{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T20:45:34Z","timestamp":1782333934465,"version":"3.54.5"},"reference-count":160,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1185918N"],"award-info":[{"award-number":["1185918N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1189120N"],"award-info":[{"award-number":["1189120N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G067314N"],"award-info":[{"award-number":["G067314N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G0D9917N"],"award-info":[{"award-number":["G0D9917N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003132","name":"Agentschap voor Innovatie door Wetenschap en Technologie","doi-asserted-by":"publisher","award":["SBO-HILIM3D"],"award-info":[{"award-number":["SBO-HILIM3D"]}],"id":[{"id":"10.13039\/501100003132","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Acute and chronic liver failure is a highly prevalent medical condition with high morbidity and mortality. Currently, the therapy is orthotopic liver transplantation. However, in some instances, chiefly in the setting of metabolic diseases, transplantation of individual cells, specifically functional hepatocytes, can be an acceptable alternative. The gold standard for this therapy is the use of primary human hepatocytes, isolated from livers that are not suitable for whole organ transplantations. Unfortunately, primary human hepatocytes are scarcely available, which has led to the evaluation of alternative sources of functional hepatocytes. In this review, we will compare the ability of most of these candidate alternative cell sources to engraft and repopulate the liver of preclinical animal models with the repopulation ability found with primary human hepatocytes. We will discuss the current shortcomings of the different cell types, and some of the next steps that we believe need to be taken to create alternative hepatocyte progeny capable of regenerating the failing liver.<\/jats:p>","DOI":"10.3390\/cells9030566","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T07:35:30Z","timestamp":1583134530000},"page":"566","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Alternative Cell Sources for Liver Parenchyma Repopulation: Where Do We Stand?"],"prefix":"10.3390","volume":"9","author":[{"given":"Tine","family":"Tricot","sequence":"first","affiliation":[{"name":"Stem Cell Institute Leuven, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolan","family":"De Boeck","sequence":"additional","affiliation":[{"name":"Stem Cell Institute Leuven, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Verfaillie","sequence":"additional","affiliation":[{"name":"Stem Cell Institute Leuven, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-pathmechdis-012419-032824","article-title":"Liver Progenitors and Adult Cell Plasticity in Hepatic Injury and Repair: Knowns and Unknowns","volume":"15","author":"Ko","year":"2020","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.5966\/sctm.2015-0260","article-title":"Concise Review: Updated Advances and Current Challenges in Cell Therapy for Inborn Liver Metabolic Defects","volume":"5","author":"Najimi","year":"2016","journal-title":"Stem Cells Transl. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/nature01531","article-title":"Cell fusion is the principal source of bone-marrow-derived hepatocytes","volume":"422","author":"Wang","year":"2003","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1096\/fj.06-6109com","article-title":"Human cord blood CD34+ cells develop into hepatocytes in the livers of NOD\/SCID\/\u03b3cnull mice through cell fusion","volume":"21","author":"Fujino","year":"2007","journal-title":"FASEB J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1053\/j.gastro.2011.11.030","article-title":"Direct and indirect contribution of human embryonic stem cellderived hepatocyte-like cells to liver repair in mice","volume":"142","author":"Woo","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1089\/scd.2012.0395","article-title":"Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Liver Fibrosis","volume":"22","author":"Li","year":"2012","journal-title":"Stem Cells Dev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nrgastro.2010.44","article-title":"Human hepatocyte transplantation: Current experience and future challenges","volume":"7","author":"Dhawan","year":"2010","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_8","first-page":"1273","article-title":"Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes","volume":"151","author":"Overturf","year":"1997","journal-title":"Am. J. Pathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1136\/gutjnl-2015-311146","article-title":"Quantitative evaluation of human bone mesenchymal stem cells rescuing fulminant hepatic failure in pigs","volume":"66","author":"Shi","year":"2017","journal-title":"Gut"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2353\/ajpath.2010.090675","article-title":"Liver regeneration after partial hepatectomy: Critical analysis of mechanistic dilemmas","volume":"176","author":"Michalopoulos","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1042\/bj1090087","article-title":"Effects of the Hepatotoxic Agents Retrorsine and Aflatoxin B1 on Hepatic Protein Synthesis in Rat","volume":"109","author":"Leavert","year":"1968","journal-title":"Biochem. