Stem Cells Loaded With Multimechanistic Oncolytic Herpes Simplex Virus Variants for Brain Tumor Therapy. J. Natl. Cancer Inst., 106.","DOI":"10.1093\/jnci\/dju090"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1479-5876-11-20","article-title":"Optimizing patient derived mesenchymal stem cells as virus carriers for a Phase I clinical trial in ovarian cancer","volume":"11","author":"Mader","year":"2013","journal-title":"J. Transl. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.ebiom.2015.08.022","article-title":"Neural Stem Cell Carriers for the Treatment of Glioblastoma Multiforme","volume":"2","author":"Miska","year":"2015","journal-title":"EBioMedicine"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jconrel.2014.11.029","article-title":"Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins","volume":"205","author":"Fuhrmann","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.phrs.2016.07.006","article-title":"Modulation of tissue tropism and biological activity of exosomes and other extracellular vesicles: New nanotools for cancer treatment","volume":"111","author":"Kooijmans","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1021\/bc500291r","article-title":"Surface Functionalization of Exosomes Using Click Chemistry","volume":"25","author":"Smyth","year":"2014","journal-title":"Bioconjugate Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"27441","DOI":"10.1021\/acsami.7b06464","article-title":"Chemically Edited Exosomes with Dual Ligand Purified by Microfluidic Device for Active Targeted Drug Delivery to Tumor Cells","volume":"9","author":"Wang","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.canlet.2013.02.019","article-title":"Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth","volume":"335","author":"Katakowski","year":"2013","journal-title":"Cancer Lett."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13045-015-0220-7","article-title":"Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma","volume":"8","author":"Lou","year":"2015","journal-title":"J. Hematol. Oncol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"241.e1","DOI":"10.1016\/j.urology.2016.01.028","article-title":"PLK-1 Silencing in Bladder Cancer by siRNA Delivered With Exosomes","volume":"91","author":"Greco","year":"2016","journal-title":"Urology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jconrel.2014.07.042","article-title":"Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery","volume":"192","author":"Pascucci","year":"2014","journal-title":"J. Control. Release"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/hon.2306","article-title":"Paclitaxel-releasing mesenchymal stromal cells inhibit the growth of multiple myeloma cells in a dynamic 3D culture system","volume":"35","author":"Bonomi","year":"2016","journal-title":"Hematol. Oncol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/bjh.12196","article-title":"Mesenchymal stromal cells primed with P aclitaxel attract and kill leukaemia cells, inhibit angiogenesis and improve survival of leukaemia-bearing mice","volume":"160","author":"Pessina","year":"2013","journal-title":"Br. J. Haematol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"9376","DOI":"10.1038\/s41598-017-09175-4","article-title":"Drug Loaded Gingival Mesenchymal Stromal Cells (GinPa-MSCs) Inhibit In Vitro Proliferation of Oral Squamous Cell Carcinoma","volume":"7","author":"Farronato","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2174\/1389201019666180418095526","article-title":"CAR T-cell Therapy: A New Era in Cancer Immunotherapy","volume":"19","author":"Miliotou","year":"2018","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1182\/blood.V124.21.2437.2437","article-title":"Stem Cell Approach to Generate Chimeric Antigen Receptor Modified Immune Effector Cells to Treat Cancer","volume":"124","author":"Dolnikov","year":"2014","journal-title":"Blood"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/cas.13892","article-title":"Toward the development of true \u201coff-the-shelf\u201d synthetic T-cell immunotherapy","volume":"110","author":"Iriguchi","year":"2019","journal-title":"Cancer Sci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1182\/blood-2004-04-1293","article-title":"Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro","volume":"105","author":"Herer","year":"2005","journal-title":"Blood"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1089\/scd.2015.0394","article-title":"Fail-Safe Therapy by Gamma-Ray Irradiation Against Tumor Formation by Human-Induced Pluripotent Stem Cell-Derived Neural Progenitors","volume":"25","author":"Katsukawa","year":"2016","journal-title":"Stem Cells Dev."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/jrr\/rrw124","article-title":"Irradiation strongly reduces tumorigenesis of human induced pluripotent stem cells","volume":"58","author":"Inui","year":"2017","journal-title":"J. Radiat. