{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:37:24Z","timestamp":1787027844558,"version":"build-2736575974"},"reference-count":56,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T00:00:00Z","timestamp":1583452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2018R1A5A2023879"],"award-info":[{"award-number":["NRF-2018R1A5A2023879"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2019R1A2C2085876"],"award-info":[{"award-number":["NRF-2019R1A2C2085876"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2017R1E1A1A01074316"],"award-info":[{"award-number":["NRF-2017R1E1A1A01074316"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Mesenchymal stromal cells (MSCs) from various sources exhibit different potential for stemness and therapeutic abilities. Recently, we reported a unique MSCs from human palatine tonsil (TMSCs) and their superior proliferation capacity compared to MSCs from other sources. However, unique characteristics of each MSC are not yet precisely elucidated. We investigated the role of stanniocalcin-1 (STC1), an anti-oxidative hormone, in the functions of TMSCs. We found that STC1 was highly expressed in TMSC compared with MSCs from bone marrow or adipose tissue. The proliferation, senescence and differentiation of TMSCs were assessed after the inhibition of STC1 expression. STC1 inhibition resulted in a significant decrease in the proliferation of TMSCs and did not affect the differentiation potential. To reveal the anti-oxidative ability of STC1 in TMSCs themselves or against other cell types, the generation of mitochondrial reactive oxygen species (ROS) in TMSC or ROS-mediated production of interleukin (IL)-1\u03b2 from macrophage-like cells were detected. Interestingly, the basal level of ROS generation in TMSCs was significantly elevated after STC1 inhibition. Moreover, down-regulation of STC1 impaired the inhibitory effect of TMSCs on IL-1\u03b2 production in macrophages. Taken together, these findings indicate that STC1 is highly expressed in TMSCs and plays a critical role in proliferating and ROS-regulatory abilities.<\/jats:p>","DOI":"10.3390\/cells9030636","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T09:26:41Z","timestamp":1583486801000},"page":"636","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Human Tonsil-Derived Mesenchymal Stromal Cells Maintain Proliferating and ROS-Regulatory Properties via Stanniocalcin-1"],"prefix":"10.3390","volume":"9","author":[{"given":"Yoojin","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Life Science in Dentistry, School of Dentistry, Pusan National University, Yangsan 50612, Korea"},{"name":"Dental and Life Science Institute, Pusan National University, Yangsan 50612, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Hoon","family":"Shin","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea"},{"name":"Translational Stem Cell Biology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Su","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Life Science in Dentistry, School of Dentistry, Pusan National University, Yangsan 50612, Korea"},{"name":"Dental and Life Science Institute, Pusan National University, Yangsan 50612, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Jeong","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Life Science in Dentistry, School of Dentistry, Pusan National University, Yangsan 50612, Korea"},{"name":"Dental and Life Science Institute, Pusan National University, Yangsan 50612, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye Young","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Life Science in Dentistry, School of Dentistry, Pusan National University, Yangsan 50612, Korea"},{"name":"Dental and Life Science Institute, Pusan National University, Yangsan 50612, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Won","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Life Science in Dentistry, School of Dentistry, Pusan National University, Yangsan 50612, Korea"},{"name":"Dental and Life Science Institute, Pusan National University, Yangsan 50612, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Young","family":"Park","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2329-0648","authenticated-orcid":false,"given":"Sung-Chan","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, College of Medicine, Pusan National University and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4089-8639","authenticated-orcid":false,"given":"Hyun-Keun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, College of Medicine, Pusan National University and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3608-765X","authenticated-orcid":false,"given":"Ji Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, College of Medicine, Pusan National University and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eui-Suk","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Biomedical Research Institute, Pusan National University School of Medicine, Yangsan Pusan National University Hospital, Yangsan 50612, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7346-8550","authenticated-orcid":false,"given":"Gi Cheol","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 51353, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Joo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, College of Medicine, Pusan National University and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung-Sik","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Life Science in Dentistry, School of Dentistry, Pusan National University, Yangsan 50612, Korea"},{"name":"Dental and Life Science Institute, Pusan National University, Yangsan 50612, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1242\/jcs.02932","article-title":"Mesenchymal stem cells reside in virtually all post-natal organs and 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