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1126\/science.8108734","article-title":"Replacement of diseased mouse liver by hepatic cell transplantation","volume":"263","author":"Rhim","year":"1994","journal-title":"Science"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0142145","article-title":"Generation of novel Chimeric mice with humanized livers by using hemizygous cDNA-uPA\/SCID mice","volume":"10","author":"Tateno","year":"2015","journal-title":"PLoS ONE"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1073\/pnas.95.1.310","article-title":"Liver repopulation with xenogenic hepatocytes in B and T cell-deficient mice leads to chronic hepadnavirus infection and clonal growth of hepatocellular carcinoma","volume":"95","author":"Petersen","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1053\/jhep.2001.23314","article-title":"Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus","volume":"33","author":"Dandri","year":"2001","journal-title":"Hepatology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.2353\/ajpath.2009.090117","article-title":"Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter- enhancer urokinase-type plasminogen activator mice","volume":"175","author":"Haridass","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/nbt1326","article-title":"Robust expansion of human hepatocytes in Fah-\/-\/Rag2-\/-\/Il2rg-\/- mice","volume":"25","author":"Azuma","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"20507","DOI":"10.1073\/pnas.0710528105","article-title":"Repopulation of adult and neonatal mice with human hepatocytes: A chimeric animal model","volume":"104","author":"Bissig","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.scr.2014.08.006","article-title":"Extensive double humanization of both liver and hematopoiesis in FRGN mice","volume":"13","author":"Wilson","year":"2014","journal-title":"Stem Cell Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2018.00908","article-title":"A chimeric humanized mouse model by engrafting the human induced pluripotent stem cell-derived hepatocyte-like cell for the chronic hepatitis B virus infection","volume":"9","author":"Yuan","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.7150\/thno.30009","article-title":"Agonist c-Met Monoclonal Antibody Augments the Proliferation of hiPSC-derived Hepatocyte-Like Cells and Improves Cell Transplantation Therapy for Liver Failure in Mice","volume":"9","author":"Yuan","year":"2019","journal-title":"Theranostics"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.bbrc.2011.01.042","article-title":"The reconstituted \u201chumanized liver\u201d in TK-NOG mice is mature and functional","volume":"405","author":"Hasegawa","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bbrc.2013.10.040","article-title":"A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections","volume":"441","author":"Kosaka","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1053\/j.gastro.2011.01.001","article-title":"A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease","volume":"140","author":"Washburn","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1038\/nprot.2012.083","article-title":"Generation of a humanized mouse model with both human immune system and liver cells to model hepatitis C virus infection and liver immunopathogenesis","volume":"7","author":"Bility","year":"2012","journal-title":"Nat. Protoc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0002-9440(10)63352-4","article-title":"Near completely humanized liver in mice shows human-type metabolic responses to drugs","volume":"165","author":"Tateno","year":"2004","journal-title":"Am. J. Pathol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cell.2014.11.050","article-title":"Long-term culture of genome-stable bipotent stem cells from adult human liver","volume":"160","author":"Huch","year":"2015","journal-title":"Cell"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1083\/jcb.43.3.506","article-title":"High-yield preparation of isolated rat liver parenchymal cells: A biochemical and fine structural study","volume":"43","author":"Berry","year":"1969","journal-title":"J. Cell Biol."},{"key":"ref_29","first-page":"313","article-title":"Correction of hyperbilirubinemia in the glucuronyltransferase-deficient rat by intraportal hepatocyte transplantation","volume":"9","author":"Groth","year":"1977","journal-title":"Transplant. Proc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/0309-1651(82)90187-4","article-title":"High yield preparation of isolated human adult hepatocytes by enzymatic perfusion of the liver","volume":"6","author":"Campion","year":"1982","journal-title":"Cell Biol. Int. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/hep.20657","article-title":"Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera","volume":"41","author":"Meuleman","year":"2005","journal-title":"Hepatology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/90968","article-title":"Hepatitis C virus replication in mice with chimeric human livers","volume":"7","author":"Mercer","year":"2001","journal-title":"Nat. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.cca.2005.09.022","article-title":"Human hepatocytes secrete soluble CD14, a process not directly influenced by HBV and HCV infection","volume":"366","author":"Meuleman","year":"2006","journal-title":"Clin. Chim. Acta"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/hep.24692","article-title":"A human monoclonal antibody targeting SR-BI precludes hepatitis C virus infection and viral spread in vitro and in vivo","volume":"55","author":"Meuleman","year":"2012","journal-title":"Hepatology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1172\/JCI40094","article-title":"Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment","volume":"120","author":"Bissig","year":"2010","journal-title":"J. Clin. Invest."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1053\/j.gastro.2013.09.009","article-title":"Mice with human livers","volume":"145","author":"Grompe","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1023\/A:1010175906791","article-title":"Investigation of functional and morphological integrity of freshly isolated and cryopreserved human hepatocytes","volume":"1","author":"Ostrowska","year":"2000","journal-title":"Cell Tissue Bank."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3727\/000000005783982765","article-title":"The effects of cryopreservation on human hepatocytes obtained from different sources of liver tissue","volume":"14","author":"Terry","year":"2005","journal-title":"Cell Transplant."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/pr.2017.284","article-title":"Human hepatocyte transplantation for liver disease: Current status and future perspectives","volume":"83","author":"Iansante","year":"2018","journal-title":"Pediatr. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1177\/096368979300200109","article-title":"Hepatocyte Transplantation in Man","volume":"2","author":"Mito","year":"1993","journal-title":"Cell Transplant."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/01.tp.0000231689.44266.ac","article-title":"Human hepatocyte transplantation: Worldwide results","volume":"82","author":"Fisher","year":"2006","journal-title":"Transplantation"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.cell.2018.11.013","article-title":"Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids","volume":"175","author":"Hu","year":"2018","journal-title":"Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"14003","DOI":"10.1038\/mtm.2014.3","article-title":"Human fetal liver cells for regulated ex vivo erythropoietin gene therapy","volume":"1","author":"Duijst","year":"2014","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.2353\/ajpath.2010.091154","article-title":"Liver xeno-repopulation with human hepatocytes in Fah -\/-Rag2-\/- mice after pharmacological immunosuppression","volume":"177","author":"He","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jhep.2016.04.022","article-title":"Humanized mice efficiently engrafted with fetal hepatoblasts and syngeneic immune cells develop human monocytes and NK cells","volume":"65","author":"Billerbeck","year":"2016","journal-title":"J. Hepatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1002\/hep.30425","article-title":"Pharmacological Induction of a Progenitor State for the Efficient Expansion of Primary Human Hepatocytes","volume":"69","author":"Unzu","year":"2019","journal-title":"Hepatology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jhep.2018.09.007","article-title":"Small molecule-mediated reprogramming of human hepatocytes into bipotent progenitor cells","volume":"70","author":"Kim","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41422-018-0103-x","article-title":"Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens","volume":"29","author":"Fu","year":"2019","journal-title":"Cell Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.stem.2018.10.018","article-title":"In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity","volume":"23","author":"Zhang","year":"2018","journal-title":"Cell Stem Cell"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e47313","DOI":"10.7554\/eLife.47313","article-title":"Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes","volume":"8","author":"Katsuda","year":"2019","journal-title":"eLife"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/stem.2710","article-title":"Long-Term Fate of Human Fetal Liver Progenitor Cells Transplanted in Injured Mouse Livers","volume":"36","author":"Irudayaswamy","year":"2018","journal-title":"Stem Cells"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/8904_2013_257","article-title":"Liver Engraftment and Repopulation by In Vitro Expanded Adult Derived Human Liver Stem Cells in a Child with Ornithine Carbamoyltransferase Deficiency","volume":"13","author":"Sokal","year":"2013","journal-title":"JIMD Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1097\/TP.0000000000002605","article-title":"Phase I\/II Trial of Liver-derived Mesenchymal Stem Cells in Pediatric Liver-based Metabolic Disorders: A Prospective, Open Label, Multicenter, Partially Randomized, Safety Study of One Cycle of Heterologous Human Adult Liver-derived Progenitor Cells (HepaStem) in Urea Cycle Disorders and Crigler-Najjar Syndrome Patients","volume":"103","author":"Smets","year":"2019","journal-title":"Transplantation"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.cell.2016.05.082","article-title":"Modeling Development and Disease with