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.7314\/APJCP.2012.13.9.4295","article-title":"Human embryonic stem cells\u2014A potential vaccine for ovarian cancer","volume":"13","author":"Zhang","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1007\/s00262-010-0899-9","article-title":"Administration of embryonic stem cells generates effective antitumor immunity in mice with minor and heavy tumor load","volume":"59","author":"Dong","year":"2010","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.cell.2018.03.034","article-title":"Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation","volume":"173","author":"Malta","year":"2018","journal-title":"Cell"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1002\/sctm.17-0138","article-title":"Concise Review: Cancer Cells, Cancer Stem Cells, and Mesenchymal Stem Cells: Influence in Cancer Development","volume":"6","author":"Papaccio","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"5331","DOI":"10.1158\/0008-5472.CAN-08-4630","article-title":"Long-term Cultures of Bone Marrow\u2013Derived Human Mesenchymal Stem Cells Frequently Undergo Spontaneous Malignant Transformation","volume":"69","author":"Svendsen","year":"2009","journal-title":"Cancer Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature06188","article-title":"Mesenchymal stem cells within tumour stroma promote breast cancer metastasis","volume":"449","author":"Karnoub","year":"2007","journal-title":"Nature"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1200\/JCO.2009.25.6693","article-title":"Life Expectancy in Patients Surviving More Than 5 Years After Hematopoietic Cell Transplantation","volume":"28","author":"Martin","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1038\/bcj.2011.14","article-title":"Long-term complications and side effects after allogeneic hematopoietic stem cell transplantation: An update","volume":"1","author":"Mohty","year":"2011","journal-title":"Blood Cancer J."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1182\/blood-2007-11-118893","article-title":"Chronic graft-versus-host disease following umbilical cord blood transplantation: Retrospective survey involving 1072 patients in Japan","volume":"112","author":"Narimatsu","year":"2008","journal-title":"Blood"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.scr.2011.05.002","article-title":"Both human and mouse mesenchymal stem cells promote breast cancer metastasis","volume":"7","author":"Albarenque","year":"2011","journal-title":"Stem Cell Res."},{"key":"ref_116","first-page":"3603","article-title":"Bone marrow-derived mesenchymal stem cells as vehicles for interferon-\u03b2 delivery into tumors","volume":"62","author":"Studeny","year":"2002","journal-title":"Cancer Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1002\/stem.187","article-title":"Direct evidence of mesenchymal stem cell tropism for tumor and wounding microenvironments using in vivo bioluminescent imaging","volume":"27","author":"Kidd","year":"2009","journal-title":"Stem Cells"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0305-7372(84)90047-1","article-title":"Studies on drug resistance in a human melanoma xenograft system","volume":"11","author":"Osieka","year":"1984","journal-title":"Cancer Treat. Rev."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1093\/jnci\/85.8.632","article-title":"Induction of Multidrug Resistance in Human Cells by Transient Exposure to Different Chemotherapeutic Drugs","volume":"85","author":"Chaudhary","year":"1993","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.3389\/fimmu.2017.01626","article-title":"Anti-Donor Immune Responses Elicited by Allogeneic Mesenchymal Stem Cells and Their Extracellular Vesicles: Are We Still Learning?","volume":"8","author":"Lohan","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1182\/blood-2005-03-1004","article-title":"Allogeneic marrow stromal cells are immune rejected by MHC class I\u2013 and class II\u2013mismatched recipient mice","volume":"106","author":"Eliopoulos","year":"2005","journal-title":"Blood"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/icb.2012.67","article-title":"Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: What have we learned so far?","volume":"91","author":"Griffin","year":"2012","journal-title":"Immunol. Cell Boil."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1182\/blood-2005-11-011650","article-title":"Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting","volume":"108","author":"Nauta","year":"2006","journal-title":"Blood"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1111\/j.1582-4934.2011.01509.x","article-title":"Immunogenicity of allogeneic mesenchymal stem cells","volume":"16","author":"Schu","year":"2012","journal-title":"J. Cell. Mol. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/S0140-6736(08)60690-X","article-title":"Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: A phase II study","volume":"371","author":"Frassoni","year":"2008","journal-title":"Lancet"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/2277-9175.98152","article-title":"Viral and nonviral delivery systems for gene delivery","volume":"1","author":"Nayerossadat","year":"2012","journal-title":"Adv. Biomed. Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/s41551-018-0310-2","article-title":"Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy","volume":"2","author":"Hu","year":"2018","journal-title":"Nat. Biomed. Eng."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/3\/563\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:02:25Z","timestamp":1760173345000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/3\/563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,28]]},"references-count":127,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3]]}},"alternative-id":["cells9030563"],"URL":"https:\/\/doi.org\/10.3390\/cells9030563","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,28]]}}}