{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:57:13Z","timestamp":1790355433144,"version":"4.1.0"},"reference-count":215,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T00:00:00Z","timestamp":1583107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u0438\u0439 \u0424\u043e\u043d\u0434 \u0424\u0443\u043d\u0434\u0430\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u044b\u0445 \u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439 (\u0420\u0424\u0424\u0418)","award":["19-515-55013"],"award-info":[{"award-number":["19-515-55013"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81961138017"],"award-info":[{"award-number":["81961138017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The Wnt signaling is one of the major pathways known to regulate embryonic development, tissue renewal and regeneration in multicellular organisms. Dysregulations of the pathway are a common cause of several types of cancer and other diseases, such as osteoporosis and rheumatoid arthritis. This makes Wnt signaling an important therapeutic target. Small molecule activators and inhibitors of signaling pathways are important biomedical tools which allow one to harness signaling processes in the organism for therapeutic purposes in affordable and specific ways. Natural products are a well known source of biologically active small molecules with therapeutic potential. In this article, we provide an up-to-date overview of existing small molecule modulators of the Wnt pathway derived from natural products. In the first part of the review, we focus on Wnt pathway activators, which can be used for regenerative therapy in various tissues such as skin, bone, cartilage and the nervous system. The second part describes inhibitors of the pathway, which are desired agents for targeted therapies against different cancers. In each part, we pay specific attention to the mechanisms of action of the natural products, to the models on which they were investigated, and to the potential of different taxa to yield bioactive molecules capable of regulating the Wnt signaling.<\/jats:p>","DOI":"10.3390\/cells9030589","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T13:06:23Z","timestamp":1583240783000},"page":"589","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives"],"prefix":"10.3390","volume":"9","author":[{"given":"Artem","family":"Blagodatski","sequence":"first","affiliation":[{"name":"School of Biomedicine, Far Eastern Federal University, Vladivostok 690090, Russia"},{"name":"Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonina","family":"Klimenko","sequence":"additional","affiliation":[{"name":"School of Biomedicine, Far Eastern Federal University, Vladivostok 690090, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Jia","sequence":"additional","affiliation":[{"name":"Institute of Oceanography, Minjiang University, Fuzhou 350108, China"},{"name":"Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou 350108, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7909-5617","authenticated-orcid":false,"given":"Vladimir L.","family":"Katanaev","sequence":"additional","affiliation":[{"name":"School of Biomedicine, Far Eastern Federal University, Vladivostok 690090, Russia"},{"name":"Institute of Oceanography, Minjiang University, Fuzhou 350108, China"},{"name":"Translational Research Center in Oncohaematology, Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,2]]},"reference":[{"key":"ref_1","first-page":"847","article-title":"Discovery and Victory of Penicillin (A. 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