Organoids","volume":"165","author":"Clevers","year":"2016","journal-title":"Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3727\/215517913X666459","article-title":"Human Liver Progenitor Cells for Liver Repair","volume":"5","author":"Lombard","year":"2013","journal-title":"Cell Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-26584-1","article-title":"Expansion of human primary hepatocytes in vitro through their amplification as liver progenitors in a 3D organoid system","volume":"8","author":"Garnier","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1126\/science.284.5417.1168","article-title":"Bone marrow as a potential source of hepatic oval cells","volume":"284","author":"Petersen","year":"1999","journal-title":"Science"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/35018642","article-title":"Hepatocytes from non-hepatic adult stem cells","volume":"406","author":"Alison","year":"2000","journal-title":"Nature"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/81326","article-title":"Purified hematopoietic stem cells can differentiate into hepatocytes in vivo","volume":"6","author":"Lagasse","year":"2000","journal-title":"Nat. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/nm1062","article-title":"Myelomonocytic cells are sufficient for therapeutic cell fusion in liver","volume":"10","author":"Willenbring","year":"2004","journal-title":"Nat. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/nature01539","article-title":"Transplanted bone marrow regenerates liver by cell fusion","volume":"422","author":"Vassilopoulos","year":"2003","journal-title":"Nature"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00428-018-2497-8","article-title":"Donor-derived hepatocytes in human hematopoietic cell transplant recipients: Evidence of fusion","volume":"474","author":"Myerson","year":"2019","journal-title":"Virchows Arch."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0002-9440(10)64212-5","article-title":"Kinetics of liver repopulation after bone marrow transplantation","volume":"161","author":"Wang","year":"2002","journal-title":"Am. J. Pathol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/ncb1132","article-title":"Hematopoietic stem cells convert into liver cells within days without fusion","volume":"6","author":"Jang","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1053\/j.gastro.2007.12.024","article-title":"Native Umbilical Cord Matrix Stem Cells Express Hepatic Markers and Differentiate Into Hepatocyte-like Cells","volume":"134","author":"Campard","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S1499-3872(15)60354-X","article-title":"Mesenchymal stem cells from the human umbilical cord ameliorate fulminant hepatic failure and increase survival in mice","volume":"14","author":"Yang","year":"2015","journal-title":"Hepatob. Pancreat. Dis. Int."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Zhang, D.G., Jiang, M.Y., and Miao, D. (2011). Transplanted human amniotic membrane-derived mesenchymal stem cells ameliorate carbon tetrachloride-induced liver cirrhosis in mouse. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0016789"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1111\/jcmm.13396","article-title":"Effect of human amniotic epithelial cells on pro-fibrogenic resident hepatic cells in a rat model of liver fibrosis","volume":"22","author":"Cargnoni","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1136\/gutjnl-2018-316091","article-title":"HBV infection-induced liver cirrhosis development in dual-humanised mice with human bone mesenchymal stem cell transplantation","volume":"68","author":"Yuan","year":"2019","journal-title":"Gut"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.jhep.2014.10.030","article-title":"Microencapsulated human mesenchymal stem cells decrease liver fibrosis in mice","volume":"62","author":"Meier","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-017-0595-1","article-title":"Transplantation of human bone marrow mesenchymal stromal cells reduces liver fibrosis more effectively than Wharton\u2019s jelly mesenchymal stromal cells","volume":"8","author":"Rengasamy","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.3727\/096368912X659853","article-title":"Adult Human Liver Mesenchymal Stem\/Progenitor Cells Participate in Mouse Liver Regeneration after Hepatectomy","volume":"22","author":"Khuu","year":"2013","journal-title":"Cell Transplant."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"725","DOI":"10.5966\/sctm.2012-0034","article-title":"Human Mesenchymal Stem Cell Transfusion Is Safe and Improves Liver Function in Acute-on-Chronic Liver Failure Patients","volume":"1","author":"Shi","year":"2012","journal-title":"Stem Cells Transl. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1440-1746.2011.07024.x","article-title":"Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients","volume":"27","author":"Zhang","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1002\/hep.28693","article-title":"Transplantation With Autologous Bone Marrow-Derived Mesenchymal Stem Cells for Alcoholic Cirrhosis: Phase 2 Trial","volume":"64","author":"Suk","year":"2016","journal-title":"Hepatology"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1111\/jcmm.14115","article-title":"Strategies to improve the efficiency of mesenchymal stem cell transplantation for reversal of liver fibrosis","volume":"23","author":"Hu","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41581-018-0023-5","article-title":"Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases","volume":"14","author":"Shi","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s13287-017-0576-4","article-title":"Role of mesenchymal stem cells, their derived factors, and extracellular vesicles in liver failure","volume":"8","author":"Wang","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"685","DOI":"10.5966\/sctm.2014-0198","article-title":"Tracking Fusion of Human Mesenchymal Stem Cells After Transplantation to the Heart","volume":"4","author":"Freeman","year":"2015","journal-title":"Stem Cells Transl. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1002\/sctm.16-0226","article-title":"Extracellular vesicles from bone marrow-derived mesenchymal stem cells improve survival from lethal hepatic failure in mice","volume":"6","author":"Haga","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Baertschiger, R.M., Serre-Beinier, V., Morel, P., Bosco, D., Peyrou, M., Cl\u00e9ment, S., Sgroi, A., Kaelin, A., Buhler, L.H., and Gonelle-Gispert, C. (2009). Fibrogenic potential of human multipotent mesenchymal stromal cells in injured liver. PLoS ONE, 4.","DOI":"10.1371\/annotation\/0c224e4f-d48d-4c12-adfa-f2afd7b9a62f"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/s13287-017-0742-8","article-title":"V Immunoprivileged no more: Measuring the immunogenicity of allogeneic adult mesenchymal stem cells","volume":"8","author":"Berglund","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1177\/0963689717742819","article-title":"The Immunomodulatory Properties of Amniotic Cells: The Two Sides of the Coin","volume":"27","author":"Magatti","year":"2018","journal-title":"Cell Transplant."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1053\/j.gastro.2006.01.036","article-title":"The Bone Marrow Functionally Contributes to Liver Fibrosis","volume":"130","author":"Russo","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1136\/gut.2008.154880","article-title":"Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo","volume":"58","author":"Aurich","year":"2009","journal-title":"Gut"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/hep.21704","article-title":"Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes","volume":"46","author":"Banas","year":"2007","journal-title":"Hepatology"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-017-0656-5","article-title":"Upregulation of sodium taurocholate cotransporter polypeptide during hepatogenic differentiation of umbilical cord matrix mesenchymal stem cells facilitates hepatitis B entry","volume":"8","author":"Sargiacomo","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1016\/j.biomaterials.2006.03.022","article-title":"Inducing hepatic differentiation of human mesenchymal stem cells in pellet culture","volume":"27","author":"Ong","year":"2006","journal-title":"Biomaterials"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1080\/14653240902849754","article-title":"Differentiation of human umbilical cord mesenchymal stromal cells into low immunogenic hepatocyte-like cells","volume":"11","author":"Zhao","year":"2009","journal-title":"Cytotherapy"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.cellbi.2008.04.020","article-title":"Transdifferentiation of mesenchymal stem cells derived from human fetal lung to hepatocyte-like cells","volume":"32","author":"Ling","year":"2008","journal-title":"Cell Biol. Int."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1478-3231.2010.02231.x","article-title":"Transdifferentiation of adipose-derived stem cells into hepatocytes: A new approach","volume":"30","author":"Lue","year":"2010","journal-title":"Liver Int."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"7461","DOI":"10.3748\/wjg.v11.i47.7461","article-title":"Fibroblast growth factor-4 and hepatocyte growth factoc induce differentiation of human umbilical cord blood-derived mesenchymal stem cells into hepatocytes","volume":"11","author":"Kang","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1172\/JCI0215182","article-title":"Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells","volume":"109","author":"Schwartz","year":"2002","journal-title":"J. Clin. Invest."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/toxsci\/kfl058","article-title":"Sequential exposure to cytokines reflecting embryogenesis: The key for in vitro differentiation of adult bone marrow stem cells into functional hepatocyte-like cells","volume":"94","author":"Snykers","year":"2006","journal-title":"Toxicol. Sci."},{"key":"ref_95","first-page":"2009","article-title":"Differentiation of umbilical cord mesenchymal stem cells into hepatocytes in comparison with bone marrow mesenchymal stem cells","volume":"18","author":"Yu","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.tice.2013.12.006","article-title":"Valproic acid promotes differentiation of hepatocyte-like cells from whole human umbilical cord-derived mesenchymal stem cells","volume":"46","author":"An","year":"2014","journal-title":"Tissue Cell"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/jcmm.13027","article-title":"Induction of hepatocyte-like cells from human umbilical cord-derived mesenchymal stem cells by defined microRNAs","volume":"21","author":"Zhou","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/cddis.2013.429","article-title":"A set of microRNAs mediate direct conversion of human umbilical cord lining-derived mesenchymal stem cells into hepatocytes","volume":"4","author":"Cui","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2018.05.028","article-title":"Differentiation of umbilical cord derived mesenchymal stem cells to hepatocyte cells by transfection of miR-106a, miR-574-3p, and miR-451","volume":"667","author":"Khosravi","year":"2018","journal-title":"Gene"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"8995","DOI":"10.1016\/j.biomaterials.2012.08.058","article-title":"The differentiation of MSCs into functional hepatocyte-like cells in a liver biomatrix scaffold and their transplantation into liver-fibrotic mice","volume":"33","author":"Ji","year":"2012","journal-title":"Biomaterials"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000187716","article-title":"In vitro differentiation of human cord blood-derived unrestricted somatic stem cells into hepatocyte-like cells on poly(\u03b5-caprolactone) nanofiber scaffolds","volume":"190","author":"Hashemi","year":"2009","journal-title":"Cells Tissues Organs"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Hang, H., Yu, Y., Wu, N., Huang, Q., Xia, Q., and Bian, J. (2014). Induction of highly functional hepatocytes from human umbilical cord mesenchymal stem cells by HNF4\u03b1 transduction. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0104133"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.transproceed.2008.01.058","article-title":"Hepatocytes Derived From Adult Stem Cells","volume":"40","author":"Stock","year":"2008","journal-title":"Transplant. Proc."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1186\/s13287-018-1063-2","article-title":"Therapeutic efficiency of human amniotic epithelial stem cell-derived functional hepatocyte-like cells in mice with acute hepatic failure","volume":"9","author":"Liu","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_105","first-page":"1","article-title":"Hepatocytic Differentiation Potential of Human Fetal Liver Mesenchymal Stem Cells: In Vitro and in Vivo Evaluation","volume":"2016","author":"Pourcher","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Magatti, M., Stefani, F.R., Papait, A., Cargnoni, A., Masserdotti, A., Silini, A.R., and Parolini, O. (2019). Perinatal Mesenchymal Stromal Cells and Their Possible Contribution to Fetal-Maternal Tolerance. Cells, 8.","DOI":"10.3390\/cells8111401"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fmed.2014.00048","article-title":"Placental amniotic epithelial cells and their therapeutic potential in liver diseases","volume":"1","author":"Tahan","year":"2014","journal-title":"Front. Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"748","DOI":"10.3389\/fphar.2017.00748","article-title":"The Human Amnion Epithelial Cell Secretome Decreases Hepatic Fibrosis in Mice with Chronic Liver Fibrosis","volume":"8","author":"Alhomrani","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Manuelpillai, U., Lourensz, D., Vaghjiani, V., Tchongue, J., Lacey, D., Tee, J.-Y., Murthi, P., Chan, J., Hodge, A., and Sievert, W. (2012). Human amniotic epithelial cell transplantation induces markers of alternative macrophage activation and reduces established hepatic fibrosis. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038631"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/sctm.16-0449","article-title":"Liver-Directed Human Amniotic Epithelial Cell Transplantation Improves Systemic Disease Phenotype in Hurler Syndrome Mouse Model","volume":"6","author":"Rodriguez","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/hep.26150","article-title":"Placental stem cell correction of murine intermediate maple syrup urine disease","volume":"57","author":"Skvorak","year":"2013","journal-title":"Hepatology"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"630","DOI":"10.3109\/14653249.2012.663485","article-title":"Therapeutic effects of human amniotic epithelial stem cells in Niemann-Pick type C1 mice","volume":"14","author":"Hong","year":"2012","journal-title":"Cytotherapy"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1002\/hep.24255","article-title":"Hepatic differentiation of amniotic epithelial cells","volume":"53","author":"Marongiu","year":"2011","journal-title":"Hepatology"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"101471","DOI":"10.1016\/j.scr.2019.101471","article-title":"Hepatocyte-like cells derived from human amniotic epithelial, bone marrow, and adipose stromal cells display enhanced functionality when cultured on decellularized liver substrate","volume":"38","author":"Coronado","year":"2019","journal-title":"Stem Cell Res."},{"key":"ref_115","first-page":"383","article-title":"Potentiation of MyoD1 activity by 5-aza-2\u2019-deoxycytidine","volume":"1","author":"Chen","year":"1990","journal-title":"Cell Growth Differ."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep38694","article-title":"Functional human induced hepatocytes (hiHeps) with bile acid synthesis and transport capacities: A novel in vitro cholestatic model","volume":"6","author":"Ni","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.stem.2014.01.003","article-title":"Direct reprogramming of human fibroblasts to functional and expandable hepatocytes","volume":"14","author":"Huang","year":"2014","journal-title":"Cell Stem Cell"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s12072-013-9432-5","article-title":"Transdifferentiation of human fibroblasts into hepatocyte-like cells by defined transcriptional factors","volume":"7","author":"Kogiso","year":"2013","journal-title":"Hepatol. Int."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nprot.2015.059","article-title":"Reprogramming fibroblasts toward cardiomyocytes, neural stem cells and hepatocytes by cell activation and signaling-directed lineage conversion","volume":"10","author":"Zhu","year":"2015","journal-title":"Nat. Protoc."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.ejcb.2015.10.003","article-title":"Transcription factor-mediated reprograming of fibroblasts to hepatocyte-like cells","volume":"94","author":"Pournasr","year":"2015","journal-title":"Eur. J. Cell Biol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature13020","article-title":"Mouse liver repopulation with hepatocytes generated from human fibroblasts","volume":"508","author":"Zhu","year":"2014","journal-title":"Nature"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.stem.2014.01.008","article-title":"Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming","volume":"14","author":"Du","year":"2014","journal-title":"Cell Stem Cell"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.stem.2016.01.010","article-title":"Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis","volume":"18","author":"Song","year":"2016","journal-title":"Cell Stem Cell"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0092-8674(00)81692-X","article-title":"Stem cells: Units of development, units of regeneration, and units in evolution","volume":"100","author":"Weissman","year":"2000","journal-title":"Cell"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tracli.2009.04.006","article-title":"Pluripotent stem cells","volume":"16","author":"Verfaillie","year":"2009","journal-title":"Transfus. Clin. Biol."},{"key":"ref_127","first-page":"185","article-title":"Totipotency, pluripotency and nuclear reprogramming","volume":"114","author":"Mitalipov","year":"2009","journal-title":"Adv. Biochem. Eng. Biotechnol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts","volume":"282","author":"Thomson","year":"1998","journal-title":"Science"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1053\/j.gastro.2008.10.047","article-title":"Differentiation and Transplantation of Human Embryonic Stem Cell-Derived Hepatocytes","volume":"136","author":"Basma","year":"2009","journal-title":"Gastroenterology"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"5994","DOI":"10.1016\/j.biomaterials.2011.05.009","article-title":"Reprogramming induced pluripotent stem cells in the absence of c-Myc for differentiation into hepatocyte-like cells","volume":"32","author":"Li","year":"2011","journal-title":"Biomaterials"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1634\/stemcells.2007-0291","article-title":"Differentiation and Enrichment of Hepatocyte-Like Cells from Human Embryonic Stem Cells In Vitro and In Vivo","volume":"25","author":"Duan","year":"2007","journal-title":"Stem Cells"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.surg.2015.04.014","article-title":"Transplantation of human stem cell-derived hepatocytes in an animal model of acute liver failure","volume":"158","author":"Ramanathan","year":"2015","journal-title":"Surgery"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1089\/scd.2005.14.643","article-title":"Defined conditions for development of functional hepatic cells from human embryonic stem cells","volume":"14","author":"Schwartz","year":"2005","journal-title":"Stem Cells Dev."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.1172\/JCI75456","article-title":"Engrafted human stem cell-derived hepatocytes establish an infectious HCV murine model","volume":"124","author":"Carpentier","year":"2014","journal-title":"J. Clin. Invest."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s12015-011-9330-y","article-title":"Differentiation and Transplantation of Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells","volume":"9","author":"Asgari","year":"2013","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"82ra39","DOI":"10.1126\/scitranslmed.3002376","article-title":"In vivo liver regeneration potential of human induced pluripotent stem cells from diverse origins","volume":"3","author":"Liu","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/hep.29134","article-title":"Human embryonic stem cell\u2013derived hepatoblasts are an optimal lineage stage for hepatitis C virus infection","volume":"66","author":"Yan","year":"2017","journal-title":"Hepatology"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jhep.2015.11.013","article-title":"Stem cell-derived hepatocytes: A novel model for hepatitis E virus replication","volume":"64","author":"Helsen","year":"2016","journal-title":"J. Hepatol."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Nakamori, D., Takayama, K., Nagamoto, Y., Mitani, S., Sakurai, F., Tachibana, M., and Mizuguchi, H. (2015). Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c\/EBP\u03b1, and PROX1 transduction. Biochem. Biophys. Res. Commun., 5\u201310.","DOI":"10.1016\/j.bbrc.2015.12.007"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.jhep.2016.01.004","article-title":"Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure","volume":"64","author":"Nagamoto","year":"2016","journal-title":"J. Hepatol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.3727\/096368914X681702","article-title":"Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA\/SCID Mice by Overexpression of FNK, a Bcl-xLMutant Gene","volume":"24","author":"Nagamoto","year":"2015","journal-title":"Cell Transplant."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jhep.2014.08.016","article-title":"MicroRNA-199a-5p inhibition enhances the liver repopulation ability of human embryonic stem cell-derived hepatic cells","volume":"62","author":"Yang","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.biomaterials.2012.11.029","article-title":"3D spheroid culture of hESC\/hiPSC-derived hepatocyte-like cells for drug toxicity testing","volume":"34","author":"Takayama","year":"2013","journal-title":"Biomaterials"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Gieseck, R.L., Hannan, N.R.F., Bort, R., Hanley, N.A., Drake, R.A.L., Cameron, G.W.W., Wynn, T.A., and Vallier, L. (2014). Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0086372"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1089\/scd.2019.0064","article-title":"Guide to the Assessment of Mature Liver Gene Expression in Stem Cell-Derived Hepatocytes","volume":"28","author":"Zabulica","year":"2019","journal-title":"Stem Cells Dev."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jhep.2014.10.016","article-title":"Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes","volume":"62","author":"Baxter","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.bcp.2013.06.029","article-title":"Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells","volume":"86","author":"Ulvestad","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jhep.2015.05.013","article-title":"Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells","volume":"63","author":"Godoy","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1038\/s41598-019-39400-1","article-title":"A proteomic time course through the differentiation of human induced pluripotent stem cells into hepatocyte-like cells","volume":"9","author":"Hurrell","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1007\/s00204-016-1761-4","article-title":"Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue","volume":"90","author":"Godoy","year":"2016","journal-title":"Arch. Toxicol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00204-016-1694-y","article-title":"Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile","volume":"91","author":"Heslop","year":"2016","journal-title":"Arch. Toxicol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1002\/hep.20889","article-title":"Hepatocyte transplantation activates hepatic stellate cells with beneficial modulation of cell engraftment in the rat","volume":"42","author":"Benten","year":"2005","journal-title":"Hepatology"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1053\/gast.2002.36592","article-title":"Kupffer cells participate in early clearance of syngeneic hepatocytes transplanted in the rat liver","volume":"123","author":"Joseph","year":"2002","journal-title":"Gastroenterology"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1053\/j.gastro.2005.08.006","article-title":"Integrin and extracellular matrix interactions regulate engraftment of transplanted hepatocytes in the rat liver","volume":"129","author":"Kumaran","year":"2005","journal-title":"Gastroenterology"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1177\/0963689717737320","article-title":"Magnetic Targeting of Stem Cell Derivatives Enhances Hepatic Engraftment into Structurally Normal Liver","volume":"26","author":"Fagg","year":"2017","journal-title":"Cell Transplant."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/00003072-200006000-00012","article-title":"Use of indium-111-labeled hepatocytes to determine the biodistribution of transplanted hepatocytes through portal vein infusion","volume":"25","author":"Bohnen","year":"2000","journal-title":"Clin. Nucl. Med."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.3727\/096368915X686788","article-title":"Hepatic Stellate Cells Improve Engraftment of Human Primary Hepatocytes: A Preclinical Transplantation Study in an Animal Model","volume":"24","author":"Dusabineza","year":"2015","journal-title":"Cell Transplant."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1053\/j.gastro.2009.03.003","article-title":"Hepatic stellate cells promote hepatocyte engraftment in rat liver after prostaglandin-endoperoxide synthase inhibition","volume":"136","author":"Enami","year":"2009","journal-title":"Gastroenterology"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"352ra108","DOI":"10.1126\/scitranslmed.aaf2304","article-title":"Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration","volume":"8","author":"Fan","year":"2016","journal-title":"Sci. Transl. 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